CONTRIBUTIONS TO THE KNOWLEDGE OF LICHENS COMMUNITIES FROM BISTRITA MOUNTAINS (EASTERN CARPATHIANS)

This paper presents two lichens communities (Parmelietum caperatae Felf. 1941 and Usneetum filipendulae Hil. 1925) from Physcietea Tomaselli and Micheli 1957 and Hypogymnietea physodes Follm. 1974 classes, identified in Bistrita Mountains territory, in 5 locations: Arşita lui Macovei, Zugreni, Tulgheş, Barnar and Pârâul Văcăriei. These associations are analyzed from the bioforms, ecological requests and floristic elements perspectives

CONTRIBUTIONS TO THE STUDY OF SAXICOLOUS LICHENS COMMUNITIES FROM BISTRITA MOUNTAINS (EASTERN CARPATHIANS)

The study of saxicolous lichens communities from Bistrita Mountains had as result the identification of two lichens associations: Parmelietum conspersae Felfödy 1941 and Umbilicarietum cylindricae Frey 1933, instaled on siliceous rocks, in 3 locations: Pietrosul Bistriţei, Zugreni and Cheile Barnarului. These two lichens communities presented in this paper are mentioned for the first time from Bistriţa Mountains territory and described by phytosociological tables and analyzed from the bioforms, floristic elements and ecological indices perspectives

Photodynamic therapy as a new therapeutic approach of oral lichen planus

Oral lichen planus (OLP) is a chronic, immunologically mediated disease, defined by periods of exacerbation and quiescence. The disease is associated with a low mortality risk, but in some instances, morbidity can be important, especially in extensive, erosive forms, with a significant impact on the quality of life. OLP is a chronic T-cell mediated inflammatory disease involving the oral cavity, the most common lesions being located on the oral mucosa, tongue and gums. Its etiology remains in part unknown, but several factors proved to be involved in the development of the disease (drugs, dental materials, infectious agents, psychological factors, autoimmunity and genetic predisposition). The therapeutic approach should take into account the type of lesion and the extent of the disease, as well as the possible adverse effects. Although several therapies are available, OLP treatment still remains a challenge. Photodynamic therapy (PDT) is widely used in dermatology, finding applicability in the treatment of an increasing number of conditions. Recent research has shown the role of PDT in the treatment of OLP. It is a minimally invasive therapy with few side effects and promising results

Treatment Options of Periodontal Disease and its Complications in Patient with Type 2 Diabetes Mellitus

Diabetes mellitus type 2 is the most commonly diagnosed metabolic disorder, and its prevalence is expected to increase so much, that by 2030 approximately 10% of the population will have diabetes (especially type 2). The aim of this study: is to assess the treatment methods used for oral odontogenic infections in patients with type 2 diabetes, as well as postoperative complications depending on the applied treatment method. Materials and methods: a group of 112 patients with marginal inflammatory pathology was selected and evaluated. The followed parameters were: age, gender, inflammatory lesions, treatment type, one week, three and six months postoperative evolution. Data were centralized in electronic format using Microsoft Excel software. Results: The average age of patients was 57.3, and gender distribution was almost equal (51.78% males vs. 48.21% females). The majority of patients (47.32%) underwent a conservative treatment, while almost 68% had a very good postoperative healing at the 7 day postoperative recall. There was also a significant improvement of the values of glycated hemoglobin at both the three and the six months recall, with almost 2/3 of the patients presenting a normal gingival status. Conclusion : Periodontal disease has a negatively impact on diabetes control, and can worsen its complications, but periodical periodontal treatment improves glycemic status, the latter contributing further to better oral status and lower the incidence of complications

Periodontal Disease in Patient with Type 2 Diabetes Mellitus

Type 2 diabetes is one of the most important growing health problems worldwide causing several complications in different parts of the organism, including the oral cavity. Aim: The purpose of this study is to assess the periodontal disease of type 2 diabetes patients which came randomly and voluntarily for evaluation of their oral health. Materials and methods: 112 patients with marginal inflammatory pathology were selected and evaluated. The followed parameters were: age, gender, environment, status of diabetes, oral non-odontogenic lesions, local aspects of marginal tissue inflammation. Data were centralized in electronic format using Microsoft Excel software. Results: The average age of patients was 57.3, 56.25% of all patients had uncompensated diabetes with HbA1c levels over 7.5%. Most of them were males (52%) and lived in an urban community (83.93%). 52.27% had severe forms of periodontitis, requiring radical treatment, while the most common oral non-odontogenic pathology was candidosis (40.98%). Conclusion: By modifying local metabolism, diabetes increases the risk of inflammatory lesions, especially periodontitis

Megacystis Microcolon Intestinal Hypoperistalsis Syndrome Berdon’s syndrome - First Report in Romania

Megacystis Microcolon Intestinal Hypoperistalsis Syndrome (MMIHS) is a rare motility disorder with high mortality rate described by Berdon in 1976. We present the first case of Berdon’s syndrome (heterozygous pathogenic variant in the ACTG2 gene) reported in Romania, a female newborn admitted in NICU “Marie S. Curie” Emergency Children’s Hospital Bucharest for intestinal obstruction after birth. Total parenteral nutrition, ileostomy, gastrostomy, clean intermittent bladder catheterisation, evaluation for multivisceral transplantation were performed. She was discharged from our NICU ward at the age of 4 years and 2 months with home total parenteral nutrition administered by her mother in sterile condition, clean intermittent catheterisation for bladder evacuation performed by her mother, monitored monthly for about three years, with normal cardio-respiratory function, no signs of thrombosis, she maintained relatively low platelet count without positive blood culture, good liver and renal function test. Normal neurological and psychomotor development according to age. Her course was complicated by multiorgan failure with death ensuing at the age of 7 years and 10 months

Photodynamic therapy as a new therapeutic approach of oral lichen planus

Oral lichen planus (OLP) is a chronic, immunologically mediated disease, defined by periods of exacerbation and quiescence. The disease is associated with a low mortality risk, but in some instances, morbidity can be important, especially in extensive, erosive forms, with a significant impact on the quality of life. OLP is a chronic T-cell mediated inflammatory disease involving the oral cavity, the most common lesions being located on the oral mucosa, tongue and gums. Its etiology remains in part unknown, but several factors proved to be involved in the development of the disease (drugs, dental materials, infectious agents, psychological factors, autoimmunity and genetic predisposition). The therapeutic approach should take into account the type of lesion and the extent of the disease, as well as the possible adverse effects. Although several therapies are available, OLP treatment still remains a challenge. Photodynamic therapy (PDT) is widely used in dermatology, finding applicability in the treatment of an increasing number of conditions. Recent research has shown the role of PDT in the treatment of OLP. It is a minimally invasive therapy with few side effects and promising results

The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

Background: Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy. Methods: Consecutive women undergoing mastectomy ± IBR for breast cancer July–December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy ± IBR were compared and risk factors associated with delays explored. Results: A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [n = 675, 26.6%]; pedicled flaps [n = 105,4.1%] and free-flaps [n = 228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays. Conclusions: IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients

Oxidative Stress in Chronic Hepatitis B—An Update

In recent years, the role of oxidative stress has been investigated in an increasing number of infections. There is a close link between the inflammation that accompanies infections and oxidative stress. Excessive reactive oxygen species induce harmful effects on cell components, including lipids, proteins, and nucleic acids. A growing body of evidence attests to the role of oxidative stress in the pathogenesis of viral liver infections, especially in hepatitis C virus (HCV) infection. Regarding hepatitis B virus (HBV) infection, the data are limited, but important progress has been achieved in recent years. This review presents the latest advances pertaining to the role of the oxidative stress byproducts in the pathogenesis of chronic hepatitis B, constituting a source of potential new markers for the evaluation and monitoring of patients with chronic hepatitis B

Recent Advances in the Management Strategies for Buruli Ulcers

Buruli ulcer (BU) is a bacterial skin infection that is caused by Mycobacterium ulcerans and mainly affects people who reside in the rural areas of Africa and in suburban and beach resort communities in Australia. The infection typically begins as a painless papule or nodule that gradually develops into a large ulcer that can cause substantial impairment, damaging soft tissues and even bones. Early detection and immediate treatment are crucial to preventing further tissue damage and any potential complications, although it is worth noting that access to proper therapeutic resources can be limited in certain areas. The most commonly used antibiotics for treating BU are rifampicin, streptomycin, and clarithromycin; efforts have recently been made to introduce new treatments that increase the effectiveness and adherence to therapy. This article presents the latest research and management strategies regarding BU, providing an updated and intriguing perspective on this topic