A New Road for the Synthesis and Characterization of New Enamino Benzodiazepines

We report here the synthesis of a new 1,5-benzodiazepines derivatives by phase transfer catalysis. The structures of these products were investigated and confirmed by 1H, 13C NMR, mass spectroscopic and X-ray diffraction. Keywords: Benzodiazepine, N,N-dimethylformamide dimethyl acetal, phase transfer catalysis

Natural phosphate as new, highly efficient and reusable heterogeneous catalyst for the selective preparation of beta-enaminoesters under solvent-free conditions

Natural phosphate (NP) has been found to be a new and highly efficient heterogeneous catalyst for the synthesis of beta-enaminoesters, by simple condensation of various primary amines with beta-dicarbonyl under solvent-free conditions. Keywords: Natural phosphate (NP), b-enaminoesters, solvent-free condition

Development of a Sustainable and Solventless Friedel-Crafts Acylation Reaction of an Aromatic Natural Product “Ar-Himachalene” over Nanostructured ZnO as a New Catalyst

We describe the development of a sustainable and solventless acylation reaction of the naturally occurring product, namely 2,5,9,9-tetramethyl-6,7,8,9-tetrahydro-5H-benzocycloheptene [ar-himachalene], with acid chlorides over a new type of flower-shaped ZnO nanosructure as a hetrogenous catalyst at room temperature. The ZnO nanoflowers can efficiently and selectively catalyze the acylation of the aromatic group of ar-himachalene and be reused up to three times by simple filtration and washing without significant loss in their catalytic activity. Keywords: Acylation, Natural product, Solventless, Zin Oxide nanostructure, Heterogenous Catalysis, Sustainability

(E)-3-[(Dimethylamino)methylidene]-4-phenyl-1-(prop-2-ynyl)-1H-1,5-benzodiazepin-2(3H)-one

A new metal-organic framework compound, poly[[mu(7)-dihydrogen (4,5-dicyano1,2-phenylene) diphosphonato](oxonium) caesium], [Cs(C8H4N2O6P2)(H3O)](n) (I), based on Cs+ and the organic linker 4,5-dicyano-1,2-phenylene) bis(phosphonic acid, (H(4)cpp), containing two distinct coordinating functional groups, has been prepared by a simple diffusion method and its crystal structure is reported. The coordination polymeric structure is based on a CsO8N2 complex unit comprising a monodentate hydronium cation, seven O-atom donors from two phosphonium groups of the (H(2)cpp)(2-) ligand, and two N-atom donors from bridging cyano groups. The high level of connectivity from both the metal cation and the organic linker allow the formation of a compact and dense three-dimensional network without any crystallization solvent. Topologically (I) is a seven-connected uninodal network with an overall Schafli symbol of {4(17).6(4)}. Metal cations form an undulating inorganic layer, which is linked by strong and highly directional O-H center dot center dot center dot O hydrogen-bonding interactions. These metallic layers are, in turn, connected by the organic ligands along the [010] direction to form the overall three-dimensional framework structure

2-Acetyl-3,5,5,9-tetra­methyl-6,7,8,9-tetra­hydro-5H-benzocyclo­hepten-7-one

The title compound, C17H22O2, was semi-synthesized from a mixture of α-atlantone (Z) and α-atlantone (E), which were isolated from the essential oil of the Atlas cedar (cedrus atlantica). The mol­ecule consists of fused six- and seven-membered rings. The seven-membered ring is in a screw-boat conformation

N-[4-Acetyl-5-isobutyl-5-(2-p-tolyl­prop­yl)-4,5-dihydro-1,3,4-thia­diazol-2-yl]acetamide ethyl acetate hemisolvate

The racemic title compound, a new terpenoid, C20H29N3O2S·0.5C4H8O2, was synthesized from Cedrus Atlantica essential oil. The compound crystallizes with a disordered ethyl acetate solvent mol­ecule. The thia­diazole ring is almost planar, with a maximum deviation from the mean plane of 0.015 (2) Å for the C atom connected to the isobutyl group and has a puckering amplitude of 0.026 (2) Å. The dihedral angle between the benzene and thia­diazole rings is 18.32 (8)°. The crystal packing involves inter­molecular N—H⋯O hydrogen bonds

N-[4-Acetyl-5-(2-methylprop-1-enyl)-5-(2-p-tolyl­prop­yl)-4,5-dihydro-1,3,4-thia­diazol-2-yl]acetamide

The title heterocyclic compound, C20H27N3O2S, was synthesized from 2-(4-methyl­cyclo­hex-3-en­yl)-6-methyl­hepta-2,5-dien-4-one, which was isolated from the essential oil Cedrus atlantica. The thia­diazole ring is essentially planar [maximum deviation 0.006 (2) Å] and it forms a dihedral angle of 18.08 (9)° with the benzene ring. The dihedral angle between the thia­diazole ring and the acetamide plane is 7.62 (10)°. In the crystal, mol­ecules are linked into chains running along the c axis by inter­molecular N—H⋯O hydrogen bonds

N-[4-Acetyl-5-methyl-5-(2-p-tolyl­prop­yl)-4,5-dihydro-1,3,4-thia­diazol-2-yl]acetamide

The title heterocyclic compound, C17H23N3O2S, was synthesized from 4-(4-methyl­cyclo­hex-3-en­yl)pent-3-en-2-one, which was isolated from Cedrus atlantica essential oil. The thia­diazole ring adopts a flattened envelope conformation, with the flap sp 3-hybridized C atom lying 0.259 (1) Å out of the plane of the other four atoms. The screw-related mol­ecules are linked into chains along the b axis by inter­molecular N—H⋯O hydrogen bonds

1,3-Dicyclo­hexyl­imidazolidine-2,4,5-trione

The title compound, C15H22N2O3, has been isolated as a by-product of an oxidative cleavage of the C—C bond linking two five-membered rings of 1,3-dicyclo­hexyl-5-(3-oxo-2,3-dihydro­benzofuran-2-yl)imidazolidine-2,4-dione. Individual mol­ecular units are engaged in weak C=O⋯C=O inter­actions [O⋯C = 2.814 (10) and 2.871 (11) Å], leading to the formation of supra­molecular chains which close pack, mediated by van der Waals contacts, in the bc plane

2-Amino-6-[(2,6-dichloro­phen­yl)imino]-3-oxocyclo­hexa-1,4-dienecarbaldehyde

The title compound, C13H8Cl2N2O2, was obtained by the oxidation of diclofenac {systematic name: 2-[2-(2,6-dichloro­phenyl­amino)­phen­yl]acetic acid}, an anti-inflammatory drug, with hydrogen peroxide catalysed by chlorido[5,10,15,20-tetra­kis­(2,6-dichloro­phen­yl)porphyrinato]manganese(III), using ammonium acetate as co-catalyst. The asymmetric unit contains two crystallographically independent mol­ecules of the title compound (Z′ = 2). The close packing of individual mol­ecules is mediated by a series of strong and rather directional N—H⋯Cl and N—H⋯O hydrogen bonds, plus weak π–π [distance between the individual double bonds of symmetry-related imino­quinone rings = 3.7604 (13) Å] and Cl⋯O inter­actions [3.0287 (18) Å]