An IoT-Aware Architecture for Smart Healthcare Systems

none7Over the last few years, the convincing forward steps in the development of Internet-of-Things (IoT) enabling solutions are spurring the advent of novel and fascinating applications. Among others, mainly Radio Frequency Identification (RFID), Wireless Sensor Network (WSN), and smart mobile technologies are leading this evolutionary trend. In the wake of this tendency, this paper proposes a novel, IoTaware, smart architecture for automatic monitoring and tracking of patients, personnel, and biomedical devices within hospitals and nursing institutes. Staying true to the IoT vision, we propose a Smart Hospital System (SHS) which relies on different, yet complementary, technologies, specifically RFID, WSN, and smart mobile, interoperating with each other through a CoAP/6LoWPAN/REST network infrastructure. The SHS is able to collect, in real time, both environmental conditions and patients’ physiological parameters via an ultra-low-power Hybrid Sensing Network (HSN) composed of 6LoWPAN nodes integrating UHF RFID functionalities. Sensed data are delivered to a control center where an advanced monitoring application makes them easily accessible by both local and remote users via a REST web service. The simple proof of concept implemented to validate the proposed SHS has highlighted a number of key capabilities and aspects of novelty which represent a significant step forward compared to the actual state of art.restrictedCATARINUCCI L.; DE DONNO D.; MAINETTI L.; PALANO L.; PATRONO L.; STEFANIZZI M.; TARRICONE L.Catarinucci, Luca; DE DONNO, Danilo; Mainetti, Luca; Palano, L.; Patrono, Luigi; Stefanizzi, MARIA LAURA; Tarricone, Lucian

Hematopoietic progenitor cell liabilities and alarmins S100A8/A9-related inflammaging associate with frailty and predict poor cardiovascular outcomes in older adults

Frailty affects the physical, cognitive, and social domains exposing older adults to an increased risk of cardiovascular disease and death. The mechanisms linking frailty and cardiovascular outcomes are mostly unknown. Here, we studied the association of abundance (flow cytometry) and gene expression profile (RNAseq) of stem/progenitor cells (HSPCs) and molecular markers of inflammaging (ELISA) with the cardiorespiratory phenotype and prospective adverse events of individuals classified according to levels of frailty. Two cohorts of older adults were enrolled in the study. In a cohort of pre‐frail 35 individuals (average age: 75 years), a physical frailty score above the median identified subjects with initial alterations in cardiorespiratory function. RNA sequencing revealed S100A8/A9 upregulation in HSPCs from the bone marrow (>10‐fold) and peripheral blood (>200‐fold) of individuals with greater physical frailty. Moreover higher frailty was associated with increased alarmins S100A8/A9 and inflammatory cytokines in peripheral blood. We then studied a cohort of 104 more frail individuals (average age: 81 years) with multidomain health deficits. Reduced levels of circulating HSPCs and increased S100A8/A9 concentrations were independently associated with the frailty index. Remarkably, low HSPCs and high S100A8/A9 simultaneously predicted major adverse cardiovascular events at 1‐year follow‐up after adjustment for age and frailty index. In conclusion, inflammaging characterized by alarmin and pro‐inflammatory cytokines in pre‐frail individuals is mirrored by the pauperization of HSPCs in frail older people with comorbidities. S100A8/A9 is upregulated within HSPCs, identifying a phenotype that associates with poor cardiovascular outcomes

DInSAR Analysis and Analytical Modeling of Mount Etna Displacements: The December 2018 Volcano‐Tectonic Crisis

We investigate the 24–27 December 2018 eruption of Mount Etna occurred from fissures located on the volcano eastern flank and accompanied by a seismic swarm, which was triggered by the magma intrusion and continued for weeks after the end of the eruption. Moreover, this swarm involved some of the shallow volcano‐tectonic structures located on the Mount Etna flanks and culminated on 26 December with the strongest event (ML 4.8), occurred along the Fiandaca Fault. In this work, we analyze seismological data and Sentinel‐1 Differential Interferometric Synthetic Aperture Radar (DInSAR) measurements, the latter inverted through analytical modeling. Our results suggest that a dike source intruded, promoting the opening of the eruptive fissures fed by a shallower dike. Moreover, our findings indicate that the activation of faults in different sectors of the volcano may be considered as a response to accommodate the deformations induced by the magma volumes injection.Published5817-58275V. Processi eruttivi e post-eruttiviJCR Journa

