Tourism projects for community development : Influences of tour operators and development organisations.

This study compares tour operators and development organisations, by analysing their role in three differently funded and operated tourism projects in Ecuador. Additionally, the study identifies links between micro level livelihood outputs of the projects, the meso level operational contexts, and macro level influences. The study reviews general assumptions that the tourism private sector is not as capable of contributing to poverty reduction to the same extent that the development sector is.Guided by a political economy approach, whilst also considering Giddens' concept of structuration theory, the study examines whether traditional structuralist views of tourism development in less economically developed countries (LEDCs) are applicable within the context of three externally-led tourism projects. Elements of critical ethnography and livelihoods analysis were employed to gather primarily qualitative data, which was obtained by interviewing, observing, carrying out ranking exercises, and analysing documents.Results of the study revealed that the tour operator project was considerably more successful in contributing to the livelihoods of residents surrounding the project. The tour operator was well equipped to respond to operational challenges of the project, and well networked with a range of organisations which provided technical expertise, and small grants. The projects supported by development organisations had notable positive outputs, but failed to create adequate networks with the private sector to sell the projects, and hence were suffering from over-supply and lack of demand.The study showed that development organisations were more confined to operating within bureaucratic processes of head offices than tour operators, which also had detrimental effects on project outputs. Development organisation projects suffer from a lack of tourism expertise, and must adhere to strict regulations regarding project design and operations, echoing the power of institutional structures over agency. Although tour operators must comply with service and product standards to satisfy their international buyers, they appear to be more influential in altering traditional structures, such as networking between the private and development sectors, thus demonstrating the potential power of agency.The evidence concluded that tour operators are better equipped to fund and operate sustainable tourism projects which contribute to community development, and that development organisations would significantly benefit from enlisting the assistance of tour operators in project design, operations, and sales outlets

The Shuffleboard Game: Effects of social drinking on mood and risky behaviour

Objective: Existing research examining how social forces and alcohol interact to impact risky behaviours has yielded contrasting findings, possibly due to the nature and variety of risk-taking tasks used and the failure to consider the role of emotion. Using a novel risk-task, akin to real world drinking games, this study examines the effect of intoxication and group contexts on risk-taking, considering mediating effects of mood. Method: 132 social drinkers (83 female) consumed an alcoholic (0.8g/kg) or placebo beverage before participating in the shuffleboard game (designed to mimic real drinking games) either individually (N = 66) or in the presence of two friends (N = 66). Mood was assessed before and after beverage consumption. Results: When controlling for group identity, intoxication (versus placebo) was associated with significantly higher risk-taking, although there was no impact of group context. No interaction between context and intoxication was observed, and mood did not mediate this relationship. Conclusions: Intoxication increases risk-taking behaviour regardless of whether an individual is in a group, or isolated, whereas groups do not appear to enhance risky behaviour. Previous evidence of an effect of groups on risk-taking may have been due to a failure to control for the effect of group identity. To reduce risky behaviours, interventions may benefit from targeting alcohol use while considering how pre-existing social norms within a friendship group may either mitigate or exacerbate risk. Results affirm the importance of considering both intoxication and group effects on affective states when investigating risk-taking behaviours

The shuffleboard game: investigating group drinking, mood, and risky behavior

Objective: Existing research examining how social forces and alcohol interact to impact risky behaviors has yielded contrasting findings, possibly due to the nature and variety of risk-taking tasks used and the failure to consider the role of emotion. Using a novel risk task, akin to real-world drinking games, this study examines the effect of intoxication and group contexts on risk-taking, considering mediating effects of mood. Method: One hundred thirty-two social drinkers (83 females) consumed an alcoholic (0.8 g/kg) or placebo beverage before participating in the shuffleboard game (designed to mimic real drinking games) either individually (N = 66) or in the presence of two friends (N = 66). Mood was assessed before and after beverage consumption. Results: When controlling for group identity, intoxication (vs. placebo) was associated with significantly higher risk-taking, although there was no impact of group context. No interaction between context and intoxication was observed, and mood did not mediate this relationship. Conclusions: Intoxication increases risk-taking behavior regardless of whether an individual is in a group, or isolated, whereas groups do not appear to enhance risky behavior. Previous evidence of an effect of groups on risk-taking may have been due to a failure to control for the effect of group identity. To reduce risky behaviors, interventions may benefit from targeting alcohol use while considering how preexisting social norms within a friendship group may either mitigate or exacerbate risk. Results affirm the importance of considering both intoxication and group effects on affective states when investigating risk-taking behaviors

Blunted hypertrophic response in old mouse muscle is associated with a lower satellite cell density and is not alleviated by resveratrol

Background Sarcopenia contributes to the decreased quality of life in the older person. While resistance exercise is an effective measure to increase muscle mass and strength, the hypertrophic response may be blunted in old age. Objectives To determine 1) whether hypertrophy in the m. plantaris of old mice was blunted compared to adult and 2) whether this was related to a reduced satellite cell (SC) density and 3) how resveratrol affects hypertrophy in old mice. Methods In adult (7.5 months, n = 11), old (23.5 months, n = 10) and old-resveratrol-treated (n = 10) male C57BL/6J mice, hypertrophy of the left m. plantaris was induced by denervation of its synergists. The contralateral leg served as control. Results After six weeks, overload-induced myofiber hypertrophy and IIB–IIA shift in myofiber type composition were less pronounced in old than adult mice (P = 0.03), irrespective of resveratrol treatment. Muscles from old mice had a lower SC density than adult muscles (P = 0.002). Overload-induced SC proliferation (P < 0.05) resulted in an increased SC density in old, but not adult muscles (P = 0.02), while a decrease occurred after resveratrol supplementation (P = 0.044). Id2 and myogenin protein expression levels were higher in old than adult muscles (P < 0.05). Caspase-3 was expressed more in hypertrophied than control muscles and was reduced with resveratrol (P < 0.05). Conclusion The blunted hypertrophic response in old mice was associated with a lower SC density, but there was no evidence for a lower capacity for proliferation. Resveratrol did not rescue the hypertrophic response and even reduced, rather than increased, the number of SCs in hypertrophied muscles

CD16 Expression on Monocytes in Healthy Individuals but Not Schistosome-Infected Patients Is Positively Associated with Levels of Parasite-Specific IgG and IgG1

Human IgG1 antibody responses are associated with protection against Schistosoma haematobium infection and are now a target for schistosome vaccine development. This study aimed to investigate the relationship between total IgG and the IgG subclasses and the monocyte IgG receptor, known as FcγRIIIa or CD16, in schistosome exposed people. Systemic levels of schistosome-specific anti-adult worm total IgG and IgG subclass titres were measured by ELISA in 100 individuals from an S. haematobium endemic area in Zimbabwe and, using parametric statistical methods and regression analysis, related to the levels of CD16 expression on individuals' circulating monocytes, determined via flow cytometry. Monocyte CD16 expression rose with parasite-specific total IgG and IgG1 in healthy participants, but not in schistosome infected patients. Similar to parasite-specific IgG and IgG1, CD16 expression in healthy individuals is associated with protection against schistosome infection. This relationship indicates a mechanistic link between the innate and adaptive immune responses to helminth infection in protection against infection. Further understanding the elements of a protective immune response in schistosomiasis may aid in efforts to develop a protective vaccine against this disease.This work was supported by the World Health Organisation and the Wellcome Trust grant WT082028MA, the Thrasher Research Fund and the Medical Research Council grant LJA-544

Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial

Background Previous evidence indicates that adjuvant, short-course androgen deprivation therapy (ADT) improves metastasis-free survival when given with primary radiotherapy for intermediate-risk and high-risk localised prostate cancer. However, the value of ADT with postoperative radiotherapy after radical prostatectomy is unclear. Methods RADICALS-HD was an international randomised controlled trial to test the efficacy of ADT used in combination with postoperative radiotherapy for prostate cancer. Key eligibility criteria were indication for radiotherapy after radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to radiotherapy alone (no ADT) or radiotherapy with 6 months of ADT (short-course ADT), using monthly subcutaneous gonadotropin-releasing hormone analogue injections, daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as distant metastasis arising from prostate cancer or death from any cause. Standard survival analysis methods were used, accounting for randomisation stratification factors. The trial had 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 80% to 86% (hazard ratio [HR] 0·67). Analyses followed the intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov, NCT00541047. Findings Between Nov 22, 2007, and June 29, 2015, 1480 patients (median age 66 years [IQR 61–69]) were randomly assigned to receive no ADT (n=737) or short-course ADT (n=743) in addition to postoperative radiotherapy at 121 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 9·0 years (IQR 7·1–10·1), metastasis-free survival events were reported for 268 participants (142 in the no ADT group and 126 in the short-course ADT group; HR 0·886 [95% CI 0·688–1·140], p=0·35). 10-year metastasis-free survival was 79·2% (95% CI 75·4–82·5) in the no ADT group and 80·4% (76·6–83·6) in the short-course ADT group. Toxicity of grade 3 or higher was reported for 121 (17%) of 737 participants in the no ADT group and 100 (14%) of 743 in the short-course ADT group (p=0·15), with no treatment-related deaths. Interpretation Metastatic disease is uncommon following postoperative bed radiotherapy after radical prostatectomy. Adding 6 months of ADT to this radiotherapy did not improve metastasis-free survival compared with no ADT. These findings do not support the use of short-course ADT with postoperative radiotherapy in this patient population

Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial

Background Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain. Methods RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and ClinicalTrials.gov , NCT00541047 . Findings Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths. Interpretation Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy. Funding Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society

RELATIONSHIP-BASED LENDING FOR DIVERSIFIED AGRICULTURE SYSTEMS IN CANADA: HOW TRUST AND COMMUNITY MAY TRANSFORM FINANCIALIZED AND GENDERED FOOD SYSTEMS

Our food systems, once controlled by community and built for regions, are now global in scale and serve the interests of international financial organizations and multinational agribusiness corporations. Financialization, the term referring to the increased presence of financial actors, markets, institutions and incentives have gained importance in the organization and functioning of the economy, including agriculture & land, is an issue of increasing attention in academic and policy circles. This new trend, an increasing role of these actors in financing agriculture, means agricultural production’s primary goal has shifted from food production to cash production. Current agricultural finance habitually chooses projects based on potential for asset development rather than community benefit. Those who are most likely to opt into diversified and sustainable production such as women, people of colour, of those new to the industry struggle to fund their projects. Current unsustainability is underpinned by work dynamics and social relationships that only further perpetuates gender inequity. In this paper I argue offering trust- based loans to under-represented farmers transforms power imbalances created by financialization. The research asks: to what extent do farm women in Canada use trust-based lending to grow and sustain their farms; how does informal lending influence how women farm; and in what ways does access to informal lending shape rural communities and their food systems in Canada? I used purposive snowball sampling to identify and interview ten participants, six farmers and four lenders, using semi-structured interviews. Results show farmers using trust-based loans indicates the way they farm includes community benefits and meet personal environmental and social outcomes, including local economic development. The farmers noted a strong sense of trust between lender, borrower, and customer. Many indicated without such trust as collateral loans, they would not be in business. As researchers, community activists, and not-for-profit organizations seek resolutions to our financialized food system, trust-based loans may be of significant import