Applications of ABM in International Legal Research The Case of Compliance

Agent-based modeling has been largely overlooked in international legal research, even though it could be used to gain insights into the highly complex processes of state behavior relevant to international law that can only be insufficiently addressed with other methods. On the basis of a concrete application – state compliance with European Court of Human Rights judgments - we show the applicability of agent-based modeling to international legal research. We discuss its implications for two levels of analysis: (1) understanding the drivers of state behavior, which contributes to the international law research with unitary state actors at its center, and (2) within state dynamics and their influence during the compliance process, which breaks the black box of the state. Agent-based models addressing the questions that arise on these levels can take a variety of shapes. We provide one line of thought on the set-up of an agent-based model for each of the two levels of analysis and discuss expected difficulties. Finally, we provide an outlook on how these aspects might come together in exploring how compliance rates can be bettered

Water Policies: Regions with Open-Pit Lignite Mining (Introduction to the IIASA Study)

There is an apparent need for the analysis of long-term regional water policies to reconcile conflicting interests in regions with open-pit lignite mining. The most important. interest groups in such regions are mining, municipal and industrial water supply, agriculture as well as the "environment". A scientifically sound and practically simple policy-oriented system of methods and computerized procedures has to be developed. To develop such a system is part of the research work in the Regional Water Policies project carried out at the International Institute for Applied Systems Analysis (IIASA) in collaboration with research institutes in the German Democratic Republic, Poland, and in other countries as well. A test area that includes typical water-related elements of mining regions and significant conflicts and interest groups has been chosen. The first stage in the analysis is oriented towards developing a scenario generating system as a tool to choose "good" policies from the regional point of view. Therefore a policy-oriented interactive decision support model system is under development, considering the dynamic, nonlinear and uncertain systems behaviour. It combines a model for multi-criteria analysis in planning periods with a simulation model for monthly systems behaviour. The paper outlines the methodological approach. describes the test region in the GDR, and the submodels for the test region

Estimation of the Required Amount of Hydrological Exploration in Lignite Mining Areas on the Basis of Hypothetical Hydrogeological Models

Mine drainage is a necessary but very costly precaution for open-pit lignite mining in sandy aquifers. Consequently, the minimization of the number of drainage wells and their optimal operation become important tasks in designing mine drainage systems. Comprehensive groundwater flow models have to be used, both, for the design of drainage wells, and for the analysis of water management strategies in mining areas . The accuracy of computations with such models depends on the precision of the underlying hydrogeological informations. In order to get these informations detailed and costly hydrogeological explorations have to be done in the mining regions. The basic informations are obtained using exploration drilling. The cost for hydrogeological exploration are approximately a linear function of the number of exploration bore holes. Therefore the reduction of drilling gets a key role in reducing costs of exploration. This might be done by: increased use of geophysical exploration methods; complex analysis of exploration results using mathematical statistical methods; precise estimation of the required amount of hydrogeological informations. The paper describes a mathematical approach to support the complex decision making procedure of estimating the optimal amount of hydrogeological exploration with respect to a given mine drainage goal

Risk factors for presentation to hospital with severe anaemia in Tanzanian children: a case-control study.

In malaria endemic areas anaemia is a usually silent condition that nevertheless places a considerable burden on health services. Cases of severe anaemia often require hospitalization and blood transfusions. The objective of this study was to assess risk factors for admission with anaemia to facilitate the design of anaemia control programmes. We conducted a prospective case-control study of children aged 2-59 months admitted to a district hospital in southern Tanzania. There were 216 cases of severe anaemia [packed cell volume (PCV) < 25%] and 234 age-matched controls (PCV > or = 25%). Most cases [55.6% (n = 120)] were < 1 year of age. Anaemia was significantly associated with the educational level of parents, type of accommodation, health-seeking behaviour, the child's nutritional status and recent and current medical history. Of these, the single most important factor was Plasmodium falciparum parasitaemia [OR 4.3, 95% confidence interval (CI) 2.9-6.5, P < 0.001]. Multivariate analysis showed that increased recent health expenditure [OR 2.2 (95% CI 1.3-3.9), P = 0.005], malnutrition [OR 2.4 (95%CI 1.3-4.3), P < 0.001], living > 10 km from the hospital [OR 3.0 (95% CI 1.9-4.9), P < 0.001], a history of previous blood transfusion [OR 3.8 (95% CI 1.7-9.1), P < 0.001] and P. falciparum parasitaemia [OR 9.5 (95% CI 4.3-21.3), P < 0.001] were independently related to risk of being admitted with anaemia. These findings are considered in terms of the pathophysiological pathway leading to anaemia. The concentration of anaemia in infants and problems of access to health services and adequate case management underline the need for targeted preventive strategies for anaemia control

Paraphrases and summaries: A means of clarification or a vehicle for articulating a preferred version of student accounts?

The use of group discussions as a means to facilitate learning from experiences is well documented in adventure education literature. Priest and Naismith (1993) assert that the use of the circular discussion method, where the leader poses questions to the participants, is the most common form of facilitation in adventure education. This paper draws on transcripts of facilitation sessions to argue that the widely advocated practice of leader summaries or paraphrases of student responses in these sessions functions as a potential mechanism to control and sponsor particular knowledge(s). Using transcripts from recorded facilitation sessions the analysis focuses on how the leader paraphrases the students’ responses and how these paraphrases or ‘formulations’ function to modify or exclude particular aspects of the students’ responses. I assert that paraphrasing is not simply a neutral activity that merely functions to clarify a student response, it is a subtle means by which the leader of the session can, often inadvertently or unknowingly, alter the student’s reply with the consequence of favouring particular knowledge(s). Revealing the subtle work that leader paraphrases perform is of importance for educators who claim to provide genuine opportunities for students to learn from their experience

Avaliação de grupos genéticos em sistema de produção leiteiro intensivo a pasto no Acre.

