1,151 research outputs found

    Sports participation and Labor Market Outcomes: A Correspondence Study

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    Discrimination contributes to gaps in employment between Whites and Blacks and increases racial inequality. Young Blacks, ages 18 to 19, are twice more likely to be unemployed compared to Whites (Bureau of Labor Statistics, 2015). This dissertation is the first study, to my knowledge, to rely on an experimental design to examine whether participation in high school sports affects labor market discrimination. This dissertation uses a correspondence study in which 6,000 fictional resumes are sent to real job openings in Chicago, Dallas, and New York. Call-backs are recorded, and any differences in call-back rates are considered evidence of discrimination. All resume characteristics are randomly assigned, and race is signaled through names. Results suggest that participation in high school sports has a positive effect on call-back rates. The effect of sports participation is particularly beneficial to Black applicants, reducing some of the discrimination Black applicants experience in the labor market. This result is consistent with theories of statistical discrimination

    Virus-Size Nanoparticles Coated with a Synthetic Self Peptide inhibit Phagocytic Clearance and Enhance Delivery of an Anti-Cancer Drug

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    Professional phagocytes are white blood cells of the innate immune system that protect humans and other animals from attacks by foreign pathogens by ingesting potentially harmful circulating particles. However, phagocytes such as macrophages may also attack elements that have been intentionally introduced into the body, such as implants, artificial tissues, artificial organs and vesicles bearing therapeutic agents, reducing their lifetime in the body. Nanoparticles and liposomes are similar in size to viruses, and are frequently decorated with antibodies for targeted therapeutics or imaging purposes. Although such particles are sufficiently small to avoid passive entrapment within capillaries in vivo, macrophages in the spleen and liver are known to clear these particles within hours or days after injection into the circulation, limiting proper delivery to target disease sites. This dissertation describes the engineering of long-circulating nanoscale carriers bearing a universal marker that avoids macrophage clearance by mimicking the process of recognition of ”self”cells in vivo. The membrane protein CD47 is a marker of ”self” that impedes phagocytosis of ”self” cells by signaling through a species-specific, highly polymorphic receptor named SIRPα. Among natural mouse variants, only NOD.SCID gamma chain (NSG) mice express a mouse polymorph of SIRPα that cross-reacts with human CD47, and thus provided an ideal platform for our in vivo assessment of human CD47 on synthetic particles. Based on the co-crystallized structure of the CD47-SIRPα complex, polypeptides were designed by simulation and then synthesized with the further reductionist goal of identifying and then exploiting the most minimal components necessary for CD47-SIRPα complex interactions. This thesis details a reductionist approach that avoids many potentially confounding biological factors, and constitutes a first example of a synthetic, human ligand that is easily attached to synthetic surfaces and can successfully mediate binding and signaling to phagocyte receptors to inhibit phagocytic uptake. By understanding how both the full-length as well as the minimal component of the hCD47-SIRPα interaction works in vivo, this dissertation was able to elucidate potential therapeutic roles for anti-hCD47 antibody targeting in biodistribution of drugs delivered to solid tumors, among other applications

    Minority Voice in Community Design Building Processes

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    AbstractAn old lady's words during the building process of a participatory design with a community: “But this is what we thought might be ideal?” Versus her husband, a construction worker: “But this is the way it should be done!” When dealing with participatory design processes sometimes the opinion of the experts are the ones always honoured and the minorities, not in quantity but in voice, are underestimated. This paper is based on a case study of three different design processes taken place on the rural community of San Jose de Olaes- Ecuador, dealing with the importance of the voice of the minority, in this case represented by the women of a community, and the men's voice, usually the working force. We will illustrate this process and how it has both positive and negative consequences on the project and community relationships

    Actos dulces

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    Actos Dulces es una búsqueda por el significado de la dulzura a través del perdón y la empatia con el otro por medio de la escritura.Actos Dulces is a pursuit for the meaning of sweetness through forgiveness and empathy of others by means of writing.Maestro (a) en Artes VisualesPregrad

    Water quality index including periphyton chlorophyll-a in forested urban watersheds from Tierra del Fuego (Argentina)