The RING GPS network: a research geodetic infrastructure to study plate boundary deformation in the Central Mediterranean

We present the INGV (Italian National Institute of Geophysics and Volcanology) geodetic research infrastructure and related facilities, dedicated to the observation and monitoring of current deformation of the plate boundary between Africa and Eurasia. The recent increase of continuous GPS (CGPS) stations in the Central Mediterranean plate boundary zone offers the opportunity to study in detail the present-day kinematics of this actively deforming region. For answering all the open questions related to this complex area, INGV deployed a permanent, integrated and real-time monitoring CGPS network (RING) all over Italy. The RING network (http:/ring.gm.ingv.it) is now constituted by more than 150 stations. All stations have high quality GPS monuments and most of them are co-located with broadband or very broadband seismometers and strong motion sensors. The RING CGPS sites acquire at 1Hz and 30s sampling rates (some of them acquire at 10 Hz) and are connected in real-time to the INGV acquisition centers located in Roma and Grottaminarda. Real-time GPS data are transmitted using different systems, such as satellite systems, Internet, GPRS/UMTS and wireless networks. The differentiation of data transmission type and the integration with seismic instruments makes this network one of the most innovative CGPS networks in Europe. Furthermore, the INGV data acquisition centers acquire, archive and analyze most of the Italian CGPS stations managed by regional or national data providers (such as local Authorities and nation-wide industries), integrating more than 350 stations of the CGPS scientific and commercial networks existing in the Italian region. To manage data acquisition, storage, distribution and access we developed dedicated facilities including new softwares for data acquisition and a web-based collaborative environment for management of data and metadata. The GPS analysis is carried out with the three main geodetic-quality softwares used in the GPS scientific community: Bernese GAMIT an GIPSY-OASIS. The resulting daily solutions are aligned to the ITRF2005 reference frame. Stable plate reference frames are realized by minimizing the horizontal velocities at sites on the Eurasia and Nubia plates, respectively. The different software-related solutions consistency RMS is within 0.3 mm/yr (Avallone et al., 2010). The solutions are then evaluated with regard to the numerous scientific motivations behind this presentation, ranging from the definition of strain distribution and microplate kinematics within the plate boundary, to the evaluation of tectonic strain accumulation on active faults. The RING network is strongly contributing to the definition of GPS velocity field in the Italian region, and now is able to furnish a newly and up to date view of this actively deforming part of the Nubia-Eurasia plate boundary. INGV is now aiming to make the RING (and integrated CGPS networks) data and related products publicly available for the scientific community. We believe that our network represents an important reality in the framework of the EPOS infrastructure and we strongly support the idea of an European research approach to data sharing among the scientific community. We will present (a) the current CGPS site distribution, (b) the technological description of the data acquisition, storage and distribution at INGV centers, (c) the results of CGPS data analysis, and (d) the planned data access for the scientific community.PublishedVienna, Geophysical Research Abstracts Vol. 13, EGU2011-8626, 20111.9. Rete GPS nazionale3.2. Tettonica attivaope

The RING GPS network: a research geodetic infrastructure to study plate boundary deformation in the Central Mediterranean

