Outflows of hot molecular gas in ultra-luminous infra-red galaxies mapped with VLT-SINFONI

We present the detection and morphological characterization of hot molecular gas outflows in nearby ultra-luminous infrared galaxies, using the near-IR integral-field spectrograph SINFONI on the VLT. We detect outflows observed in the 2.12 micron H$_{2}$ 1-0 S(1) line for three out of four ULIRGs analyzed; IRAS 12112+0305, 14348-1447, and 22491-1808. The outflows are mapped on scales of 0.7-1.6 kpc, show typical outflow velocities of 300-500 km/s, and appear to originate from the nuclear region. The outflows comprise hot molecular gas masses of ~6-8x10$^3$ M(sun). Assuming a hot-to-cold molecular gas mass ratio of 6x10$^{-5}$, as found in nearby luminous IR galaxies, the total (hot+cold) molecular gas mass in these outflows is expected to be ~1x10$^{8}$ M(sun). This translates into molecular mass outflow rates of ~30-85 M(sun)/yr, which is a factor of a few lower than the star formation rate in these ULIRGs. In addition, most of the outflowing molecular gas does not reach the escape velocity of these merger systems, which implies that the bulk of the outflowing molecular gas is re-distributed within the system and thus remains available for future star formation. The fastest H$_{2}$ outflow is seen in the Compton-thick AGN of IRAS 14348-1447, reaching a maximum outflow velocity of ~900 km/s. Another ULIRG, IRAS 17208-0014, shows asymmetric H$_{2}$ line profiles different from the outflows seen in the other three ULIRGs. We discuss several alternative explanations for its line asymmetries, including a very gentle galactic wind, internal gas dynamics, low-velocity gas outside the disk, or two superposed gas disks. We do not detect the hot molecular counterpart to the outflow previously detected in CO(2-1) in IRAS 17208-0014, but we note that our SINFONI data are not sensitive enough to detect this outflow if it has a small hot-to-cold molecular gas mass ratio of < 9x10$^{-6}$.Comment: Accepted for publication in A&A (11 pages, 10 figures

ALMA polarimetry measures magnetically aligned dust grains in the torus of NGC 1068

The obscuring structure surrounding active galactic nuclei (AGN) can be explained as a dust and gas flow cycle that fundamentally connects the AGN with their host galaxies. This structure is believed to be associated with dusty winds driven by radiation pressure. However, the role of magnetic fields, which are invoked in almost all models for accretion onto a supermassive black hole and outflows, is not thoroughly studied. Here we report the first detection of polarized thermal emission by means of magnetically aligned dust grains in the dusty torus of NGC 1068 using ALMA Cycle 4 polarimetric dust continuum observations ($0.07"$, $4.2$ pc; 348.5 GHz, $860$ $\mu$m). The polarized torus has an asymmetric variation across the equatorial axis with a peak polarization of $3.7\pm0.5$\% and position angle of $109\pm2^{\circ}$ (B-vector) at $\sim8$ pc east from the core. We compute synthetic polarimetric observations of magnetically aligned dust grains assuming a toroidal magnetic field and homogeneous grain alignment. We conclude that the measured 860 $\mu$m continuum polarization arises from magnetically aligned dust grains in an optically thin region of the torus. The asymmetric polarization across the equatorial axis of the torus arises from 1) an inhomogeneous optical depth, and 2) a variation of the velocity dispersion, i.e. variation of the magnetic field turbulence at sub-pc scales, from the eastern to the western region of the torus. These observations and modeling constrain the torus properties beyond spectral energy distribution results. This study strongly supports that magnetic fields up to a few pc contribute to the accretion flow onto the active nuclei.Comment: 19 pages, 11 figures (Accepted for Publication to ApJ

Extreme Starbursts in the Local Universe

The "Extreme starbursts in the local universe" workshop was held at the Insituto de Astrofisica de Andalucia in Granada, Spain on 21-25 June 2010. Bearing in mind the advent of a new generation of facilities such as JWST, Herschel, ALMA, eVLA and eMerlin, the aim of the workshop was to bring together observers and theorists to review the latest results. The purpose of the workshop was to address the following issues: what are the main modes of triggering extreme starbursts in the local Universe? How efficiently are stars formed in extreme starbursts? What are the star formation histories of local starburst galaxies? How well do the theoretical simulations model the observations? What can we learn about starbursts in the distant Universe through studies of their local counterparts? How important is the role of extreme starbursts in the hierarchical assembly of galaxies? How are extreme starbursts related to the triggering of AGN in the nuclei of galaxies? Overall, 41 talks and 4 posters with their corresponding 10 minutes short talks were presented during the workshop. In addition, the workshop was designed with emphasis on discussions, and therefore, there were 6 discussion sessions of up to one hour during the workshop. Here is presented a summary of the purposes of the workshop as well as a compilation of the abstracts corresponding to each of the presentations. The summary and conclusions of the workshop along with a description of the future prospects by Sylvain Veilleux can be found in the last section of this document. A photo of the assistants is included.Comment: worksho

