1,895 research outputs found
Magnetic exchange coupling and Curie temperature of Ni(1+x)MnSb (x=0, 0.25, 0.5, 0.75, 1) from first principles
We study the dependence of magnetic interactions and Curie temperature in
Ni(1+x)MnSb system on the Ni concentration within the framework of the
density-functional theory. The calculation of the exchange parameters is based
on the super-cell and frozen-magnon approaches. The Curie temperatures, Tc, are
calculated within the random-phase approximation. In agreement with experiment
we obtain decrease of the Curie temperature with increasing Ni content.Comment: 3 pages, 2 figure
Norm violation versus punishment risk in a social model of corruption
We analyze the onset of social-norm-violating behaviors when social punishment is present. To this aim, a compartmental model is introduced to illustrate the flows among the three possible states: Honest, corrupt, and ostracism. With this simple model we attempt to capture some essential ingredients such as the contagion of corrupt behaviors to honest agents, the delation of corrupt individuals by honest ones, and the warning to wrongdoers (fear like that triggers the conversion of corrupt people into honesty). In nonequilibrium statistical physics terms, the former dynamics can be viewed as a non-Hamiltonian kinetic spin-1 Ising model. After developing in full detail its mean-field theory and comparing its predictions with simulations made on regular networks, we derive the conditions for the emergence of corrupt behaviors and, more importantly, illustrate the key role of the warning-to-wrongdoers mechanism in the latter
Spectral hardness evolution characteristics of tracking Gamma-ray Burst pulses
Employing a sample presented by Kaneko et al. (2006) and Kocevski et al.
(2003), we select 42 individual tracking pulses (here we defined tracking as
the cases in which the hardness follows the same pattern as the flux or count
rate time profile) within 36 Gamma-ray Bursts (GRBs) containing 527
time-resolved spectra and investigate the spectral hardness, (where
is the maximum of the spectrum), evolutionary
characteristics. The evolution of these pulses follow soft-to-hard-to-soft (the
phase of soft-to-hard and hard-to-soft are denoted by rise phase and decay
phase, respectively) with time. It is found that the overall characteristics of
of our selected sample are: 1) the evolution in the rise
phase always start on the high state (the values of are always
higher than 50 keV); 2) the spectra of rise phase clearly start at higher
energy (the median of are about 300 keV), whereas the spectra of
decay phase end at much lower energy (the median of are about 200
keV); 3) the spectra of rise phase are harder than that of the decay phase and
the duration of rise phase are much shorter than that of decay phase as well.
In other words, for a complete pulse the initial is higher than the
final and the duration of initial phase (rise phase) are much
shorter than the final phase (decay phase). This results are in good agreement
with the predictions of Lu et al. (2007) and current popular view on the
production of GRBs. We argue that the spectral evolution of tracking pulses may
be relate to both of kinematic and dynamic process even if we currently can not
provide further evidences to distinguish which one is dominant. Moreover, our
statistical results give some witnesses to constrain the current GRB model.Comment: 32 pages, 26 figures, 3 tables, accepted for publication in New
Astronom
Molecular cytogenetic aberrations in patients with multiple myeloma studied by interphase fluorescence in situ hybridization
Background: Multiple myeloma (MM) is an incurable hematological disorder characterized by the accumulation of malignant plasma cells within the bone marrow (BM). The clinical heterogeneity of MM is dictated by the cytogenetic aberrations present in the clonal plasma cells (PCs). Cytogenetic studies in MM are hampered by the hypoproliferative nature of plasma cells in MM. Therefore, fluorescence in situ hybridization (FISH) analysis combined with magnetic-activated cell sorting (MACS) is an attractive alternative for evaluation of numerical and structural chromosomal changes in MM. Methods: Interphase FISH studies with three different specific probes for the regions containing 13q14.3 (D13S319), 14q32 (IGHC/IGHV) and 1q12(CEP1 ) were performed in 48 MM patients. Interphase FISH studies with LSI IGH/CCND1, LSI IGH/FGFR3, and LSI IGH/MAF probes were used to detect t(11;14)(q13;q32), t(4;14)(p16;q32), and t(14;16)(q32;q23) in patients with 14q32 rearrangement. Results: Molecular cytogenetic aberrations were found in 40 (83.3%) of the 48 MM patients. 