Gay Men and the Intentional Pursuit of HIV

Hidden deep within the gay male underground lives a small population of gay men who imagined the intentional pursuit of HIV as a means to some end. In terms of nursing care for such marginalized pockets of gay men, most nurses are unaware of their existence or lack sufficient knowledge and compassion to care for this population. Bug chaser is a metaphor used to describe the gay men who intentionally sought the bug--HIV infection. Essential to caring for these men is first discovering them, and then understanding them. The purpose of this narrative study was to understand the life experiences of gay men who intentionally sought or seek to become infected with HIV. Using queer theory as its framework, the study was constructed from two research questions: 1) What are the life-stories of gay men who seek HIV infection? 2) How do these life-stories describe and give meaning to sexuality and HIV? In this qualitative study, 18 adult gay men were interviewed three times over a period of three months. Chain referral sampling wherein initial participants spread word of the study in their associate networks limited racial diversity; 15 men self-identified as African American, one as other (i.e., Italian and African American), one as Latino, and one as Caucasian. Their ages ranged from 33 years to 61 years (M=48). Most considered themselves Christians (n=13). Socioeconomically, 10 of the men lived in poverty. Sixteen were HIV positive; two were pursuing HIV. Most (n=16) secured health care through one of the Medicare or Medicaid products. Through semi-structured interviews and narrative analyses, their life stories portray who these men were and why they imagined HIV to be a fitting means to an end. Results illustrate that the intentional pursuit of HIV was well thought out and strategically planned, and aligned with lifetime struggles, for example, difficulty accepting one\u27s gay identity. Narrative life patterns that culminated in purposeful pursuit of HIV included addictions, wanting to connect to an HIV positive lover, childhood abuses, secrets, punishment for wrongdoings, and, in one case, HIV as an imagined progression for gay men

Opening up Pandora’s box? How centre-right parties can outperform the radical right on immigration

It is often assumed that populist radical-right parties have dominated European politics throughout the refugee crisis period (2015–18) and laid claim to the immigration issue. James F. Downes, Matthew Loveless and Andrew Lam argue that this narrative is far too simplistic and that incumbent (governing) centre-right parties have responded to the electoral threat of the radical right by highlighting their own anti-immigrant positions. This strategy has helped the centre right to outperform the far right and even offset electoral challenges from them. However, it may also be a double-edged sword that benefits the radical right in the longer term

Do centre-right parties win back votes from the far right by talking about immigration?

With the rise of far-right parties in Europe during the 2000s, some centre-right parties spotted an opportunity to win back votes by pivoting towards immigration. James F Downes and Matthew Loveless find that they were more successful if they were out of government at the time. Incumbent centre-right parties, on the other hand, struggled to cut through on the issue

Winning back votes from the far right: does the centre right's focus on immigration pay off?

With the rise of far-right parties in Europe during the 2000s, some centre-right parties spotted an opportunity to win back votes by pivoting towards immigration. James F Downes and Matthew Loveless find that they were more successful if they were out of government at the time. Incumbent centre-right parties, on the other hand, struggled to cut through on the issue

Physiological Profile of Male Competitive and Recreational Surfers

Surfing consists of both high- and low-intensity paddling of varying durations, using both the aerobic and anaerobic systems. Surf-specific physiological studies lack adequate group sample sizes, and V[Combining Dot Above]O2peak values are yet to determine the differences between competitive and recreational surfers. The purpose of this study was therefore to provide a comprehensive physiological profile of both recreational and competitive surfers. This multisite study involved 62 male surfers, recreational (n = 47) and competitive (n = 15). Anthropometric measurements were conducted followed by dual-energy x-ray absorptiometry, anaerobic testing and finally aerobic testing. V[Combining Dot Above]O2peak was significantly greater in competitive surfers than in recreational surfers (M = 40.71 ± 3.28 vs. 31.25 ± 6.31 ml·kg·min, p \u3c 0.001). This was also paralleled for anaerobic power (M = 303.93 vs. 264.58 W) for competitive surfers. Arm span and lean total muscle mass was significantly (p ≤ 0.01) correlated with key performance variables (V[Combining Dot Above]O2peak and anaerobic power). No significant (p ≥ 0.05) correlations were revealed between season rank and each of the variables of interest (V[Combining Dot Above]O2peak and anaerobic power). Key performance variables (V[Combining Dot Above]O2peak and anaerobic power) are significantly higher in competitive surfers, indicating that this is both an adaptation and requirement in this cohort. This battery of physiological tests could be used as a screening tool to identify an athlete\u27s weaknesses or strengths. Coaches and clinicians could then select appropriate training regimes to address weaknesses

Stress and eating behaviors

Studies pertaining to obesity, stress, and their impact on organizations are plentiful. Further, there is an abundance of research surrounding stress at work and eating behaviors. However, studies regarding work stress and fasting are absent. Because of this, our study aims to examine the relationship between stress, fasting behaviors, and interoception. Interoception is the perception of physical (body) sensations, such as hunger. We argue that interoceptive awareness will mediate the positive relationships between stress and fasting behavior. We argue that stress fasting behaviors are likely to occur during periods of high stress, such as balancing work and midterm exams. Therefore, we propose to gather data from working college students to test our hypotheses