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    The city of Ushuaia, Argentina, has experienced a rapid and unorganized population growth with possible consequences on the dynamics and functioning of urban lotic ecosystems. Urban expansion was not largely accompanied by the development of infrastructure for the provision of services such as drinking water and sewers to all the population. Currently, only 65% of the population is connected to the main sewage system (pre-treatment) and the city does not have a secondary wastewater treatment plant yet. We evaluated the impact of wastewater discharges and non-point contamination on the water quality of the three main water courses that cross the city of Ushuaia: Pipo river (PR), Buena Esperanza stream (BES) and Arroyo Grande river (AGR). We sampled four sites per watershed from spring to autumn in two consecutive years (2018 and 2019): S1 (not urbanized at the upper section), S2 (transitional section), S3 (urbanized at the middle-low section), and S4 (urbanized, close to the outlet). We developed the Fuegian Water Quality Index (F_WQI) as a tool for environmental monitoring in forest streams which includes several indicators of organic inputs (dissolved oxygen, nitrogen-ammonium, total phosphorus, fecal coliform bacteria) and periphyton chlorophyll-a (Peri Chl-a). The variables were ranked and weighed, and the index was constructed using a mathematical formula. Urbanization negatively impacted the water quality of these ecosystems; the F_WQI showed “very bad” and “bad” water quality categories at S4 in BES and AGR, both sites impacted by wastewater discharges and large percentage of urbanized area. Likewise, in the PR watershed, with less urbanization and sewage discharges, the F_WQI indicated “very good” water quality. The F_WQI summarizes the water quality of forested watersheds in a simple numerical scale, resulting in a useful tool for monitoring studies in temperate rivers and streams. We encourage the inclusion of Peri Chl-a in water quality indices, due to its ubiquity in these ecosystems and the fact that it increased the sensitivity of the index.Fil: Granitto, María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; ArgentinaFil: Diodato, Soledad Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; Argentina. Universidad Nacional de Tierra del Fuego; ArgentinaFil: Rodriguez, Patricia Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Austral de Investigaciones Científicas; Argentina. Universidad Nacional de Tierra del Fuego; Argentin

    Playing with your mind

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    A Brain-Computer Interface (BCI) is a communication system between the brainand a machine like a computer. Some BCI systems have been used to help people withdisabilities and sometimes, with entertainment purposes. In this paper, a BCI-game system is developed. It allows controlling the altitude of a ball inside of a glass pipe according to mental concentration level, which is measured on EEG signals of the user. The system is automatically adjusted to each user, hence, it is not needed any calibration step. Ten subjects participated in the experiments. They achieved effective control of the ball in a few minutes, demonstratingthe feasibility of the BCI-game system.Fil: Rodriguez, Mauro. Universidad Nacional de San Juan. Facultad de Ingeniería. Departamento de Electrónica y Automática. Gabinete de Tecnología Médica; ArgentinaFil: Gimenez, Ramiro. Universidad Nacional de San Juan. Facultad de Ingeniería. Departamento de Electrónica y Automática. Gabinete de Tecnología Médica; ArgentinaFil: Diez, Pablo Federico. Universidad Nacional de San Juan. Facultad de Ingeniería. Departamento de Electrónica y Automática. Gabinete de Tecnología Médica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Avila Perona, Enrique Mario. Universidad Nacional de San Juan. Facultad de Ingeniería. Departamento de Electrónica y Automática. Gabinete de Tecnología Médica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Laciar Leber, Eric. Universidad Nacional de San Juan. Facultad de Ingeniería. Departamento de Electrónica y Automática. Gabinete de Tecnología Médica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Orosco, Lorena Liliana. Universidad Nacional de San Juan. Facultad de Ingeniería. Departamento de Electrónica y Automática. Gabinete de Tecnología Médica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garces, Agustina. Universidad Nacional de San Juan. Facultad de Ingeniería. Departamento de Electrónica y Automática. Gabinete de Tecnología Médica; Argentin

    Cuidar la salud y la seguridad en el trabajo agropecuario

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    Reflexionamos acerca de la importancia de la información y capacitación en relación a nuevas formas de gestión en condiciones laborales y de trabajo, así como acerca de aspectos de seguridad, salud ocupacional y medio ambienteEEA BalcarceFil: Rodriguez Urroz, Lorena. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce. Agencia de Extensión Rural Mar del Plata; Argentina
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