Unravelling the male aspect of reproductive rheumatology:Evaluating the effect of immune-mediated diseases and its treatment on male sexual and reproductive health

This thesis explores the impact of immune-mediated inflammatory diseases, particularly inflammatory arthritis, on male sexual and reproductive health. Using a holistic approach, multiple studies were conducted to address critical clinical questions:How do immune-mediated inflammatory diseases and their pharmacological treatments affect male sexual and reproductive health outcomes?Is fertility impaired in males diagnosed with inflammatory arthritis?How does inflammatory arthritis impact male sexual health?Is methotrexate safe for men with immune-mediated diseases who wish to conceive?The chapters of this thesis delve into these questions, offering comprehensive insights into the intricate relationships between these diseases and male health. Through detailed analysis and rigorous research, this work sheds light on the often-overlooked aspects of male reproductive health in the context of inflammatory conditions. The findings underscore the importance of considering these factors in clinical practice to improve patient outcomes.<br/

Unravelling the male aspect of reproductive rheumatology:Evaluating the effect of immune-mediated diseases and its treatment on male sexual and reproductive health

This thesis explores the impact of immune-mediated inflammatory diseases, particularly inflammatory arthritis, on male sexual and reproductive health. Using a holistic approach, multiple studies were conducted to address critical clinical questions:How do immune-mediated inflammatory diseases and their pharmacological treatments affect male sexual and reproductive health outcomes?Is fertility impaired in males diagnosed with inflammatory arthritis?How does inflammatory arthritis impact male sexual health?Is methotrexate safe for men with immune-mediated diseases who wish to conceive?The chapters of this thesis delve into these questions, offering comprehensive insights into the intricate relationships between these diseases and male health. Through detailed analysis and rigorous research, this work sheds light on the often-overlooked aspects of male reproductive health in the context of inflammatory conditions. The findings underscore the importance of considering these factors in clinical practice to improve patient outcomes.<br/

Mechanical Impedance Matching Using a Magnetic Linear Gear

As part of the Fp7 Clean Sky Project, a linear magnetic gear prototype, called Z-transmitter, for aerospace application was designed, built, and tested. It demonstrates a maximum force capacity of 4700 N at 25°C and 4500 N at 90°C. Force ratio between slow and fast stages remains constant and equal to the design value: 7.0. The behavior of the real Z-transmitter as a mechanical impedance matching device when any stiffness is attached to the fast stage including the limit cases of a blocked fast stage or a free to move fast stage is experimentally explored. Although the real Z-transmitter deviates from the ideal, frictionless and massless, device, it still provides an impedance matching effect large enough to potentially become an extremely useful technology for vibration control when combined with other elements such as dampers, springs, or active elements

Plasmonic nanodevice with magnetic funcionalities: fabrication and characterization

We have designed and fabricated a nanodevice exhibiting simultaneously ferromagnetic properties of nanostructures with plasmonic properties of continuous films. Our device consists of an array of nanomagnets on top of a continuous plasmonic film. The patterned nanomagnets magnetic state is single domain and well-defined shape anisotropy. Despite the presence of the patterned media on top of the Au film, the system exhibits surface plasmon resonance characteristics of a continuous film, i.e., propagating surface plasmon-polaritons

Nationwide trends of invasive pneumococcal disease in Spain (2009-2019) in children and adults during the pneumococcal conjugate vaccine era.

Introduction of pneumococcal conjugate vaccines (PCVs) has shown a marked reduction in the disease caused by vaccine serotypes in children providing herd protection to the elderly group. However, the emergence of non-vaccine serotypes is of great concern worldwide. This study includes national laboratory data from invasive pneumococcal disease (IPD) cases affecting pediatric and adult population during 2009-2019. The impact of implementing different vaccine strategies for immunocompetent adults comparing Spanish regions using PCV13 vs regions using PPV23 vaccine was also analyzed for 2017-2019. The overall reductions of IPD cases by PCV13 serotypes in children and adults were 88% and 59% respectively during 2009-2019 with a constant increase of serotype 8 in adults since 2015. IPD cases by additional serotypes covered by PPV23 increased from 20% in 2009 to 52% in 2019. In children, serotype 24F was the most frequent in 2019 whereas in adults, serotypes 3 and 8 accounted for 36% of IPD cases. Introduction of PCV13 or PPV23 in the adult calendar of certain Spanish regions reduced up to 25% and 11% respectively the IPD cases by PCV13 serotypes, showing a decrease of serotype 3 when PCV13 was used. Use of PCV13 in children has shown a clear impact in pneumococcal epidemiology reducing the burden of IPD in children but also in adults by herd protection although the increase of serotype 8 in adults is worrisome. Vaccination with PCV13 in immunocompetent adults seems to control IPD cases by PCV13 serotypes including serotype 3.This work was supported by Ministerio de Economía, Industria y Competitividad (MINECO) [grant SAF2017-83388] and internal funding fromS

