Prescribed medication and malnourishment at risk of malnutrition

ResumenXunta de Galicia; GPC2014/08

Muon and electron g−2g-2 and lepton masses in flavor models

The stringent experimental bound on $\mu \rightarrow e \gamma$ is compatible with a simultaneous and sizable new physics contribution to the electron and muon anomalous magnetic moments $(g-2)_\ell$ ($\ell=e,\,\mu$), only if we assume a non-trivial flavor structure of the dipole operator coefficients. We propose a mechanism in which the realization of the $(g-2)_\ell$ correction is manifestly related to the mass generation through a flavor symmetry. A radiative flavon correction to the fermion mass gives a contribution to the anomalous magnetic moment. In this framework, we introduce a chiral enhancement from a non-trivial $\mathcal{O}(1)$ quartic coupling of the scalar potential. We show that the muon and electron anomalies can be simultaneously explained in a vast region of the parameter space with predicted vector-like mediators of masses as large as $M_\chi\in [0.6,2.5]$~TeV.Comment: 18 pages, 3 figures, 2 table

Implications of the Muon g-2 result on the flavour structure of the lepton mass matrix

The confirmation of the discrepancy with the Standard Model predictions in the anomalous magnetic moment by the Muon g-2 experiment at Fermilab points to a low scale of new physics. Flavour symmetries broken at low energies can account for this discrepancy but these models are much more restricted, as they would also generate off-diagonal entries in the dipole moment matrix. Therefore, if we assume that the observed discrepancy in the muon $g-2$ is explained by the contributions of a low-energy flavor symmetry, lepton flavour violating processes can constrain the structure of the lepton mass matrices and therefore the flavour symmetries themselves predicting these structures. We apply these ideas to several discrete flavour symmetries popular in the leptonic sector, such as $\Delta (27)$, $A_4$, and $A_5 \ltimes {\rm CP}$.Comment: 21 pages; v3: comments added, typos corrected, version accepted for publication in EPJ

Trigo y poblamiento en La Española durante la segunda mitad del siglo XVI.

Sin resume

Hombres y ganados en la tierra del oro: Comienzos de la ganadería en Indias.

Sin resume

El comercio azucarero de La Española en el siglo XI/I. Presión rnonopolística y alternativas locales.

Sin resume

El trigo en la ciudad de México. Industria y comercio de un cultivo importado (1521 - 1564)

Sin resume

La ganadería vacuna en la isla Española (1508 - 1587)

Sin resume

Estudio de la biocompatibilidad in vitro de formulaciones acrílicas autocurables portadoras de bisfosfonatos de nueva síntesis

En este trabajo se presenta el estudio de la biocompatibilidad in vitro, empleando cultivos celulares de fibroblastos embrionarios humanos, de tres sistemas acrílicos de liberación controlada de bisfosfonatos (BFs). Estos sistemas, basados en metacrilato de metilo (MMA), metacrilato de vitamina E (MVE) y trietilenglicol dimetacrilato (TEGDMA), han sido diseñados para su aplicación en el tratamiento de enfermedades caracterizadas por una elevada resorción osteoclástica. En su preparación se ha empleado un BP comercializado (alendronato; ALN) y dos de nueva síntesis, pertenecientes a la segunda y tercera generaciones, el ácido 1-hidroxi-2-[4-aminofenil]etano-1,1-difosfónico (APBP) y el ácido 1-hidroxi-2-[3-indolil]etano-1,1-difosfónico (IBP), respectivamente. La citotoxicidad de MVE ha sido notablemente inferior a la medida para TEGDMA. La citotoxicidad de APBP e IBP se ha comparado con la de ALN, obteniéndose unos valores para la concentración IC50, de15,56, 9,86 y 6,25 mmol/l para APBP, ALN e IBP, respectivamente. Los niveles de citotoxicidad liberada han sido superiores para la formulación portadora de ALN, situándose a continuación los cementos cargados con IBP y APBP. Cuando los cultivos se han establecido sobre la superficie de las formulaciones, se han detectado unos niveles de proliferación celular y adhesión superiores para los sistemas de liberación de IBP y APBP, siendo además inferior en estos casos la mortalidad celular.This paper reports the in vitro biocompatibility study, using human embryonic fibroblast cultures, of three acrylic systems for controlled release of bisphosphonates (BFs). These systems, that are based on methyl methacrylate (MMA), vitamin E methacrylate (MVE) and triethyleneglycol dimethacrylate (TEGDMA), have been designed for its application in the treatment of pathologies characterized by a high osteoclastic resorption. A commercial BP (alendronate; ALN) and two novel BPs, belonging to the second and third generations, 1-hydroxy-2-[4-aminophenyl]ethane-1,1-diphosphonic acid (APBP) and 1-hydroxy-2-[3-indolyl]ethane-1,1-diphosphonic acid (IBP), respectively, have been used in their preparation. The cytotoxicity of MVE has been notably lower than that measured for TEGDMA. Cytotoxicity of APBP and IBP was evaluated along with that of ALN, and the following values of the IC50, concentration were obtained for APBP, ALN and IBP respectively: 15.56, 9.86 and 6.25 mmol/l. The cytotoxicity levels obtained from the extracts of the cured systems were higher for the formulation containing ALN, followed by the cements loaded with IBP and APBP. When the cultures were seeded directly on the formulations surface, higher levels of cellular proliferation and adhesion were obtained for the systems containing IBP and APBP, the cellular mortality being also inferior in these cases

Xylotrechus arvicola (Olivier) (Coleoptera, Cerambycidae), a new impacting pest on Spanish vineyards

Research NoteInfestation caused by Xylotrechus arvicola (Olivier) (Coleoptera, Cerambycidae) is becoming a new sanitary problem in some Spanish vine-producing areas. Symptoms caused by the pest, the identification of 7 associated wood fungal species living in galleries excavated by larvae, some data about the evolution of the infestation during 8 years in the same plot and the different levels of susceptibility exhibited by three grape varieties are presented in this paper