Recoding Product Design Education: Visual Coding for Human Machine Interfaces

This paper evaluates the impact of visual coding on the Industrial Design and 3D Design disciplines, in particular the role it plays in developing new products and services that would previously require interdisciplinary teams, or significant training beyond the scope of these disciplines into text-based coding and electrical engineering. The professional practice of designers working at the intersection of product design and coding is discussed, and design education evaluated in relation to the opportunities of electronics and visual coding. Quantitative research data is provided to support an argument that visual coding can enable designers to control their designs in new ways throughout the design and prototyping process

Addressing cultural and gender project bias: engaged learning for diverse student cohorts

Engaged student learning is based on creating significant learning experiences for every student. Attracting a more diverse student body into Engineering requires a re-evaluation of the conventional project topics that dominate the discipline. Recognising and addressing cultural and gender bias in the development of project work allows for the education of Engineering faculty on the development of a range of project work opportunities that support the learning for a more diverse cohort. The selection of set project work has the potential to negatively impact the learning experience of minority students. This chapter considers the elements influencing set project work and provides strategies for understanding cultural and gender bias, and for redesigning project work that provides for a more diverse cohort.Arts, Education & Law Group, Queensland College of ArtNo Full Tex

Whose Job is it? 3D Scanning Design for Innovation

There are often references in design education to the idea that design graduates of the future will be working in jobs that do not yet exist. There are therefore opportunities emerging that are not currently recognised as within the designers’ purview. One such area of growth is emerging out around the potentials created by technological developments relating to 3D scanning. This technology is proving to be a catalyst for not only new product outcomes but also innovations in thinking and practice. This is particularly in relation to new workflows that are permeating traditional discipline boundaries. The wide range of advances in digital scanning over the last twenty years have resulted in a myriad of complex capabilities, and the potential of these technologies to support innovation in practice, outcome and thinking are only beginning to be explored. Examples of these explorations are considered in this paper, demonstrating how they can provide a basis for redirecting design for a future of digital immersion. This paper questions the rigour in current approaches to teaching 3D scanning technologies in design education.  It provides an argument that 3D scanning is part of a rapidly evolving suite of digital enablers that are challenging conventional design practice and suggests that educators need to more effectively research and understand the innovations that 3D scanning technologies can inspire.

Digital technologies and 4D customized design: challenging conventions with responsive design

Digital design tools are rapidly changing and blurring the boundaries between design disciplines. By extension, the relationship between humans and products is also changing, to the point where opportunities are emerging for products that can co-evolve with their human users over time. This chapter highlights how these ‘4D products' respond to the vision laid out three decades ago for ubiquitous computing, and have the potential to enhance human experiences by creating more seamless human-centered relationships with technology. These developments are examined in context with broader shifts in sociocultural and environmental concerns, as well as similar developments being researched in Responsive Architecture, 4D printing and systems designed to empower individuals during the design process through interactive, parametric model platforms. Technology is fundamentally changing the way designers create physical products, and new understandings are needed to positively guide these changes.Arts, Education & Law Group, Queensland College of ArtNo Full Tex

Development of a Multiplex Real-Time PCR Assay for Predicting Macrolide and Tetracycline Resistance Associated with Bacterial Pathogens of Bovine Respiratory Disease

Antimicrobial resistance (AMR) in bovine respiratory disease (BRD) is an emerging concern that may threaten both animal and public health. Rapid and accurate detection of AMR is essential for prudent drug therapy selection during BRD outbreaks. This study aimed to develop a multiplex quantitative real-time polymerase chain reaction assay (qPCR) to provide culture-independent information regarding the phenotypic AMR status of BRD cases and an alternative to the gold-standard, culture-dependent test. Bovine clinical samples (297 lung and 111 nasal) collected in Nebraska were subjected to qPCR quantification of macrolide (MAC) and tetracycline (TET) resistance genes and gold-standard determinations of AMR of BRD pathogens. Receiver operating characteristic curve analysis was used to classify AMR based on the qPCR results. For lung tissues, the qPCR method showed good agreement with the gold-standard test for both MACs and TETs, with a sensitivity of 67–81% and a specificity higher than 80%. For nasal swabs, qPCR results passed validation criteria only for TET resistance detection, with a sensitivity of 88%, a specificity of 80% and moderate agreement. The culture-independent assay developed here provides the potential for more rapid AMR characterization of BRD cases directly from clinical samples at equivalent accuracy and higher time efficiency compared with the gold-standard, culture-based test

Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival

<p>Abstract</p> <p>Background</p> <p>Constitutive activation of signal transducer and activator of transcription 3 (Stat3) signaling pathway plays an important role in several human cancers. Activation of Stat3 is dependent on the phosphorylation at the tyrosine residue 705 by upstream kinases and subsequent nuclear translocation after dimerization. It remains unclear whether oncogenic Stat3 signaling pathway is involved in the oncogenesis of bladder cancer.</p> <p>Results</p> <p>We found that elevated Stat3 phosphorylation in 19 of 100 (19%) bladder cancer tissues as well as bladder cancer cell lines, WH, UMUC-3 and 253J. To explore whether Stat3 activation is associated with cell growth and survival of bladder cancer, we targeted the Stat3 signaling pathway in bladder cancer cells using an adenovirus-mediated dominant-negative Stat3 (Y705F) and a small molecule compound, STA-21. Both prohibited cell growth and induction of apoptosis in these bladder cancer cell lines but not in normal bladder smooth muscle cell (BdSMC). The survival inhibition might be mediated through apoptotic caspase 3, 8 and 9 pathways. Moreover, down-regulation of anti-apoptotic genes (Bcl-2, Bcl-xL and survivin) and a cell cycle regulating gene (cyclin D1) was associated with the cell growth inhibition and apoptosis.</p> <p>Conclusion</p> <p>These results indicated that activation of Stat3 is crucial for bladder cancer cell growth and survival. Therefore, interference of Stat3 signaling pathway emerges as a potential therapeutic approach for bladder cancer.</p