Estudio del uso de drones en el flujo de trabajo BIM (Building Information Modeling)

Máster Univ. en Gestión e Innovac.Tecnológica en la Construcción Por la UllMáster Universitario en Gestión e Innovación Tecnológica en la ConstrucciónEl desarrollo del presente trabajo pretende dar una visión sobre el uso de los drones dentro de la construcción, exactamente en su aplicación dentro del flujo de trabajo BIM (Building Information Modeling). Para ello, se introduce al lector en antecedentes históricos y conceptuales exponiendo, posteriormente, la normativa que recae sobre dichas aeronaves. De este modo conoceremos las limitaciones dentro del espacio aéreo. También, se estudian y analizan distintas soluciones que puedan ser de utilidad para abordar los retos de este trabajo. Para ello, se realizan varios estudios del caso llevando a cabo dos levantamientos fotogramétricos. Cada uno de ellos con distintas condiciones de trabajo para realizar una evaluación más completa sobre el estudio. Se ha realizado el levantamiento del Elevador de Aguas de Gordejuela situado en las isla de Santa Cruz de Tenerife (Islas Canarias) mediante la información obtenida con un dron. Con ello, conoceremos los parámetros necesarios para planificar un vuelo, obtener información útil, cómo recibirla y gestionarla en un programa BIM. Sin embargo, previamente se realiza un vuelo de familiarización del dron utilizado realizando el levantamiento fotogramétrico del Sanatorio de Abades situado en la Leprosería de Arico. En resumen, el objetivo del trabajo es que el presente documento sirva como guía práctica sobre el uso de drones en la obtención de información que pueda trasladarse en BIM y analizar, si cabe, las posibles aplicaciones futuras de aeronaves pilotadas remotamente en dicha metodología.The development of the dissertation pretends to give a vision about the use of drones within the construction, mainly in the application within the BIM (Building Information Modeling) workflow. For this reason, the reader is introduced in historical and conceptual records exposing, after all, the regulations that fall on said aircraft. In this way we will know the limitations within the airspace. Also, the different applications that may have within the building and which of them are useful, in terms of information, in BIM methodology are mentioned. For this reason, it has been done the survey of the Gordejuela Water’s Elevator located on the island of Santa Cruz de Tenerife (Canary Islands) through the information obtained with a RPAS (Remotely Piloted Aircraft System). With this, we will know the fundamental parameters to plan a flight, obtain useful information, how to receive it and manage it in a BIM software. However, previously we will do a familiarization flight of the drone doing the photogrammetric survey of the Abades’ Sanatorium located in the Arico’s Leprosarium. In summary, the objective of the work is that this document serves as a practical guide about the use of drones in obtaining information that can be transferred in BIM and analyse the possible future applications on the use of remotely piloted aircraft in said methodology

In Vitro Priming Recapitulates In Vivo HIV-1 Specific T Cell Responses, Revealing Rapid Loss of Virus Reactive CD4+ T Cells in Acute HIV-1 Infection

Background: The requirements for priming of HIV-specific T cell responses initially seen in infected individuals remain to be defined. Activation of T cell responses in lymph nodes requires cell-cell contact between T cells and DCs, which can give concurrent activation of T cells and HIV transmission. Methodology: The study aim was to establish whether DCs pulsed with HIV-1 could prime HIV-specific T cell responses and to characterize these responses. Both infectious and aldrithiol-2 inactivated noninfectious HIV-1 were compared to establish efficiencies in priming and the type of responses elicited. Findings: Our findings show that both infectious and inactivated HIV-1 pulsed DCs can prime HIV-specific responses from naïve T cells. Responses included several CD4+ and CD8+ T cell epitopes shown to be recognized in vivo by acutely and chronically infected individuals and some CD4+ T cell epitopes not identified previously. Follow up studies of acute and recent HIV infected samples revealed that these latter epitopes are among the earliest recognized in vivo, but the responses are lost rapidly, presumably through activation-induced general CD4+ T cell depletion which renders the newly activated HIV-specific CD4+ T cells prime targets for elimination. Conclusion: Our studies highlight the ability of DCs to efficiently prime naïve T cells and induce a broad repertoire of HIV-specific responses and also provide valuable insights to the pathogenesis of HIV-1 infection in vivo

