Exploring novel inhibitory mechanism on megakaryopoiesis in immune thrombocytopenia

TesisAnaliza y define la trombocitopenia inmune a la reducción de plaquetas por debajo de 100 x 109/L en ausencia de causa evidente . Para analizar los objetivos , se diferenció células madre en megacarocitos (MK) por 10 días. En el día 7 de diferenciación se aplicó plasma de 4 pacientes con ITP y de 3 donantes sanos como control. En los días 3,5,7 y 10 se estudió la expresión de CD34, CD38, CD41, CD42b, CD274 y HLA-DR por medio de citometría de flujo. La confirmación de expresión de CD274 fue por medio de microscopía confocal. Se confirmó la expresión de CD274 (PD-L1) en MK maduros. El uso de plasma de pacientes con trombocitopenia inmune produce mayor expresión de HLA-DR.Tesi

Visualization of Sensor Data in Virtual Globes

Ponència presentada en AGILE’2012 International Conference on Geographic Information Science, "Multidisciplinary Research on Geographical Information in Europe and Beyond" celebrat a Avignon, els dies 24-27 d'abril de 2012Virtual Globes have become a common platform for visualizing geographical data. The capability for customization, extensibility and the support of interaction with the visualized elements are some of the aspects to consider when selecting a Virtual Globe for visualization. For visualizing sensor data, aspects such as cardinality, the nature of the data and its temporal and spatial dimensions have to be considered. In this paper we present a prototype application to visualize sensor data retrieved from SOS servers over the NASA World Wind virtual Globe. For implementing the prototype application we relied on a categorization of the sensor data that provides possible visualization methods. The prototype has integrated the SEXTANTE library to enable data analysis over sensor data and include the results as part of the visualizations

Mobile Application for Noise Pollution Monitoring through Gamification Techniques

Full data coverage of urban environments is crucial to monitor the status of the area to detect, for instance, trends and detrimental environmental changes. Collecting observations related to environmental factors such as noise pollution in urban environments through classical approaches implies the deployment of Sensor Networks. The cost of deployment and maintenance of such infrastructure might be relatively high for local and regional governments. On the other hand recent mass-market mobile devices such as smartphones are full of sensors. For instance, it is possible to perform measurements of noise through its microphone. Therefore they become low-cost measuring devices that many citizens have in their pocket. In this paper we present an approach for gathering noise pollution data by using mobile applications. The applications are designed following gamification techniques to encourage users to participate using their personal smartphones. In this way the users are involved in taking and sharing noise pollution measurements in their cities that other stakeholders can use in their analysis and decision making processes

Conceptual Architecture and Service-oriented Implementation of a Regional Geoportal for Rice Monitoring

Agricultural monitoring has greatly benefited from the increased availability of a wide variety of remote-sensed satellite imagery, ground-sensed data (e.g., weather station networks) and crop models, delivering a wealth of actionable information to stakeholders to better streamline and improve agricultural practices. Nevertheless, as the degree of sophistication of agriculture monitoring systems increases, significant challenges arise due to the handling and integration of multi-scale data sources to present information to decision-makers in a way which is useful, understandable and user friendly. To address these issues, in this article we present the conceptual architecture and service-oriented implementation of a regional geoportal, specifically focused on rice crop monitoring in order to perform unified monitoring with a supporting system at regional scale. It is capable of storing, processing, managing, serving and visualizing monitoring and generated data products with different granularity and originating from different data sources. Specifically, we focus on data sources and data flow, and their importance for and in relation to different stakeholders. In the context of an EU-funded research project, we present an implementation of the regional geoportal for rice monitoring, which is currently in use in Europe’s three largest rice-producing countries, Italy, Greece and Spain

A Novel Noninvasive Method Based on Salivary Inflammatory Biomarkers for the Screening of Celiac Disease

This study was supported by a grant from theSpanish Ministry of Science, Universities andInnovation (SAF2017-91873-EXP), a grant fromthe Department of Health from the BasqueGovernment (EJ-2017111082), and a researchfellowship from the Asociación de Celiacos ySensibles al Gluten de Madrid (A.C.R.). Alsosupported by a predoctoral fellowship from theUniversity of the Basque Country (M.S.dlC.) andthe Basque Government (A.O.G.)