The Antioxidant Role of Xanthurenic Acid in the Aedes aegypti Midgut during Digestion of a Blood Meal

In the midgut of the mosquito Aedes aegypti, a vector of dengue and yellow fever, an intense release of heme and iron takes place during the digestion of a blood meal. Here, we demonstrated via chromatography, light absorption and mass spectrometry that xanthurenic acid (XA), a product of the oxidative metabolism of tryptophan, is produced in the digestive apparatus after the ingestion of a blood meal and reaches milimolar levels after 24 h, the period of maximal digestive activity. XA formation does not occur in the White Eye (WE) strain, which lacks kynurenine hydroxylase and accumulates kynurenic acid. The formation of XA can be diminished by feeding the insect with 3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl] benzenesulfonamide (Ro-61-8048), an inhibitor of XA biosynthesis. Moreover, XA inhibits the phospholipid oxidation induced by heme or iron. A major fraction of this antioxidant activity is due to the capacity of XA to bind both heme and iron, which occurs at a slightly alkaline pH (7.5-8.0), a condition found in the insect midgut. The midgut epithelial cells of the WE mosquito has a marked increase in occurrence of cell death, which is reversed to levels similar to the wild type mosquitoes by feeding the insects with blood supplemented with XA, confirming the protective role of this molecule. Collectively, these results suggest a new role for XA as a heme and iron chelator that provides protection as an antioxidant and may help these animals adapt to a blood feeding habit

Clinical phenotypes of acute heart failure based on signs and symptoms of perfusion and congestion at emergency department presentation and their relationship with patient management and outcomes

Objective To compare the clinical characteristics and outcomes of patients with acute heart failure (AHF) according to clinical profiles based on congestion and perfusion determined in the emergency department (ED). Methods and results Overall, 11 261 unselected AHF patients from 41 Spanish EDs were classified according to perfusion (normoperfusion = warm; hypoperfusion = cold) and congestion (not = dry; yes = wet). Baseline and decompensation characteristics were recorded as were the main wards to which patients were admitted. The primary outcome was 1-year all-cause mortality; secondary outcomes were need for hospitalisation during the index AHF event, in-hospital all-cause mortality, prolonged hospitalisation, 7-day post-discharge ED revisit for AHF and 30-day post-discharge rehospitalisation for AHF. A total of 8558 patients (76.0%) were warm+ wet, 1929 (17.1%) cold+ wet, 675 (6.0%) warm+ dry, and 99 (0.9%) cold+ dry; hypoperfused (cold) patients were more frequently admitted to intensive care units and geriatrics departments, and warm+ wet patients were discharged home without admission. The four phenotypes differed in most of the baseline and decompensation characteristics. The 1-year mortality was 30.8%, and compared to warm+ dry, the adjusted hazard ratios were significantly increased for cold+ wet (1.660; 95% confidence interval 1.400-1.968) and cold+ dry (1.672; 95% confidence interval 1.189-2.351). Hypoperfused (cold) phenotypes also showed higher rates of index episode hospitalisation and in-hospital mortality, while congestive (wet) phenotypes had a higher risk of prolonged hospitalisation but decreased risk of rehospitalisation. No differences were observed among phenotypes in ED revisit risk. Conclusions Bedside clinical evaluation of congestion and perfusion of AHF patients upon ED arrival and classification according to phenotypic profiles proposed by the latest European Society of Cardiology guidelines provide useful complementary information and help to rapidly predict patient outcomes shortly after ED patient arrival

Spatially resolved cold molecular outflows in ULIRGs

We present new CO(2–1) observations of three low-z (d ∼350 Mpc) ultra-luminous infrared galaxy (ULIRG) systems (six nuclei) observed with the Atacama large millimeter/submillimeter array (ALMA) at high spatial resolution (∼500 pc). We detect massive cold molecular gas outflows in five out of six nuclei (Mout ∼ (0.3 − 5) × 108 Mo). These outflows are spatially resolved with deprojected effective radii between 250 pc and 1 kpc although high-velocity molecular gas is detected up to Rmax ∼ 0.5 − 1.8 kpc (1 − 6 kpc deprojected). The mass outflow rates are 12 − 400 Mo yr−1 and the inclination corrected average velocity of the outflowing gas is 350 − 550 km s−1 (vmax = 500 − 900 km s−1 ). The origin of these outflows can be explained by the strong nuclear starbursts although the contribution of an obscured active galactic nucleus cannot be completely ruled out. The position angle (PA) of the outflowing gas along the kinematic minor axis of the nuclear molecular disk suggests that the outflow axis is perpendicular to the disk for three of these outflows. Only in one case is the outflow PA clearly not along the kinematic minor axis, which might indicate a different outflow geometry. The outflow depletion times are 15 − 80 Myr. These are comparable to, although slightly shorter than, the starformation (SF) depletion times (30 − 80 Myr). However, we estimate that only 15 − 30% of the outflowing molecular gas will escape the gravitational potential of the nucleus. The majority of the outflowing gas will return to the disk after 5 − 10 Myr and become available to form new stars. Therefore, these outflows will not likely completely quench the nuclear starbursts. These star-forming powered molecular outflows would be consistent with being driven by radiation pressure from young stars (i.e., momentum-driven) only if the coupling between radiation and dust increases with increasing SF rates. This can be achieved if the dust optical depth is higher in objects with higher SF. This is the case in at least one of the studied objects. Alternatively, if the outflows are mainly driven by supernovae (SNe), the coupling efficiency between the interstellar medium and SNe must increase with increasing SF levels. The relatively small sizes (&lt;1 kpc) and dynamical times (&lt;3 Myr) of the cold molecular outflows suggests that molecular gas cannot survive longer in the outflow environment or that it cannot form efficiently beyond these distances or times. In addition, the ionized and hot molecular phases have been detected for several of these outflows, so this suggests that outflowing gas can experience phase changes and indicates that the outflowing gas is intrinsically multiphase, likely sharing similar kinematics, but different mass and, therefore, different energy and momentum contributions

