Yang-Lee Zeros of the Ising model on Random Graphs of Non Planar Topology

We obtain in a closed form the 1/N^2 contribution to the free energy of the two Hermitian N\times N random matrix model with non symmetric quartic potential. From this result, we calculate numerically the Yang-Lee zeros of the 2D Ising model on dynamical random graphs with the topology of a torus up to n=16 vertices. They are found to be located on the unit circle on the complex fugacity plane. In order to include contributions of even higher topologies we calculated analytically the nonperturbative (sum over all genus) partition function of the model Z_n = \sum_{h=0}^{\infty} \frac{Z_n^{(h)}}{N^{2h}} for the special cases of N=1,2 and graphs with n\le 20 vertices. Once again the Yang-Lee zeros are shown numerically to lie on the unit circle on the complex fugacity plane. Our results thus generalize previous numerical results on random graphs by going beyond the planar approximation and strongly indicate that there might be a generalization of the Lee-Yang circle theorem for dynamical random graphs.Comment: 19 pages, 7 figures ,1 reference and a note added ,To Appear in Nucl.Phys

Microencapsulation of beta-carotene by spray drying effect of wall material concentration and drying inlet temperature

Research ArticleCarotenoids are a class of natural pigments found mainly in fruits and vegetables. Among them, -carotene is regarded the most potent precursor of vitamin A. However, it is susceptible to oxidation upon exposure to oxygen, light, and heat, which can result in loss of colour, antioxidant activity, and vitamin activity.Thus, the objective of thiswork was to study themicroencapsulation process of -carotene by spray drying, using arabic gum as wall material, to protect it against adverse environmental conditions. This was carried out using the response surfacemethodology coupled to a central composite rotatable design, evaluating simultaneously the effect of drying air inlet temperature (110-200∘C) and the wall material concentration (5-35%) on the drying yield, encapsulation efficiency, loading capacity, and antioxidant activity. In addition, morphology and particles size distribution were evaluated. Scanning electron microscopy images have shown that the particles were microcapsules with a smooth surface when produced at the higher drying temperatures tested,most of them having a diameter lower than 10 m.The conditions that enabled obtaining simultaneously arabic gummicroparticles with higher -carotene content, higher encapsulation efficiency, and higher drying yield were a wall material concentration of 11.9% and a drying inlet temperature of 173∘C.The systematic approach used for the study of -carotene microencapsulation process by spray drying using arabic gum may be easily applied for other core and wall materialsinfo:eu-repo/semantics/publishedVersio

Microencapsulation of tomato (Solanum lycopersicon L.) pomace ethanolic extract by spray drying: optimization of process conditions

Microencapsulation by spray-drying is a process used in the stabilization of active compounds from various natural sources, such as tomato by-products, with the purpose to be used as additives in the food industry. The aim of this work was to study the effects of wall material and spray drying conditions on physicochemical properties of microcapsules loaded with lycopene rich extract from tomato pomace. The assays were carried out with ethanolic tomato pomace extract as core material and arabic gum or inulin as wall materials. A central composite rotatable design was used to evaluate the effect of drying air inlet temperature (110–200 C) and concentration of arabic gum (5–35 wt %) or inulin (5–25 wt %) on the antioxidant activity, encapsulation efficiency, loading capacity, and drying yield. SEM images showed that the produced particles were in the category of skin-forming structures. The most suitable conditions, within the ranges studied, to obtain lycopene loaded microparticles were a biopolymer concentration of 10 wt % for both materials and an inlet temperature of 200 and 160 C for arabic gum and inulin, respectively. Arabic gum and inulin possessed a good performance in the encapsulation of tomato pomace extract by spray drying. It is envisaged that the capsules produced have good potential to be incorporated in foods systems with diverse chemical and physical propertiesinfo:eu-repo/semantics/publishedVersio

Abdominoperineal resection does not decrease quality of life in patients with low rectal cancer

PURPOSE: Issues related to body image and a permanent stoma after abdominoperineal resection may decrease quality of life in rectal cancer patients. However, specific problems associated with a low anastomosis may similarly affect quality of life for patients undergoing low anterior resection. The aim of this study was to compare quality of life of low rectal cancer patients after undergoing abdominoperineal resection versus low anterior resection. METHODS: Demographics, tumor and treatment characteristics, and prospectively collected preoperative quality-of-life data for patients undergoing low anterior resection or abdominoperineal resection for low rectal cancer between 1995 and 2009 were compared. Quality of life collected at specific time intervals was compared for the two groups, adjusting for age, body mass index, use of chemoradiation, and 30 days postoperative complications. The short-form-36 questionnaire was used to determine quality of life. RESULTS: The query returned 153 patients (abdominoperineal resection = 68, low anterior resection = 85) with a median follow-up of 24 (3-64) mo. The after abdominoperineal resection group had a higher mean age (63 + 12 vs. 54 + 12, p < 0.001) and more American Society of Anesthesiologists classification 3/4 patients (65 percent vs. 43 percent, p = 0.03) than low anterior resection. Other demographics, tumor stage, use of chemoradiation, overall postoperative complication rates, and quality-of-life follow-up time were not statistically different in both groups. Patients undergoing abdominoperineal resection had a lower baseline short-form-36 mental component score than those undergoing low anterior resection. However, 6 mo after surgery this difference was no longer statistically significant and essentially disappeared at 36 mo after surgery. CONCLUSION: Patients undergoing abdominoperineal resection for low rectal cancer have a similar long-term quality of life as those undergoing low anterior resection. These findings can help clinicians to better counsel patients with low rectal cancer who are being considered for abdominoperineal resection

Storage Stability and In Vitro Bioaccessibility of Microencapsulated Tomato (Solanum Lycopersicum L.) Pomace Extract

Tomato pomace is rich in carotenoids (mainly lycopene), which are related to important bioactive properties. In general, carotenoids are known to react easily under environmental conditions, which may create a barrier in producing stable functional components for food. This work intended to evaluate the storage stability and in vitro release of lycopene from encapsulated tomato pomace extract, and its bioaccessibility when encapsulates were incorporated in yogurt. Microencapsulation assays were carried out with tomato pomace extract as the core material and arabic gum or inulin (10 and 20 wt%) as wall materials by spray drying (160 and 200 C). The storage stability results indicate that lycopene degradation was highly influenced by the presence of oxygen and light, even when encapsulated. In vitro release studies revealed that 63% of encapsulated lycopene was released from the arabic gum particles in simulated gastric fluid, whereas for the inulin particles, the release was only around 13%. The feed composition with 20% inulin showed the best protective ability and the one that enabled releasing the bioactives preferentially in the intestine. The bioaccessibility of the microencapsulated lycopene added to yogurt increased during simulated gastrointestinal digestion as compared to the microencapsulated lycopene alone. We anticipate a high potential for the inulin microparticles containing lycopene to be used in functional food formulationsinfo:eu-repo/semantics/publishedVersio

Comparative Genomics of Cryptosporidium

Until recently, the apicomplexan parasites, Cryptosporidium hominis andC. parvum, were considered the same species. However, the two parasites, now considered distinct species, exhibit significant differences in host range, infectivity, and pathogenicity, and their sequenced genomes exhibit only 95–97% identity. The availability of the complete genome sequences of these organisms provides the potential to identify the genetic variations that are responsible for the phenotypic differences between the two parasites. We compared the genome organization and structure, gene composition, the metabolic and other pathways, and the local sequence identity between the genes of these two Cryptosporidium species. Our observations show that the phenotypic differences between C. hominisand C. parvum are not due to gross genome rearrangements, structural alterations, gene deletions or insertions, metabolic capabilities, or other obvious genomic alterations. Rather, the results indicate that these genomes exhibit a remarkable structural and compositional conservation and suggest that the phenotypic differences observed are due to subtle variations in the sequences of proteins that act at the interface between the parasite and its host

Estudio de la mortalidad de los médicos en el estado de São Paulo, Brasil, durante el período de 2000 a 2009

This study presents the distribution of causes of death among physicians in the State of São Paulo, Brazil, from 2000 to 2009. The study used the database of the Mortality Information System, Secretariat of Health Surveillance, Brazilian Ministry of Health, limited to death certificates in which the item on occupation was reported as physician. Underlying causes of death were classified according to ICD-10 chapters. The study showed that cardiovascular diseases were the leading cause of death among physicians, followed by cancer and respiratory diseases. Under age 40, doctors of both genders died mainly from external causes. Among cancer deaths, breast cancer was the leading cause in women and lung cancer the first cause in men. The results show the need to promote adequate health habits and disease prevention among physicians, seeking to raise awareness in this group of professionals.El estudio presenta la distribución de las causas de muerte de los médicos en el estado de São Paulo, Brasil, entre los años 2000 y 2009. Se utilizó la base de datos del Sistema de Información sobre Mortalidad del Ministerio de Salud, limitándose a los certificados de defunción, cuya ocupación del finado figuraba como médico. Las principales causas de muerte fueron clasificadas de acuerdo con los capítulos del CIE-10. El estudio muestra que las enfermedades cardiovasculares son la principal causa de muerte entre los médicos durante la última década, seguido del cáncer y las enfermedades respiratorias. Las causas externas fueron las principales causas de muerte en menores de 40 años. El cáncer de mama es responsable de la mayoría de las muertes por cáncer entre las mujeres, mientras que entre los hombres el cáncer de pulmón ocupa el primer lugar. Se sugiere la necesidad de estimular los hábitos adecuados de salud y prevención de enfermedades entre los médicos, buscando informar y sensibilizar a este colectivo de profesionales.O presente estudo apresenta a distribuição das causas de morte de médicos do Estado de São Paulo, Brasil, cujos óbitos ocorreram entre os anos de 2000 e 2009. Utilizou-se o banco de dados do Sistema de Informações sobre Mortalidade, do Ministério da Saúde, limitando-se às declarações de óbito cujo campo de ocupação estava preenchido como médico. As causas básicas de morte foram classificadas de acordo com os capítulos da CID-10. O estudo revela que doenças do aparelho circulatório foram a principal causa de morte entre os médicos na última década, seguidas das neoplasias e doenças do aparelho respiratório. As causas externas constituíram as principais causas de morte abaixo de 40 anos. Câncer da mama foi responsável pela maior parte dos óbitos por neoplasias entre mulheres, enquanto entre os homens a neoplasia de pulmão ocupou a primeira posição. Sugere-se a necessidade de se estimular hábitos adequados de saúde e prevenção de doenças entre os médicos, buscando informar e sensibilizar este grupo de profissionais.Universidade Federal de São Paulo (UNIFESP) Departamento de Medicina PreventivaUniversidade Federal de São Paulo (UNIFESP) Departamento de PsiquiatriaUNIFESP, Depto. de Medicina PreventivaUNIFESP, Depto. de PsiquiatriaSciEL