Jacques Tixier (1925-2018)

Jacques Tixier was an internationally known prehistorian and the founder of the technological “reading” of lithic industries. The first approach to this interpretation is based on experiments and the recognition of the chronological order of technical gestures

The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses

SummaryThe molecular mechanisms whereby the CD45 tyrosine phosphatase (PTPase) regulates T cell receptor (TCR) signaling responses remain to be elucidated. To investigate this question, we have reconstituted CD45 (encoded by Ptprc)-deficient mice, which display severe defects in thymic development, with five different expression levels of transgenic CD45RO, or with mutant PTPase null or PTPase-low CD45R0. Whereas CD45 PTPase activity was absolutely required for the reconstitution of thymic development, only 3% of wild-type CD45 activity restored T cell numbers and normal cytotoxic T cell responses. Lowering the CD45 expression increased CD4 lineage commitment. Peripheral T cells with very low activity of CD45 phosphatase displayed reduced TCR signaling, whereas intermediate activity caused hyperactivation of CD4+ and CD8+ T cells. These results are explained by a rheostat mechanism whereby CD45 differentially regulates the negatively acting pTyr-505 and positively acting pTyr-394 p56lck tyrosine kinase phosphorylation sites. We propose that high wild-type CD45 expression is necessary to dephosphorylate p56lck pTyr-394, suppressing CD4 T+ cell lineage commitment and hyperactivity

Renewing an undergraduate science curriculum for the 21st century

IntroductionThe rapid pace of technological advancement, globalisation, and complex socio-economic challenges facing 21st-century society necessitates a rethinking of undergraduate science education. Undergraduate science curriculum reform is essential to prepare students for the demands of the modern workforce in an ever-changing world. Accordingly, in Trinity College Dublin (the University of Dublin), the oldest science degree course in Ireland was intensively reviewed and redeveloped between 2014 and 2021. This study aims to collate and disseminate the knowledge acquired by university staff through the experience of undertaking a major science curriculum redevelopment.MethodsNine senior staff members closely involved with the redevelopment were interviewed about why the curriculum reform was necessary, what it had achieved, and how the process could have been improved.ResultsThe reasons behind the curriculum changes are described and placed in the context of contemporary pedagogical research. Reflections from the academic and administrative staff involved in the redevelopment process are presented, emphasising the challenges and opportunities that emerged from that process.DiscussionRecommendations for other universities undertaking similar reforms are included. Aligning undergraduate science curriculum reform with the needs of 21st-century society is vital for ensuring that science graduates are well-prepared to make positive contributions to a sustainable future

The Lantern Vol. 22, No. 2, March 1954

• Checkmate • An Impression • The Excavation at Ursinus College • Chant d\u27Antomne • Impasse At Dick\u27s Dell • The Master\u27s Hands • Wanderer • The Wiser Tongue • Time Passing • Achoo! Or It\u27s All In Your Head • From The Tower Windowhttps://digitalcommons.ursinus.edu/lantern/1062/thumbnail.jp

Nurses Alumni Association Bulletin, Fall 1987

Alumni Calendar Officers and Committee Chairmen The President\u27s Message Treasurer\u27s Report Nurses\u27 Relief Fund Scholarship Fund School Nurses- Ahead of Their Time Remember? Happy Ending Florence Nightingale End of an Era Little Jeff - As I Remember It Happy Retirement Peg Distinguished Career Ends Special Achievement Award Fiftieth Anniversary 1986 Alumni Directory Happy Birthday Resume of Minutes of Alumni Association Meetings Bequests Alumni Office News Committee Reports Bulletin Scholarship Satellite Social Finance Luncheon Pictures In Memoriam, Names of Deceased Graduates Class News Caps, Pins, Transcripts, Class Address Lists Change of Address Form Relief Fund Application Scholarship Fund Application Membership Applicatio

Nurses\u27 Alumnae Association Bulletin, June 1965

President\u27s Page Officers and Committee Chairmen Financial Report Hospital and School of Nursing Report Student Activities Annual Report Students Activities Annual Report Student Activities Annual Report Jefferson Expansion Program Psychiatric Unit Progress of the Alumnae Association Nightingale Pledge Resume of Alumnae Meetings Nursing Service Staff Association Scholarship Program Sick and Welfare Social Committee Report Bulletin Membership- WHY JOIN? Private Duty Report Annual Giving Report - 1964 PIT Alumnae Day Notes Building Fund Report - 1965 Vital Statistics IN MEMORIAM Class News Affiliated Institutions Notice

