35 research outputs found
Acute Pancreatitis in the Emergency Department
- Author
- Publication venue
- Jefferson Digital Commons
- Publication date
- 01/02/2019
- Field of study
Introduction: Acute pancreatitis (AP) is a common emergency department (ED) presentation with a variety of outcomes. Stratifying AP severity with scoring systems can allow physicians to effectively manage patient disposition.
Objective: To identify ED pancreatitis patients who will likely be admitted to the ICU or be discharged within 48 hours, and to validate existing pancreatitis severity scores.
Methods: Patients with a final ED diagnosis of AP and/or lipase â„ 3 times the upper limit of normal were enrolled in a prospective, observational chart review study. Parametric and non-parametric descriptive statistics were used to describe the patient population. Area under receiver operating curve (AUC) was used to determine the predictive accuracy of existing pancreatitis scores.
Results: Ranson criteria, Glasgow-Imrie (GI) criteria, Bedside Index of Severity in Acute Pancreatitis (BISAP), and Harmless Acute Pancreatitis Score (HAPS) were assessed. GI criteria (AUC = 0.77) had the highest predictive accuracy for ICU admission, while Ranson criteria (AUC = 0.62) had the highest predictive accuracy for early discharge. Mean scores of ICU patients were significantly (p \u3c 0.05) higher than those of non-ICU patients in all four scoring systems; however, mean scores in ICU patients failed to meet the severe case threshold for all four scoring systems.
Discussion: Existing pancreatitis scoring systems cannot consistently predict AP severity in ED patients. The small difference in mean ICU and non-ICU patient scores illustrates the difficulty of using scoring systems to stratify AP severity in the ED. Further efforts to develop an ED-specific scoring system could allow physicians to more efficiently admit patients
Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malignant breast cancer progression
- Author
- A Alberga
- A Fusco
- AB Firulli
- AJ Evans
- AJ Trimboli
- AP Morel
- B Aktas
- B De Craene
- B Kreike
- B Krishnamachary
- Bram De Craene
- BS Wiseman
- BT Hennessy
- BW Sutherland
- C Come
- C Kuperwasser
- C Vandewalle
- CJ Creighton
- CM Croce
- D Bonnet
- D Olmeda
- D Sarrio
- D Sosic
- DC Radisky
- E Charafe-Jauffret
- Ellen Foubert
- F Bertucci
- F van Roy
- F Yu
- FC Geyer
- FJ Fleming
- G Berx
- G Moreno-Bueno
- G Storci
- GB Silberstein
- Geert Berx
- GZ Cheng
- H Peinado
- H Peinado
- HE Ryan
- IK Park
- J Condeelis
- J Debnath
- J Debnath
- J Massagué
- J Yang
- J Yang
- JI Herschkowitz
- JM Lopez-Novoa
- JP Thiery
- K Gumireddy
- K Takahashi
- L Hennighausen
- L Kozlowski
- L Ma
- L Qin
- LA Boyer
- M Al-Hajj
- M Guarino
- M Kajita
- M Santisteban
- M Yu
- MA Nieto
- MA Smit
- MH Yang
- N Fujita
- NJ Sullivan
- O De Wever
- PA Gregory
- PJ Miettinen
- Q Huang
- QQ Li
- R Salgado
- S Ansieau
- S Bergmann
- S Thuault
- S Thuault
- S Vega
- SA Mani
- SA McDonald
- SE Moody
- SF Tavazoie
- SM Park
- T Okubo
- T Vincent
- TA DiMeo
- U Burk
- U Wellner
- V Evdokimova
- VM Evdokimova
- WS Wu
- Y Shimono
- Y Wang
- Y Wu
- ZF Chen
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
Breast cancer is the most common cancer among women, and despite significant advances in diagnosing and treating it, metastatic spread of cancer cells results in a high mortality rate. Epithelial-to-mesenchymal transition (EMT) is an embryonic program in which epithelial cells lose their characteristics and gain mesenchymal features. Therefore, EMT might play a very important role during malignant tumour progression. In this review we summarise recent advances in breast cancer research with a particular focus on the transcription factors Snail1 and Twist1. Besides discussing the role of EMT in normal mammary gland development, we describe regulatory mechanisms involving newly discovered upstream regulators and microRNAs, the association of EMT with breast cancer stem cells, and the involvement of the tumour microenvironment in breast cancer progression
Distinct Type of Transmission Barrier Revealed by Study of Multiple Prion Determinants of Rnq1
- Author
- A Brachmann
- AA Gorfe
- AB Meriin
- AB Meriin
- AF Hill
- AH DePace
- B Chen
- B Rost
- BH Toyama
- BK Patel
- BS Cox
- C Ritter
- C Soto
- CG Resende
- CY King
- CY King
- CY King
- D Eisenberg
- DC Masison
- DL Vanik
- DM Fowler
- E Cancellotti
- EE Ganusova
- F Chiti
- F Sherman
- F Shewmaker
- G Bertho
- Gregory S. Barsh
- Gulnara Articov
- H LeVine 3rd
- H True
- HA Lashuel
- HL True
- HY Chang
- IH Pattison
- IL Derkatch
- IL Derkatch
- IL Derkatch
- IL Derkatch
- IL Derkatch
- IL Derkatch
- IN Alexandrov