We present the INGV (Italian National Institute of Geophysics and Volcanology) geodetic research infrastructure and related facilities, dedicated to the observation and monitoring of current deformation of the plate boundary between Africa and Eurasia. The recent increase of continuous GPS (CGPS) stations in the Central Mediterranean plate boundary zone offers the opportunity to study in detail the present-day kinematics of this actively deforming region. For answering all the open questions related to this complex area, INGV deployed a permanent, integrated and real-time monitoring CGPS network (RING) all over Italy. The RING network (http:/ring.gm.ingv.it) is now constituted by more than 150 stations. All stations have high quality GPS monuments and most of them are co-located with broadband or very broadband seismometers and strong motion sensors. The RING CGPS sites acquire at 1Hz and 30s sampling rates (some of them acquire at 10 Hz) and are connected in real-time to the INGV acquisition centers located in Roma and Grottaminarda. Real-time GPS data are transmitted using different systems, such as satellite systems, Internet, GPRS/UMTS and wireless networks. The differentiation of data transmission type and the integration with seismic instruments makes this network one of the most innovative CGPS networks in Europe. Furthermore, the INGV data acquisition centers acquire, archive and analyze most of the Italian CGPS stations managed by regional or national data providers (such as local Authorities and nation-wide industries), integrating more than 350 stations of the CGPS scientific and commercial networks existing in the Italian region. To manage data acquisition, storage, distribution and access we developed dedicated facilities including new softwares for data acquisition and a web-based collaborative environment for management of data and metadata. The GPS analysis is carried out with the three main geodetic-quality softwares used in the GPS scientific community: Bernese GAMIT an GIPSY-OASIS. The resulting daily solutions are aligned to the ITRF2005 reference frame. Stable plate reference frames are realized by minimizing the horizontal velocities at sites on the Eurasia and Nubia plates, respectively. The different software-related solutions consistency RMS is within 0.3 mm/yr (Avallone et al., 2010). The solutions are then evaluated with regard to the numerous scientific motivations behind this presentation, ranging from the definition of strain distribution and microplate kinematics within the plate boundary, to the evaluation of tectonic strain accumulation on active faults. The RING network is strongly contributing to the definition of GPS velocity field in the Italian region, and now is able to furnish a newly and up to date view of this actively deforming part of the Nubia-Eurasia plate boundary. INGV is now aiming to make the RING (and integrated CGPS networks) data and related products publicly available for the scientific community. We believe that our network represents an important reality in the framework of the EPOS infrastructure and we strongly support the idea of an European research approach to data sharing among the scientific community. We will present (a) the current CGPS site distribution, (b) the technological description of the data acquisition, storage and distribution at INGV centers, (c) the results of CGPS data analysis, and (d) the planned data access for the scientific community

Les droits disciplinaires des fonctions publiques : « unification », « harmonisation » ou « distanciation ». A propos de la loi du 26 avril 2016 relative à la déontologie et aux droits et obligations des fonctionnaires

The production of tt‾ , W+bb‾ and W+cc‾ is studied in the forward region of proton–proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98±0.02 fb−1 . The W bosons are reconstructed in the decays W→ℓν , where ℓ denotes muon or electron, while the b and c quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions.The production of $t\overline{t}$, $W+b\overline{b}$ and $W+c\overline{c}$ is studied in the forward region of proton-proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98 $\pm$ 0.02 \mbox{fb}^{-1}. The $W$ bosons are reconstructed in the decays $W\rightarrow\ell\nu$, where $\ell$ denotes muon or electron, while the $b$ and $c$ quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions

Measurement of the ratios of branching fractions R(D∗)\mathcal{R}(D^{*}) and R(D0)\mathcal{R}(D^{0})

The ratios of branching fractions $\mathcal{R}(D^{*})\equiv\mathcal{B}(\bar{B}\to D^{*}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(\bar{B}\to D^{*}\mu^{-}\bar{\nu}_{\mu})$ and $\mathcal{R}(D^{0})\equiv\mathcal{B}(B^{-}\to D^{0}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(B^{-}\to D^{0}\mu^{-}\bar{\nu}_{\mu})$ are measured, assuming isospin symmetry, using a sample of proton-proton collision data corresponding to 3.0 fb${ }^{-1}$ of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode $\tau^{-}\to\mu^{-}\nu_{\tau}\bar{\nu}_{\mu}$. The measured values are $\mathcal{R}(D^{*})=0.281\pm0.018\pm0.024$ and $\mathcal{R}(D^{0})=0.441\pm0.060\pm0.066$, where the first uncertainty is statistical and the second is systematic. The correlation between these measurements is $\rho=-0.43$. Results are consistent with the current average of these quantities and are at a combined 1.9 standard deviations from the predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb public pages

Multidifferential study of identified charged hadron distributions in ZZ-tagged jets in proton-proton collisions at s=\sqrt{s}=13 TeV

Jet fragmentation functions are measured for the first time in proton-proton collisions for charged pions, kaons, and protons within jets recoiling against a $Z$ boson. The charged-hadron distributions are studied longitudinally and transversely to the jet direction for jets with transverse momentum 20 $< p_{\textrm{T}} < 100$ GeV and in the pseudorapidity range $2.5 < \eta < 4$. The data sample was collected with the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.64 fb$^{-1}$. Triple differential distributions as a function of the hadron longitudinal momentum fraction, hadron transverse momentum, and jet transverse momentum are also measured for the first time. This helps constrain transverse-momentum-dependent fragmentation functions. Differences in the shapes and magnitudes of the measured distributions for the different hadron species provide insights into the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb public pages

Study of the B−→Λc+Λˉc−K−B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-} decay

The decay $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ is studied in proton-proton collisions at a center-of-mass energy of $\sqrt{s}=13$ TeV using data corresponding to an integrated luminosity of 5 $\mathrm{fb}^{-1}$ collected by the LHCb experiment. In the $\Lambda_{c}^+ K^{-}$ system, the $\Xi_{c}(2930)^{0}$ state observed at the BaBar and Belle experiments is resolved into two narrower states, $\Xi_{c}(2923)^{0}$ and $\Xi_{c}(2939)^{0}$, whose masses and widths are measured to be $$m(\Xi_{c}(2923)^{0}) = 2924.5 \pm 0.4 \pm 1.1 \,\mathrm{MeV}, \\ m(\Xi_{c}(2939)^{0}) = 2938.5 \pm 0.9 \pm 2.3 \,\mathrm{MeV}, \\ \Gamma(\Xi_{c}(2923)^{0}) = \phantom{000}4.8 \pm 0.9 \pm 1.5 \,\mathrm{MeV},\\ \Gamma(\Xi_{c}(2939)^{0}) = \phantom{00}11.0 \pm 1.9 \pm 7.5 \,\mathrm{MeV},$$ where the first uncertainties are statistical and the second systematic. The results are consistent with a previous LHCb measurement using a prompt $\Lambda_{c}^{+} K^{-}$ sample. Evidence of a new $\Xi_{c}(2880)^{0}$ state is found with a local significance of $3.8\,\sigma$, whose mass and width are measured to be $2881.8 \pm 3.1 \pm 8.5\,\mathrm{MeV}$ and $12.4 \pm 5.3 \pm 5.8 \,\mathrm{MeV}$, respectively. In addition, evidence of a new decay mode $\Xi_{c}(2790)^{0} \to \Lambda_{c}^{+} K^{-}$ is found with a significance of $3.7\,\sigma$. The relative branching fraction of $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ with respect to the $B^{-} \to D^{+} D^{-} K^{-}$ decay is measured to be $2.36 \pm 0.11 \pm 0.22 \pm 0.25$, where the first uncertainty is statistical, the second systematic and the third originates from the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb public pages

Observation of the B0 → ρ0ρ0 decay from an amplitude analysis of B0 → (π+π−)(π+π−) decays

Proton–proton collision data recorded in 2011 and 2012 by the LHCb experiment, corresponding to an integrated luminosity of 3.0 fb−1 , are analysed to search for the charmless B0→ρ0ρ0 decay. More than 600 B0→(π+π−)(π+π−) signal decays are selected and used to perform an amplitude analysis, under the assumption of no CP violation in the decay, from which the B0→ρ0ρ0 decay is observed for the first time with 7.1 standard deviations significance. The fraction of B0→ρ0ρ0 decays yielding a longitudinally polarised final state is measured to be fL=0.745−0.058+0.048(stat)±0.034(syst) . The B0→ρ0ρ0 branching fraction, using the B0→ϕK⁎(892)0 decay as reference, is also reported as B(B0→ρ0ρ0)=(0.94±0.17(stat)±0.09(syst)±0.06(BF))×10−6