Contribuciones de las iniciativas y propuestas de educación propia de las comunidades achagua y yukpa a la construcción de un proyecto educativo decolonial en Colombia

DiagramasEste trabajo consta de un breve recorrido por algunas fuentes documentales como la Constitución de 1991, el Plan Decenal de Educación en Colombia 2012-2016 y dos Proyectos Educativos Comunitarios de las comunidades Yukpa y Achagua; a partir de los cuales se hace una reflexión a la luz de la autora Katherine Walsh, poniendo en contraste los aportes de los proyectos educativos comunitarios hacia un horizonte de propuesta de educación decolonial en Colombia, frente a los elementos colonizadores de la educación oficial. Así mismo dejar aportes para una educación que libera, empodera y visibilza a los sujetos otros.This work consists of a brief tour of some documentary sources such as the 1991 Constitution , the Ten-Year Education Plan Colombia from 2012 to 2016 and two Community Educational Projects from the Yukpa communities and Achagua peopple ; which it is a thouhg avobe Katherine Walsh's words , contrasting the contributions of community education projects towards a horizon for unless-colonial Colombian's education proposal, against the colonizers elements of formal education . Also leave something behind for an education that liberates, empowers and visibilza subjects other

Nivel de autoestima de estudiantes de Educación Primaria de la Institución Educativa N°88042-Las Palmas- Nuevo Chimbote, 2020

La presente investigación, tuvo por propósito describir el Nivel de Autoestima en los estudiantes de educación primaria de la I.E N° 88042 Las Palmas, 2020. La metodología de investigación cuenta con un diseño descriptivo simple, cuya población muestral estará conformada por 50 estudiantes de sexto grado de Educación Primaria. Como técnica de recojo de información se utilizó la observación indirecta y como instrumento para el recojo de la información fue escala valorativa y se, procesó mediante el software SPSS y representó y se interpretó en tablas y figuras estadísticos para demostrar la confiabilidad del coeficiente Alfa de Crobanch. Los resultados muestran que la tercera parte de dichos estudiantes manifiestan una alta autoestima en dos, de las cinco dimensiones, como la ética, académica, social, física, y la afectiva es una autoestima muy baja evidenciándose la necesidad de una intervención oportuna a fin de mejorarla. (A. afectiva, 5, 356 = 7,30, pTesi

An L-lactate amperometric enzyme electrode based on L-lactate oxidase immobilized in a laponite gel on a glassy carbon electrode. Application to dairy products and red wine

A biosensor based on the immobilization of Lactate oxidase in laponite - organosilasesquioxane films on glassy carbon electrode for the quantification of l-lactate in wine and dairy products is presented. The bioelectrode showed a very high sensitivity (0.33 ± 0.01) A cm-2 M-1 and a short time response (10 s) for less than 1 U of enzyme. No significant interferences, including ascorbic acid, were detected. For red wine, matrix effects assigned to polyphenols and anthocyanins were observed, which ware easily overcome by sample dilution. Our l-lactate determinations were in good agreement with those of two standard methods.Fil: Paz Zanini, Veronica Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Lopez, Beatriz Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Labbé, Pierre. Centre National de la Recherche Scientifique; FranciaFil: Solis, Velia Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentin

Effects of Anionic Liposome Delivery of All–Trans–Retinoic Acid on Neuroblastoma Cell Differentiation

