Get Tired of Socializing as Social Animal? An Empirical Explanation on Discontinuous Usage Behavior in Social Network Services

This research aims to explain users’ discontinuous usage behavior in social network context. With system features increasing, information flooding and personal network expanding of SNSs, users begin to emerge social network fatigue, and ultimately induce discontinuous usage intention. To explain this phenomenon, we develop a research model based on a cognition-affection-conation framework. This study examines the role of perceived overload (in terms of system feature overload, information overload and social overload) in influencing users’ negative affections of SNSs including social network fatigue and dissatisfaction, and the effects of such emotions on users’ discontinuous intention, which are validated through an empirical survey. The findings of this study contribute to a better understanding of the relationship among perceived overload, social network fatigue and users’ discontinuous usage behavior, and give some implications to SNSs providers to improve this situation

Analytical solutions of seawater intrusion in sloping confined and unconfined coastal aquifers

Sloping coastal aquifers in reality are ubiquitous and well documented. Steady state sharp-interface analytical solutions for describing seawater intrusion in sloping confined and unconfined coastal aquifers are developed based on the Dupuit-Forchheimer approximation. Specifically, analytical solutions based on the constant-flux inland boundary condition are derived by solving the discharge equation for the interface zone with the continuity conditions of the head and flux applied at the interface between the freshwater zone and the interface zone. Analytical solutions for the constant-head inland boundary are then obtained by developing the relationship between the inland freshwater flux and hydraulic head and combining this relationship with the solutions of the constant-flux inland boundary. It is found that for the constant-flux inland boundary, the shape of the saltwater interface is independent of the geometry of the bottom confining layer for both aquifer types, despite that the geometry of the bottom confining layer determines the location of the interface tip. This is attributed to that the hydraulic head at the interface is identical to that of the coastal boundary, so the shape of the bed below the interface is irrelevant to the interface position. Moreover, developed analytical solutions with an empirical factor on the density factor are in good agreement with the results of variable-density flow numerical modeling. Analytical solutions developed in this study provide a powerful tool for assessment of seawater intrusion in sloping coastal aquifers as well as in coastal aquifers with a known freshwater flux but an arbitrary geometry of the bottom confining layer

Protein-Protein Affinity Determination by Quantitative FRET Quenching.

The molecular dissociation constant, Kd, is a well-established parameter to quantitate the affinity of protein-protein or other molecular interactions. Recently, we reported the theoretical basis and experimental procedure for Kd determination using a quantitative FRET method. Here we report a new development of Kd determination by measuring the reduction in donor fluorescence due to acceptor quenching in FRET. A new method of Kd determination was developed from the quantitative measurement of donor fluorescence quenching. The estimated Kd values of SUMO1-Ubc9 interaction based on this method are in good agreement with those determined by other technologies, including FRET acceptor emission. Thus, the acceptor-quenched approach can be used as a complement to the previously developed acceptor excitation method. The new methodology has more general applications regardless whether the acceptor is an excitable fluorophore or a quencher. Thus, these developments provide a complete methodology for protein or other molecule interaction affinity determinations in solution

A local structural descriptor for image matching via normalized graph laplacian embedding

This paper investigates graph spectral approaches to the problem of point pattern matching. Specifically, we concentrate on the issue of how to effectively use graph spectral properties to characterize point patterns in the presence of positional jitter and outliers. A novel local spectral descriptor is proposed to represent the attribute domain of feature points. For a point in a given point-set, weight graphs are constructed on its neighboring points and then their normalized Laplacian matrices are computed. According to the known spectral radius of the normalized Laplacian matrix, the distribution of the eigenvalues of these normalized Laplacian matrices is summarized as a histogram to form a descriptor. The proposed spectral descriptor is finally combined with the approximate distance order for recovering correspondences between point-sets. Extensive experiments demonstrate the effectiveness of the proposed approach and its superiority to the existing methods

Market promotion of paid socket: A feasiblility analysis

This study analyzed an innovation product i.e. paid socket, not on the market yet, and aimed at the feasibility analysis of paid socket market. We used survey method to investigate the end users. Firstly, in view of the "public", we surveyed people about what factors affecting the consumers' willingness to use this socket. The Second part was to understand merchants' ideas about the socket by in-depth interviews. Through SEM analysis, we found that safety and environmental friendliness are two important factors for the users to use the socket, and through in-depth interviews, we found the "installation convenience" and "marketing activities" are most considered by the stores. The implication of the results show that business opportunities behind the paid socket are large, whether in public area or stores , and the viewpoints of using the paid socket were different. Enhanced design and development of the socket could solve the two sides' problems and meet needs of the public and merchants by recovering the cost and expending marketing spots. Consumers didn't have to spend a lot of money to enjoy convenience, fairness and justice caused by paid sockets

Classical-driving-assisted quantum synchronization in non-Markovian environments

We study the quantum phase synchronization of a driven two-level system (TLS) coupled to a structured environment and demonstrate that quantum synchronization can be enhanced by the classical driving field. We use the Husimi $Q$-function to characterize the phase preference and find the in-phase and anti-phase locking phenomenon in the phase diagram. Remarkably, we show that the classical driving enables a TLS to reach stable anti-phase locking in the Markovian regime. However, we find that the synergistic action of classical driving and non-Markovian effects significantly enhances the in-phase locking. By introducing the $S$-function and its maximal value to quantify the strength of synchronization and sketch the synchronization regions, we observe the typical signatures of the hollowed Arnold tongue in the parameter regions of synchronization. In the hollowed Arnold tongue, the synchronization regions exist both inside and outside the tongue while unsynchronized regions only lie on the boundary line. We also provide an intuitive interpretation of the above results by using the quasimode theory.Comment: 10 pages, 5 figures, revised versio