Estudio de la situación financiera y económica de la empresa Nutresa S.A 2019-2021

Con este trabajo de investigación se busca alcanzar como objetivo principal mostrar a tutores, docentes, a estudiantes y todo el cuerpo de activos académicos, como a través del análisis se puede llegar al conocimiento de la situación actual económica y financiera del Grupo Nutresa S.A, aun mas cuando se lleva a cabo la aplicación de la disciplina de la contaduría y las finanzas, por medio de las cuales se llaga a poder determinar a través de las herramientas financieras, como se encuentra la compañía desde un momento de histórico hasta la actualidad en la parte financiera, económica y competitiva, como también se puede determinar sus estado de rentabilidad haciendo un análisis de sus últimos años de actividad, donde se observa su situación financiera y su estado de resultados, de sus inversiones, teniendo en cuenta que estos análisis a través de ratios e indicadores financieros, mostraran los resultados indicando de qué manera se puede llevar a cabo las conclusiones sobre el estado real financiero y económico del Grupo Nutresa S.A, los que demuestra la importancia del entendimiento sobre los aspectos financieros y económicos que son importantes en el marco empresarial al momento de realizar una inversión real, donde se identifican que tan positiva o negativa puede ser esta en un momento determinado.The main objective of this research work is to show tutors, teachers, students and the whole body of academic assets how, through the analysis, it is possible to obtain an understanding of the current economic and financial situation of the Nutresa Group S. A even more so when it is carried out the application of the discipline of accounting and finance, by means of which it is possible to determine by means of the results obtained. financial tools, such as the company’s financial, economic and competitive position from a historical moment to the present, as well as its profitability status can be determined by analyzing its last years of activity, where its financial situation and its statement of results, of its investments can be observed, taking into account that these analyses by means of financial ratios and indicators, will show the results indicating how to carry out the conclusions on the actual financial and economic status of the Nutresa Group S. A. , which demonstrates the importance of understanding the financial and economic aspects that are important in the business context at the time of making a real investment, identifying how positive or negative this may be at a given time

Plan de responsabilidad social empresarial empresa Tejar Arcillas del Rosario.

Plan de responsabilidad social empresarial empresa Tejar Arcillas del Rosario.En esta fase final del curso en Gerencia estratégica y Responsabilidad Social empresarial; presentamos el Plan de Responsabilidad Social Empresarial para la Empresa Tejar Arcillas del Rosario el cual se basa inicialmente en la evaluación de impactos en las dimensiones Económica, Social y Ambiental. El diseño de este plan justifica la permanencia de la empresa en el tiempo, toda vez que, de acuerdo con las consecuencias que generen las labores productivas en las dimensiones mencionadas, se puede generar rechazo o aceptación en la sociedad. Los beneficiarios directos para este plan son todos los Stakeholders o grupos de interés; quienes en cierta medida todos tiene participación; los dueños mejorarán sus ganancias, las condiciones laborares de los empleados y directivos serán mejoradas, recibirán capacitaciones para su desarrollo personal, a los proveedores se les garantiza las medidas contractuales, en la comunidad se minimizan los niveles de contaminación, siendo responsables con el mejoramiento del medio ambiente, cumpliendo la normatividad vigente y ayudando a mitigar las afectaciones; a los clientes se continuará ofreciendo productos de excelente calidad, y se mejorará la relación con ellos en términos éticos.We introduce the corporate Social Responsibility Plan for the company Tejar Arcillas of Rosario which is initially based on the evaluation of impacts in the economic, social and environmental dimensions. This design justifies the permanence of the company in time, due to the fact that, according to the consequences that the productive work may cause in the aforementioned conditions, it can generate acceptance or rejection by the society. The direct recipients of this plan are all Stakeholders, or interest groups, whom to some extend have participation; owners will improve their earnings, working conditions for both employees and managers will be improved, they will also have access to training for personal development; contractual conditions are ensured for suppliers, the levels of pollution will be reduced in the community in order to be responsible with the environment, in compliance with the environmental regulations and helping to mitigate possible affections. With clients, the company will continue to offer high quality products, and the relationship with this target group, in terms of ethics, will be improved