- Irina L. Derkatch
- IS Shkundina
- IV Baskakov
- J Collinge
- J Shorter
- JD Boeke
- JP Langedijk
- JR Glover
- KC Gokhale
- KD Allen
- L Solforosi
- LC Walker
- LZ Osherovich
- LZ Osherovich
- M Barnhart
- M Firoozan
- M Schlumpberger
- M Tanaka
- M Tanaka
- MD Rose
- MD Ter-Avanesyan
- ME Bradley
- ME Bradley
- ME Bradley
- ME Bruce
- MF Tuite
- Michele L. Kadnar
- ML Maddelein
- MM Patino
- MT Bishop
- N Hosada
- N Lopez
- N Sondheimer
- N Talarek
- O Namy
- P Chien
- P Zhou
- PM Douglas
- PM Tessier
- R Krishnan
- R Nelson
- RB Wickner
- RB Wickner
- RB Wickner
- S Prusiner
- SB Prusiner
- SJ Saupe
- SN Parham
- SS Eaglestone
- SW Liebman
- T Nakayashiki
- TL Orr-Weaver
- V Taneja
- VG Ostapchenko
- WK Surewicz
- YA Vitrenko
- YA Vitrenko
- YO Chernoff
- YO Chernoff
- Z Du
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2010
- Field of study
Prions are self-propagating protein conformations. Transmission of the prion state between non-identical proteins, e.g. between homologous proteins from different species, is frequently inefficient. Transmission barriers are attributed to sequence differences in prion proteins, but their underlying mechanisms are not clear. Here we use a yeast Rnq1/[PIN+]-based experimental system to explore the nature of transmission barriers. [PIN+], the prion form of Rnq1, is common in wild and laboratory yeast strains, where it facilitates the appearance of other prions. Rnq1's prion domain carries four discrete QN-rich regions. We start by showing that Rnq1 encompasses multiple prion determinants that can independently drive amyloid formation in vitro and transmit the [PIN+] prion state in vivo. Subsequent analysis of [PIN+] transmission between Rnq1 fragments with different sets of prion determinants established that (i) one common QN-rich region is required and usually sufficient for the transmission; (ii) despite identical sequences of the common QNs, such transmissions are impeded by barriers of different strength. Existence of transmission barriers in the absence of amino acid mismatches in transmitting regions indicates that in complex prion domains multiple prion determinants act cooperatively to attain the final prion conformation, and reveals transmission barriers determined by this cooperative fold
Self-help interventions for depressive disorders and depressive symptoms: a systematic review
- Author
- A Danzer
- A Lavender
- A Tuunainen
- A Wirz-Justice
- A Wood
- A-A Noorbala
- A-L Williams
- A-L Williams
- A-L Williams
- A-M Hvas
- AA Basti
- AC Toornvliet
- AD Lopez
- AF Jorm
- AF Jorm
- AF Jorm
- AF Jorm
- AF Jorm
- AF Jorm
- AF Thachil
- Amy J Morgan
- Anonymous
- Anthony F Jorm
- AP Smith
- AR Singer
- ATG Lansdowne
- BG Berger
- BJ Cardinal
- BS Oken
- C Kuehner
- C Williams
- C-M Kao
- CA Moyer
- CN Alexander
- D Benton
- D Benton
- D Benton
- D Benton
- D Benton
- D Benton
- D Carroll
- D Greenberger
- D Micklewright
- DB Wolf
- DD Burns
- DG Herron
- DL Ginsberd
- DL Roth
- DM Houston
- DO Kennedy
- DR Brown
- DR Casden
- E Moshiri
- F Hasson
- G Andrews
- G Colombo
- G Fontani
- G Krampen
- G Parker
- G Parker
- G Stathopoulou
- GA Fava
- GE Murphy
- GS Stavros
- H Christensen
- H Giedke
- IL McCann
- J Bryan
- J Jessen
- J Jones
- J Joormann
- J Kingston
- J Morrow
- J Panksepp
- J Sarris
- JA Blumenthal
- JC Dumville
- JC Overholser
- JE James
- JM Ussher
- JM Ussher
- JP Docherty
- JS Kahn
- JW Pettegrew
- K Linde
- K Pilkington
- K Pilkington
- K Pilkington
- KM Burnett
- KS Dobson
- KS Vickers
- L Anderson
- L Larun
- LB Marangell
- LL Judd
- LM Goodfellow
- LM Juliano
- M Casas
- M Rayman
- M Sayyah
- M Spinella
- M Terman
- M Terman
- MA Farne
- MG Newman
- MJ Genhart
- MJ Taylor
- MJV Fennell
- MJV Fennell
- ML Hardy
- MM Unwin
- MR Cutler
- MW Taylor
- N Goel
- N Goel
- N Perry
- N Sjosten
- N Titov
- NE Rosenthal
- NR Burns
- O LinjĂŠrde
- P Broderick
- P Cuijpers
- P Cuijpers
- P Cuijpers
- P Cuijpers
- P Cuijpers
- P Cuijpers
- P Disayavanish
- P Gilbert
- P Jin
- P Jin
- PA Campo
- PC Broderick
- PC Trask
- PD McLean
- PH Wilson
- PM Lewinsohn
- R Bella
- R Markus
- R O'Kearney
- R Westermann
- R Zanardi
- RA Baron
- RA Berk
- RA Catanese
- RC Kessler
- RC Kessler
- RJ Fehring
- RJ Gregory
- RJ Park
- RN Golden
- S Akhondzadeh
- S Akhondzadeh
- S Akhondzadeh
- S Brody
- S DeBerry
- S Devaney
- S Harris
- S Kasper
- S Kasper
- S Leppamaki
- S Lyubomirsky
- S Lyubomirsky
- S Lyubomirsky
- S Nolen-Hoeksema
- S Nolen-Hoeksema
- SE Hetrick
- SK Rowe
- SM Cockle
- T Field
- T Field
- T Field
- T Field
- T Field
- T Fulgente
- TM Skeie
- U Werneke
- V Kjos
- V Spek
- V Srinivasan
- WM Reynolds
- WN Robiner
- WT Phillips
- Publication venue
- BioMed Central
- