Chip-Based Laser with 1 Hertz Integrated Linewidth

Lasers with hertz-level linewidths on timescales up to seconds are critical for precision metrology, timekeeping, and manipulation of quantum systems. Such frequency stability typically relies on bulk-optic lasers and reference cavities, where increased size is leveraged to improve noise performance, but with the trade-off of cost, hand assembly, and limited application environments. On the other hand, planar waveguide lasers and cavities exploit the benefits of CMOS scalability but are fundamentally limited from achieving hertz-level linewidths at longer times by stochastic noise and thermal sensitivity inherent to the waveguide medium. These physical limits have inhibited the development of compact laser systems with frequency noise required for portable optical clocks that have performance well beyond conventional microwave counterparts. In this work, we break this paradigm to demonstrate a compact, high-coherence laser system at 1548 nm with a 1 s integrated linewidth of 1.1 Hz and fractional frequency instability less than 10$^{-14}$ from 1 ms to 1 s. The frequency noise at 1 Hz offset is suppressed by 11 orders of magnitude from that of the free-running diode laser down to the cavity thermal noise limit near 1 Hz$^2$/Hz, decreasing to 10$^{-3}$ Hz$^2$/Hz at 4 kHz offset. This low noise performance leverages wafer-scale integrated lasers together with an 8 mL vacuum-gap cavity that employs micro-fabricated mirrors with sub-angstrom roughness to yield an optical $Q$ of 11.8 billion. Significantly, all the critical components are lithographically defined on planar substrates and hold the potential for parallel high-volume manufacturing. Consequently, this work provides an important advance towards compact lasers with hertz-level linewidths for applications such as portable optical clocks, low-noise RF photonic oscillators, and related communication and navigation systems

Photonic chip-based low noise microwave oscillator

Numerous modern technologies are reliant on the low-phase noise and exquisite timing stability of microwave signals. Substantial progress has been made in the field of microwave photonics, whereby low noise microwave signals are generated by the down-conversion of ultra-stable optical references using a frequency comb. Such systems, however, are constructed with bulk or fiber optics and are difficult to further reduce in size and power consumption. Our work addresses this challenge by leveraging advances in integrated photonics to demonstrate low-noise microwave generation via two-point optical frequency division. Narrow linewidth self-injection locked integrated lasers are stabilized to a miniature Fabry-P\'{e}rot cavity, and the frequency gap between the lasers is divided with an efficient dark-soliton frequency comb. The stabilized output of the microcomb is photodetected to produce a microwave signal at 20 GHz with phase noise of -96 dBc/Hz at 100 Hz offset frequency that decreases to -135 dBc/Hz at 10 kHz offset--values which are unprecedented for an integrated photonic system. All photonic components can be heterogeneously integrated on a single chip, providing a significant advance for the application of photonics to high-precision navigation, communication and timing systems

A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression

Introduction: We hypothesized that common Alzheimer's disease (AD)-associated variants within the triggering receptor expressed on myeloid (TREM) gene cluster influence disease through gene expression. Methods: Expression microarrays on temporal cortex and cerebellum from ∼400 neuropathologically diagnosed subjects and two independent RNAseq replication cohorts were used for expression quantitative trait locus analysis. Results: A variant within a DNase hypersensitive site 5′ of TREM2, rs9357347-C, associates with reduced AD risk and increased TREML1 and TREM2 levels (uncorrected P = 6.3 × 10−3 and 4.6 × 10−2, respectively). Meta-analysis on expression quantitative trait locus results from three independent data sets (n = 1006) confirmed these associations (uncorrected P = 3.4 × 10−2 and 3.5 × 10−3, Bonferroni-corrected P = 6.7 × 10−2 and 7.1 × 10−3, respectively). Discussion: Our findings point to rs9357347 as a functional regulatory variant that contributes to a protective effect observed at the TREM locus in the International Genomics of Alzheimer's Project genome-wide association study meta-analysis and suggest concomitant increase in TREML1 and TREM2 brain levels as a potential mechanism for protection from AD

Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice

BACKGROUND: It is well established that vaccination of humans and transgenic animals against fibrillar Aβ prevents amyloid accumulation in plaques and preserves cognitive function in transgenic mouse models. However, autoimmune side effects have halted the development of vaccines based on full length human Aβ. Further development of an effective vaccine depends on overcoming these side effects while maintaining an effective immune response. RESULTS: We have previously reported that the immune response to amyloid oligomers is largely directed against generic epitopes that are common to amyloid oligomers of many different proteins and independent of a specific amino acid sequence. Here we have examined whether we can exploit this generic immune response to develop a vaccine that targets amyloid oligomers using a non-human random sequence amyloid oligomer. In order to study the effect of vaccination against generic oligomer epitopes, a random sequence oligomer (3A) was selected as it forms oligomers that react with the oligomer specific A11 antibody. Oligomer mimics from 3A peptide, Aβ, islet amyloid polypeptide (IAPP), and Aβ fibrils were used to vaccinate Tg2576 mice, which develop a progressive accumulation of plaques and cognitive impairment. Vaccination with the 3A random sequence antigen was just as effective as vaccination with the other antigens in improving cognitive function and reducing total plaque load (Aβ burden) in the Tg2576 mouse brains, but was associated with a much lower incidence of micro hemorrhage than Aβ antigens. CONCLUSION: These results shows that the amyloid Aβ sequence is not necessary to produce a protective immune response that specifically targets generic amyloid oligomers. Using a non-human, random sequence antigen may facilitate the development of a vaccine that avoids autoimmune side effects

Reflektion av solvindsprotoner från månen : Dataanalys av SARA-instrumentet

The Moon has neither a strong magnetic field nor a dense atmosphere to stand-off the solar wind. However, some areas of the lunar crust are permanently magnetized and several studies indicate that these magnetic anomalies can form mini-magnetospheres, partially deflecting the solar wind.Here, ion data from the SARA instrument onboard Chandrayaan-1 is analyzed, to improve the understanding of the interaction dynamics between the solar wind protons and the Moon.A clear and strong interaction is observed between the solar wind protons and the lunar magnetic anomalies. ~50 % of the incoming solar wind protons are reflected above the strongest magnetic anomalies. An average of ~1 % of the solar wind protons are reflected over the entire lunar far-side.This implies that the regolith in magnetic anomaly areas is partially protected from proton precipitation, and that the near-Moon plasma environment is highly influenced by the magnetic anomalies.Even small (<100 km), weak (<3 nT at 30 km altitude) magnetic anomalies reflect some of the solar wind protons, which is surprising considering the large gyro radius of a proton in such a field. Further studies are required to understand the reflection mechanism.Validerat; 20110504 (anonymous

Solvindsprotoners växelverkan med månens magnetiska anomalier och yta

The lunar space environment is shaped by the interaction between the Moon and the solar wind. In the present thesis, we investigate two aspects of this interaction, namely the interaction between solar wind protons and lunar crustal magnetic anomalies, and the interaction between solar wind protons and lunar regolith. We use particle sensors that were carried onboard the Chandrayaan-1 lunar orbiter to analyze solar wind protons that reflect from the Moon, including protons that capture an electron from the lunar regolith and reflect as energetic neutral atoms of hydrogen. We also employ computer simulations and use a hybrid plasma solver to expand on the results from the satellite measurements. The observations from Chandrayaan-1 reveal that the reflection of solar wind protons from magnetic anomalies is a common phenomenon on the Moon, occurring even at relatively small anomalies that have a lateral extent of less than 100 km. At the largest magnetic anomaly cluster (with a diameter of 1000 km), an average of ~10% of the incoming solar wind protons are reflected to space. Our computer simulations show that these reflected proton streams significantly modify the global lunar plasma environment. The reflected protons can enter the lunar wake and impact the lunar nightside surface. They can also reach far upstream of the Moon and disturb the solar wind flow. In the local environment at a 200 km-scale magnetic anomaly, our simulations show a heated and deflected plasma flow and the formation of regions with reduced or increased proton precipitation. We also observe solar wind protons reflected from the lunar regolith. These proton fluxes are generally lower than those from the magnetic anomalies. We find that the proton reflection efficiency from the regolith varies between ~0.01% and ~1%, in correlation with changes in the solar wind speed. We link this to a velocity dependent charge-exchange process occurring when the particles leave the lunar regolith. Further, we investigate how the properties of the reflected neutral hydrogen atoms depend on the solar wind temperature. We develop a model to describe this dependence, and use this model to study the plasma precipitation on the Moon when it is in the terrestrial magnetosheath. We then use the results from these and other studies, to model solar wind reflection from the surface of the planet Mercury.Rymdmiljön runt månen formas av den växelverkan som sker mellan månen och solvinden. I den föreliggande avhandlingen undersöker vi två aspekter av denna växerverkan, nämligen växelverkan mellan solvindsprotoner och magnetiserade områden i månskorpan, och växelverkan mellan solvindsprotoner och månens ytdamm. Vi använder oss av partikelsensorer på månsatelliten Chandrayaan-1 för att analysera solvindsprotoner som reflekteras från månen, även de protoner som fångar upp en elektron från ytan och reflekteras som neutrala väteatomer. Vi använder oss också av datorsimuleringar för att bygga vidare på de uppmätta resultaten. Observationerna från Chandrayaan-1 visar att reflektion av solvindsprotoner från magnetiserade områden är ett vanligt förekommande fenomen på månen, som inträffar även vid magnetiseringar som är utbredda över mindre än 100 km. Vid det största magnetiserade området på månen (1000 km i diameter), reflekteras i genomsnitt ~10% av de infallande solvindsprotonerna. Våra datorsimuleringar visar att dessa protonflöden har globala effekter på månens plasmamiljö. De reflekterade protonerna kan nå månens nattsida. De kan också nå långt uppströms om månen och störa solvindsflödet. I den lokala plasmamiljön vid ett magnetiserat område av storleken 200 km visar våra simuleringar ett förändrat solvindsflöde, där det skapas områden som delvis skyddas från solvinden, likväl som områden som utsätts för mer solvind. Vi observerar även solvindsprotoner som reflekterats från ytdammet på månen. Dessa protonflöden är lägre än de från de magnetiska fälten. Reflektionen från ytan varierar mellan ~0.01% och 1% av solvindsflödet, i samband med förändringar i solvindshastigheten. Vi förklarar detta med att partiklarnas laddning bestäms av den hastighet de har när de lämnar måndammet. Vidare undersöker vi hur egenskaperna hos de reflekterade neutrala väteatomerna beror på solvindstemperaturen. Vi skapar en modell för att beskriva sambandet och använder sedan denna modell för att studera hur solvinden faller in mot månens yta när den befinner sig i jordens magnetoskikt, där jordens magnetfält orsakar en upphettning av solvindsflödet. Resultaten från dessa och andra studier använder vi sedan för att modellera solvindsreflektion från planeten Merkurius yta, för jämförelse med framtida observationer

Chandrayaan-1 observations of backscattered solar wind protons from the lunar regolith: Dependence on the solar wind speed

We study the backscattering of solar wind protons from the lunar regolith using the Solar Wind Monitor of the Sub-keV Atom Reflecting Analyzer on Chandrayaan-1. Our study focuses on the component of the backscattered particles that leaves the regolith with a positive charge. We find that the fraction of the incident solar wind protons that backscatter as protons, i.e., the proton-backscattering efficiency, has an exponential dependence on the solar wind speed that varies from ~0.01% to ~1% for solar wind speeds of 250 km/s to 550 km/s. We also study the speed distribution of the backscattered protons in the fast (~550 km/s) solar wind case and find both a peak speed at ~80% of the solar wind speed and a spread of ~85 km/s. The observed flux variations and speed distribution of the backscattered protons can be explained by a speed-dependent charge state of the backscattered particles

Solar wind scattering from the surface of Mercury: Lessons from the Moon

We discuss the surface-scattering of solar wind protons at Mercury based on observed scattering characteristics from lunar regolith. The properties of the impinging plasma are expected to be different between different regions on Mercury, and between Mercury and the Moon. Here, we review the expected Hermean plasma conditions and lunar empirical scattering models. We present observed and modeled energy spectra for scattered protons and hydrogen energetic neutral atoms (ENAs) for three cases of very different plasma conditions at the Moon. Then, we simulate scattering from the Hermean surface by applying the empirical models to four different scenarios of plasma precipitation on Mercury. The results suggest that surface-scattering is a strong source of ENAs at Mercury (up to ~10⁸ cm⁻² s⁻¹), which can be very useful for remote-sensing of the plasma conditions at the surface. Protons scattered from the surface back into space are also expected with high fluxes up to ~10⁷ cm⁻² s⁻¹, and may be important for wave generation and the filling in of the loss cone of mirroring and quasi-trapped populations. Scattered protons at the cusp region (of ~10⁶ cm⁻² s⁻¹) can potentially be detected by orbiters as outflowing protons within the loss cone