Cold hardiness of Phauda flammans (Lepidoptera: Zygaenidae) larvae

This study aimed to determine the cold hardiness of Phauda flammans (Lepidoptera: Zygaenidae) larvae. Supercooling points of the 1st–6th instar larvae of P. flammans ranged from –7.7 to –13.0 °C. The lethal temperatures were –8 °C for 1st, –5 °C for 2nd, and –7 °C for 3rd–6th instars. Lethal times at the instar-specific lethal temperatures were 12 h for 1st, 14 h for 2nd, 15 h for 3rd, 17 h for 4th, and 18 h for 5th–6th instars. The times required for all larvae to die in an incubator at 5 °C were 30 d for 1st, 3rd, 4th, and 5th instars, and 25 d for 2nd and 6th instars. The findings suggest that P. flammans is a chill-intolerant species, and larvae will die if the air temperature decreases to –5 to –8 °C for 12–18 h or to 5 °C for 25–30 d. Such conditions are, however, unlikely to occur in southern China

Diagnostic Accuracy of CEUS LI-RADS for the Characterization of Liver Nodules 20 mm or Smaller in Patients at Risk for Hepatocellular Carcinoma.

Background: American College of Radiology contrast agent–enhanced US Liver Imaging Reporting and Data System (CEUS LI-RADS) was developed to improve the accuracy of hepatocellular carcinoma (HCC) diagnosis at contrast agent2enhanced US. However, to the knowledge of the authors, the diagnostic accuracy of the system in characterization of liver nodules 20 mm or smaller has not been fully evaluated. Purpose: To evaluate the diagnostic accuracy of CEUS LI-RADS in diagnosing HCC in liver nodules 20 mm or smaller in patients at risk for HCC. Materials and Methods: Between January 2015 and February 2018, consecutive patients at risk for HCC presenting with untreated liver nodules 20 mm or less were enrolled in this retrospective double-reader study. Each nodule was categorized according to the CEUS LI-RADS and World Federation for Ultrasound in Medicine and Biology (WFUMB)–European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) criteria. Diagnostic performance of CEUS LI-RADS and WFUMB-EFSUMB characterization was evaluated by using tissue histologic analysis, multiphase contrast-enhanced CT and MRI, and imaging follow-up as reference standard and compared by using McNemar test. Results: The study included 175 nodules (mean diameter, 16.1 mm 6 3.4) in 172 patients (mean age, 51.8 years 6 10.6; 136 men). The sensitivity of CEUS LR-5 versus WFUMB-EFSUMB criteria in diagnosing HCC was 73.3% (95% confidence inter-val [CI]: 63.8%, 81.5%) versus 88.6% (95% CI: 80.9%, 94%), respectively (P, .001). The specificity of CEUS LR-5 versus WFUMB-EFSUMB criteria was 97.1% (95% CI: 90.1%, 99.7%) versus 87.1% (95% CI: 77%, 94%), respectively (P = .02). No malignant lesions were found in CEUS LR-1 and LR-2 categories. Only two nodules (of 41; 5%, both HCC) were malignant in CEUS LR-3 category. The incidences of HCC in CEUS LR-4, LR-5, and LR-M were 48% (11 of 23), 98% (77 of 79), and 75% (15 of 20), respectively. Two of 175 (1.1%) histologic analysis2confirmed intrahepatic cholangiocarcinomas were categorized as CEUS LR-M by CEUS LI-RADS and misdiagnosed as HCC by WFUMB-EFSUMB criteria. Conclusion: The contrast-enhanced US Liver Imaging Reporting and Data System (CEUS LI-RADS) algorithm was an effective tool for characterization of small (≤20 mm) liver nodules in patients at risk for hepatocellular carcinoma (HCC). Compared with World Federation for Ultrasound in Medicine and Biology2European Federation of Societies for Ultrasound in Medicine and Biology criteria, CEUS LR-5 demonstrated higher specificity for diagnosing small HCCs with lower sensitivity

The prevalence of autism spectrum disorders in China: A comprehensive meta-analysis

There are conflicting prevalence estimates of autism spectrum disorders (ASDs) in mainland China (China thereafter). This study is a comprehensive meta-analysis of the pooled prevalence of ASDs in the general population in China. Study investigators independently conducted a systematic literature search of the following databases: PubMed, EMBASE, PsycINFO, China National Knowledge Infrastructure, Chinese biomedical literature service system, and Wan Fang. Studies reporting prevalence of ASDs and autism in Chinese population were identified and analysed using the Comprehensive Meta-Analysis program with the random effects model. Forty-four studies were included in the meta-analysis comprising 2,337,321 subjects of whom 46.66 % were females. The mean age of subjects ranged from 1.6 to 8 years. Based on diagnostic criteria the pooled prevalence of ASDs was 39.23 per 10,000 (95% CI: 28.44-50.03 per 10,000, I2=89.2%); specifically, the prevalence of autism was 10.18 per 10,000 (95% CI: 8.46-11.89 per 10,000, I2=92.5%). Subgroup analyses revealed significant difference in the prevalence of ASDs between genders (72.77 per 10,000 in males vs. 16.45 per 10,000 in females). In conclusion, the prevalence of ASDs and autism in China was found generally lower than those reported in other countries. Further studies are needed to clarify the variation in prevalence