O objetivo deste estudo foi avaliar o uso de grupos genéticos bovinos para produção de leite em sistema intensivo de pastagem no Acre. Foram utilizados dados de produção leiteira de 46 matrizes do grupo genético Girolando e 59 do cruzamento Nelore x Holandesa denominado Nelorando em propriedade localizada no município de Rio Branco, AC. Foram analisados os parâmetros de produção de leite, intervalo entre partos, duração de lactação e produção de leite ajustada para 270 dias de 167 lactações com 1.499 controles de produção diária agrupados em quatro épocas do ano de controle. As estimativas dos parâmetros genéticos foram obtidas pelo método REML/BLUP. A média estimada para produção de leite aos 270 dias de lactação e o desvio-padrão foram de 2.474,70 ± 256,52 para o grupo Girolando e 2.542,03 ± 269,36 para o grupo Nelorando com médias diárias de produção e desvio-padrão de 9,28 ± 2,49 e 10,23 ± 2,8, respectivamente. O intervalo entre partos médio encontrado na propriedade foi 12,85 meses (12,88 para Girolando e 12,83 para Nelorando). A duração de lactação para o grupo Girolando foi de 288,13 dias e para Nelorando de 273,47 dias. Para os parâmetros estudados não houve diferença significativa entre os grupos. Conclui-se que os grupos genéticos não divergem entre si e os efeitos ambientais são contornados quando se faz uso de tecnologias que favorecem a uniformidade de forrageiras com boa qualidade nutricional.Editores técnicos: Rodrigo Souza Santos; Fabiano Marçal Estanislau

Impact of Plasmodium falciparum infection on the frequency of moderate to severe anaemia in children below 10 years of age in Gabon

BACKGROUND: Improving the understanding of childhood malarial anaemia may help in the design of appropriate management strategies. METHODS: A prospective observational study over a two-year period to assess the burden of anaemia and its relationship to Plasmodium falciparum infection and age was conducted in 8,195 febrile Gabonese children. RESULTS: The proportion of children with anaemia was 83.6% (n = 6830), higher in children between the ages of six and 23 months. Those under three years old were more likely to develop moderate to severe anaemia (68%). The prevalence of malaria was 42.7% and P. falciparum infection was more frequent in children aged 36-47 months (54.5%). The proportion of anaemic children increased with parasite density (p 60%), but was unrelated to P. falciparum parasitaemia. CONCLUSION: Malaria is one of the main risk factors for childhood anaemia which represents a public health problem in Gabon. The risk of severe malarial anaemia increases up the age of three years. Efforts to improve strategies for controlling anaemia and malaria are needed

Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check

Nucleoid occlusion (NO) restricts bacterial cell division to prevent chromosome guillotining in the cell midzone when replication or segregation is delayed. Structural work suggests that the NO factor SlmA (synthetic lethal with a defective Min system) interferes with formation of the cytokinetic Z-ring by altering associations between FtsZ protofilaments

Diversity in collaborative research communities: a multicultural, multidisciplinary thesis writing group in public health

Writing groups for doctoral students are generally agreed to provide valuable learning spaces for Ph.D. candidates. Here an academic developer and the eight members of a writing group formed in a Discipline of Public Health provide an account of their experiences of collaborating in a multicultural, multidisciplinary thesis writing group. We consider the benefits of belonging to such a group for Ph.D. students who are operating in a research climate in which disciplinary boundaries are blurring and where an increasing number of doctoral projects are interdisciplinary in nature; in which both academic staff and students come from enormously diverse cultural and language backgrounds; and in which teamwork, networking and collaboration are prized but not always proactively facilitated. We argue that doctoral writing groups comprising students from diverse cultural and disciplinary backgrounds can be of significant value for postgraduates who wish to collaborate on their own academic development to improve their research writing and communication skills; at the same time, such collaborative work effectively builds an inclusive, dynamic research community.Cally Guerin, Vicki Xafis, Diana V. Doda, Marianne H. Gillam, Allison J. Larg, Helene Luckner, Nasreen Jahan, Aris Widayati and Chuangzhou X

Identification of KasA as the cellular target of an anti-tubercular scaffold

Phenotypic screens for bactericidal compounds are starting to yield promising hits against tuberculosis. In this regard, whole-genome sequencing of spontaneous resistant mutants generated against an indazole sulfonamide (GSK3011724A) identifies several specific single-nucleotide polymorphisms in the essential Mycobacterium tuberculosis β-ketoacyl synthase (kas) A gene. Here, this genomic-based target assignment is confirmed by biochemical assays, chemical proteomics and structural resolution of a KasA-GSK3011724A complex by X-ray crystallography. Finally, M. tuberculosis GSK3011724A-resistant mutants increase the in vitro minimum inhibitory concentration and the in vivo 99% effective dose in mice, establishing in vitro and in vivo target engagement. Surprisingly, the lack of target engagement of the related β-ketoacyl synthases (FabH and KasB) suggests a different mode of inhibition when compared with other Kas inhibitors of fatty acid biosynthesis in bacteria. These results clearly identify KasA as the biological target of GSK3011724A and validate this enzyme for further drug discovery efforts against tuberculosis