Proteomic analysis of intraluminal thrombus highlights complement activation in human abdominal aortic aneurysms

OBJECTIVE: To identify proteins related to intraluminal thrombus biological activities that could help to find novel pathological mechanisms and therapeutic targets for human abdominal aortic aneurysm (AAA). APPROACH AND RESULTS: Tissue-conditioned media from patients with AAA were analyzed by a mass spectrometry-based strategy using liquid chromatography coupled to tandem mass spectrometry. Global pathway analysis by Ingenuity software highlighted the presence of several circulating proteins, among them were proteins from the complement system. Complement C3 concentration and activation were assessed in plasma from AAA patients (small AAA, AAA diameter=3-5 cm and large AAA, AAA diameter >5 cm), showing decreased C3 levels and activation in large AAA patients. No association of a combination of single-nucleotide polymorphisms in complement genes between large and small AAA patients was observed. Intense extracellular C3 inmunostaining, along with C9, was observed in AAA thrombus. Analysis of C3 in AAA tissue homogenates and tissue-conditioned media showed increased levels of C3 in AAA thrombus, as well as proteolytic fragments (C3a/C3c/C3dg), suggesting its local deposition and activation. Finally, the functional role of local complement activation in polymorphonuclear (PMN) cell activation was tested, showing that C3 blockade by anti-C3 antibody was able to decrease thrombus-induced neutrophil chemotaxis and reactive oxygen species production. CONCLUSIONS: A decrease of systemic C3 concentration and activity in the later stages of AAA associated with local complement retention, consumption, and proteolysis in the thrombus could induce PMN chemotaxis and activation, playing a detrimental role in AAA progression.The article has been supported by the European Community, Fighting Aneurysmal Disease project (FP-7, HEALTH F2-2008–200647), the Spanish MICIN (SAF2010/21852), Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III, Red RIC (RD12/0042/00038), and biobancos (RD09/0076/00101), Fundación Lilly and Fundacion Pro Centro Nacional de Investigaciones.S

Proteomic Analysis of Intraluminal Thrombus Highlights Complement Activation in Human Abdominal Aortic Aneurysms

Objective: To identify proteins related to intraluminal thrombus biological activities that could help to find novel pathological mechanisms and therapeutic targets for human abdominal aortic aneurysm (AAA). Approach and results: Tissue-conditioned media from patients with AAA were analyzed by a mass spectrometry-based strategy using liquid chromatography coupled to tandem mass spectrometry. Global pathway analysis by Ingenuity software highlighted the presence of several circulating proteins, among them were proteins from the complement system. Complement C3 concentration and activation were assessed in plasma from AAA patients (small AAA, AAA diameter=3-5 cm and large AAA, AAA diameter >5 cm), showing decreased C3 levels and activation in large AAA patients. No association of a combination of single-nucleotide polymorphisms in complement genes between large and small AAA patients was observed. Intense extracellular C3 inmunostaining, along with C9, was observed in AAA thrombus. Analysis of C3 in AAA tissue homogenates and tissue-conditioned media showed increased levels of C3 in AAA thrombus, as well as proteolytic fragments (C3a/C3c/C3dg), suggesting its local deposition and activation. Finally, the functional role of local complement activation in polymorphonuclear (PMN) cell activation was tested, showing that C3 blockade by anti-C3 antibody was able to decrease thrombus-induced neutrophil chemotaxis and reactive oxygen species production. Conclusions: A decrease of systemic C3 concentration and activity in the later stages of AAA associated with local complement retention, consumption, and proteolysis in the thrombus could induce PMN chemotaxis and activation, playing a detrimental role in AAA progression.Depto. de Bioquímica y Biología MolecularFac. de Ciencias QuímicasTRUEpu