Características clínicas y epidemiológicas del recién nacido de madre adolescente en hospital regional Huacho 2021

Objetivo: Determinar y describir las características clínicas y epidemiológicas del recién nacido hijo de madre adolescente en Hospital Regional Huacho 2021. Materiales y métodos: fue un estudio descriptivo y transversal, por medio de revisión de historias clínicas correspondientes al Hospital Regional de Huacho del periodo que comprendió todo el año 2021, encontrándose 347 casos de recién nacidos de madre adolescente de los 393 casos registrados en la base de datos del hospital en mención, recolectados mediante un instrumento previamente validado por juicio de expertos. Resultados: de los 2898 nacimientos en el 2021 el 13,6% (393) provenían de madres adolescentes. De los 347 casos estudiados, el 91,6% fue a término, 8,4% fueron pretérmino y ningún postérmino. El 87,9% de los neonatos presentaron un adecuado peso al nacer, 6,1% bajo peso, un 4,3% elevado peso al nacer y 1,4% muy bajo peso al nacer. Se encontró 135 casos de morbilidad, de los cuales 20,7% presentaron ictericia neonatal y 6,7% incompatibilidad ABO, 20% fueron grandes para edad gestacional y 14,07% pequeños para edad gestacional. El tipo de parto más frecuente fue el eutócico con un 63%. El Apgar fue normal en un 94,2%. La edad materna predominante correspondió a la adolescencia tardía (17-19 años) en un 74,9%. El sexo que predominó fue el masculino en un 54,2%. El 66,6% de madres adolescentes provenía de zonas urbanas. El estado civil conviviente representó un 77,2%. El nivel de instrucción más frecuente fue la secundaria completa en un 46,3%. Las primíparas representaron un 79%. Conclusiones: Se evidenció con más frecuencia en los recién nacidos de madre adolescente: la edad gestacional a término, un adecuado peso al nacer, la ictericia neonatal, el parto eutócico, el Apgar normal, la edad materna adolescente tardía, el sexo masculino, la procedencia urbana, el estado civil conviviente, nivel de instrucción secundario y la primiparida

Relationship between olive oil consumption and ankle-brachial pressure index in a population at high cardiovascular risk

The aim of this study was to ascertain the association between the consumption of different categories of edible olive oils (virgin olive oils and olive oil) and olive pomace oil and ankle-brachial pressure index (ABI) in participants in the PREDIMED-Plus study, a trial of lifestyle modification for weight and cardiovascular event reduction in individuals with overweight/obesity harboring the metabolic syndrome. Methods: We performed a cross-sectional analysis of the PREDIMED-Plus trial. Consumption of any category of olive oil and olive pomace oil was assessed through a validated food-frequency questionnaire. Multivariable linear regression models were fitted to assess associations between olive oil consumption and ABI. Additionally, ABI ≤1 was considered as the outcome in logistic models with different categories of olive oil and olive pomace oil as exposure. Results: Among 4330 participants, the highest quintile of total olive oil consumption (sum of all categories of olive oil and olive pomace oil) was associated with higher mean values of ABI (beta coefficient: 0.014, 95% confidence interval [CI]: 0.002, 0.027) (p for trend = 0.010). Logistic models comparing the consumption of different categories of olive oils, olive pomace oil and ABI ≤1 values revealed an inverse association between virgin olive oils consumption and the likelihood of a low ABI (odds ratio [OR] 0.73, 95% CI [0.56, 0.97]), while consumption of olive pomace oil was positively associated with a low ABI (OR 1.22 95% CI [1.00, 1.48]). Conclusions: In a Mediterranean population at high cardiovascular risk, total olive oil consumption was associated with a higher mean ABI. These results suggest that olive oil consumption may be beneficial for peripheral artery disease prevention, but longitudinal studies are needed

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Anales del III Congreso Internacional de Vivienda y Ciudad "Debate en torno a la nueva agenda urbana"

Acta de congresoEl III Congreso Internacional de Vivienda y Ciudad “Debates en torno a la NUEVa Agenda Urbana”, ha sido una apuesta de alto compromiso por acercar los debates centrales y urgentes que tensionan el pleno ejercicio del derecho a la ciudad. Para ello las instituciones organizadoras (INVIHAB –Instituto de Investigación de Vivienda y Hábitat y MGyDH-Maestría en Gestión y Desarrollo Habitacional-1), hemos convidado un espacio que se concretó con potencia en un debate transdisciplinario. Convocó a intelectuales de prestigio internacional, investigadores, académicos y gestores estatales, y en una metodología de innovación articuló las voces académicas con las de las organizaciones sociales y/o barriales en el Foro de las Organizaciones Sociales que tuvo su espacio propio para dar voz a quienes están trabajando en los desafíos para garantizar los derechos a la vivienda y los bienes urbanos en nuestras ciudades del Siglo XXI

Retos, avances y reflexiones transdisciplinares desde contextos educativos diversos

