Free-carrier screening of polarization fields in wurtzite GaN/InGaN laser structures

The free-carrier screening of macroscopic polarization fields in wurtzite GaN/InGaN quantum wells lasers is investigated via a self-consistent tight-binding approach. We show that the high carrier concentrations found experimentally in nitride laser structures effectively screen the built-in spontaneous and piezoelectric polarization fields, thus inducing a ``field-free'' band profile. Our results explain some heretofore puzzling experimental data on nitride lasers, such as the unusually high lasing excitation thresholds and emission blue-shifts for increasing excitation levels.Comment: RevTeX 4 pages, 4 figure

Cell line derived xenograft mouse models are a suitable in vivo model for studying tumor budding in colorectal cancer

Tumor budding (TB) is an important prognostic parameter in colorectal cancer (CRC) and associated with metastasis. However, the mechanisms of TB have not been fully elucidated and a major limitation is the absence of in vivo models. Here, we determine the suitability of human cell line derived xenografts (CDX) as models of TB in CRC. Pan-cytokeratin (CK)-stained next-generation Tissue Microarrays (ngTMA) of two CDX models (HT-29, n = 12 and HCT-8, n = 8) and human CRC (n = 27 high-grade and 25 low-grade budding tumors, each) were evaluated for TB. Immunohistochemistry for E-cadherin, β-catenin, Ki-67, ZEB1, and TWIST1 was performed. HT-29 and HCT-8 were predominantly high-grade and no/low-grade TB tumors, respectively. TB counts in the tumor center (intratumoral budding, ITB) were significantly higher in HT-29 CDX tumors compared to human CRC (p = 0.0099). No difference was found in TB counts at the invasion front (peritumoral budding, PTB; p=0.07). ITB and PTB were strongly correlated (r = 0.438 and r = 0.62 in CDX and human CRC, respectively). Immunohistochemistry profiles were comparable in CDX and human CRC tissues. TB in the CDX mouse models is phenotypically similar to human CRCs and highlights comparable protein profiles. The HT-29 CDX could be a suitable model for the in vivo assessment of TB.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Sea Tide Influence on Ice Flow of David Drygalski’s Ice Tongue Inferred from Geodetic GNSS Observations and SAR Offset Tracking Analysis

David Glacier and Drygalski Ice Tongue are massive glaciers in Victoria Land, Antarctica. The ice from the East Antarctic Ice Sheet is drained through the former, and then discharged into the western Ross Sea through the latter. David Drygalski is the largest outlet glacier in Northern Victoria Land, floating kilometers out to sea. The floating and grounded part of the David Glacier are the main focus of this article. During the XXI Italian Antarctic Expedition (2005-2006), within the framework of the National Antarctic Research Programme (PNRA), two GNSS stations were installed at different points: the first close to the grounding line of David Glacier, and the second approximately 40 km downstream of the first one. Simultaneous data logging was performed by both GNSS stations for 24 days. In the latest data processing, the kinematic PPP technique was adopted to evaluate the dominant diurnal components and the very small semi-diurnal variations in ice motion induced by the ocean tide and the mean ice flow rates of both GNSS stations. Comparison of the GNSS time series with predicted ocean tide calculated from harmonic coefficients of the nearest tide gauge stations, installed at Cape Roberts and Mario Zucchelli Station, highlight different local response of the glacier to ocean tide, with a minor amplitude of vertical motion at a point partially anchored at the bedrock close to the grounding line. During low tide, the velocity of the ice flow reaches its daily maximum, in accordance with the direction of seawater outflow from the fjord into the ocean, while the greatest daily tidal excursion generates an increase in the horizontal ice flow velocity. With the aim to extend the analysis in spatial terms, five COSMO-SkyMED Stripmap scenes were processed. The comparison of the co-registered offset tracking rates, obtained from SAR images, with the GNSS estimation shows good agreement

Insights on the origin of vitrified rocks from serravuda, acri (Italy): Rock fulgurite or anthropogenic activity?

In this study, twenty five partially vitrified rocks and four samples of vitrified rocks collected on the top hill called Serravuda (Acri, Calabria, Italy) are analyzed. The goal is to shed light on the origin of these enigmatic vitrified materials. The analyzed vitrified rocks are a breccia of cemented rock fragments (gneiss, granitoid, and amphibolite fragments) which extends for more than 10 m, forming a continuous mass along the northern and north-west border of the flat top hill. Surrounded by the vitrified accumulation, exposed Paleozoic granitoid substrate rocks show limited melting or heat-alteration processes. By mapping minerals embedded in the glass matrix via X-ray powder diffraction (XRPD) and scanning electron microscopy (SEM), an interpretation of source rock material, reactions, and thermometric indications to form vitrified materials on the top hill of Serravuda, Acri (Italy), is provided. The mineralogical composition of heated or partially vitrified samples is heterogeneous owing to the effects of heating events, but it mostly recalls the parent rock composition (gneiss, granitoid, and amphibolite). The presence of quartz, cristobalite, tridymite, mullite, plagioclase, hercynite, cordierite, and olivine in Serravuda partially vitrified rocks and glasses suggests that samples were subjected to pyrometamorphism and the temperature range at which the glass formed was about 1000–1100◦C in the presence of hydrous gas, burning organic material (e.g., wood), and assuming thermodynamic equilibrium. Lithologies of the heated or partially vitrified rock fragments are a mixture of parent rocks not outcropping on the top of the hill such as gneiss and amphibolite. Data suggest that Serravuda vitrified rocks are most likely the result of anthropic activities and could represent remnants of vitrified fort walls. The mineral assemblage of partially vitrified rocks and glasses suggests that the fort walls were made of slabs derived from the local metamorphic rocks with the addition of Serravuda substrate Paleozoic granitoid rocks to improve the strength and insulation of the fort walls

Rare KIT (CD117) expression in multiple myeloma abrogates the usefulness of imatinib mesylate treatment

Background: Imatinib mesylate blocks the tyrosine kinase activity of KIT (CD117) and is an effective treatment for gastrointestinal stromal tumors. In multiple myeloma, KIT expression has been detected by flow cytometry in about 33% of specimens, but no previous immunohistochemical assessment has yet been made of the expression pattern of KIT. Materials and methods: We performed immunohistochemical analyses of 100 patients, including 72 with multiple myeloma (MM), 8 with lymphoplasmacytic lymphoma (LPL), 10 with monoclonal gammopathy of undetermined significance (MGUS) and 10 with reactive plasmocytosis. One KIT-positive MM was sequenced using polymerase chain reaction analysis. Results: In MM, only 2 cases (2.8%) were KIT positive. The great majority of the cases (97, 2%) did not express the KIT receptor tyrosine kinase. No mutation of the c-kit gene was detected. Conclusions: KIT expression is a rare event in MM and not detectable in MGUS and LPL. Therefore, treatment with imatinib is unlikely to be effective in these patient

Photonic Bloch oscillations in laterally confined Bragg mirrors

We show that the photons in laterally confined Bragg mirrors may experience Bloch oscillations similar to those of electrons in semiconductor superlattices subjected to electric fields. An effective electric field is produced in the photonic case by variation of the lateral size of the structure as one moves along the structure axis. The temporal behavior of a short pulse of light oscillating within a miniband of such an optical superlattice made from the porous silicon has been modeled by a proper scattering-state simulation scheme