Does digital, multimedia information increase recruitment and retention in a children’s wrist fracture treatment trial, and what do people think of it? A randomised controlled Study Within A Trial (SWAT)

Objectives To evaluate digital, multimedia information (MMI) for its effects on trial recruitment, retention, decisions about participation and acceptability by patients, compared with printed information. Design Study Within A Trial using random cluster allocation within the Forearm Fracture Recovery in Children Evaluation (FORCE) study. Setting Emergency departments in 23 UK hospitals. Participants 1409 children aged 4–16 years attending with a torus (buckle) fracture, and their parents/guardian. Children’s mean age was 9.2 years, 41.0% were female, 77.4% were ethnically White and 90.0% spoke English as a first language. Interventions Participants and their parents/guardian received trial information either via multimedia, including animated videos, talking head videos and text (revised for readability and age appropriateness when needed) on tablet computer (MMI group; n=681), or printed participant information sheet (PIS group; n=728). Outcome measures Primary outcome was recruitment rate to FORCE. Secondary outcomes were Decision Making Questionnaire (nine Likert items, analysed summatively and individually), three ‘free text’ questions (deriving subjective evaluations) and trial retention. Results MMI produced a small, not statistically significant increase in recruitment: 475 (69.8%) participants were recruited from the MMI group; 484 (66.5%) from the PIS group (OR=1.35; 95% CI 0.76 to 2.40, p=0.31). A total of 324 (23.0%) questionnaires were returned and analysed. There was no difference in total Decision-Making Questionnaire scores: adjusted mean difference 0.05 (95% CI −1.23 to 1.32, p=0.94). The MMI group was more likely to report the information ‘very easy’ to understand (89; 57.8% vs 67; 39.4%; Z=2.60, p=0.01) and identify information that was explained well (96; 62.3% vs 71; 41.8%). Almost all FORCE recruits were retained at the 6 weeks’ timepoint and there was no difference in retention rate between the information groups: MMI (473; 99.6%); PIS (481; 99.4%)

Utilizing TAPBPR to promote exogenous peptide loading onto cell surface MHC I molecules.

The repertoire of peptides displayed at the cell surface by MHC I molecules is shaped by two intracellular peptide editors, tapasin and TAPBPR. While cell-free assays have proven extremely useful in identifying the function of both of these proteins, here we explored whether a more physiological system could be developed to assess TAPBPR-mediated peptide editing on MHC I. We reveal that membrane-associated TAPBPR targeted to the plasma membrane retains its ability to function as a peptide editor and efficiently catalyzes peptide exchange on surface-expressed MHC I molecules. Additionally, we show that soluble TAPBPR, consisting of the luminal domain alone, added to intact cells, also functions as an effective peptide editor on surface MHC I molecules. Thus, we have established two systems in which TAPBPR-mediated peptide exchange on MHC class I can be interrogated. Furthermore, we could use both plasma membrane-targeted and exogenous soluble TAPBPR to display immunogenic peptides on surface MHC I molecules and consequently induce T cell receptor engagement, IFN-γ secretion, and T cell-mediated killing of target cells. Thus, we have developed an efficient way to by-pass the natural antigen presentation pathway of cells and load immunogenic peptides of choice onto cells. Our findings highlight a potential therapeutic use for TAPBPR in increasing the immunogenicity of tumors in the future

Nurses Alumni Association Bulletin, Fall 1984

Alumni Calendar 2 Officers and Committee Chairmen The President\u27s Message Treasurer\u27s Report Nurses\u27 Relief Fund Scholarship Fund By-Laws Letter Computer Education : Teaching Students the New Way Life of Service Twenty Ways to Kill an Organization Keeping the Jeff Spirit Alive Do You Remember? Fiftieth Anniversary The Best Medicine Happy Birthday Down Memory Lane On the Lighter Side Pavilion Renovations are Complete Resume of Minutes of Alumni Association Meetings Committee Reports Social Scholarship Sick & Welfare Satellite Alumni Office News Finance Marguerite Barnett Memorial Student Loan Fund In Memoriam, Names of Deceased Graduates Luncheon Photos Class Notes History of the Jefferson Cap Alumni Special Award Goes to Doris Bowman Caps, Pins, Transcripts, Class Address Lists Change of Address Form Relief Fund Application Scholarship Fund Application Notice, Alumni Luncheo