Radionécrose cérébrale chez des patients irradiés pour cancers du nasopharynx: à propos de 3 cas

La radionécrose cérébrale est une complication tardive, iatrogène, relativement rare de la radiothérapie qui survient après plus de six mois suivant le début du traitement. Elle pourrait s'expliquer par la conjonction de lésions vasculaires, gliales et d'ordre immunologiques. Elle peut mettre en jeu le pronostic fonctionnel et vital du malade. La prévention de cette affection redoutable est fondamentale vu l'absence de traitement potentiellement efficace. Nous rapportons 03 nouveaux cas, chez des patients traités par chimiothérapie  d'induction puis radio- chimiothérapie concomitante pour des cancers localement avancés du nasopharynx. Le diagnostic a été orienté par l'IRM spectroscopique et l'évolution était favorable sous corticothérapie dans les 03 cas.Key words: Radionécrose cérébrale, Cancers du nasopharynx , IRM spectroscopiqu

Rôle de la radiothérapie dans le traitement de l’améloblastome: à propos de deux cas

L'améloblastome est une tumeur odontogène bénigne mais à pouvoir agressif et invasif local important. C'est une tumeur rare, elle représente 1% des tumeurs des maxillaires. Le rôle de la radiothérapie dans son  traitement est actuellement démontré pour les tumeurs inopérables. Nous rapportons 2 cas  d'améloblastomes mandibulaires chez deux patients qui ont bénéficié d'une radiothérapie externe à la dose de 60 Gy. L'évolution a été marquée par une rémission complète de la maladie dans les deux cas avec un recul de 2 et 5 ans.Key words: Améloblastome, mandibule, radiothérapie, tumeur bénign

Exploring the Multi-Faceted Potential of Carob (<i>Ceratonia siliqua</i> var. Rahma) Leaves from Morocco: A Comprehensive Analysis of Polyphenols Profile, Antimicrobial Activity, Cytotoxicity against Breast Cancer Cell Lines, and Genotoxicity

The botanical species Ceratonia siliqua L., commonly referred to as the Carob tree, and locally as “L’Kharrûb”, holds significance as an agro-sylvo-pastoral species, and is traditionally utilized in Morocco for treating a variety of ailments. This current investigation aims to ascertain the antioxidant, antimicrobial, and cytotoxic properties of the ethanolic extract of C. siliqua leaves (CSEE). Initially, we analyzed the chemical composition of CSEE through high-performance liquid chromatography with Diode-Array Detection (HPLC-DAD). Subsequently, we conducted various assessments, including DPPH scavenging capacity, β-carotene bleaching assay, ABTS scavenging, and total antioxidant capacity assays to evaluate the antioxidant activity of the extract. In this study, we investigated the antimicrobial properties of CSEE against five bacterial strains (two gram-positive, Staphylococcus aureus, and Enterococcus faecalis; and three gram-negative bacteria, Escherichia coli, Escherichia vekanda, and Pseudomonas aeruginosa) and two fungi (Candida albicans, and Geotrichum candidum). Additionally, we evaluated the cytotoxicity of CSEE on three human breast cancer cell lines (MCF-7, MDA-MB-231, and MDA-MB-436) and assessed the potential genotoxicity of the extract using the comet assay. Through HPLC-DAD analysis, we determined that phenolic acids and flavonoids were the primary constituents of the CSEE extract. The results of the DPPH test indicated a potent scavenging capacity of the extract with an IC50 of 302.78 ± 7.55 µg/mL, which was comparable to that of ascorbic acid with an IC50 of 260.24 ± 6.45 µg/mL. Similarly, the β-carotene test demonstrated an IC50 of 352.06 ± 12.16 µg/mL, signifying the extract’s potential to inhibit oxidative damage. The ABTS assay revealed IC50 values of 48.13 ± 3.66 TE µmol/mL, indicating a strong ability of CSEE to scavenge ABTS radicals, and the TAC assay demonstrated an IC50 value of 165 ± 7.66 µg AAE/mg. The results suggest that the CSEE extract had potent antioxidant activity. Regarding its antimicrobial activity, the CSEE extract was effective against all five tested bacterial strains, indicating its broad-spectrum antibacterial properties. However, it only showed moderate activity against the two tested fungal strains, suggesting it may not be as effective against fungi. The CSEE exhibited a noteworthy dose-dependent inhibitory activity against all the tested tumor cell lines in vitro. The extract did not induce DNA damage at the concentrations of 6.25, 12.5, 25, and 50 µg/mL, as assessed by the comet assay. However, the 100 µg/mL concentration of CSEE resulted in a significant genotoxic effect compared to the negative control. A computational analysis was conducted to determine the physicochemical and pharmacokinetic characteristics of the constituent molecules present in the extract. The Prediction of Activity Spectra of Substances (PASS) test was employed to forecast the potential biological activities of these molecules. Additionally, the toxicity of the molecules was evaluated using the Protox II webserver

Política de saúde e de cuidados continuados integrados em Portugal: O planeamento da alta em Serviço Social

This paper presents the construction of the policy for integrated and continued, social assistance and healthcare in the realm of healthcare policy in Portugal, highlighting the planning for release in Social Work. Since 2006, when continued care was recognized as a right and integrated into policy and the healthcare system, the Social Work profession has been highlighted in this process of planning for release and in the development of procedures that are implicit in the relation of assistance, particularly in the reception and diagnosis, meetings and reports, action plans, accompaniment and evaluation of the process and integration in the community. The technical-operative dimension of Social Work in planning for release highlights the role of the profession within the healthcare system, improving access to the benefits of care, the well-being of the ill and of families, and consolidates the Social Work profession in society.Este texto pretende evidenciar a construção da política de cuidados continuados integrados, social e de saúde, no âmbito da política de saúde em Portugal, destacando o planeamento da alta em Serviço Social. Desde 2006 que os cuidados continuados são assumidos como direitos e integrados na política e no sistema de saúde. A profissão do Serviço Social tem recebido destaque no processo de planeamento das altas e no desenvolvimento de procedimentos implícitos na relação de ajuda, nomeadamente no acolhimento e diagnóstico, reuniões e pareceres, planos de ação, acompanhamento e avaliação do processo e integração na comunidade. A dimensão técnico-operativa do Serviço Social no planeamento da alta contribui para destacar a profissão no sistema de saúde, potenciar o usufruto de cuidados, melhorar o bem-estar dos doentes e das famílias, assim como consolidar a profissão de Serviço Social na sociedade