Immunopositivity for Histone MacroH2A1 Isoforms Marks Steatosis-Associated Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Prevention and risk reduction are important and the identification of specific biomarkers for early diagnosis of HCC represents an active field of research. Increasing evidence indicates that fat accumulation in the liver, defined as hepatosteatosis, is an independent and strong risk factor for developing an HCC. MacroH2A1, a histone protein generally associated with the repressed regions of chromosomes, is involved in hepatic lipid metabolism and is present in two alternative spliced isoforms, macroH2A1.1 and macroH2A1.2. These isoforms have been shown to predict lung and colon cancer recurrence but to our knowledge, their role in fatty-liver associated HCC has not been investigated previously

The Potential of Liver Fibrosis Indexes/Scores for the Screening of Cryptic Liver Fibrosis in Patients with NASH Risk Factors: A Case Report

The unintentional discovery of cirrhosis in a patient with prostate cancer lead us to enquire if some of the indexes/scored designed for the evaluation of liver fi brosis/cirrhosis, in Chronic Hepatitis C patients, could have helped us in the detection of incipient liver fi brosis, and its follow up, in this patient.We applied seven indexes/scores using the analytical results obtained throughout eighteen years before the diagnosis of cirrhosis. The analysis of the results leads us to hypothesize that AP index, Forns Index, FIB4, and modifi ed Phol Score, could alert of initial fi brosis stages and its progression to cirrhosis in NASH patients.</p

An analysis of performance in elite young cross-country skiing: classical style vs skate skiing.

Problem statement: The aim of this study was to assess the differences in the skiing performance of two skiing styles (classical style Vs. skate skiing), in a group of young high-level skiers. Approach: Four high-level male junior cross-country skiers from the Centre of Winter Sports of Aragon (Spain), were selected for this study that was developed during two competitions: 10 km free technique and 10 km classical technique performed in the same circuit and under the same conditions (snow quality, temperature, wind and relative humidity). Physiological variables, maximal and medium heart rate, blood lactate concentration (basal, final and during the recovery, after 2, 4, 6, 8 and 10 min) and medium skiing speed, were analyzed with GPS Garmin Forerruner 305® Heart Rate Pulse and Lactate Dr. Lange analyzer®. Normally distributed data (Kolmogorov-Smirnov Test and Shapiro-Wilk) were statistically analyzed with one way ANOVA and t-Test for post-hoc comparisons (p<0.05). No-normally distributed data were analyzed with the Friedman and Wilcoxon Tests (p<0.05). Results: No significant differences have been recorded in the medium skiing speed, maximal and medium heart rate between the two styles. The peak heart rate was the same in both styles (188 bpm), although medium heart rate was lower in skate skiing vs. classical skiing (165 bpm Vs. 175 bpm). Blood lactate concentrations recorded significant differences during 4, 6, 8 and 10 min of recovery, being higher in free technique (12.7±1.7; 11.4±1.8; 10.4±1.4 and 8.9±1.6 mmol L−1 Vs. 8.7±1.3; 7.5±1.6; 6.3±1.3 and 5.6±1.1 mmol L−1, respectively). Conclusion: The results of this study suggest that skate skiing generates a higher impact on the cross-country skier than classical skiing, due to higher blood lactate concentrations during 4, 6, 8 and 10 min of recovery. The own characteristics of the free technique may be the reason of the lower mean heart rate