Um Sistema de Following para ampliar a interação em Comunidades de Prática

Este artigo apresenta um sistema de following, de usuários e temas, desenvolvido para ampliar e estimular a interação entre os participantes de comunidades de prática. Neste ambiente, conhecer e interagir com outros indivíduos é fundamental no processo de aprendizagem e a existência de ferramentas que apoiem as práticas é o que define o sucesso de uma comunidade. Esta rede de relacionamentos representa um interesse distribuído dos participantes por determinados assuntos. O sistema de following captura e representa estes interesses de modo a considerá-los para recomendações na plataforma CoPPLA. É por meio destas sugestões oferecidas pelo sistema de recomendação, que os usuários são convidados a colaborar com outros participantes ou a conhecer novos temas de interesse

Chatbots na educação: uma Revisão Sistemática da Literatura

Um chatbot é um sistema capaz de conversar com um usuário em linguagem natural, de maneira a simular um diálogo humano. Exemplos de chatbots podem ser encontrados nas áreas de saúde, entretenimento, negócios e educação. Este artigo apresenta uma Revisão Sistemática da Literatura acerca da aplicação dos chatbots para fins educacionais em bases de dados nacionais e internacionais. Por meio da análise, constatou-se que a maior parcela dos chatbots foca na área de conhecimento da Ciência da Computação e que é destinada para o nível de ensino superior. Em geral, os estudos reportaram resultados positivos na construção do conhecimento dos alunos e destacaram os principais fatores que poderiam ser aprimorados para maior consistência do diálogo

ESTUDO DOS TERCEIROS MOLARES RETIDOS EM RADIOGRAFIAS PANORÂMICAS

Third molars present the highest frequency of unerupted teeth, followed by the upper canines and supernumerary teeth. Generally, the presence of these teeth, under stagnant circumstances, is verified by performing a panoramic radiography. In view of this, the last molars can be grouped according to the classifications proposed by Winter and Pell & Gregory. The present study evaluated the frequency of the positions of impacted third molars in relation to the classifications of Winter and Pell & Gregory, in a subpopulation of the northern region of Brazil. A retrospective, descriptive study was carried out using panoramic radiographs of adult patients of a School of Dentistry in the northern region of Brazil. The results showed 500 images (62.1%) of the female gender and 305 (37.9%) of the male gender. Of the total of impacted third molars observed, 1,334 were found in the maxilla and 1316 in the mandible, being more common on the right side (1,359) than on the left side (1,291). It is concluded that the highest frequency of third molars was observed in female; the most common position of the upper third molars was vertical, and mesioangular in the lower ones.Los terceros molares tienen las frecuencias más altas de retención dental, seguidos por los colinos superiores y los dientes supernumerarios. Generalmente, la presencia de estos dientes, en circunstancias de estancamiento, se verifica mediante la realización de radiografías panorámicas. Por lo tanto, los últimos molares se pueden agrupar según las clasificaciones propuestas por Winter y Pell & Gregory. El presente estudio evaluó la frecuencia de los terceros molares retenidos en relación a las clasificaciones de Pell y Gregory en una subpoblación del norte de Brasil. Se realizó un estudio descriptivo retrospectivo con datos de radiografías panorámicas de pacientes adultos atendidos en la clínica dental de una Institución de Educación Superior del norte de Brasil. Los resultados mostraron 500 imágenes (62,1%) mujeres y 305 (37,9%) Machos. Del total de terceros molares retenidos observados, 1.334 estaban en el maxilar y 1.316 en la mandíbula, siendo más frecuentes en el lado derecho (1.359) que en el izquierdo (1.291). Fue concluido que la frecuencia más alta de terceras muelas conservadas fue observada en pacientes femeninos; la posición más común de las terceras muelas superiores era vertical, y en la más baja a mesio-angular.Os terceiros molares apresentam as maiores frequências de retenção dental, seguidos dos caninos superiores e dentes supranumerários. Geralmente, a presença desses dentes, sob circunstâncias de estagnação, é constatada por meio da efetuação da radiografia panorâmica. Diante disso, os últimos molares podem ser agrupados de acordo com as classificações propostas por Winter e Pell & Gregory. O presente estudo avaliou a frequência dos terceiros molares retidos em relação às classificações de Winter e Pell & Gregory, em uma subpopulação da região norte do Brasil. Realizou-se um estudo retrospectivo, descritivo, com dados de radiografias panorâmicas de pacientes adultos atendidos na clínica odontológica de uma Instituição de Ensino Superior da região Norte do Brasil. Os resultados apontaram 500 imagens (62,1%) do gênero feminino e 305 (37,9%) do gênero masculino. Do total de terceiros molares retidos observados, 1.334 encontravam-se na maxila e 1.316 na mandíbula, sendo mais comum no lado direito (1.359) do que no lado esquerdo (1.291). Conclui-se que a maior frequência de terceiros molares retidos foi observada em pacientes do gênero feminino; a posição mais comum dos terceiros molares superiores foi vertical, e nos inferiores a mésio-angular

Rabbit derived VL single-domains as promising scaffolds to generate antibody–drug conjugates

© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Antibody-drug conjugates (ADCs) are among the fastest-growing classes of therapeutics in oncology. Although ADCs are in the spotlight, they still present significant engineering challenges. Therefore, there is an urgent need to develop more stable and effective ADCs. Most rabbit light chains have an extra disulfide bridge, that links the variable and constant domains, between Cys80 and Cys171, which is not found in the human or mouse. Thus, to develop a new generation of ADCs, we explored the potential of rabbit-derived VL-single-domain antibody scaffolds (sdAbs) to selectively conjugate a payload to Cys80. Hence, a rabbit sdAb library directed towards canine non-Hodgkin lymphoma (cNHL) was subjected to in vitro and in vivo phage display. This allowed the identification of several highly specific VL-sdAbs, including C5, which specifically target cNHL cells in vitro and present promising in vivo tumor uptake. C5 was selected for SN-38 site-selective payload conjugation through its exposed free Cys80 to generate a stable and homogenous C5-DAB-SN-38. C5-DAB-SN-38 exhibited potent cytotoxicity activity against cNHL cells while inhibiting DNA-TopoI activity. Overall, our strategy validates a platform to develop a novel class of ADCs that combines the benefits of rabbit VL-sdAb scaffolds and the canine lymphoma model as a powerful framework for clinically translation of novel therapeutics for cancer.This work was supported by the Portuguese Funding Agency, Fundação para a Ciência e Tecnologia, FCT IP (SAICT/2017/32085, PTDC/QUI-OUT/3989/2021 and Ph.D. fellowship SFRH/BD/131468/2017 to ASA and SFRH/BD/90514/2012 to JD). CIISA has provided support through Project UIDB/00276/2020, funded by FCT and LA/P/0059/2020-AL4AnimalS. Research Institute for Medicines (iMed.ULisboa) acknowledges the financial support of Fundação para a Ciência e Tecnologia (Projects: PTDC/QUI-OUT/3989/2021; UIDB/04138/2020 and UIDP/04138/2020). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project Nº 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC).info:eu-repo/semantics/publishedVersio

Integrando Educação em Saúde como Estratégia-Chave na Prevenção do Câncer de Colo de Útero: Uma Revisão Sistemática

Introduction: Cervical cancer prevention poses a significant challenge in the global public health arena, as this pathology continues to affect women worldwide. In this context, the integration of health education emerges as a key strategy, playing a crucial role in raising awareness, prevention, and promoting women's health. Methodology: The search was restricted to the last 5 years, considering the timeliness of the information. The applied filters included the requirement for access to the full text, prioritizing systematic reviews as a means to ensure a comprehensive and consolidated analysis of the existing scientific literature. The initial number of identified articles was 33. Results: Promoting proactive attitudes towards cervical cancer prevention goes beyond simple information dissemination. It involves cultivating a preventive mindset, encouraging women to adopt regular care practices and integrate preventive measures into their health routines. Conclusion: When considering patient profiles, risk factors, the importance of educational initiatives, screening, and the use of protective measures, it is possible to develop comprehensive and culturally sensitive approaches. These approaches aim not only to reduce the incidence of cervical cancer but also to promote women's overall health.Introdução: A prevenção do câncer de colo de útero representa um desafio significativo na arena global de saúde pública, uma vez que essa patologia continua a afetar mulheres em todo o mundo. Nesse contexto, a integração da educação em saúde surge como uma estratégia-chave, desempenhando um papel crucial na conscientização, prevenção e promoção da saúde feminina. Metodologia: A busca foi restrita aos últimos 5 anos, considerando a atualidade das informações, e os filtros aplicados incluíram a necessidade de acesso ao texto completo, priorizando revisões sistemáticas como forma de garantir uma análise abrangente e consolidada da literatura científica existente. O número inicial de artigos identificados foi de 33. Resultados: Promover atitudes proativas em relação à prevenção do câncer cervical vai além da simples disseminação de informações. Envolve cultivar uma mentalidade preventiva, encorajando as mulheres a adotarem práticas de cuidado regular e a integrarem medidas preventivas em suas rotinas de saúde Conclusão: Ao considerar o perfil do paciente, os fatores de risco, a importância das ações educativas, do rastreamento e da utilização de preservativos, é possível desenvolver abordagens abrangentes e culturalmente sensíveis, visando não apenas à redução da incidência, mas também à promoção da saúde feminina em sua totalidade.   &nbsp

Performance of the ATLAS Track Reconstruction Algorithms in Dense Environments in LHC Run 2

With the increase in energy of the Large Hadron Collider to a centre-of-mass energy of 13  $\text {TeV}$ for Run 2, events with dense environments, such as in the cores of high-energy jets, became a focus for new physics searches as well as measurements of the Standard Model. These environments are characterized by charged-particle separations of the order of the tracking detectors sensor granularity. Basic track quantities are compared between 3.2 fb$^{-1}$ of data collected by the ATLAS experiment and simulation of proton–proton collisions producing high-transverse-momentum jets at a centre-of-mass energy of 13  $\text {TeV}$ . The impact of charged-particle separations and multiplicities on the track reconstruction performance is discussed. The track reconstruction efficiency in the cores of jets with transverse momenta between 200 and 1600 $\text {GeV}$ is quantified using a novel, data-driven, method. The method uses the energy loss, ${\text { d}}{} \textit{E}/d\textit{x}$ , to identify pixel clusters originating from two charged particles. Of the charged particles creating these clusters, the measured fraction that fail to be reconstructed is $0.061 \pm 0.006\ {\text {(stat.)}} \pm 0.014\ {\text {(syst.)}}$ and $0.093 \pm 0.017\ {\text {(stat.)}}\pm 0.021\ {\text {(syst.)}}$ for jet transverse momenta of 200–400  $\text {GeV}$ and 1400–1600  $\text {GeV}$ , respectively.Peer Reviewe

Measurement of charged-particle distributions sensitive to the underlying event in s=13 \sqrt{s}=13 TeV proton-proton collisions with the ATLAS detector at the LHC

We present charged-particle distributions sensitive to the underlying event, measured by the ATLAS detector in proton-proton collisions at a centre-of-mass energy of 13 TeV, in low-luminosity Large Hadron Collider fills corresponding to an integrated luminosity of 1.6 nb$^{−1}$. The distributions were constructed using charged particles with absolute pseudorapidity less than 2.5 and with transverse momentum greater than 500 MeV, in events with at least one such charged particle with transverse momentum above 1 GeV. These distributions characterise the angular distribution of energy and particle flows with respect to the charged particle with highest transverse momentum, as a function of both that momentum and of charged-particle multiplicity. The results have been corrected for detector effects and are compared to the predictions of various Monte Carlo event generators, experimentally establishing the level of underlying-event activity at LHC Run 2 energies and providing inputs for the development of event generator modelling. The current models in use for UE modelling typically describe this data to 5% accuracy, compared with data uncertainties of less than 1%.Peer Reviewe

Measurements of top-quark pair differential cross-sections in the eμe\mu channel in pppp collisions at s=13\sqrt{s} = 13 TeV using the ATLAS detector

This article presents measurements of $t\bar{t}$ differential cross-sections in a fiducial phase-space region, using an integrated luminosity of 3.2 fb$^{-1}$ of proton–proton data at a centre-of-mass energy of $\sqrt{s} = 13$  TeV recorded by the ATLAS experiment at the LHC in 2015. Differential cross-sections are measured as a function of the transverse momentum and absolute rapidity of the top quark, and of the transverse momentum, absolute rapidity and invariant mass of the $t\bar{t}$ system. The $t\bar{t}$ events are selected by requiring one electron and one muon of opposite electric charge, and at least two jets, one of which must be tagged as containing a b-hadron. The measured differential cross-sections are compared to predictions of next-to-leading order generators matched to parton showers and the measurements are found to be consistent with all models within the experimental uncertainties with the exception of the Powheg-Box $+$ Herwig++ predictions, which differ significantly from the data in both the transverse momentum of the top quark and the mass of the $t\bar{t}$ system.Peer Reviewe

Measurement of the inclusive jet cross-sections in proton-proton collisions at s=8 \sqrt{s}=8 TeV with the ATLAS detector

Inclusive jet production cross-sections are measured in proton-proton collisions at a centre-of-mass energy of $\sqrt{s}=8$ TeV recorded by the ATLAS experiment at the Large Hadron Collider at CERN. The total integrated luminosity of the analysed data set amounts to 20.2 fb$^{−1}$. Double-differential cross-sections are measured for jets defined by the anti-k$_{t}$ jet clustering algorithm with radius parameters of R = 0.4 and R = 0.6 and are presented as a function of the jet transverse momentum, in the range between 70 GeV and 2.5 TeV and in six bins of the absolute jet rapidity, between 0 and 3.0. The measured cross-sections are compared to predictions of quantum chromodynamics, calculated at next-to-leading order in perturbation theory, and corrected for non-perturbative and electroweak effects. The level of agreement with predictions, using a selection of different parton distribution functions for the proton, is quantified. Tensions between the data and the theory predictions are observed.Peer Reviewe

A search for top squarks with R-parity-violating decays to all-hadronic final states with the ATLAS detector in s\sqrt{s} = 8 TeV proton-proton collisions

A search for the pair production of top squarks, each with R-parity-violating decays into two Standard Model quarks, is performed using 17.4 fb$^{−1}$ of $\sqrt{s}=8$ TeV proton-proton collision data recorded by the ATLAS experiment at the LHC. Each top squark is assumed to decay to a b- and an s-quark, leading to four quarks in the final state. Background discrimination is achieved with the use of b-tagging and selections on the mass and substructure of large-radius jets, providing sensitivity to top squark masses as low as 100 GeV. No evidence of an excess beyond the Standard Model background prediction is observed and top squarks decaying to $\overline{b}\overline{s}$ are excluded for top squark masses in the range $100\ \le {m}_{\overline{t}}\le\ 315$ GeV at 95% confidence level.Peer Reviewe