13 patients (27.1%) simultaneously had 13q deletion/monosomy 13 [del(13q14)], illegitimate IGH rearrangement and chromosome 1 abnormality. Del(13q14) was detected in 21 cases (43.7%), and illegitimate IGH rearrangements in 29 (60.4%) including 6 with t(11;14) and 5 with t(4;14). None of 9 patients with illegitimate IGH rearrangements and without t(11;14) or t(4;14) we detected had t(14;16) (q32;q23). 24 of the 48 MM patients (50%) had chromosome 1 abnormalities. Among 21 patients with del(13q14), 15 patients had Amp1q12;16 had IgH rearrangements. Whereas, among 27 cases without del(13q14), 8 had Amp1q12; 13 had IgH rearrangements. There was a strong association between del(13q14) and Amp1q12(c2 = 8.26, р < 0.01), and between del(13q14) and IgH rearrangement(c2 = 3.88, p < 0.05). Conclusion: 13q deletion/monosomy 13, IGH rearrangement and chromosome 1 abnormality are frequent in MM. They are not randomly distributed, but strongly interconnected. Interphase FISH technique combined with MACS using CD138-specific antibody is a highly sensitive technique at detecting molecular cytogenetic aberrations in MM.Обоснование: множественная миелома (MM) — неизлечимое гематологическое заболевание, характеризирующееся
накоплением злокачественных плазматических клеток в костном мозге (КM). Клиническая гетерогенность MM определяется
цитогенетическими аберрациями, присутствующими в клоне плазматических клеток (ПК). Цитогенетические исследования
MM осложнены гипопролиферативными особенностями ПК. В связи с этим флуоресцентная гибридизация in situ (FISH)
в комбинации с сортировкой клеток, активированных магнитными полями (MACS) представляется достойной альтернативой
методам оценки точечных и структурных изменений хромосом при MM. Методы: интерфазные исследования методом
FISH с использованием трех различных специфических зондов для участков, содержащих 13q14.3 (D13S319), 14q32
(IGHC/IGHV) и 1q12(CEP1), проводили у 48 больных с MM. Интерфазные исследования методом FISH с использованием
зондов LSI IGH/CCND1, LSI IGH/FGFR3 и LSI IGH/MAF применяли для детекции t(11;14)(q13;q32), t(4;14)(p16;q32), и
t(14;16)(q32;q23) у пациентов с перестройкой 14q32. Результаты: молекулярные цитогенетические аберрации выявляли у
40 (83,3%) из 48 больных с MM. У 13 пациентов (27,1%) одновременно определены 13q делеция/моносомия 13 [del(13q14)],
аномальная перестройка IGH и аномалия хромосомы 1. Del(13q14) детектировали в 21 случае (43,7%), а аномальные
перестройки IGH — в 29 (60,4%), в том числе у 6 пациентов с t(11;14) и 5 с t(4;14). Ни у одного из 9 больных с аномальными
перестройками IGH и без t(11;14) или t(4;14) не выявляли транслокацию t(14;16) (q32;q23). У 24 из 48 пациентов с MM
(50%) определяли аномалии хромосомы 1. В группе из 21 больных с del(13q14) в 15 случаях имелись перестройки IgH
Amp1q12;16. В то же время из 27 случаев без del(13q14) у 8 содержались Amp1q12; в 13 случаях отмечали перестройки
IgH. Выявлена взаимосвязь между del(13q14) и Amp1q12(χ2
= 8,26, p < 0,01) и между del(13q14) и перестройками IgH
(χ2 = 3,88, p < 0,05). Выводы: 13q делецию/моносомию 13, перестройку IGH и аномалию хромосомы 1 часто отмечают
при MM, причем их распределение не случайно и тесно взаимосвязано. Интерфазный анализ FISH в комбинации с
MACS с использованием CD138-специфичных антител является высокочувствительным методом детекции молекулярных
цитогенетических аберраций при MM
Online change detection for energy-efficient mobilec crowdsensing
Mobile crowdsensing is power hungry since it requires continuously and simultaneously sensing, processing and uploading fused data from various sensor types including motion sensors and environment sensors. Realizing that being able to pinpoint change points of contexts enables energy-efficient mobile crowdsensing, we modify histogram-based techniques to efficiently detect changes, which has less computational complexity and performs better than the conventional techniques. To evaluate our proposed technique, we conducted experiments on real audio databases comprising 200 sound tracks. We also compare our change detection with multivariate normal distribution and one-class support vector machine. The results show that our proposed technique is more practical for mobile crowdsensing. For example, we show that it is possible to save 80% resource compared to standard continuous sensing while remaining detection sensitivity above 95%. This work enables energy-efficient mobile crowdsensing applications by adapting to contexts
Continuous-distribution puddle model for conduction in trilayer graphene
An insulator-to-metal transition is observed in trilayer graphene based on
the temperature dependence of the resistance under different applied gate
voltages. At small gate voltages the resistance decreases with increasing
temperature due to the increase in carrier concentration resulting from thermal
excitation of electron-hole pairs. At large gate voltages excitation of
electron-hole pairs is suppressed, and the resistance increases with increasing
temperature because of the enhanced electron-phonon scattering. We find that
