Genetic algorithms

Genetic algorithms are mathematical, highly parallel, adaptive search procedures (i.e., problem solving methods) based loosely on the processes of natural genetics and Darwinian survival of the fittest. Basic genetic algorithms concepts are introduced, genetic algorithm applications are introduced, and results are presented from a project to develop a software tool that will enable the widespread use of genetic algorithm technology

Pulsed Gas Chromatographic Separation Final Report

Feasibility of separating binary-gas mixtures based on pulsed-mode gas adsorption/desorptio

Distinct Scaling Regimes of Energy Release Dynamics in the Nighttime Magnetosphere

Based on a spatiotemporal analysis of POLAR UVI images, we show that the auroral emission events that initiate equatorward of the isotropic boundary (IB) obtained from a time-dependent empirical model, have systematically steeper power-law slopes of energy, power, area and lifetime probability distributions compared to the events that initiate poleward of the IB. The low-latitude group of events contains a distinct subpopulation of substorm-scale disturbances violating the power-law behavior, while the high latitude group is described by nearly perfect power-law statistics over the entire range of scales studied. The results obtained indicate that the inner and outer portions of the plasma sheet are characterized by substantially different scaling regimes of bursty energy dissipation suggestive of different physics in these regions.Comment: 11 pages, 2 figures, 2 table

Empirical modeling of the quiet time nightside magnetosphere

Empirical modeling of plasma pressure and magnetic field for the quiet time nightside magnetosphere is investigated. Two models are constructed for this study. One model, referred to here as T89R, is basically the magnetic field model of Tsyganenko (1989) but is modified by the addition of an inner eastward ring current at a radial distance of ∼3 RE as suggested by observation. The other is a combination of the T89R model and the long version of the magnetic field model of Tsyganenko (1987) such that the former dominates the magnetic field in the inner magnetosphere, whereas the latter prevails in the distant tail. The distribution of plasma pressure, which is required to balance the magnetic force for each of these two field models, is computed along the tail axis in the midnight meridian. The occurrence of pressure anisotropy in the inner magnetospheric region is also taken into account by determining an empirical fit to the observed plasma pressure anisotropy. This effort is the first attempt to obtain the plasma pressure distribution in force equilibrium with magnetic stresses from an empirical field model with the inclusion of pressure anisotropy. The inclusion of pressure anisotropy alters the plasma pressure by as much as a factor of ∼3 in the inner magnetosphere. The deduced plasma pressure profile along the tail axis is found to be in good agreement with the observed quiet time plasma pressure for geocentric distances between ∼2 and ∼35 RE

Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer.

BackgroundHyperactivation of STAT3 via constitutive phosphorylation of tyrosine 705 (Y705) is common in most human cancers, including head and neck squamous carcinoma (HNSCC). STAT3 is rarely mutated in cancer and the (epi)genetic alterations that lead to STAT3 activation are incompletely understood. Here we used an unbiased approach to identify genomic and epigenomic changes associated with pSTAT3(Y705) expression using data generated by The Cancer Genome Atlas (TCGA).Methods and findingsMutation, mRNA expression, promoter methylation, and copy number alteration data were extracted from TCGA and examined in the context of pSTAT3(Y705) protein expression. mRNA expression levels of 1279 genes were found to be associated with pSTAT3(705) expression. Association of pSTAT3(Y705) expression with caspase-8 mRNA expression was validated by immunoblot analysis in HNSCC cells. Mutation, promoter hypermethylation, and copy number alteration of any gene were not significantly associated with increased pSTAT3(Y705) protein expression.ConclusionsThese cumulative results suggest that unbiased approaches may be useful in identifying the molecular underpinnings of oncogenic signaling, including STAT3 activation, in HNSCC. Larger datasets will likely be necessary to elucidate signaling consequences of infrequent alterations

Gender gap in Hong Kong: an update

postprin

Electric Scooter Injuries and Hospital Admissions in the United States, 2014-2018.

This study investigates trends of injury and hospital admission associated with electric scooter use

AMPTE/CCE‐SCATHA simultaneous observations of substorm‐associated magnetic fluctuations

This study examines substorm-associated magnetic field fluctuations observed by the AMPTE/CCE and SCATHA satellites in the near-Earth tail. Three tail reconfiguration events are selected, one event on August 28, 1986, and two consecutive events on August 30, 1986. The fractal analysis was applied to magnetic field measurements of each satellite. The result indicates that (1) the amplitude of the fluctuation of the north-south magnetic component is larger, though not overwhelmingly, than the amplitudes of the other two components and (2) the magnetic fluctuations do have a characteristic timescale, which is several times the proton gyroperiod. In the examined events the satellite separation was less than 10 times the proton gyroradius. Nevertheless, the comparison between the AMPTE/CCE and SCATHA observations indicates that (3) there was a noticeable time delay between the onsets of the magnetic fluctuations at the two satellite positions, which is too long to ascribe to the propagation of a fast magnetosonic wave, and (4) the coherence of the magnetic fluctuations was low in the August 28, 1986, event and the fluctuations had different characteristic timescales in the first event of August 30, 1986, whereas some similarities can be found for the second event of August 30, 1986. Result 1 indicates that perturbation electric currents associated with the magnetic fluctuations tend to flow parallel to the tail current sheet and are presumably related to the reduction of the tail current intensity. Results 2 and 3 suggest that the excitation of the magnetic fluctuations and therefore the trigger of the tail current disruption is a kinetic process in which ions play an important role. It is inferred from results 3 and 4 that the characteristic spatial scale of the associated instability is of the order of the proton gyroradius or even shorter, and therefore the tail current disruption is described as a system of chaotic filamentary electric currents. However, result 4 suggests that the nature of the tail current disruption can vary from event to event

East meets West: The Role and Value of Inter-Cultural Competence in a Short-Term Academic Exchange Program

In October, 2014, eleven Masters students and one professor from the University of Puerto Rico Graduate School of Planning visited Feng-Chia University, located in Taichung, Taiwan, to participate in a week long academic and cultural exchange program. Both Taiwanese and Puerto Rican students actively participated in a curriculum centered on three urban intervention projects located in Taichung. We will explore how cultural disequilibrium affects students’ ability to work together in an assigned Planning project. There were two key parallel learning processes: one centered on bridging the culture gap and another on sharing knowledge and applying tools to solve a planning problem. Changes in visions, values and practices that transcended the duration of the academic exercise in Taiwan were also studied. We conducted two focus groups with participating Puerto Rican and Taiwanese students, to describe learning processes and overall cultural experiences during the short-term exchange program. Findings show that both hosting and visiting students were able to benefit from the learning experience, although in different ways. Taiwanese students strengthened their leadership and language skills, while Puerto Rican students gained insight that allowed them to view urban problems and processes differently. Both groups gained competency as intercultural communicators, as evidenced by the ways they faced communication challenges, their capacity to overcome them, and an increased sensitivity, acceptance and respect of cultural differences.En este trabajo, se analiza los efectos de la desigualdad socioeconómica en el éxito de los estudiantes en la escuela, los factores en el sistema escolar que acentúan la desigualdad y cómo las escuelas exitosas y la educación alternativa superan esos factores. A partir de este análisis, se propone un plan educacional para el desarrollo de alternativas para disminuir los efectos de la desigualdad en la educación. Las alternativas están dirigidas al desarrollo integral a través de la educación personalizada, la integración de la familia y la comunidad y el apoyo al desarrollo emocional y social del estudiante