All–trans–retinoic acid (ATRA) has long been known to affect cell growth and differentiation. To improve ATRA’s therapeutic efficacy and pharmacodynamics, several delivery systems have been used. In this study, free ATRA and anionic–liposome–encapsulated ATRA were compared for their effects on SK–N–SH human neuroblastoma cell growth and differentiation. Anionic liposomes made of L–α –phosphatidylcholine (PC) and L–α –phosphatidic acid (PA), empty (PC–PA) and loaded with ATRA (PC–PA–ATRA), were characterized by dynamic light scattering (DLS) and electrophoretic mobility measurements, and drug entrapment efficiency (EE%) was measured to evaluate the applicability of the new colloidal formulation. The results of brightfield microscopy and cell growth curves indicated that ATRA, whether free or encapsulated, reduced growth and induced differentiation, resulting in SK–N–SH cells changing from epithelioid to neuronal–like morphologies, and producing a significant increase in neurite growth. To further characterize the neuro-differentiation of SK–N–SH cells, the expression of βIII–Tubulin and synaptophysin and mitochondria localization were analyzed via immunofluorescence. Increased expression of neuronal markers and a peculiar localization of mitochondria in the neuritic extensions were apparent both in ATRA– and PC–PA–ATRA–differentiated cells. As a whole, our results strongly indicate that ATRA treatment, by any means, can induce the differentiation of parent SK–N–SH, and they highlight that its encapsulation in anionic liposomes increases its differentiation ability in terms of the percentage of neurite–bearing cells. Interestingly, our data also suggest an unexpected differentiation capability of anionic liposomes per se. This work highlights the importance of developing and carefully testing novel delivery nanocarriers, which are a necessary first “step” in the development of new therapeutic settings

The 2017 PREDICT Key Facts Report. An Analysis of ICT R&D in the EU and Beyond

The 2017 PREDICT Key Facts Report provides a detailed analysis of the state of ICT R&D activities in the European Union. This is the tenth edition of a series that is published annually. Like the previous editions, an online version is available at: https://ec.europa.eu/jrc/en/predict. The PREDICT dataset 2017 is based on the latest data available from official sources (such as the Eurostat and OECD, National Accounts and R&D statistics). It also includes the novelty of backwards reconstruction of the series from 1995, which allows it to cover the period from 1995 to 2014. Therefore, it provides a long-term analysis of the EU ICT sector and its R&D, covering a whole cycle since the initial expansion years, the double recession that began in early 2008, and the most recent evolution up to 2014.JRC.B.6-Digital Econom

Serum levels of proinflammatory cytokines in prostate cancer

Prostate cancer has become an important public health problem affecting millions of men worldwide every year. Like other malignant tumors, prostate cancer shows evidence of a strong inflammatory component that is dependent on the release of pro-inflammatory cytokines,which might play a major role in the development and progression of the tumor, helping in its early stage, progression and aggressiveness. Aims: The goal of this study was to determine the relationships between the serum levels of pro-inflammatory cytokines and the different stages of prostate cancer. To this end, sera from patients enrolled by The Laboratory of Metabolic Diseases and Cancer of the Faculty of Pharmacy and Biochemistry at the University Juan Agustín Maza in Argentina, were analyzed through ELISA and their pro-inflammatory cytokines (IL-6, TNF-α and MCP-1) quantified. Patients were first classified into three groups (Control, at Risk, and Cancer subjects) and anthropometric, biochemical and histological parameters of prostate were then determined for all groups. Results and Conclusions: Despite displaying elevated serum concentrations of IL-6 and TNF-α in the Cancer and the Risk groups compared to the Control group, the differences did not reach significance. However, there was a positive correlation between these cytokines only in the Risk and Cancer groups, showing a general inflammatory behavior in these patients. The results obtained provide general data about the behavior of pro-inflammatory cytokines in prostate cancer. However, they do not demonstrate a direct correlation betweenserum levels and neoplastic progression. Nevertheless, these findings do not rule out a possible relationship between prostate cancer and serum levels of pro-inflammatory cytokines.Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Huilcaman, Ricardo. Universidad de Talca; ChileFil: Lopez, José. Universidad Nacional de Cuyo; ArgentinaFil: Moore Carrasco, Rodrigo. Universidad de Talca; Chile. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chil

Insights into Mechanical Behavior and Biological Properties of Chia Seed Mucilage Hydrogels