Smart Farming Controlling Sprinkler System in The Net House by Using Internet of Things (IoT)

Most of the farming centre in Sarawak, either in small scale or big scale activity, they are still using the manual way to water their crops. To be specific, the net house will use the water hose to water them and manually open the water tap and sprinkle them on the crop. This way consume time if they are working on a large many area of net house. The aim of this project is to solve the farmers problem in watering their crops in the net house. In the era of technology, everything can be solved from our fingertips without wasting and using our energy. The expectation in the end of this project is to expose to every farming centre the possibilities of becoming “Smart Farming Centre” and can contribute to community wellbeing in managing their crops and improving the productivity

Differential Impairment of Lytic and Cytokine Functions in Senescent Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes

Telomere length is abnormally short in the CD8(+) T-cell compartment of human immunodeficiency virus type 1 (HIV-1)-infected persons, likely because of chronic cell turnover. Although clonal exhaustion of CD8(+) cytotoxic T lymphocytes (CTL) has been proposed as a mechanism for loss of antigen-specific responses, the functional consequences of exhaustion are poorly understood. Here we used telomerase transduction to evaluate the impact of senescence on CTL effector functions. Constitutive expression of telomerase in an HIV-1-specific CTL clone results in enhanced proliferative capacity, in agreement with prior studies of other human cell types. Whereas the CTL remain phenotypically normal in terms of antigenic specificity and requirements for proliferation, their cytolytic and antiviral capabilities are superior to those of control CTL. In contrast, their ability to produce gamma interferon and RANTES is essentially unchanged. The selective enhancement of cytolytic function in memory CTL by ectopic telomerase expression implies that loss of this function (but not cytokine production) is a specific consequence of replicative senescence. These data suggest a unifying mechanism for the in vivo observations that telomere lengths are shortened in the CD8(+) cells of HIV-1-infected persons and that HIV-1-specific CTL are deficient in perforin. Telomerase transduction could therefore be a tool with which to explore a potential therapeutic approach to an important pathophysiologic process of immune dysfunction in chronic viral infection

Impacts of Epitope Expression Kinetics and Class I Downregulation on the Antiviral Activity of Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes

The determinants of CD8(+) cytotoxic T-lymphocyte (CTL) antiviral activity against human immunodeficiency virus type 1 (HIV-1) remain poorly defined. Although recent technological advances have markedly enhanced the ability to detect HIV-1-specific T cells, commonly used assays do not reveal their direct interaction with virus. We investigated two determinants of CTL antiviral efficiency by manipulating HIV-1 and measuring the effects on CTL suppression of viral replication in acutely infected cells. Translocation of a Gag epitope into the early protein Nef markedly increased the activity of CTL recognizing that epitope, in comparison to HIV-1 expressing the epitope normally in the late protein Gag. Because this epitope translocation resulted not only in earlier expression but also in loss of major histocompatibility complex class I downregulation by Nef, the activities of CTL against a panel of viral constructs differing in kinetics of epitope expression and class I downmodulation were compared. The results indicated that both the timing of epitope expression and the reduction of class I have profound effects on the ability of CTL to suppress HIV-1 replication in acutely infected cells. The epitope targeting of CTL and viral control of class I therefore likely play important roles in the ability of CTL to exert pressure on HIV-1

Cálculos SIG en el navegador usando gpu.js

JavaScript ha evolucionado mucho en los últimos años, pero algunas capacidades han sido poco exploradas en código abierto. La API WebGL permite el cálculo en paralelo de muchos algoritmos y librerías como gpu.js lo facilitan mucho. Entre estos cálculos, los algoritmos de SIG sobre datos raster destacan por las posibilidades de hacerse en paralelo. Entre ellos, las reproyecciones, cálculo de campos a partir de puntos, shaded relief, interpolaciones, etc. El cambio a usar WebGL mejora mucho la velocidad de los cálculos, hasta permitir que el navegador los haga en tiempo real, controlados por el usuario. Las posibilidades son muy grandes ya que la técnica permite descargar al servidor de los cálculo. No obstante, no hay librerías que proporcionen los algoritmos fácilmente usables por el usuarioPresentació a http://geoexamples.com/sigte2018/#/titl