Faktor-Faktor yang Berhubungan dengan Dukungan Keluarga dalam Pencegahan Primer Hipertensi

Kementerian Kesehatan menyatakan bahwa di Indonesia terjadi peningkatan prevalensi hipertensi delam tiga tahun terakhir. Kabupaten Kuningan merupakan wilayah dengan prevalensi hipertensi terbanyak di Indonesia. Kasus hipertensi merupakan salah satu penyakit yang termasuk sepuluh penyakit terbesar selama tiga tahun di seluruh Puskesmas di Kabupaten Kuningan termasuk Puskesmas Windusengkahan yang memiliki catatan kenaikan hipertensi tiga tahun terakhir. Tujuan dari penelitian ini adalah untuk menentukan faktor yang paling berhubungan dengan dukungan keluarga dalam pencegahan primer hipertensi pada di Wilayah Kerja Puskesmas Windusengkahan Kabupaten Kuningan. Jenis penelitian adalah penelitian kuantitatif analitik korelasional dengan menggunakan multivariat regresi liniear. Responden pada penelitian ini adalah anggota keluarga usia dewasa baik pria maupun wanita di Wilayah Kerja Puskesmas Windusengkahan yang memiliki riwayat keluarga hipertensi dan memiliki minimal dua faktor dari risiko hipertensi yang bertempat tinggal bersama keluarga. Pengambilan sampel di setiap kelurahan dalam pada wilayah kerja Puskesmas Windusengkahan ini menggunakan proporsional random sampling. Hasil dari penelitian ini yaitu semua variabel bebas seperti tingkat pengetahuan, faktor spiritual, faktor emosional, tingkat ekonomi, latar belakang budaya, dan praktik keluarga berhubungan dengan dukungan keluarga dalam pencegahan primer hipertensi. Faktor yang paling dominan berhubungan dengan dukungan keluarga dalam pencegahan primer hipertensi adalah paktor praktik. Persamaan yang muncul dari penelitian ini yaitu dukungan keluarga = 0.442 + 5.331 (Tingkat Pengetahuan Keluarga) + 2.532 (emosional)+ 3.112 (spiritual) + 7.330 (Faktor Praktik Keluarga). Kesimpulan penelitian adalah pengetahuan keluarga, faktor emosional, faktor spiritual dan praktik keluarga lebih ditingkatkan lagi di keluarga dalam memberikan dukungan pencegahan primer hipertensi. Keluarga menjadi faktor penting bagi anggota keluarga dalam pemeliharaan kesehatannya khususnya pada pencegahan primer hipertensi

Novel kinase platform for the validation of the anti-tubercular activities of Pelargonium sidoides (Geraniaceae)

Abstract Background Pelargonium sidoides is an important traditional medicine in South Africa with a well-defined history of both traditional and documented use of an aqueous-ethanolic formulation of the roots of P. sidoides (EPs 7630), which is successfully employed for the treatment of respiratory tract infections. There is also historical evidence of use in the treatment of tuberculosis. The aim of this study was to develop a platform of Mycobacterium tuberculosis (Mtb) kinase enzymes that may be used for the identification of therapeutically relevant ethnobotanical extracts that will allow drug target identification, as well as the subsequent isolation of the active compounds. Results Mtb kinases, Nucleoside diphosphokinase, Homoserine kinase, Acetate kinase, Glycerol kinase, Thiamine monophosphate kinase, Ribokinase, Aspartokinase and Shikimate kinase were cloned, produced in Escherichia coli and characterized. HPLC-based assays were used to determine the enzyme activities and subsequently the inhibitory potentials of varying concentrations of a P. sidoides extract against the produced enzymes. The enzyme activity assays indicated that these enzymes were active at low ATP concentrations. The 50% inhibitory concentration (IC50) of an aqueous root extract of P. sidoides against the kinases indicated SK has an IC50 of 1.2 μg/ml and GK 1.4 μg/ml. These enzyme targets were further assessed for compound identification from the P. sidoides literature. Conclusion This study suggests P. sidoides is potentially a source of anti-tubercular compounds and the Mtb kinase platform has significant potential as a tool for the subsequent screening of P. sidoides extracts and plant extracts in general, for compound identification and elaboration by selected extract target inhibitor profiling

Quality of life satisfaction among converted Kelantan Chinese Muslims

This article investigates the quality of life of the Kelantan Chinese Muslim community before and after conversion to Islam, focusing on their level of satisfaction in term of economic aspect. This research was carried out using the sequential explanatory mixed method design involving 75 respondents selected for quantitative and five respondents for qualitative. The sampling method adopted was convenience and snowball samplings. The research data was collected using questionnaires and semi-structured interviews. The results revealed that respondents were moderately satisfied before conversion and satisfied after conversion. Besides that, there is no significant difference of quality of life before and after conversion to Islam (F = 0.868, p = 0.355) and it was not influenced by the period of conversion to Islam (F = 0.832, p = 0.589). This analysis indicates numerous respondents are still moderately satisfied in their quality of life even though the average data shows they are satisfied after conversion

Spin density encodes intramolecular singlet exciton fission in pentacene dimers.

The formation of two triplet excitons at the cost of one photon via singlet exciton fission in organic semiconductors can potentially enhance the photocurrent in photovoltaic devices. However, the role of spin density distribution in driving this photophysical process has been unclear until now. Here we present the significance of electronic spin density distribution in facilitating efficient intramolecular singlet exciton fission (iSEF) in π-bridged pentacene dimers. We synthetically modulate the spin density distribution in a series of pentacene dimers using phenyl-, thienyl- and selenyl- flanked diketopyrrolopyrrole (DPP) derivatives as π-bridges. Using femtosecond transient absorption spectroscopy, we find that efficient iSEF is only observed for the phenyl-derivative in ~2.4 ps while absent in the other two dimers. Electronic structure calculations reveal that phenyl-DPP bridge localizes α- and β-spin densities on distinct terminal pentacenes. Upon photoexcitation, a spin exchange mechanism enables iSEF from a singlet state which has an innate triplet pair character