In this contribution we report insights on the rheological properties of chia (Salvia hispanica) seed mucilage hydrogels. Specifically, we studied the influence of temperature and polymer concentration on the viscoelastic properties of resulting networks. Creep experiments performed in steady-state conditions allowed calculating Newtonian viscosities for chia hydrogels at different polymer concentrations, pointing at inter-chain interactions as the main responsible for the different behavior toward network slipping under constant stress. The combination of oscillatory frequency and stress sweep tests highlighted a moderate effect of temperature in influencing hydrogel mechanics. The latter results prompted us to investigate potential biological functions for this set of biomaterials. Lactate Dehydrogenase assay proved lack of cytotoxicity of chia suspensions toward Human Mesenchymal Stem Cells from adipose tissue here used as cell model. Differentiation experiments were finally undertaken to verify the influence of chia samples on osteo-induction triggered by chemical differentiation factors. Alkaline Phosphatase enzyme activity assay and Alizarin red staining demonstrated that chia mucilage did not alter in vitro stem cell differentiation. Collectively, this set of experiments revealed an almost inert role associated with chia suspensions, indicating a possible application of chia-based networks as scaffold models to study osteogenesis in vitro

Serum levels of proinflammatory cytokines in prostate cancer

Prostate cancer has become an important public health problem affecting millions of men worldwide every year. Like other malignant tumors, prostate cancer shows evidence of a strong inflammatory component that is dependent on the release of pro-inflammatory cytokines,which might play a major role in the development and progression of the tumor, helping in its early stage, progression and aggressiveness. Aims: The goal of this study was to determine the relationships between the serum levels of pro-inflammatory cytokines and the different stages of prostate cancer. To this end, sera from patients enrolled by The Laboratory of Metabolic Diseases and Cancer of the Faculty of Pharmacy and Biochemistry at the University Juan Agustín Maza in Argentina, were analyzed through ELISA and their pro-inflammatory cytokines (IL-6, TNF-α and MCP-1) quantified. Patients were first classified into three groups (Control, at Risk, and Cancer subjects) and anthropometric, biochemical and histological parameters of prostate were then determined for all groups. Results and Conclusions: Despite displaying elevated serum concentrations of IL-6 and TNF-α in the Cancer and the Risk groups compared to the Control group, the differences did not reach significance. However, there was a positive correlation between these cytokines only in the Risk and Cancer groups, showing a general inflammatory behavior in these patients. The results obtained provide general data about the behavior of pro-inflammatory cytokines in prostate cancer. However, they do not demonstrate a direct correlation betweenserum levels and neoplastic progression. Nevertheless, these findings do not rule out a possible relationship between prostate cancer and serum levels of pro-inflammatory cytokines.Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Defagó, María Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Huilcaman, Ricardo. Universidad de Talca; ChileFil: Lopez, José. Universidad Nacional de Cuyo; ArgentinaFil: Moore Carrasco, Rodrigo. Universidad de Talca; Chile. Universidad de Talca. Programa de Investigación Asociativa en Cáncer Gástrico; Chil

Daily physical activity and macronutrient distribution of low-calorie diets jointly affect body fat reduction in obese women.

Inadequate dietary patterns and sedentary lifestyles are believed to be important factors in predisposing people to obesity. This study analyzed the potential interaction between habitual physical activity and the carbohydrate (CHO)-fat distribution in 2 hypocaloric diets and the impact of such interplay on body composition changes. Forty healthy obese women, 20–50 years old, were randomly assigned to a high- or low-CHO energy-restricted diet, which was low or high in fat, respectively, during 10 weeks. Baseline and final measurements were performed to assess dietary habits, resting metabolic rate, and body composition changes. Physical activity was measured with a triaxial accelerometer and with a questionnaire. There were no significant differences in anthropometric and metabolic variables between both dietary groups at baseline. However, there was a positive correlation between total free-living physical activity and arm muscle preservation after 10 weeks (r = 0.371; p = 0.024). Interestingly, an interaction between macronutrient (CHO–fat distribution) intake and physical activity was found, since less-active subjects with a high-CHO–low-fat diet showed a greater fat loss than those more active with a lower-CHO–high-fat diet, whereas more-active subjects with a high-CHO–low-fat diet showed a smaller fat loss than those receiving a low-CHO–high-fat diet. Physical activity and the macronutrient content of energyrestricted diets, when designed to promote body fat mass reduction, should be considered together to better predict the outcome