The Broadband Infrared Emission Spectrum of the Exoplanet HD 189733b

We present Spitzer Space Telescope time series photometry of the exoplanet system HD 189733 spanning two times of secondary eclipse, when the planet passes out of view behind the parent star. We estimate the relative eclipse depth in 5 distinct bands and find the planet-to-star flux ratio to be 0.256 +/- 0.014% (3.6 microns), 0.214 +/- 0.020% (4.5 microns), 0.310 +/- 0.034% (5.8 microns), 0.391 +/- 0.022% (8.0 microns), and 0.598 +/- 0.038% (24 microns). For consistency, we re-analyze a previously published time series to deduce a contrast ratio in an additional band, 0.519 +/- 0.020% (16 microns). Our data are strongly inconsistent with a Planck spectrum, and we clearly detect emission near 4 microns as predicted by published theoretical models in which this feature arises from a corresponding opacity window. Unlike recent results for the exoplanet HD 209458b, we find that the emergent spectrum from HD 189733b is best matched by models that do not include an atmospheric temperature inversion. Taken together, these two studies provide initial observational support for the idea that hot Jupiter atmospheres diverge into two classes, in which a thermal inversion layer is present for the more strongly irradiated objects.Comment: 20 pages, 3 figures, accepted to the Astrophysical Journal, minor revision

Resolving Intravoxel White Matter Structures in the Human Brain Using Regularized Regression and Clustering

The human brain is a complex system of neural tissue that varies significantly between individuals. Although the technology that delineates these neural pathways does not currently exist, medical imaging modalities, such as diffusion magnetic resonance imaging (dMRI), can be leveraged for mathematical identification. The purpose of this work is to develop a novel method employing machine learning techniques to determine intravoxel nerve number and direction from dMRI data. The method was tested on multiple synthetic datasets and showed promising estimation accuracy and robustness for multi-nerve systems under a variety of conditions, including highly noisy data and imprecision in parameter assumptions

SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

Abstract: The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state of Maharashtra in late 2020 and spread throughout India, outcompeting pre-existing lineages including B.1.617.1 (Kappa) and B.1.1.7 (Alpha)1. In vitro, B.1.617.2 is sixfold less sensitive to serum neutralizing antibodies from recovered individuals, and eightfold less sensitive to vaccine-elicited antibodies, compared with wild-type Wuhan-1 bearing D614G. Serum neutralizing titres against B.1.617.2 were lower in ChAdOx1 vaccinees than in BNT162b2 vaccinees. B.1.617.2 spike pseudotyped viruses exhibited compromised sensitivity to monoclonal antibodies to the receptor-binding domain and the amino-terminal domain. B.1.617.2 demonstrated higher replication efficiency than B.1.1.7 in both airway organoid and human airway epithelial systems, associated with B.1.617.2 spike being in a predominantly cleaved state compared with B.1.1.7 spike. The B.1.617.2 spike protein was able to mediate highly efficient syncytium formation that was less sensitive to inhibition by neutralizing antibody, compared with that of wild-type spike. We also observed that B.1.617.2 had higher replication and spike-mediated entry than B.1.617.1, potentially explaining the B.1.617.2 dominance. In an analysis of more than 130 SARS-CoV-2-infected health care workers across three centres in India during a period of mixed lineage circulation, we observed reduced ChAdOx1 vaccine effectiveness against B.1.617.2 relative to non-B.1.617.2, with the caveat of possible residual confounding. Compromised vaccine efficacy against the highly fit and immune-evasive B.1.617.2 Delta variant warrants continued infection control measures in the post-vaccination era

Negotiating Sexualities: Magazine Representations of Sexualities and the Talk of Teen and Young Adult Readers

In response to contemporary moral and feminist criticisms regarding the hypothesised effect magazine discourses of sexuality have on readers, this thesis explores how six groups of adolescents and young adults respond to representations of sexualities from the teen and women's magazines Cosmopolitan, Cleo, Girlfriend and Dolly. Drawing upon theories of poststructural feminism, cultural studies and audience reception this work expands upon existing magazine literature by attending to the ways teen and women's magazines are interpreted and talked about by different groups of adolescents and young adults. This analysis fills a gap in contemporary magazine research, which has generally failed to address how gender and sexuality, as they are portrayed in contemporary periodical publications, are made sense of by readers. Therefore, in focusing on reader talk this thesis is also able to address the ways in which individual and collective identities are constructed interactively in the socially specific context of focus group discussions. Attention is given to looking at the complexities surrounding the relationships that exist between magazine reading, representations of sexuality and adolescents and young adults through an examination of the discourses girls, boys, young women and young men draw upon in their talk on magazine representations of sexualities. I argue that readers of magazines are active producers of meaning who think and talk about magazine representations of sexualities in a variety of complex, contradictory and often ambiguous ways. Research participants employ interpretive repertoires, drawn together from various new, traditional and alternative discourses about sexuality, in the process of attributing meaning to contemporary sexualities, as both cultural objects and aspects of everyday life. Thus, rather than take up and accept the sexual subject positions that magazines make available to readers, the talk of the research participants in this project illustrates how sexualities are constantly being negotiated. The articulation and performance of masculine and feminine sexualities is therefore recognized within this thesis as a highly contradictory, contextual and negotiated process

Prevalence of Plasmodium falciparum infection among pregnant women at first antenatal visit in post-Ebola Monrovia, Liberia

Abstract Background Disruption of malaria control strategies during the West African 2014–2016 Ebola epidemic led to an increase in malaria-attributable mortality. However, recent data on malaria infection in vulnerable groups, such as pregnant women, are lacking in this post-Ebola scenario. This cross-sectional study aimed to assess the prevalence of Plasmodium falciparum infection and of molecular markers of drug resistance among pregnant women attending antenatal care in Monrovia, capital of Liberia. Methods From October 2016 to June 2017, all pregnant women attending their first antenatal care visit at the Saint Joseph’s Catholic Hospital, Monrovia, were invited to participate in the study. In addition to their routine antenatal care tests, capillary blood spotted onto filter papers were collected from all consenting participants to determine presence of P. falciparum by real-time quantitative PCR. Molecular markers of anti-malarial drug resistance were assessed through Sanger sequencing and quantitative PCR in specimens positive for P. falciparum analysis. Results Of the 195 women participants, 24 (12.3%) were P. falciparum-positive by qPCR. Infected women tended to be more commonly primigravidae and younger than uninfected ones. Parasite densities were higher in primigravidae. Fever was more frequently detected among the infected women. No statistically significant association between P. falciparum infection and haemoglobin levels or insecticide-treated net use was found. While high prevalence of genetic polymorphisms associated with chloroquine and amodiaquine resistance were detected, no molecular markers of artemisinin resistance were observed. Conclusion Plasmodium falciparum infections are expected to occur in at least one in every eight women attending first ANC at private clinics in Monrovia and outside the peak of the rainy season. Young primigravidae are at increased risk of P. falciparum infection. Molecular analyses did not provide evidence of resistance to artemisinins among the P. falciparum isolates tested. Further epidemiological studies involving pregnant women are necessary to describe the risk of malaria in this highly susceptible group outside Monrovia, as well as to closely monitor the emergence of resistance to anti-malarials, as recommended by the Liberian National Malaria Control Programme