Versatile protein-templated TiO2 nanocomposite for energy storage and catalytic applications

A protein-templated titania nanocomposite (PT-TiO2) was successfully synthesized by a water-free mechanochemical approach. A biomass valorization strategy was developed by employing egg white from expired eggs to control the morphology and textural features of the prepared titania. A remarkable enhancement of the surface area was achieved, in comparison with the synthesis of the material in absence of the biomass-derived template. Several techniques, such as scanning electron microscopy-mapping and CNHS analysis, supported the presence of carbon, nitrogen and sulfur residues in the obtained composite. Catalytic performance of PT-TiO2 was explored in the oxidation of diphenyl sulfide, displaying promising results in terms of conversion, selectivity and stability. The effect of the oxidant agent was additionally investigated by using hydrogen peroxide, urea hydrogen peroxide, oxygen and t-butyl-hydroperoxide. On the other hand, PT-TiO2 nanocomposite was successfully proved as anodic material for lithium-ion batteries delivering a reversible capacity of 107 mAh g–1 at 0.1C with an excellent Coulombic efficiency of 100% from the second cycle. In addition, the as-synthesized material showed significant capacity retention values of 76% among the 2nd cycle and 100th cycle. PT-TiO2 resulted to be a versatile material with potential catalytic and energy storage applications

Dialogicidades y actuaciones multiculturales del buen vivir en la Institución Etnoeducativa Rural Bilingüe Artesanal Kamentzá

Maestría en Educación desde la Diversidad, Facultad de Ciencias Sociales y Humanas.El presente artículo contempla los principales aspectos en torno a las dialogicidades y actuaciones multiculturales del Buen Vivir, en donde se reconocen los fenómenos sociales, afectaciones y sentires en un mismo territorio. El estudio investigativo devela el reconocimiento de lo Propio, el fortaleciendo de la identidad de la comunidad indígena Kamëntšá y el protagonismo de la Institución Etnoeducativa Rural Bilingüe Artesanal Kamëntšá, con su Proyecto Educativo Institucional Diferencial. La investigación se inscribe en el paradigma cualitativo, que permite reconocer el comportamiento social de los individuos y el estudio sistemático de las realidades colectivas y su diseño se cimentó en la Ruta Propia de la comunidad Indígena, en donde se establecen criterios identitarios de los Kamëntšá, el cual se configuró como una construcción colectiva y se encuentra documentado en su plan de Salvaguarda. La aplicación de las técnicas interactivas de recolección de información y el análisis de los datos en el transcurso investigativo develaron las condiciones que permiten el Buen Vivir tras la lucha de la salvaguarda de los saberes ancestrales y el concepto del Buen Vivir como guía aplicable a la praxis social, para la construcción de conocimiento multicultural

Dialogicidades y actuaciones multiculturales del buen vivir en la institución etnoeducativa rural bilingue artesal Kamentsa.

Maestría en Educación desde la Diversidad, Facultad de Ciencias Sociales y Humanas.El presente documento contempla los principales aspectos en torno a las dialogicidades y actuaciones multiculturales del Buen Vivir, en donde se reconocen los fenómenos sociales, afectaciones y sentires en un mismo territorio. El estudio investigativo devela el reconocimiento de lo Propio, el fortaleciendo de la identidad de la comunidad indígena Kamëntšá y el protagonismo de la Institución Etnoeducativa Rural Bilingüe Artesanal Kamëntšá, con su Proyecto Educativo Institucional Diferencial. La investigación se inscribe en el paradigma cualitativo, que permite reconocer el comportamiento social de los individuos y el estudio sistemático de las realidades colectivas y su diseño se cimentó en la Ruta Propia de la comunidad Indígena, en donde se establecen criterios identitarios de los Kamëntšá, el cual se configuró como una construcción colectiva y se encuentra documentado en su plan de Salvaguarda. La aplicación de las técnicas interactivas de recolección de información y el análisis de los datos en el transcurso investigativo develaron las condiciones que permiten el Buen Vivir tras la lucha de la salvaguarda de los saberes ancestrales y el concepto del Buen Vivir como guía aplicable a la praxis social, para la construcción de conocimiento multicultural

Complex innovations in agriculture, environment, and health – the perceptions of rice farmers in the Jequetepeque Valley, Peru

