14,452 research outputs found
Development of a drive system for a sequential space camera contract modification 4(S)
The brush type dc motor and clutch were eliminated from the design of the 16 mm space sequential camera design and replaced by an electronically commutated motor. The new drive system reduces the current consumption at 24 fps to 220 mA. The drive can be programmed and controlled externally from the multipurpose programmable timer/intervalometer, as well as being controlled locally from the camera
Effective slip boundary conditions for flows over nanoscale chemical heterogeneities
We study slip boundary conditions for simple fluids at surfaces with
nanoscale chemical heterogeneities. Using a perturbative approach, we examine
the flow of a Newtonian fluid far from a surface described by a heterogeneous
Navier slip boundary condition. In the far-field, we obtain expressions for an
effective slip boundary condition in certain limiting cases. These expressions
are compared to numerical solutions which show they work well when applied in
the appropriate limits. The implications for experimental measurements and for
the design of surfaces that exhibit large slip lengths are discussed.Comment: 14 pages, 3 figure
Organising for self-advocacy in mental health: Experiences from seven African countries
Objective: This paper reports on overarching strategies which supported the establishment and sustainability of 9 mental health self-help organisations in seven African countries. Method: Eleven key informants were identified through snowballing andinterviewed regarding their experience in the organisations. Thematic analysis of the interview data and other documentary evidence was guided by a coding scheme derived using a framework analysis approach to defining, categorising, mapping and interpreting textual data. Results: Sustainability strategies include: commitment to members’ advocating for their rights and rebuilding their lives within their communities; independent decision-making, user-led membership and leadership; financial selfsufficiency, alliances with donor organisations, non-governmental organisations (NGOs), disabled people’s organisations (DPOs) and ministries which support self-determination and promote control over agenda-setting and responsiveness to members’ needs.Organisations’ work include advocacy to destigmatise mental disorders and promote the protection of users rights, activities to improve access to health care and to income generation and social support, participation in legislative and policy reform, and capacity building of members. Conclusion: Self-help organisations can provide crucial support to users’ recovery in resourcepoor settings in Africa. Support of Ministries, NGOs, DPOs, development agencies and professionals can assist to buildorganisations’ capacity for sustainable support to members’ recovery.Keywords: Mental health, Self-help, Advocacy, Recovery, Afric
Fault-tolerant linear optical quantum computing with small-amplitude coherent states
Quantum computing using two optical coherent states as qubit basis states has
been suggested as an interesting alternative to single photon optical quantum
computing with lower physical resource overheads. These proposals have been
questioned as a practical way of performing quantum computing in the short term
due to the requirement of generating fragile diagonal states with large
coherent amplitudes. Here we show that by using a fault-tolerant error
correction scheme, one need only use relatively small coherent state amplitudes
() to achieve universal quantum computing. We study the effects
of small coherent state amplitude and photon loss on fault tolerance within the
error correction scheme using a Monte Carlo simulation and show the quantity of
resources used for the first level of encoding is orders of magnitude lower
than the best known single photon scheme. %We study this reigem using a Monte
Carlo simulation and incorporate %the effects of photon loss in this
simulation
Scattering of second sound waves by quantum vorticity
A new method of detection and measurement of quantum vorticity by scattering
second sound off quantized vortices in superfluid Helium is suggested.
Theoretical calculations of the relative amplitude of the scattered second
sound waves from a single quantum vortex, a vortex ring, and bulk vorticity are
presented. The relevant estimates show that an experimental verification of the
method is feasible. Moreover, it can even be used for the detection of a single
quantum vortex.Comment: Latex file, 9 page
Boson Sampling from Gaussian States
We pose a generalized Boson Sampling problem. Strong evidence exists that
such a problem becomes intractable on a classical computer as a function of the
number of Bosons. We describe a quantum optical processor that can solve this
problem efficiently based on Gaussian input states, a linear optical network
and non-adaptive photon counting measurements. All the elements required to
build such a processor currently exist. The demonstration of such a device
would provide the first empirical evidence that quantum computers can indeed
outperform classical computers and could lead to applications
A Protocol for Generating Random Elements with their Probabilities
We give an AM protocol that allows the verifier to sample elements x from a
probability distribution P, which is held by the prover. If the prover is
honest, the verifier outputs (x, P(x)) with probability close to P(x). In case
the prover is dishonest, one may hope for the following guarantee: if the
verifier outputs (x, p), then the probability that the verifier outputs x is
close to p. Simple examples show that this cannot be achieved. Instead, we show
that the following weaker condition holds (in a well defined sense) on average:
If (x, p) is output, then p is an upper bound on the probability that x is
output. Our protocol yields a new transformation to turn interactive proofs
where the verifier uses private random coins into proofs with public coins. The
verifier has better running time compared to the well-known Goldwasser-Sipser
transformation (STOC, 1986). For constant-round protocols, we only lose an
arbitrarily small constant in soundness and completeness, while our public-coin
verifier calls the private-coin verifier only once
Scattering of first and second sound waves by quantum vorticity in superfluid Helium
We study the scattering of first and second sound waves by quantum vorticity
in superfluid Helium using two-fluid hydrodynamics. The vorticity of the
superfluid component and the sound interact because of the nonlinear character
of these equations. Explicit expressions for the scattered pressure and
temperature are worked out in a first Born approximation, and care is exercised
in delimiting the range of validity of the assumptions needed for this
approximation to hold. An incident second sound wave will partly convert into
first sound, and an incident first sound wave will partly convert into second
sound. General considerations show that most incident first sound converts into
second sound, but not the other way around. These considerations are validated
using a vortex dipole as an explicitely worked out example.Comment: 24 pages, Latex, to appear in Journal of Low Temperature Physic
The Successful Operation of Hole-type Gaseous Detectors at Cryogenic Temperatures
We have demonstrated that hole-type gaseous detectors, GEMs and capillary
plates, can operate up to 77 K. For example, a single capillary plate can
operate at gains of above 10E3 in the entire temperature interval between 300
until 77 K. The same capillary plate combined with CsI photocathodes could
operate perfectly well at gains (depending on gas mixtures) of 100-1000.
Obtained results may open new fields of applications for capillary plates as
detectors of UV light and charge particles at cryogenic temperatures: noble
liquid TPCs, WIMP detectors or LXe scintillating calorimeters and cryogenic
PETs.Comment: Presented at the IEEE Nuclear Science Symposium, Roma, 200
Biochemical and clinical response after umbilical cord blood transplant in a boy with early childhood-onset beta-mannosidosis.
BACKGROUND: Deficiency in the enzyme β-mannosidase was described over three decades ago. Although rare in occurrence, the presentation of childhood-onset β-mannosidase deficiency consists of hypotonia in the newborn period followed by global development delay, behavior problems, and intellectual disability. No effective pharmacologic treatments have been available.
METHODS: We report 2-year outcomes following the first umbilical cord blood transplant in a 4-year-old boy with early childhood-onset disease.
RESULTS: We show restoration of leukocyte β-mannosidase activity which remained normal at 2 years posttransplant, and a simultaneous increase in plasma β-mannosidase activity and dramatic decrease in urine-free oligosaccharides were also observed. MRI of the brain remained stable. Neurocognitive evaluation revealed test point gains, although the magnitude of improvement was less than expected for age, causing lower IQ scores that represent a wider developmental gap between the patient and unaffected peers.
CONCLUSION: Our findings suggest that hematopoietic cell transplant can correct the biochemical defect in β-mannosidosis, although preservation of the neurocognitive trajectory may be a challenge
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