Risk levels for suffering a traffic injury in primary health care. The LESIONAT* project

Background: Literature shows that not only are traffic injuries due to accidents, but that there is also a correlation between different chronic conditions, the consumption of certain types of drugs, the intake of psychoactive substances and the self perception of risk (Health Belief Model) and the impact/incidence of traffic accidents. There are few studies on these aspects in primary health care. The objectives of our study are: Main aim: To outline the distribution of risk factors associated with Road Traffic Injuries (RTI) in a driving population assigned to a group of primary health care centres in Barcelona province. Secondly, we aim to study the distribution of diverse risk factors related to the possibility of suffering an RTI according to age, sex and population groups, to assess the relationship between these same risk factors and self risk perception for suffering an RTI, and to outline the association between the number of risk factors and the history of reported collisions. Methods/Design: Design: Cross-sectional, multicentre study. Setting: 25 urban health care centres. Study population: Randomly selected sample of Spanish/Catalan speakers age 16 or above with a medical register in any of the 25 participating primary health care centres. N = 1540. Unit of study: Basic unit of care, consisting of a general practitioner and a nurse, both of whom caring for the same population (1,500 to 2,000 people per unit). Instruments of measurement: Data collection will be performed using a survey carried out by health professionals, who will use the clinical registers and the information reported by the patient during the visit to collect the baseline data: illnesses, medication intake, alcohol and psychoactive consumption, and self perception of risk. Discussion: We expect to obtain a risk profile of the subjects in relation to RTI in the primary health care field, and to create a group for a prospective follow-up. Trial Registration: Clinical Trials.gov Identifier: NCT00778440. </p

An Ultrahigh CO2-Loaded Silicalite-1 Zeolite: Structural Stability and Physical Properties at High Pressures and Temperatures

[EN] We report the formation of an ultrahigh CO2-loaded pure-SiO2, silicalite-1 structure at high pressure (0.7 GPa) from the interaction of empty zeolite and fluid CO, medium. The CO2-filled structure was characterized in situ by means of synchrotron powder X-ray diffraction. Rietveld refinements and Fourier recycling allowed the location of 16 guest carbon dioxide molecules per unit cell within the straight and sinusoidal channels of the porous framework to be analyzed. The complete filling of pores by CO, molecules favors structural stability under compression, avoiding pressure-induced amorphization below 20 GPa, and significantly reduces the compressibility of the system compared to that of the parental empty one. The structure of CO2-loaded silicalite-1 was also monitored at high pressures and temperatures, and its thermal expansivity was estimated.The authors thank the Spanish Ministerio de Economia y Competitividad (MINECO), the Spanish Research Agency (AEI), and the European Fund for Regional Development (FEDER) for their financial support (MAT2016-75586-C4-1-P, MAT2016-75586-C4-3-P, MAT2015-71842-P; Severo Ochoa SEV-2012-0267; and MAT2015-71070-REDC (MALTA Consolider)). D.S.-P. and J.R-F. acknowledge MINECO for a Ramon y Cajal (RyC-2014-15643) and a Juan de la Cierva (IJCI-2014-20513) contract, respectively. A.K. acknowledges the support of the University of Valencia through the Grant UV-INV-EPC17-548561. Portions of this work were performed at GeoSoilEnviroCARS (Sector 13), Advanced Photon Source (APS), and Argonne National Laboratory. GeoSoilEnviroCARS is supported by the National Science Foundation, Earth Sciences (EAR-1128799), and the Department of Energy, GeoSciences (DE-FG02-94ER14466). This research used resources from the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory (DE-AC02-06CH11357). Use of the COMPRES-GSECARS gas loading system was supported by COMPRES under NSF Cooperative Agreement EAR 11-57758. CO2 gas was also loaded at Diamond Light Source. The authors thank the synchrotron facility ALBA-CELLS for beamtime allocation at MSPD line.Marqueno, T.; Santamaria-Perez, D.; Ruiz-Fuertes, J.; Chulia-Jordan, R.; Jorda Moret, JL.; Rey Garcia, F.; Mcguire, C.... (2018). An Ultrahigh CO2-Loaded Silicalite-1 Zeolite: Structural Stability and Physical Properties at High Pressures and Temperatures. Inorganic Chemistry. 57(11):6447-6455. https://doi.org/10.1021/acs.inorgchem.8b00523S64476455571