the simple model with overlapping conduction and valence bands, each with
quadratic dispersion relations, is unsatisfactory. Instead, we conclude that
impurities in the substrate that create local puddles of higher electron or
hole densities are responsible for the residual conductivity at low
temperatures. The best fit is obtained using a continuous distribution of
puddles. From the fit the average of the electron and hole effective masses can
be determined.Comment: 18 pages, 5 figure
Revisiting Generalized Chaplygin Gas as a Unified Dark Matter and Dark Energy Model
In this paper, we revisit generalized Chaplygin gas (GCG) model as a unified
dark matter and dark energy model. The energy density of GCG model is given as
,
where and are two model parameters which will be constrained by
type Ia supernova as standard candles, baryon acoustic oscillation as standard
rulers and the seventh year full WMAP data points. In this paper, we will not
separate GCG into dark matter and dark energy parts any more as adopted in the
literatures. By using Markov Chain Monte Carlo method, we find the result:
and .Comment: 6 pages, 4 figure
Toward Elucidating the Human Gut Microbiota-Brain Axis: Molecules, Biochemistry, and Implications for Health and Diseases
In recent years, a substantial amount of data have supported an active role of gut microbiota in mediating mammalian brain function and health. Mining gut microbiota and their metabolites for neuroprotection is enticing but requires that the fundamental biochemical details underlying such microbiota-brain crosstalk be deciphered. While a neuronal gut-brain axis (through the vagus nerve) is not disputable, accumulating studies also point to a humoral route (via blood/lymphatic circulation) by which innumerable microbial molecular cues translocate from local gut epithelia to circulation with potentials to further cross the blood-brain barrier and reach the brain. In this Perspective, we review a realm of gut microbial molecules to evaluate their fate, function, and neuroactivities in vivo as mediated by microbiota. We turn to seminal studies of neurophysiology and neurologic disease models for the elucidation of biochemical pathways that link microbiota to gut-brain signaling. In addition, we discuss opportunities and challenges for advancing the microbiota-brain axis field while calling for high-throughput discovery of microbial molecules and studies for resolving the interspecies, interorgan, and interclass interaction among these neuroactive microbial molecules
Does accelerating universe indicates Brans-Dicke theory
The evolution of universe in Brans-Dicke (BD) theory is discussed in this
paper.
Considering a parameterized scenario for BD scalar field
which plays the role of gravitational "constant" ,
we apply the Markov Chain Monte Carlo method to investigate a global
constraints on BD theory with a self-interacting potential according to the
current observational data: Union2 dataset of type supernovae Ia (SNIa),
high-redshift Gamma-Ray Bursts (GRBs) data, observational Hubble data (OHD),
the cluster X-ray gas mass fraction, the baryon acoustic oscillation (BAO), and
the cosmic microwave background (CMB) data. It is shown that an expanded
universe from deceleration to acceleration is given in this theory, and the
constraint results of dimensionless matter density and parameter
are, and
which is consistent with the
result of current experiment exploration, . In
addition, we use the geometrical diagnostic method, jerk parameter , to
distinguish the BD theory and cosmological constant model in Einstein's theory
of general relativity.Comment: 16 pages, 3 figure
Role of the Laboratory in Ensuring Global Access to ARV Treatment for HIV-Infected Children: Consensus Statement on the Performance of Laboratory Assays for Early Infant Diagnosis
A two day meeting hosted by the World Health Organization (WHO) and the U.S. Centers for Disease Control and Prevention (CDC) was held in May 2006 in Entebbe, Uganda to review the laboratory performance of virologic molecular methods, particularly the Roche Amplicor DNA PCR version 1.5 assay, in the diagnosis of HIV-1 infection in infants. The meeting was attended by approximately 60 participants from 17 countries. Data on the performance and limitations of the HIV-1 DNA PCR assay from 9 African countries with high-burdens of HIV/AIDS were shared with respect to different settings and HIV- subtypes. A consensus statement on the use of the assay for early infant diagnosis was developed and areas of needed operational research were identified. In addition, consensus was reached on the usefulness of dried blood spot (DBS) specimens in childhood as a means for ensuring greater accessibility to serologic and virologic HIV testing for the paediatric population
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