Aligning the CMS Muon Endcap Detector with a System of Optical Sensors

The positions and orientations of one sixth of 468 large cathode strip chambers in the endcaps of the CMS muon detector are directly monitored by several hundred sensors including 2-D optical sensors with linear CCDs illuminated by cross-hair lasers. Position measurements obtained by photogrammetry and survey under field-off conditions show that chambers in the +Z endcap have been placed on the yoke disks with an average accuracy of $\approx 1$ mm in all 3 dimensions. We reconstruct absolute Z$_{CMS}$ positions and orientations of chambers at B=0T and B=4T using data from the optical alignment system. The measured position resolution and sensitivity to relative motion is about 60 $\mu m$. The precision for measuring chamber positions taking into account mechanical tolerances is \mbox{$\approx 270 \mu m$}. Comparing reconstruction of optical alignment data and photogrammetry measurements at B=0T indicates an accuracy of $\approx$ 680 $\mu m$ currently achieved with the hardware alignment system. Optical position measurements at B=4T show significant chamber displacements of up to 13 mm due to yoke disk deformation

Neuroethics, Painience, and Neurocentric Criteria for the Moral Treatment of Animals

Neuroscience affords knowledge that can be leveraged in the ontological valuation of individuals, groups, and species. Sociocultural sentiments, norms, and mores may impede embracing such knowledge to revise moral attitudes, ethics, and policies. We argue that the practices of neuroethics will be valuable in that they ground ethico-legal discourse in (1) naturalistic philosophy; (2) the current epistemological capital of neuroscience; (3) the issues, problems, and solutions arising in and from neuroscientific research and its applications; and 4) the use of neurocentric criteria—such as painience—to define and resolve ethical decisions regarding attitudes toward and treatment of nonhuman animals

Design and Performance of the Alignment System for the CMS Muon Endcaps

The alignment system for the CMS Muon Endcap detector employs several hundred sensors such as optical 1-D CCD sensors illuminated by lasers and analog distance- and tilt-sensors to monitor the positions of one sixth of 468 large Cathode Strip Chambers. The chambers mounted on the endcap yoke disks undergo substantial deformation on the order of centimeters when the 4T field is switched on and off. The Muon Endcap alignment system is required to monitor chamber positions with \mbox{75-200 $\mu$m} accuracy in the R$\phi$ plane, $\approx$400 $\mu$m in the radial direction, and $\approx$1 mm in the z-direction along the beam axis. The complete alignment hardware for one of the two endcaps has been installed at CERN. A major system test was performed when the 4T solenoid magnet was ramped up to full field for the first time in August 2006. We present the overall system design and first results on disk deformations, which indicate that the measurements agree with expectations

CSF-resident CD4+ T-cells display a distinct gene expression profile with relevance to immune surveillance and multiple sclerosis

The CNS has traditionally been considered an immune privileged site, but is now understood to have a system of immune surveillance, predominantly involving CD4+ T-cells. Identifying functional differences between CNS and blood CD4+ T-cells, therefore, have relevance to CNS immune surveillance as well as to neurological conditions, such as multiple sclerosis, in which CD4+ T-cells play a central role. Here, CD4+ T-cells were purified from CSF and blood from 21 patients with newly diagnosed treatment-naïve multiple sclerosis and 20 individuals with non-inflammatory disorders using fluorescence-activated cell sorting, and their transcriptomes were profiled by RNA sequencing. Paired comparisons between CD4+ T-cells from CSF and blood identified 5156 differentially expressed genes in controls and 4263 differentially expressed in multiple sclerosis patients at false discovery rate <5%. Differential expression analysis of CD4+ T-cells collected from the CSF highlighted genes involved in migration, activation, cholesterol biosynthesis and signalling, including those with known relevance to multiple sclerosis pathogenesis and treatment. Expression of markers of CD4+ T-cell subtypes suggested an increased proportion of Th1 and Th17 cells in CSF. Gene ontology terms significant only in multiple sclerosis were predominantly those involved in cellular proliferation. A two-way comparison of CSF versus blood CD4+ T-cells in multiple sclerosis compared with non-inflammatory disorder controls identified four significant genes at false discovery rate <5% (CYP51A1, LRRD1, YES1 and PASK), further implicating cholesterol biosynthesis and migration mechanisms. Analysis of CSF CD4+ T-cells in an extended cohort of multiple sclerosis cases (total N = 41) compared with non-inflammatory disorder controls (total N = 38) identified 140 differentially expressed genes at false discovery rate < 5%, many of which have known relevance to multiple sclerosis, including XBP1, BHLHE40, CD40LG, DPP4 and ITGB1. This study provides the largest transcriptomic analysis of purified cell subpopulations in CSF to date and has relevance for the understanding of CNS immune surveillance, as well as multiple sclerosis pathogenesis and treatment discovery