Interhypothalamic adhesion and multiple cerebral abnormalities in a 2-year-old boy.

International audienceInterhypothalamic adhesion (IHA) is a band of tissue spanning the anterior recess of the third ventricle, linear in the transverse and frontal planes. Recently described, in 2008 [1] in a patient with a Chiari type II malformation, IHA is commonly associated with multiple congenital anomalies [2] particularly midline disorders but can also be isolated. IHA is related with hypothalamo-pituitary dysfunctions and seizures in most of patient, but asymptomatic patients have been reported [3]. Here, we present a case of IHA associated with corpus callosum agenesis (CCA)

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Azygos Vein Mimicking Aortic Dissection.

An asymptomatic 45 year old woman who underwent open surgical correction of a coarctation 25 years ago was under cardiac surveillance. [...

The high-affinity metal Transporters NRAMP1 and IRT1 Team up to Take up Iron under Sufficient Metal Provision.

Iron (Fe) and manganese (Mn) are essential metals which, when scarce in the growth medium, are respectively taken up by the root high affinity transporters IRT1 and NRAMP1 in Arabidopsis thaliana. The molecular bases for low affinity transport however remained unknown. Since IRT1 and NRAMP1 have a broad range of substrates among metals, we tested the hypothesis that they might be functionally redundant by generating nramp1 irt1 double mutants. These plants showed extreme Fe-deficiency symptoms despite optimal provision of the metal. Their phenotype, which includes low Fe and Mn contents and a defect of Fe entry into root cells as revealed by Fe staining, is rescued by high Fe supply. Using a promoter swap-based strategy, we showed that root endodermis retains the ability to carry out high affinity Fe transport and furthermore might be important to high-affinity Mn uptake. We concluded that NRAMP1 plays a pivotal role in Fe transport by cooperating with IRT1 to take up Fe in roots under replete conditions, thus providing the first evidence for a low affinity Fe uptake system in plants

Comparing ammonia volatilisation of livestock effluents having undergone different treatments in field conditions

Comparing ammonia volatilisation of livestock effluents having undergone different treatments in field conditions. 20th N Workshop and Side even

Comparing ammonia volatilisation of livestock effluents having undergone different treatments in field conditions

Comparing ammonia volatilisation of livestock effluents having undergone different treatments in field conditions. 20th N Workshop and Side even

Linkage of impact pathways to cultural perspectives to account for multiple aspects of mineral resource use in life cycle assessment

Important advances have been made to define the multiple impact pathways relating mineral resource use to the area of protection (AoP) natural resources in life cycle assessment (LCA). Yet, the link between stakeholders’ interests and the aspects relevant to resource use as addressed by existing impact assessment methods has so far only marginally been explored. This article proposes to go beyond the case-specific determination of stake­ holders’ interests (and the associated selection of impact assessment method) by defining multiple groups of different values based on cultural perspectives, in order to determine the corresponding relevant impact path­ ways and assessment methods. Relying on the Cultural Theory and related potential development scenarios, we identify socio-economicobjectives and resource management strategies that fit the egalitarian, individualist and hierarchist perspec­ tives. Our analysis reveals that different aspects of resource use may be most relevant to assess for each perspective since they pursue different socio-economic objectives. Egalitarians are expected to prioritize the long-term availability of geological stocks for future generations by keeping extraction flows to a minimum to reach global sufficiency, and individualists, to safeguard their short-term accessibility to resources by managing their supply risk. Hierarchists are likely to aim to maximize the value obtained from resources globally, and could thus focus on addressing dissipative flows. Building on this analysis, we provide a proposal for a more holistic assessment of the impact pathways linked to mineral resource use using existing LCIA methods, and identify ways forward for method developments to come.French agency for ecological transition (ADEME) French geological survey (BRGM

Impact of anaerobic digestion on n balance in a crop succession fertilized with treated or untreated manures: first results

Impact of anaerobic digestion on n balance in a crop succession fertilized with treated or untreated manures: first results. 20th N Workshop and Side even