La publicación de las ponencias que conformaron el V Congreso Internacional de Educación de la Universidad Nacional de Educación, titulado Retos, avances y reflexiones transdisciplinares desde contextos educativos diversos, ofrece una visión comprensiva y multifacética de la educación contemporánea. A través de ocho ejes temáticos, entre los que se incluye la formación integral y el desarrollo profesional, la teoría y la práctica en la formación profesional docente, la relación entre sociedad y escuela, la gestión educativa y las tecnologías para la educación, esta recopilación busca contribuir al conocimiento académico sobre la educación y, al mismo tiempo, ser fuente de información e inspiración para educadores, investigadores y todas aquellas personas interesadas en el desarrollo educativo

Confirmation of the presence of the Striped Lizard Eater, Mastigodryas dorsalis (Bocourt, 1890) (Squamata, Colubridae), in Mexico

The snake Mastigodryas dorsalis (Bocourt, 1890) is generally considered absent from Mexico, but a few sources indicate otherwise. Herein we resolve this issue by re-examining a historical specimen and by reporting new records for M. dorsalis in Chiapas, Mexico. These records extend the known distribution of the species 87 km northwest of the nearest pre-existing record in Guatemala. Additionally, based on these new records and an exhaustive literature review, we present an updated distribution for the species and revise its known elevational range to 300–2110 m. A complete Spanish translation of this paper is available in the Supplemental Data. Una traducción completa al español de este artículo está disponible en los Datos Suplementarios

Dispositivo óptico para identificación de regiones tumorales

ABSTRACT: The present invention relates to an optical device for identifying tumour regions in different organs, for example such as the brain.RESUMEN: La presente invención se refiere a un dispositivo óptico para identificación de regiones tumorales en distintos órganos, como por ejemplo el cerebro.Solicitud Internacional: PCT/ES2021070450W (18.06.2021)Nº Pub. Internacional: WO2021/260244A1 (30.12.2021

Dispositivo óptico para identificación de regiones tumorales

ABSTRACT: The present invention relates to an optical device for identifying tumour regions in different organs, such as the brain. The device comprises: a plurality of chips, each chip having a metallic nanostructured surface; means for receiving a tissue sample to be analysed and depositing it on one of the chips when the chip is disposed in an illumination area; a light source configured to provide a light beam to illuminate the chip on which the sample has been deposited; and a spectrometer for receiving a light beam reflected by the chip, configured to extract the spectral response of the light reflected by same. The spectral response depends on the refractive index of the tissue sample analysed, which, in turn, depends on whether the tissue is necrotic, tumoural or peritumoural.RESUMEN: La presente invención se refiere a un dispositivo óptico para identificación de regiones tumorales en distintos órganos, como por ejemplo el cerebro. El dispositivo comprende una pluralidad de chips, cada chip con una superficie metálica nanoestructurada, medios para recibir una muestra de tejido a analizar y para depositarla sobre uno de los chips cuando esté situado en una zona de iluminación, una fuente de luz configurada para proporcionar un haz de luz para iluminar el chip sobre el que se ha depositado la muestra, un espectrógrafo para recibir un haz de luz reflejado por dicho chip configurado para extraer la respuesta espectral de la luz reflejada por el mismo. La respuesta espectral depende del índice de refracción de la muestra de tejido analizado, que a su vez depende de si el tejido es un tejido necrosado, tumoral o peritumoral.Solicitud Internacional: PCT/ES2021/070451 (18.06.2020)Nº de Pub. Internacional: WO/2021/260245A1 (30.12.2021

Discriminating glioblastoma from peritumoral tissue by a nanohole array-based optical and label-free biosensor

In glioblastoma (GBM) patients, maximal safe resection remains a challenge today due to its invasiveness and diffuse parenchymal infiltration. In this context, plasmonic biosensors could potentially help to discriminate tumor tissue from peritumoral parenchyma based on differences in their optical properties. A nanostructured gold biosensor was used ex vivo to identify tumor tissue in a prospective series of 35 GBM patients who underwent surgical treatment. For each patient, two paired samples, tumor and peritumoral tissue, were extracted. Then, the imprint left by each sample on the surface of the biosensor was individually analyzed, obtaining the difference between their refractive indices. The tumor and non-tumor origins of each tissue were assessed by histopathological analysis. The refractive index (RI) values obtained by analyzing the imprint of the tissue were significantly lower (p = 0.0047) in the peritumoral samples (1.341, Interquartile Range (IQR) 1.339–1.349) compared with the tumor samples (1.350, IQR 1.344–1.363). The ROC (receiver operating characteristic) curve showed the capacity of the biosensor to discriminate between both tissues (area under the curve, 0.8779, p < 0.0001). The Youden index provided an optimal RI cut-off point of 0.003. The sensitivity and specificity of the biosensor were 81% and 80%, respectively. Overall, the plasmonic-based nanostructured biosensor is a label-free system with the potential to be used for real-time intraoperative discrimination between tumor and peritumoral tissue in patients with GBM.Funding: This work was supported by the Ministerio de Ciencia e Innovación grant PID2021- 128220NB-100, the Instituto de Salud Carlos III through grant DTS18/00141, co-funded by the European Regional Development Fund/European Social Fund, “A way to make Europe/Investing in your future”, and the Instituto de Investigación Valdecilla (IDIVAL) (APG/03). Acknowledgments: The authors are grateful to Olga Gutierrez and Paula Calzada for their technical help