The increased use of water in irrigated rice monocultures in the Jequetepeque Valley, on the northern coast of Peru, has exacerbated environmental, socioeconomic and health problems. The Alternate Wetting and Drying (AWD) irrigation technique aims to increase water management efficiency in rice cultivation. The objective of the present article is to understand farmers’ perceptions about the benefits and risks of implementing AWD. Data from interviews with 319 farmers showed that they recognise nine interactions between AWD's economic, environmental and health aspects but prioritise economic factors when assessing its benefits. We also identified the main channels and spaces of communication and debate on issues related to agriculture and health that are likely to be effective in promoting the diffusion of AWD. The study demonstrated the relevance of integrated actions to encourage the adoption of agricultural innovations which consider the interactions between environmental sustainability, health issues, and producers' economic priorities.The increased use of water in irrigated rice monocultures in the Jequetepeque Valley, on the northern coast of Peru, has exacerbated environmental, socioeconomic and health problems. The Alternate Wetting and Drying (AWD) irrigation technique aims to increase water management efficiency in rice cultivation. The objective of the present article is to understand farmers’ perceptions about the benefits and risks of implementing AWD. Data from interviews with 319 farmers showed that they recognise nine interactions between AWD's economic, environmental and health aspects but prioritise economic factors when assessing its benefits. We also identified the main channels and spaces of communication and debate on issues related to agriculture and health that are likely to be effective in promoting the diffusion of AWD. The study demonstrated the relevance of integrated actions to encourage the adoption of agricultural innovations which consider the interactions between environmental sustainability, health issues, and producers' economic priorities.The increased use of water in irrigated rice monocultures in the Jequetepeque Valley, on the northern coast of Peru, has exacerbated environmental, socioeconomic and health problems. The Alternate Wetting and Drying (AWD) irrigation technique aims to increase water management efficiency in rice cultivation. The objective of the present article is to understand farmers’ perceptions about the benefits and risks of implementing AWD. Data from interviews with 319 farmers showed that they recognise nine interactions between AWD's economic, environmental and health aspects but prioritise economic factors when assessing its benefits. We also identified the main channels and spaces of communication and debate on issues related to agriculture and health that are likely to be effective in promoting the diffusion of AWD. The study demonstrated the relevance of integrated actions to encourage the adoption of agricultural innovations which consider the interactions between environmental sustainability, health issues, and producers' economic priorities.The increased use of water in irrigated rice monocultures in the Jequetepeque Valley, on the northern coast of Peru, has exacerbated environmental, socioeconomic and health problems. The Alternate Wetting and Drying (AWD) irrigation technique aims to increase water management efficiency in rice cultivation. The objective of the present article is to understand farmers’ perceptions about the benefits and risks of implementing AWD. Data from interviews with 319 farmers showed that they recognise nine interactions between AWD's economic, environmental and health aspects but prioritise economic factors when assessing its benefits. We also identified the main channels and spaces of communication and debate on issues related to agriculture and health that are likely to be effective in promoting the diffusion of AWD. The study demonstrated the relevance of integrated actions to encourage the adoption of agricultural innovations which consider the interactions between environmental sustainability, health issues, and producers' economic priorities

Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region

Background: We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region Methods: Women ages 15-26 and 24-45 years from 5 regions were enrolled in qHPV vaccine clinical trials. Among 10,706 women (placebo arms), 1539 CIN1, 945 CIN2/3, and 24 adenocarcinoma in situ (AIS) cases were diagnosed by pathology panel consensus. Results: Predominant HPV types were 16/51/52/56 (anogenital infection), 16/39/51/52/56 (CIN1), and 16/31/52/58 (CIN2/3). In regions with largest sample sizes, minimal regional variation was observed in 9vHPV type prevalence in CIN1 (similar to 50%) and CIN2/3 (81-85%). Types 31/33/45/52/58 accounted for 25-30% of CIN1 in Latin America and Europe, but 14-18% in North America and Asia. Types 31/33/45/52/58 accounted for 33-38% of CIN2/3 in Latin America (younger women), Europe, and Asia, but 17-18% of CIN2/3 in Latin America (older women) and North America. Non-vaccine HPV types 35/39/51/56/59 had similar or higher prevalence than qHPV types in CIN1 and were attributed to 2-11% of CIN2/3. Conclusions: The 9vHPV vaccine could potentially prevent the majority of CIN1-3, irrespective of geographic region. Notwithstanding, non-vaccine types 35/39/51/56/59 may still be responsible for some CIN1, and to a lesser extent CIN2/3. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment