Novel Biomarkers and the Future Potential of Biomarkers in Inflammatory Bowel Disease.

There is increasing importance placed upon noninvasive assessment of gut inflammation. These tools are likely to be the key in differentiating intestinal inflammatory disease from functional disorders and in monitoring the response to intervention in individuals with known inflammatory conditions. Although various noninvasive markers are currently available, they have limitations and do not provide ideal utility. This review focuses on emerging markers of gut inflammation, highlighting the potential of specific markers

Dataset of why inclusion matters for Alzheimer's disease biomarker discovery in plasma

Here we present a plasma proteomics dataset that was generated to understand the importance of self-reported race for biomarker discovery in Alzheimer's disease. This dataset is related to the article “Why inclusion matters for Alzheimer's disease biomarker discovery in plasma” [1]. Plasma samples were obtained from clinically diagnosed Alzheimer's disease and cognitively normal adults of African American/Black and non-Hispanic White racial and ethnic backgrounds. Plasma was immunodepleted, digested, and isobarically tagged with commercial reagents. Tagged peptides were fractionated using high pH fractionation and resulting fractions analysed by liquid chromatography – mass spectrometry (LC-MS/MS & MS3) analysis on an Orbitrap Fusion Lumos mass spectrometer. The resulting data was processed using Proteome Discoverer to produce a list of identified proteins with corresponding tandem mass tag (TMT) intensity information

Fatigue crack characterisation in 2024-T351 aluminium alloy through SEM observation combined with the CJP model

This work characterises crack growth in AA2024-T315 by combining different methods to further increase the reliability of the results. The Christopher-James-Patterson (CJP) model was fitted to experimental data obtained by digital image correlation (DIC). The effective value of the CJP stress intensity factors were successfully correlated with the ΔK-da/dN curve as obtained with Scanning Electron Microscopy measurements of the depth of striations on the fracture surface. This approach based on fitting the CJP model with DIC data and SEM observations allowed estimation of opening and closure loads and allowed the propagation rate and fracture mode to be effectively characterised.The authors would like to acknowledge the financial support of Programa Operativo FEDER from the Junta de Andalucia (Spain) through grant reference UMA18-FEDERJA-250. Industrial support from Bettergy SL and from Dr N Ordonez and M Carrera is also greatly acknowledged, as well as access to different components and materials in the energy industry. The authors would also like to acknowledge the financial support from Junta de Andalucia through the research project “1380786” funded by the program “Proyectos de I + D + I en el Marco del Programa Operativo FEDER Andalucia 2014-2020. Convocatoria 2020.” We would also like to acknowledge funding for open access charge: Universidad de Malaga / CBU

Toxina botulínica para uso terapéutico

From the year 1980 the intramuscular inoculation of botulinal neurotoxin (BoNT) is realized for treatment of disorders of the muscular tone. The simplicity of the treatment does an excellent alternative to the surgery. The p rincipal action is a flaccid muscular palsy that needs between 2 and 6 months for its rec overy. As for the therapeutic rank, the BoNT would overcome in safety to the majority o f the drugs. In the latter decade the use of the therapy with BoNT has experimented an am azing growth, with new and mul- tiple indications, especially neurological, and has turned into the treatment of aesthetic medicine with more rapid growth into his demand. It would be ideal to obtain prepara- tions that: during the making and storage the toxic ity does not diminish significantly, could be stored to ambient temperature, support maj or time the activity and with dimin- ished capacity of diffusion and of formation of ant ibodies. The effect is not instantane- ous, but progressive in the first days and ideally between 1 and 2 weeks later. Between 3 and 4 months later, the effect starts diminishing and the muscles contract again. The result is not the definitive remedy, and repeated d oses being needed. Its use is limited by economic reasons.Fil: Fernandez, Rafael Alfredo. Universidad Nacional de Cuyo; ArgentinaFil: Lopez Laur, J.D.. Universidad Nacional de Cuyo; ArgentinaFil: Ciccarelli, A.S.. Universidad Nacional de Cuyo; ArgentinaFil: de Jong, L.I.T.. Universidad Nacional de Cuyo; ArgentinaFil: Caballero, Patricia Alejandra. Universidad Nacional de Cuyo; ArgentinaFil: Bianco, María Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ciencia y Tecnología ; Argentin

Hidrogenionic potential (pH) of the attractant, trap density and control threshold for Ceratitis capitata (Diptera: tephritidae) on Hamlin oranges in São Paulo central region, Brazil

