Tissue plasminogen activator and intravitreal gas for the treatment of Terson's syndrome: case report

Relata-se o caso de um paciente de 35 anos de idade, sexo masculino, com história de trauma cranioencefálico, que evoluiu com hemorragia pré-macular da síndrome de Terson no olho esquerdo. Após 45 dias de conduta expectante, sem resolução da hemorragia, foi realizada injeção intravítrea de gás hexafluoreto de enxofre e tPA, evoluindo com absorção quase completa da hemorragia após uma semana e considerável melhora da acuidade visual. Descreve-se também aspectos importantes da síndrome de Terson e da injeção intravítrea de gás e tPA por meio de revisão da literatura.The case of a 35 year-old male patient is reported. The patient had a clinical history of craniocerebral trauma and premacular hemorrhage of Terson syndrome in the left eye. After waiting for 45 days, without hemorrhage resolution, the patient received an intravitreal injection of sulfur hexafluoride gas and tPA; an almost complete hemorrhage absorption occurred after a week as well as a considerable improvement of visual acuity. In the report, relevant aspects of Terson syndrome and of intravitreal injection of gas and tPA are also described through a literature review

Aprendizagem autônoma no contexto da Educação a Distância: um olhar a partir da atividade orientadora de ensino

[ES] En esta tesis doctoral, se expondrán los puntos centrales sobre el aprendizaje a distancia y el aprendizaje autónomo. La educación a distancia se caracteriza por procesos de enseñanza y aprendizaje mediados por tecnologías en las que profesores y estudiantes están separados espacial y/o temporalmente, condicionando para la educación en línea. En la modalidad online, los estudiantes deben desarrollar habilidades de aprendizaje autónomo como el dominio tecnológico, la capacidad de buscar información relevante en la red, aplicar información en situaciones reales, trabajar en equipo y tomar decisiones solos y en grupos. A partir de esto, se puede afirmar que las concepciones del aprendizaje autónomo son importantes en la educación a distancia; y puede mejorar el uso de herramientas de interactividad en el Entorno Virtual de Enseñanza-Aprendizaje con el fin de optimizar la enseñanza y, en consecuencia, buenos resultados, incluyendo evitar la evasión y actuar para un aprendizaje eficaz, después de lo anterior las siguientes son nuestras preguntas iniciales: ¿cómo proporciona la educación en línea la educación autónoma? El método de enfoque elegido para esta investigación fue cualitativo y cuantitativo, el método cuantitativo complementa y se integra con el enfoque cualitativo, a partir de un diseño de investigación mixto. Para los datos cuantitativos, se utilizó la técnica estadística descriptiva, inferencial y multivariante, adaptada a la naturaleza de las variables incluidas en los cuestionarios, la información siempre estaba relacionada con partir de las categorías indicadas por los estudios de teoría de la actividad, la actividad rectora de la enseñanza y el aprendizaje autorregulado. El análisis de frecuencia, el coeficiente de correlación de Pearson, las mediciones de tendencia, el centro de dispersión y el análisis final del gráfico se realizaron en comparación con las hipótesis. Fue posible verificar en la educación en línea que los estudiantes desarrollan habilidades para el aprendizaje autónomo con dominio de las tecnologías en colaboración con instituciones y tutores y otras materias involucradas en el proceso de enseñanza y que la concepción didácticapedagógica del aprendizaje a distancia, con el apoyo de los medios tradicionales y las tecnologías de comunicación e información más avanzadas, requiere una concepción específica de la práctica docente, así como estrategias diferenciadas para el desarrollo de relaciones de enseñanza y aprendizaje. Se concluye que de lo que se presentó el estudio autónomo no es sinónimo de estudio individual, es colectivo e intencional, los intercambios son significativos y espontáneamente el profesor presenta situaciones desafiantes dirigiéndoles que es realmente significativo, desafiando un posicionamiento crítico y cuestionador, por lo que este trabajo mostró importante para el área de la educación y específicamente para la educación a distancia porque presentó autonomía como propuesta para la realización del aprendizaje y para la retención de los estudiantes

VCube-PS: A Causal Broadcast Topic-based Publish/Subscribe System

In this work we present VCube-PS, a topic-based Publish/Subscribe system built on the top of a virtual hypercube-like topology. Membership information and published messages are broadcast to subscribers (members) of a topic group over dynamically built spanning trees rooted at the publisher. For a given topic, the delivery of published messages respects the causal order. VCube-PS was implemented on the PeerSim simulator, and experiments are reported including a comparison with the traditional Publish/Subscribe approach that employs a single rooted static spanning-tree for message distribution. Results confirm the efficiency of VCube-PS in terms of scalability, latency, number and size of messages.Comment: Improved text and performance evaluation. Added proof for the algorithms (Section 3.4

TERCEIRO SETOR E AGRICULTURA: COOPERAÇÃO ENTRE O PODER PÚBLICO E A INICIATIVA PRIVADA PARA A PROMOÇÃO DO DESENVOLVIMENTO RURAL SUSTENTÁVEL

