Higher-Derivative Terms in N=2 Supersymmetric Effective Actions

We show how to systematically construct higher-derivative terms in effective actions in harmonic superspace despite the infinite redundancy in their description due to the infinite number of auxiliary fields. Making an assumption about the absence of certain superspace Chern-Simons-like terms involving vector multiplets, we write all 3- and 4-derivative terms on Higgs, Coulomb, and mixed branches. Among these terms are several with only holomorphic dependence on fields, and at least one satisfies a non-renormalization theorem. These holomorphic terms include a novel 3-derivative term on mixed branches given as an integral over 3/4 of superspace. As an illustration of our method, we search for Wess-Zumino terms in the low energy effective action of N=2 supersymmetric QCD. We show that such terms occur only on mixed branches. We also present an argument showing that the combination of space-time locality with supersymmetry implies locality in the anticommuting superspace coordinates of for unconstrained superfields.Comment: 30 pages. Added references and simplified final form of WZ ter

Competing biosecurity and risk rationalities in the Chittagong poultry commodity chain, Bangladesh

This paper anthropologically explores how key actors in the Chittagong live bird trading network perceive biosecurity and risk in relation to avian influenza between production sites, market maker scenes and outlets. They pay attention to the past and the present, rather than the future, downplaying the need for strict risk management, as outbreaks have not been reported frequently for a number of years. This is analysed as ‘temporalities of risk perception regarding biosecurity’, through Black Swan theory, the idea that unexpected events with major effects are often inappropriately rationalized (Taleb in The Black Swan. The impact of the highly improbable, Random House, New York, 2007). This incorporates a sociocultural perspective on risk, emphasizing the contexts in which risk is understood, lived, embodied and experienced. Their risk calculation is explained in terms of social consent, practical intelligibility and convergence of constraints and motivation. The pragmatic and practical orientation towards risk stands in contrast to how risk is calculated in the avian influenza preparedness paradigm. It is argued that disease risk on the ground has become a normalized part of everyday business, as implied in Black Swan theory. Risk which is calculated retrospectively is unlikely to encourage investment in biosecurity and, thereby, points to the danger of unpredictable outlier events

“Lest we forget” : An overview of Australia’s response to the recovery and identification of unrecovered historic military remains

Peer reviewedPostprin

Black Holes and Five-brane Thermodynamics

The phase diagram for Dp-branes in M-theory compactified on $T^4$, $T^4/Z_2$, $T^5$, and $T^6$ is constructed. As for the lower-dimensional tori considered in our previous work (hep-th/9810224), the black brane phase at high entropy connects onto matrix theory at low entropy; we thus recover all known instances of matrix theory as consequences of the Maldacena conjecture. The difficulties that arise for $T^6$ are reviewed. We also analyze the D1-D5 system on $T^5$; we exhibit its relation to matrix models of M5-branes, and use spectral flow as a tool to investigate the dependence of the phase structure on angular momentum.Comment: 57 pages, 6 eps figures, latex. v2: DLCQ limit of 5-brane corrected; typos corrected, references added. v3: reference added, typos corrected v4: comments on DLCQ limit of 5-brane corrected one last time. Final version, to appear in Phys. Rev.

The Epstein-Barr Virus G-Protein-Coupled Receptor Contributes to Immune Evasion by Targeting MHC Class I Molecules for Degradation

Epstein-Barr virus (EBV) is a human herpesvirus that persists as a largely subclinical infection in the vast majority of adults worldwide. Recent evidence indicates that an important component of the persistence strategy involves active interference with the MHC class I antigen processing pathway during the lytic replication cycle. We have now identified a novel role for the lytic cycle gene, BILF1, which encodes a glycoprotein with the properties of a constitutive signaling G-protein-coupled receptor (GPCR). BILF1 reduced the levels of MHC class I at the cell surface and inhibited CD8+ T cell recognition of endogenous target antigens. The underlying mechanism involves physical association of BILF1 with MHC class I molecules, an increased turnover from the cell surface, and enhanced degradation via lysosomal proteases. The BILF1 protein of the closely related CeHV15 c1-herpesvirus of the Rhesus Old World primate (80% amino acid sequence identity) downregulated surface MHC class I similarly to EBV BILF1. Amongst the human herpesviruses, the GPCR encoded by the ORF74 of the KSHV c2-herpesvirus is most closely related to EBV BILF1 (15% amino acid sequence identity) but did not affect levels of surface MHC class I. An engineered mutant of BILF1 that was unable to activate G protein signaling pathways retained the ability to downregulate MHC class I, indicating that the immune-modulating and GPCR-signaling properties are two distinct functions of BILF1. These findings extend our understanding of the normal biology of an important human pathogen. The discovery of a third EBV lytic cycle gene that cooperates to interfere with MHC class I antigen processing underscores the importance of the need for EBV to be able to evade CD8+ T cell responses during the lytic replication cycle, at a time when such a large number of potential viral targets are expressed