This study evaluated the effect of initial pH values of 4.5, 6.5 and 8.5 of the attractant (protein bait) Milhocina® and borax (sodium borate) in the feld, on the capture of fruit flies in McPhail traps, using 1, 2, 4 and 8 traps per hectare, in order to estimate control thresholds in a Hamlin orange grove in the central region of the state of São Paulo. The most abundant fruit fly species was Ceratitis capitata, comprising almost 99% of the fruit flies captured, of which 80% were females. The largest captures of C. capitata were found in traps baited with Milhocina® and borax at pH 8.5. Captures per trap for the four densities were similar, indicating that the population can be estimated with one trap per hectare in areas with high populations. It was found positive relationships between captures of C. capitata and the number of Hamlin oranges damaged, 2 and 3 weeks after capture. It was obtained equations that correlate captures and damage levels which can be used to estimate control thresholds. The average loss caused in Hamlin orange fruits by C. capitata was 2.5 tons per hectare or 7.5% of production.Esta pesquisa teve como objetivos: avaliar o efeito do pH inicial, 4.5; 6.5 e 8.5, do atrativo proteico Milhocina® e bórax (tetraborato de sódio) na captura de moscas-das-frutas em armadilhas McPhail; estudar densidades de armadilhas, 1; 2; 4 e 8 por hectare, para estimar níveis de controle em laranja cv. Hamlin, na região central de São Paulo. A espécie predominante, com 99% das moscas-das-frutas capturadas, foi Ceratitis capitata, sendo 80% de fêmeas. As maiores capturas de C. capitata ocorreram nas armadilhas com Milhocina® e bórax em pH 8.5. As capturas, nas 4 densidades, foram semelhantes, indicando que a população pode ser estimada com uma armadilha por hectare em áreas de altas populações. Houve relações positivas entre capturas de C. capitata e o número de frutos danificados, 2 e 3 semanas após a captura. Assim, foram obtidas equações que relacionam a captura e o dano, possibilitando estimar níveis de controle desse inseto. As perdas médias causadas por C. capitata em laranja cv. Hamlin chegaram a 2,5 toneladas de frutos por hectare ou 7,5% da produção.info:eu-repo/semantics/publishedVersio

Nuclear multifragmentation and fission: similarity and differences

Thermal multifragmentation of hot nuclei is interpreted as the nuclear liquid--fog phase transition deep inside the spinodal region. The experimental data for p(8.1GeV) + Au collisions are analyzed. It is concluded that the decay process of hot nuclei is characterized by two size parameters: transition state and freeze-out volumes. The similarity between dynamics of fragmentation and ordinary fission is discussed. The IMF emission time is related to the mean rupture time at the multi-scission point, which corresponds to the kinetic freeze-out configuration.Comment: 7 pages, 3 Postscript figures, Proceedings of IWM 2005, Catani

Short and long distance contributions to B→K∗γγB \to K^* \gamma \gamma

We study the decay of the neutral B meson to $K^* \gamma \gamma$ within the framework of the Standard Model, including long distance contributions.Comment: 14 pages, 2 figures; A sign error in the numerical estimation corrected. Results and figures changed. Results for resonance contributions also updated to match with the experimetal values in the narrow width approximatio

Non equilibrium effects in fragmentation

We study, using molecular dynamics techniques, how boundary conditions affect the process of fragmentation of finite, highly excited, Lennard-Jones systems. We analyze the behavior of the caloric curves (CC), the associated thermal response functions (TRF) and cluster mass distributions for constrained and unconstrained hot drops. It is shown that the resulting CC's for the constrained case differ from the one in the unconstrained case, mainly in the presence of a ``vapor branch''. This branch is absent in the free expanding case even at high energies . This effect is traced to the role played by the collective expansion motion. On the other hand, we found that the recently proposed characteristic features of a first order phase transition taking place in a finite isolated system, i.e. abnormally large kinetic energy fluctuations and a negative branch in the TRF, are present for the constrained (dilute) as well the unconstrained case. The microscopic origin of this behavior is also analyzed.Comment: 21 pages, 11 figure

Production of Neutron-rich Heavy Residues and the Freeze-out Temperature in the Fragmentation of Relativistic 238U Projectiles Determined by the Isospin Thermometer

Isotope yields of heavy residues produced in collisions of 238U with lead at 1AGeV show indications for a simultaneous break-up process. From the average N-over-Z ratio of the final residues up to Z = 70, the average limiting temperature of the break-up configuration at freeze out was determined to T approximately 5 MeV using the isospin-thermometer method. Consequences for the understanding of other phenomena in highly excited nuclear systems are discussed.Comment: 22 pages, 9 figures, accepted by Nucl. Phys.

Spinodal decomposition, nuclear fog and two characteristic volumes in thermal multifragmentation

Thermal multifragmentation of hot nuclei is interpreted as the nuclear liquid-fog phase transition inside the spinodal region. The experimental data for p(8.1GeV) + Au collisions are analyzed within the framework of the statistical multifragmentation model (SMM) for the events with emission of at least two IMFs. It is found that the partition of hot nuclei is specified after expansion to a volume equal to Vt = (2.6+-0.3) Vo, with Vo as the volume at normal density. However, the freeze-out volume is found to be twice as large: Vf = (5+-1) Vo.Comment: 8 pages, 6 figures, to be published in Nucl.Phys.