O artigo discute a preservação ambiental no meio rural e a participação do Terceiro Setor como forma de atender à responsabilidade constitucional de assegurar o direito humano à alimentação e o acesso à terra. O trabalho apresenta o conceito de Terceiro Setor, bem como aspectos legislativos e históricos de sua atuação. Discute-se a cooperação entre a iniciativa privada e o Estado com o fim de promover o meio ambiente ecologicamente no campo permitindo que agricultores familiares se aproveitem de sua tradição de cooperação e sua capacidade colaborativa para promover desenvolvimento rural sustentável. A pesquisa utiliza o método qualitativo

HGF Secreted by Activated Kupffer Cells Induces Apoptosis of Plasmodium-Infected Hepatocytes

This deposit is composed by the main article plus the supplementary materials of the publicationMalaria liver stage infection is an obligatory parasite development step and represents a population bottleneck in Plasmodium infections, providing an advantageous target for blocking parasite cycle progression. Parasite development inside hepatocytes implies a gross cellular insult evoking innate host responses to counteract intra-hepatocytic infection. Using primary hepatocyte cultures, we investigated the role of Kupffer cell-derived hepatocyte growth factor (HGF) in malaria liver stage infection. We found that Kupffer cells from Plasmodium-infected livers produced high levels of HGF, which trigger apoptosis of infected hepatocytes through a mitochondrial-independent apoptosis pathway. HGF action in infected hepatocyte primary cultures results in a potent reduction of parasite yield by specifically sensitizing hepatocytes carrying established parasite exo-erythrocytic forms to undergo apoptosis. This apoptosis mechanism is distinct from cell death that is spontaneously induced in infected cultures and is governed by Fas signaling modulation through a mitochondrial-dependent apoptosis pathway. This work indicates that HGF and Fas signaling pathways are part of an orchestrated host apoptosis response that occurs during malaria liver stage infection, decreasing the success of infection of individual hepatocytes. Our results raise the hypothesis that paracrine signals derived from Kupffer cell activation are implicated in directing death of hepatocytes infected with the malaria parasite.info:eu-repo/semantics/publishedVersio

Importância da tomografia de coerência óptica e do eletrorretinograma na retinosquise senil

Retinoschisis diagnosis can be very difficult in atypical forms. Special exams are necessary to differentiate retinoschisis from other pathologies such as retinal detachment. Case Report: A 61-year-old black woman presented for routine examination. Fundus of the right eye reveled a superior periphery lesion extending to the posterior pole. The ultrassonography of the same eye showed a high reflective membrane. An inferior field absolute scotoma was detected. The OCT scan that was positioned at lesion in the outer retinal break demonstrated the fragmentation of the retinal layer. The scotopic ERG showed a reduction of the b wave amplitude of the right eye compared to the left eye (Negative electroretinogram). The multifocal ERG was normal in both eyes. The OCT demonstrated to be an useful toll to detect morphological alterations. The ERG and the absolute scotoma in the inferior field, demonstrated the retinal functional defect. A negative electroretinogram, showed a normal a wave and a reduced b wave demonstrating that the photoreceptor inner segments were relatively intact and that the initial damage in this disorder would seem to occur in the inner retinal layers. In doubtful cases especial exams are necessary and a careful investigation must confirm the diagnosis. The indications for treatment should be seriously analysed to avoid any intervention that can be harmful for the patient's prognosis

Placental Malaria: From Infection to Malfunction

Malaria during pregnancy is a major factor in infant morbidity and mortality. In this issue of Cell Host and Microbe, Conroy et al. (2013) propose that C5a, a product of complement cascade activation, counteracts the placental vascular remodeling response induced by Plasmodium infection and contributes to fetal growth restriction

Earnings quality : empirical analysis of accounting accruals applied to the brazilian stock market

O lucro é utilizado como fonte principal dos usuários de informações contábeis. Assim, a qualidade do lucro tem relevância no cenário nacional, principalmente no auxílio ao processo decisório. Nesse sentido, o artigo busca verificar a relação entre os níveis de accruals (proxy para qualidade do lucro) e fluxos de caixa de empresas brasileiras, baseando-se na premissa de que maiores accruals acompanhados por maiores lucros sugerem baixa qualidade dos mesmos. Para isso, foi utilizada estatística descritiva e regressão linear simples. Os resultados indicam que os aumentos nos lucros, acompanhados de aumentos nos accruals sugerem baixa earnings quality. Foi observado, ainda, que empresas com grandes accruals apresentam uma relação inversa com os fluxos de caixas e, também, lucros elevados. Esses resultados sugerem que os valores podem estar sendo influenciados por manipulação dos componentes discricionários dos accruals. _______________________________________________________________________________ ABSTRACTProfit is used as the mains source for the users of financial information. Thus, earnings quality is important on the national scene, especially in aid making. This research aims to verify the relationship between the levels of accruals (a proxy for earnings quality) and cash flows of Brazilian companies, in the assumption that higher accruals accompanied by higher profits suggest low quality. Therefore, descritional statistics and classical linear regression model was applied. The results indicate that increases in profits, accompanied by increases in accruals suggest low earnings quality. It was also found that companies with large accruals have an inverse relationship with the cash flows and high profits. These results suggest that the values may be being influenced by manipulation of accrual’s discretionary components