Linking the Web of Things: LDP-CoAP Mapping

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A Mobile and Web Platform for Crowdsourcing OBD-II Vehicle Data

On-Board Diagnostics 2 (OBD-II) protocol allows monitoring vehicle status parameters. Analyzing them is highly useful for Intelligent Transportation Systems (ITS) research, applications and services. Unfortunately, large-scale OBD datasets are not publicly available due to the effort of producing them as well as due to competitiveness in the automotive sector. This paper proposes a framework to enable a worldwide crowdsourcing approach to the generation of OBD-II data, similarly to OpenStreetMap (OSM) for cartography. The proposal comprises: (i) an extension of the GPX data format for route logging, augmented with OBD-II parameters; (ii) a fork of an open source Android OBD-II data logger to store and upload route traces, and (iii) a Web platform extending the OSM codebase to support storage, search and editing of traces with embedded OBD data. A full platform prototype has been developed and early scalability tests have been carried out in various workloads to assess the sustainability of the proposal

Linked Data (in Low-Resource) Platforms: A Mapping for Constrained Application Protocol

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Can SPET/CT Technique Improve the Sentinel Lymph Node Radio- Guided Research in Cutaneous Malignant Melanoma?

Background: the aim of the study is to define the role of SPET/CT in radio-guided sentinel lymph node surgery identification in cutaneous Malignant Melanoma (MM) and to assess if SPET/CT data can modify surgery time.Materials and Methods: 96 patients with MM (58 men and 38 women, mean age of 44 years, range 14-71 years) were divided into two groups. 66 patients (group I) were submitted to sentinel node (SN) research by planarlymphoscintigraphy; 30 patients (group II) performed both planar and SPET/CT lymphoscintigraphy. SN surgery identification percentage, SN anatomical site identification and surgery times were evaluated in each group.Results: Group II presented a percentage of SN surgery identification, both globally (96.5%) and in specific sites (axilla lymph nodes 94.5%; upon clavicle lymph nodes 100%), better than group I. Furthermore surgery time was shorter in the group II (10’-20’).Conclusions: SPET/CT allows a more accurate SN identification than planar lymphoscintigraphy, especially in axillar and upon-clavicular nodes and contributes to a correct staging of cutaneous MM. It can improve surgery success percentage and shortens surgery time, reducing also surgery team irradiation

Brentuximab vedotin as salvage treatment in Hodgkin lymphoma naïve transplant patients or failing ASCT: the real life experience of Rete Ematologica Pugliese (REP)

Brentuximab vedotin (BV) shows a high overall response rate (ORR) in relapsed/refractory (R/R) Hodgkin lymphoma (HL) after autologous transplant (ASCT). The aim of this multicenter study, conducted in nine Hematology Departments of Rete Ematologica Pugliese, was to retrospectively evaluate the efficacy and safety of BV as salvage therapy and as bridge regimen to ASCT or allogeneic transplant (alloSCT) in R/R HL patients. Seventy patients received BV. Forty-five patients (64%) were treated with BV as bridge to transplant:16 (23%) patients as bridge to ASCT and 29 (41%) as bridge to alloSCT. Twenty-five patients (36%), not eligible for transplant, received BV as salvage treatment. The ORR was 59% (CR 26%). The ORR in transplant naïve patients was 75% (CR 31%). In patients treated with BV as bridge to alloSCT, the ORR was 62% (CR 24%). In a multivariate analysis, the ORR was lower in refractory patients (p < 0.005). The 2y-OS was 70%. The median PFS was 17 months. Ten of the 16 (63%) naïve-transplant patients received ASCT, with 50% in CR before ASCT. In the 29 patients treated with BV as bridge to alloSCT, 28 (97%) proceeded to alloSCT with 25% in CR prior to alloSCT. The most common adverse events were peripheral neuropathy (50%), neutropenia (29%) and anemia (12%). These data suggest that BV is well tolerated and very effective in R/R HL, producing a substantial level of CR. BV may also be a key therapeutic agent to achieve good disease control before transplant, improving post- transplant outcomes, also in refractory and heavily pretreated patients, without significant overlapping toxicities with prior therapies

MYC Rearranged Aggressive B-Cell Lymphomas: A Report on 100 Patients of the Fondazione Italiana Linfomi (FIL)

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LDP-DL: A Language to Define the Design of Linked Data Platforms

International audienceLinked Data Platform 1.0 (LDP) is the W3C Recommendation for exposing linked data in a RESTful manner. While several implementations of the LDP standard exist, deploying an LDP from existing data sources still involves much manual development. This is because there is currently no support for automatizing generation of LDP on these implementations. To this end, we propose an approach whose core is a language for specifying how existing data sources should be used to generate LDPs in a way that is independent of and compatible with any LDP implementation and deployable on any of them. We formally describe the syntax and semantics of the language and its implementation. We show that our approach (1) allows the reuse of the same design for multiple deployments, or (2) the same data with different designs, (3) is open to heterogeneous data sources, (4) can cope with hosting constraints and (5) significantly automatizes deployment of LDPs