5 research outputs found
Assessment of exposure determinants and exposure levels by using stationary concentration measurements and a probabilistic near-field/far-field exposure model
Funding Information: The authors thank Prof. Paul Hewett (Exposure Assessment Solutions, Inc., Morgantown, WV) for his assistance with revising the probabilistic exposure model parametrization and interpretation of the results. Publisher Copyright: © 2021 Koivisto AJ et al.Background: The Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation requires the establishment of Conditions of Use (CoU) for all exposure scenarios to ensure good communication of safe working practices. Setting CoU requires the risk assessment of all relevant Contributing Scenarios (CSs) in the exposure scenario. A new CS has to be created whenever an Operational Condition (OC) is changed, resulting in an excessive number of exposure assessments. An efficient solution is to quantify OC concentrations and to identify reasonable worst-case scenarios with probabilistic exposure modeling. Methods: Here, we appoint CoU for powder pouring during the industrial manufacturing of a paint batch by quantifying OC exposure levels and exposure determinants. The quantification was performed by using stationary measurements and a probabilistic Near-Field/Far-Field (NF/FF) exposure model. Work shift and OC concentration levels were quantified for pouring TiO 2 from big bags and small bags, pouring Micro Mica from small bags, and cleaning. The impact of exposure determinants on NF concentration level was quantified by (1) assessing exposure determinants correlation with the NF exposure level and (2) by performing simulations with different OCs. Results: Emission rate, air mixing between NF and FF and local ventilation were the most relevant exposure determinants affecting NF concentrations. Potentially risky OCs were identified by performing Reasonable Worst Case (RWC) simulations and by comparing the exposure 95 th percentile distribution with 10% of the occupational exposure limit value (OELV). The CS was shown safe except in RWC scenario (ventilation rate from 0.4 to 1.6 1/h, 100 m 3 room, no local ventilation, and NF ventilation of 1.6 m 3/min). Conclusions: The CoU assessment was considered to comply with European Chemicals Agency (ECHA) legislation and EN 689 exposure assessment strategy for testing compliance with OEL values. One RWC scenario would require measurements since the exposure level was 12.5% of the OELV.Peer reviewe
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Field testing of low-cost particulate matter sensors for Digital Twin applications in nanomanufacturing processes
Abstract
The EU-project ASINA is testing Low-Cost Particulate Matter Sensors (LCPMS) for industrial monitoring of the concentration of airborne particles, with the purpose of integrating this sensor technology within the data collection layer of Digital Twins (DTs) for manufacturing.
This paper shows the results of field performance evaluations carried out with five LCPMS from different manufacturers (Alphasense OPC-N3, Plantower 9003, Sensirion SPS30, Sensirion SEN55 and Tera Sensor NetxPM), during several field sampling campaigns, conducted in four pre-commercial and commercial pilot lines (PLs) that manufacture nano-enabled products, belonging to the ASINA and OASIS H2020 EU-projects [2,28]. Field tests consisted of deploying LCPMS in manufacturing process, measuring in parallel with collocated reference and informative instruments (OPS TSI 3330/CPC TSI 3007), to enable intercomparison.
The results show the complexity and differential response of the LCPMS depending on the characteristics of the monitored scenario (PL). Overall, they exhibit uneven precision and linearity and significant bias, so their use in industrial digital systems without proper calibration can lead to uncertain and biased measurements. In this sense, simple linear models are not able to capture the complexity of the problem (non-linear systems) and advanced calibration schemes (e.g. based on machine learning), applied “scenario by scenario” and in operating conditions as close as possible to the final application, are suggested to achieve reliable measurements with the LCPMS.</jats:p
Alzheimer disease diagnosis based on automatic spontaneous speech analysis
Alzheimer's disease (AD) is the most prevalent form of progressive degenerative dementia and it has a high socio-economic impact in Western countries, therefore is one of the most active research areas today. Its diagnosis is sometimes made by excluding other dementias, and definitive confirmation must be done trough a post-mortem study of the brain tissue of the patient. The purpose of this paper is to contribute to im-provement of early diagnosis of AD and its degree of severity, from an automatic analysis performed by non-invasive intelligent methods. The methods selected in this case are Automatic Spontaneous Speech Analysis (ASSA) and Emotional Temperature (ET), that have the great advantage of being non invasive, low cost and without any side effects.Peer ReviewedPostprint (published version
Alzheimer disease diagnosis based on automatic spontaneous speech analysis
Alzheimer's disease (AD) is the most prevalent form of progressive degenerative dementia and it has a high socio-economic impact in Western countries, therefore is one of the most active research areas today. Its diagnosis is sometimes made by excluding other dementias, and definitive confirmation must be done trough a post-mortem study of the brain tissue of the patient. The purpose of this paper is to contribute to im-provement of early diagnosis of AD and its degree of severity, from an automatic analysis performed by non-invasive intelligent methods. The methods selected in this case are Automatic Spontaneous Speech Analysis (ASSA) and Emotional Temperature (ET), that have the great advantage of being non invasive, low cost and without any side effects.Peer Reviewe