Sunyaev Zel'dovich observations of a statistically complete sample of galaxy clusters with OCRA-p

We present 30 GHz Sunyaev Zel'dovich observations of a statistically complete sample of galaxy clusters with OCRA-p. The clusters are the 18 most X-ray luminous clusters at z > 0.2 in the ROSAT Brightest Cluster Sample. We correct for contaminant radio sources via supplementary observations with the Green Bank Telescope, also at 30 GHz, and remove a cluster that is contaminated by an unresolved X-ray source. All 17 remaining clusters have central SZ effects with Comptonisation parameter y_0 exceeding 1.9x10^-4, and 13 are detected at significance > 3 sigma. We use our data to examine scalings between y_0 and X-ray temperature, X-ray luminosity, and the X-ray mass proxy Y_X, and find good agreement with predictions from self-similar models of cluster formation, with an intrinsic scatter in y_0 of about 25%. We also comment on the success of the observations in the face of the contaminant source population, and the implications for upcoming cm-wave surveys.Comment: 14 pages, 2 figures, accepted by MNRA

Correction to: Concepts and Terminology for Sea Level: Mean, Variability and Change, Both Local and Global

In the author group at the start of the article and in the affiliations section at the end of the article, the sixth author’s name was incorrectly spelled as “Ichiro Fukimori”. However, the correct name should read as “Ichiro Fukumori”

IL2RA/CD25 Gene Polymorphisms: Uneven Association with Multiple Sclerosis (MS) and Type 1 Diabetes (T1D)

[Background] IL-2 receptor (IL2R) alpha is the specific component of the high affinity IL2R system involved in the immune response and in the control of autoimmunity. [Methods and Results] Here we perform a replication and fine mapping of the IL2RA gene region analyzing 3 SNPs previously associated with multiple sclerosis (MS) and 5 SNPs associated with type 1 diabetes (T1D) in a collection of 798 MS patients and 927 matched Caucasian controls from the south of Spain. We observed association with MS in 6 of 8 SNPs. The rs1570538, at the 3′- UTR extreme of the gene, previously reported to have a weak association with MS, is replicated here (P = 0.032). The most associated T1D SNP (rs41295061) was not associated with MS in the present study. However, the rs35285258, belonging to another independent group of SNPs associated with T1D, showed the maximal association in this study but different risk allele. We replicated the association of only one (rs2104286) of the two IL2RA SNPs identified in the recently performed genome-wide association study of MS. [Conclusions] These findings confirm and extend the association of this gene with MS and reveal a genetic heterogeneity of the associated polymorphisms and risk alleles between MS and T1D suggesting different immunopathological roles of IL2RA in these two diseases.Financial support for the study was provided by the Ministerio de Educación y Ciencia (grants PN-SAF2006-02023 and TIN2007-67418-C03-03) and Junta de Andalucía (P07-CVI-02551) to A. Alcina and Servicio Andaluz de Salud de la Junta de Andalucía (grant PI0168/2007) to F. Matesanz. María Fedetz is a holder of a fellowship from Fundación IMABIS. Dorothy Ndagire is a holder of AECI-Ministerio de Asuntos Exteriores fellowship

A high-resolution map of human evolutionary constraint using 29 mammals.

The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at least 5.5% of the human genome has undergone purifying selection, and locate constrained elements covering ∼4.2% of the genome. We use evolutionary signatures and comparisons with experimental data sets to suggest candidate functions for ∼60% of constrained bases. These elements reveal a small number of new coding exons, candidate stop codon readthrough events and over 10,000 regions of overlapping synonymous constraint within protein-coding exons. We find 220 candidate RNA structural families, and nearly a million elements overlapping potential promoter, enhancer and insulator regions. We report specific amino acid residues that have undergone positive selection, 280,000 non-coding elements exapted from mobile elements and more than 1,000 primate- and human-accelerated elements. Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease

Transoral resection of pharyngeal cancer: Summary of a National Cancer Institute Head and Neck Cancer Steering Committee Clinical Trials Planning Meeting, November 6–7, 2011, Arlington, Virginia

Recent advances now permit resection of many pharyngeal tumors through the open mouth, an approach that can greatly reduce the morbidity of surgical exposure. These transoral techniques are being rapidly adopted by the surgical community and hold considerable promise. On November 6–7, 2011, the National Cancer Institute sponsored a Clinical Trials Planning Meeting to address how to further investigate the use of transoral surgery, both in the good prognosis human papillomavirus (HPV)–initiated oropharyngeal cancers, and in those with HPV‐unrelated disease. The proceedings of this meeting are summarized. © 2012 Wiley Periodicals, Inc. Head Neck, 2012Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94490/1/23136_ftp.pd