Flexible Management on BSP Process Rescheduling: Offering Migration at Middleware and Application Levels

This article describes the rationales for developing jMigBSP - a Java programming library that offers object rescheduling. It was designed to work on grid computing environments and offers an interface that follows the BSP (Bulk Synchronous Parallel) style. jMigBSP’s main contribution focuses on the rescheduling facility in two different ways: (i) by using migration directives on the application coded irectly and (ii) through automatic load balancing at middleware level. Especially, this second idea is feasible thanks to the Java’s inheritance feature, in which transforms a simple jMigBSP application in amigratable one only by changing a single line of code. In addition, the presented library makes the object interaction easier by providing one-sided message passing directives and hides network latency through asynchronous communications. Finally, we developed three BSP applications: (i) Prefix Sum; (ii) Fractal Image Compression (FIC) and; (iii) Fast Fourier Transform (FFT).They show our library as viable solution to offer load balancing on BSP applications. Specially, the FIC results present gains up to 37% when applying migration directives inside the code. Finally, the FFT tests emphasize strength of jMigBSP. In this situation, it outperforms a native library denoted BSPlib when migration facilities take place.Keywords: Bulk Synchronous Parallel, rescheduling, Java, adaptation, object migration, grid computing

A CONSTRUÇÃO DE MEMÓRIA SIMBÓLICO-RELIGIOSA E LASSALISTA A PARTIR DOS VITRAIS DA CAPELA SÃO JOSÉ, EM CANOAS/RS

This paper presents and discusses some results of a survey analyzing the iconographic and iconological contents of thirty-three stained glass windows of St. Joseph Chapel in Canoas/RS, Brazil. It shows the intimate relationship between symbolism and Lasallian memory from theoretical considerations about symbolism and social memory. The research method is qualitative, gathering primary and secondary research sources such as manuscripts, photographs, iconography, bulletins, newsletters, interviews and memos. The interpretation of the symbolic meanings of the stained glass was performed according to the three levels of iconological and iconographic analysis proposed by Erwin Panofsky. The six stained glass windows described in this paper represent the realization of collective and spiritual memories of the Lasallian tradition. In this sense, to rebuild the symbolic significance of the stained glass windows of the St. Joseph Chapel is to confirm it as a symbolic-religious memory space and of Lasallian identity.O artigo apresenta e discute os resultados de uma pesquisa que analisou os conteúdos iconográficos e iconológicos dos trinta e três vitrais da Capela São José, em Canoas/RS. Demonstra-se as íntimas relações entre o simbolismo e a memória lassalista, a partir de considerações teóricas sobre simbolismo e memória social. O método de pesquisa foi qualitativo, reunindo fontes primárias e secundárias como manuscritos, fotos, iconografias, boletins, informativos, memorandos localizados no Museu e Arquivo Histórico La Salle (Unilasalle Canoas), além de entrevistas com Irmãos Lassalistas. A interpretação dos significados simbólicos dos vitrais realizou-se segundo os três níveis de análise iconográfica e iconológica propostos por Erwin Panofsky. Os seis vitrais descritos neste trabalho representam a materialização das lembranças coletivas e espirituais da tradição lassalista. Neste sentido, reconstruir o significado simbólico dos vitrais da capela São José é confirmá-la como espaço de memória simbólico-religiosa e de identidade lassalista

Narrativas de protagonismos: memórias de mulheres negras em “Olhos de azeviche”

Este artigo traz análise da obra “Olhos de azeviche - dez escritoras negras que estão renovando a literatura brasileira” (2017), pelo viés da memória social. Tratam-se de narrativas de mulheres negras que consolidam o não silenciamento em prol do seu reconhecimento identitário.  Teoricamente nos fundamentamos em: Assmann (2018), Bosi (2003), Pollak e Ricouer (2007) quanto à discussão sobre memória social; Evaristo (2020), Todorov (2009) e Paz (1993) quanto aos estudos de literatura e Bernd (2018), Rosário (2007) e Broose (2008) quanto aos de negritude, dentre outros autores. Espera-se contribuir para a relação entre memória e literatura afro-brasileira, comparando narrativas e formas de evidenciar a presença do negro na cultura brasileira

GetLB: Balanceamento de Carga Eficiente para o Escalonamento de Transações Eletrônicas Financeiras

Este artigo tem como objetivo apresentar as idéias para o desenvolvimento de um framework para balanceamento de carga chamado GetLB. Considerando o contexto de transferência eletrônica de fundos (TEF), GetLB oferece uma nova forma de organizar as interações entre o chaveador e as máquinas processadoras. Esta organização permite que o chaveador combine informações atualizadas para a execução de um algoritmo de programação dinâmica em vez de usar a abordagem Round-Robin entre as máquinas de processamento. O algoritmo de agendamento de GetLB divide as transações em diferentes tipos, combinando suas necessidades de CPU, memória e disco de dados de máquinas processadoras para oferecer um balanceamento de carga eficiente. Implementou-se um protótipo com RMI e testes revelaram que o quadro é viável para processamento de transações sobre os ambientes homogêneos e heterogêneos. Além disso, a avaliação apresentou as vantagens da adoção de algoritmos GetLB em vez da abordagem Round-Robin tradicional

The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure

Cyclic nucleotide phosphodiesterases (PDEs) are a superfamily of enzymes known to play a critical role in the indirect regulation of several intracellular metabolism pathways through the selective hydrolysis of the phosphodiester bonds of specific second messenger substrates such as cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate), influencing the hypertrophy, contractility, apoptosis and fibroses in the cardiovascular system. The expression and/or activity of multiple PDEs is altered during heart failure (HF), which leads to changes in levels of cyclic nucleotides and function of cardiac muscle. Within the cardiovascular system, PDEs 1–5, 8 and 9 are expressed and are interesting targets for the HF treatment. In this comprehensive review we will present a briefly description of the biochemical importance of each cardiovascular related PDE to the HF, and cover almost all the “long and winding road” of designing and discovering ligands, hits, lead compounds, clinical candidates and drugs as PDE inhibitors in the last decade.</p

El magisterio español : Revista General de la Enseñanza: Epoca 4ª Año XLVI Número 3929 - 1912 Abril 02

Incluye índices.Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 200

The design of multi-target drugs to treat cardiovascular diseases:Two (or more) birds on one stone

Cardiovascular diseases (CVDs) comprise a group of diseases and disorders of the heart and blood vessels, which together are the number one cause of death worldwide, being associated with multiple genetic and modifiable risk factors, and that may directly arise from different etiologies. For a long time, the search for cardiovascular drugs was based on the old paradigm "one compound one target", aiming to obtain a highly potent and selective molecule with only one desired molecular target. Although historically successful in the last decades, this approach ignores the multiple causes and the multifactorial nature of CVDs. Thus, over time, treatment strategies for cardiovascular diseases have changed, and, currently, pharmacological therapies for CVD are mainly based on the association of two or more drugs to control symptoms and reduce cardiovascular death. In this context, the development of multitarget drugs, ie, compounds having the ability to act simultaneously at multiple sites, is an attractive and relevant strategy that can be even more advantageous to achieve predictable pharmacokinetic and pharmacodynamics correlations as well as better patient compliance. In this review, we aim to highlight the efforts and rational pharmacological bases for the design of some promising multitargeted compounds to treat important cardiovascular diseases like heart failure, atherosclerosis, acute myocardial infarction, pulmonary arterial hypertension, and arrhythmia.</p