2,408 research outputs found

    College Students Succeed with Basic Needs

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    The Basic Needs Initiative at CSUMB advocates for overall wellness security and offers six programs to support their mission. Students facing food insecurity experienced lack of stability, mental health issues from past trauma, and lack of college readiness. Some consequences are poor health, worsen mental health and low academic standing. Prior to the shelter-in-place, Basic Needs offered food pantries, in-person CalFresh assistance and events which offered students hot foods. The quarantine caused a decrease in the services within Basic Needs while there was an increase of need within the student body. The internet barrier affected the services the organization offered which made it difficult for students to participate. My capstone project focused on increasing the social media content by sharing useful resources at least five times a week. About 41% of CalFresh applications in 2020 were submitted during the eight weeks of the project. Overall there was a 21% increase of followers with an average of one new follower per post throughout August 31st and November 6th

    Current Methods for the Treatment and Prevention of Drug-Induced Parkinsonism and Tardive Dyskinesia in the Elderly

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    Drug-induced parkinsonism (DIP) and tardive dyskinesia (TD) are iatrogenic consequences of antidopaminergic drugs. Both are particularly prevalent among the elderly and those with dementia. However, despite their prevalence, these disorders are often overlooked. Both entities share risk factors, physiopathological mechanisms and, to some degree, therapeutic approaches. Withdrawing the causal agent, reducing the dose or switching to a less potent antidopaminergic drug should be the first therapeutic options. Here we review both entities and emerging therapies including the recently approved drugs deutetrabenazine and valbenazine. We discuss relevant aspects for clinical practice such as new diagnostic techniques and the latest advances in the understanding of DIP and TD

    Scalability of an Eulerian-Lagrangian large-eddy simulation solver with hybrid MPI/OpenMP parallelisation

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    Eulerian-Lagrangian approaches capable of accurately reproducing complex fluid flows are becoming more and more popular due to the increasing availability and capacity of High Performance Computing facilities. However, the parallelisation of the Lagrangian part of such methods is challenging when a large number of Lagrangian markers are employed. In this study, a hybrid MPI/OpenMP parallelisation strategy is presented and implemented in a finite difference based large-eddy simulation code featuring the immersed boundary method which generally employs a large number of Lagrangian markers. A master-scattering-gathering strategy is used to deal with the handling of the Lagrangian markers and OpenMP is employed to distribute their computational load across several CPU threads. A classical domain-decomposition-based MPI approach is used to carry out the Eulerian, fixed-mesh fluid calculations. The results demonstrate that by using an effective combination of MPI and OpenMP the code can outperform a pure MPI parallelisation approach by up to 20%. Outcomes from this paper are of interest to various Eulerian-Lagrangian applications including the immersed boundary method, discrete element method or Lagrangian particle tracking

    Scalability of an Eulerian-Lagrangian large-eddy simulation solver with hybrid MPI/OpenMP parallelisation

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    Eulerian-Lagrangian approaches capable of accurately reproducing complex fluid flows are becoming more and more popular due to the increasing availability and capacity of High Performance Computing facilities. However, the parallelisation of the Lagrangian part of such methods is challenging when a large number of Lagrangian markers are employed. In this study, a hybrid MPI/OpenMP parallelisation strategy is presented and implemented in a finite difference based large-eddy simulation code featuring the immersed boundary method which generally employs a large number of Lagrangian markers. A master-scattering-gathering strategy is used to deal with the handling of the Lagrangian markers and OpenMP is employed to distribute their computational load across several CPU threads. A classical domain-decomposition-based MPI approach is used to carry out the Eulerian, fixed-mesh fluid calculations. The results demonstrate that by using an effective combination of MPI and OpenMP the code can outperform a pure MPI parallelisation approach by up to 20%. Outcomes from this paper are of interest to various Eulerian-Lagrangian applications including the immersed boundary method, discrete element method or Lagrangian particle tracking

    Monitoring of freshwater toxins in European environmental waters by using novel multi-detection methods

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    Monitoring the quality of freshwater is an important issue for public health. In the context of the European project μAqua, 150 samples were collected from several waters in France, Germany, Ireland, Italy, and Turkey for 2 yr. These samples were analyzed using 2 multitoxin detection methods previously developed: a microsphere-based method coupled to flow-cytometry, and an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method. The presence of microcystins, nodularin, domoic acid, cylindrospermopsin, and several analogues of anatoxin-a (ATX-a) was monitored. No traces of cylindrospermopsin or domoic acid were found in any of the environmental samples. Microcystin-LR and microcystin-RR were detected in 2 samples from Turkey and Germany. In the case of ATX-a derivatives, 75% of samples contained mainly H2 -ATX-a and small amounts of H2 -homoanatoxin-a, whereas ATX-a and homoanatoxin-a were found in only 1 sample. These results confirm the presence and wide distribution of dihydro derivatives of ATX-a toxins in European freshwaters. Environ Toxicol Chem 2017;36:645-654. © 2016 SETAC

    Biological action mechanisms of fucoxanthin extracted from algae for application in food and cosmetic industries

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    Fucoxanthin is a pigment present in diverse marine organisms such as micro and macro-algae. The most relevant source of fucoxanthin has been described to be the group of the brown macroalgae, also known as Phaeophyceae. The presence of the fucoxanthin, a xanthophyll, found as an accessory pigment in the chloroplasts of the brown algae is responsible for providing them their characteristic color. The market size of this carotenoid, expected to reach US$ 120 million by 2022, reflects its industrial importance, especially remarkable as a food or cosmetic ingredient. Scope and approach: Therefore, it is critical to recognize the main sources of fucoxanthin as well as the most efficient extraction and purification methods that allow obtaining the best production ratio for such a valuable molecule. Throughout this review very different preventive properties of the fucoxanthin have been included, such as antioxidant, anticancer, antiangiogenic, anti-inflammatory, cytoprotective, antiobesity, neuroprotective and its skin protective effects. The stability, bioavailability and toxicity of the fucoxanthin have also been reviewed through diverse biological, in vitro and in vivo assays. Key findings and conclusions: Thus, the main aim of this work is to provide a wide and global vision of the fucoxanthin in terms of productive species, efficient recovery techniques and multiple industrial applications.The research leading to these results was funded by FEDER under the program Interreg V Spain-Portugal (POPTEC, ref. 0377-Iberphenol-6-E); by MICINN supporting the Ram on&Cajal grant for M.A. Prieto (RYC- 2017-22891); by Xunta de Galicia and University of Vigo supporting the post-doctoral grant of M.Fraga-Corral (ED481B-2019/096), the predoctoral grants for A.G. Pereira (ED481A-2019/0228) and P. Garc a- Oliveira (ED481A-2019/295); by Axudas Conecta Peme (Xunta de Galicia) supporting the IN852A 2018/58 NeuroFood Project and AlgaMar (www.algamar.com) for supporting the pre-doctoral grant for C. Louren o-Lopes; NANOEATERS Project (0181_NANOEATERS_01_E) for supporting the pre-doctoral work of C. Jimenez-Lopez; EcoChestnut Project (Erasmus+KA202) for supporting the work of M. Carpena; Ibero- American Program on Science and Technology (CYTED - AQUA-CIBUS, P317RT0003) and UP4HEALTH Project (H2020-BBI-JTI-2019) for financial support.info:eu-repo/semantics/publishedVersio

    Challenges in the application of circular economy models to agricultural by-products: pesticides in Spain as a case study

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    The income and residue production from agriculture has a strong impact in Spain. A circular economy and a bioeconomy are two alternative sustainable models that include the revalorization of agri-food by-products to recover healthy biomolecules. However, most crops are conventional, implying the use of pesticides. Hence, the reutilization of agri-food by-products may involve the accumulation of pesticides. Even though the waste-to-bioproducts trend has been widely studied, the potential accumulation of pesticides during by-product revalorization has been scarcely assessed. Therefore, in this study, the most common pesticides found in eight highly productive crops in Spain are evaluated according to the available published data, mainly from EFSA reports. Among these, oranges, berries and peppers showed an increasing tendency regarding pesticide exceedances. In addition, the adverse effects of pesticides on human and animal health and the environment were considered. Finally, a safety assessment was developed to understand if the reutilization of citrus peels to recover ascorbic acid (AA) would represent a risk to human health. The results obtained seem to indicate the safety of this by-product to recover AA concentrations to avoid scurvy (45 mg/day) and improve health (200 mg/day). Therefore, this work evaluates the potential risk of pesticide exposure through the revalorization of agri-food by-products using peels from citruses, one of the major agricultural crops in Spain, as a case study.Xunta de Galicia | Ref. ED481B-2019/096Xunta de Galicia | Ref. ED481B-2021/152Ibero-American Program on Science and Technology | Ref. CYTED—AQUA-CIBUS, P317RT0003ERA-NET ERA-HDHL | Ref. 696295Ministerio de Ciencia e Innovación | Ref. RYC-2017-22891Ministerio de Ciencia e Innovación | Ref. FPU2020/0614
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