438 research outputs found

    Polar warming in the Mars thermosphere: Seasonal variations owing to changing insolation and dust distributions

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94781/1/grl20448.pd

    p21(Cip1) plays a critical role in the physiological adaptation to fasting through activation of PPARα.

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    Fasting is a physiological stress that elicits well-known metabolic adaptations, however, little is known about the role of stress-responsive tumor suppressors in fasting. Here, we have examined the expression of several tumor suppressors upon fasting in mice. Interestingly, p21 mRNA is uniquely induced in all the tissues tested, particularly in liver and muscle (>10 fold), and this upregulation is independent of p53. Remarkably, in contrast to wild-type mice, p21-null mice become severely morbid after prolonged fasting. The defective adaptation to fasting of p21-null mice is associated to elevated energy expenditure, accelerated depletion of fat stores, and premature activation of protein catabolism in the muscle. Analysis of the liver transcriptome and cell-based assays revealed that the absence of p21 partially impairs the transcriptional program of PPARα, a key regulator of fasting metabolism. Finally, treatment of p21-null mice with a PPARα agonist substantially protects them from their accelerated loss of fat upon fasting. We conclude that p21 plays a relevant role in fasting adaptation through the positive regulation of PPARα

    Influence of the oxidizing agent in the synthesis of graphite oxide

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    The oxidation capacity of several procedures described in the literature which use different oxidizing agents has been exhaustively studied in order to describe the best route for oxidation of this material. The oxidation capacities of different types of materials were evaluated in the synthesis of graphite oxide in an effort to obtain a product with similar characteristics to those provided by commonly employed methods. The results obtained show that graphite oxide structures are greatly influenced by the nature of the oxidizing agent used. It was concluded that it is possible not only to establish the number of oxygenated groups attached to the structure but also, and depending on the oxidizing agent used, to know the stability of graphite oxide. The different characteristics of each graphite oxide obtained could facilitate their use in multiple applications.La capacidad de oxidación de varios procedimientos descritos en la literatura que utilizan diferentes agentes oxidantes ha sido exhaustivamente estudiada con el fin de describir la mejor ruta de oxidación de este material. Se evaluaron las capacidades de oxidación de diferentes tipos de materiales en la síntesis de óxido de grafito en un esfuerzo por obtener un producto con características similares a las proporcionadas por los métodos comúnmente empleados. Los resultados obtenidos muestran que las estructuras del óxido de grafito están muy influenciadas por la naturaleza del agente oxidante utilizado. Se concluyó que es posible no solo establecer el número de grupos oxigenados adheridos a la estructura sino también, y dependiendo del agente oxidante utilizado, conocer la estabilidad del óxido de grafito

    Measurements of stratospheric constituents by ISAMS

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    ISAMS is a limb sounding radiometer flying on the UARS, and designed to measure temperature, pressure, O3, CO, NO, NO2, N2O5, HNO3, CH4, H2O, N2O, and aerosol. Its capabilities are described, together with the present status of validation of its data products, and plans for future improvement
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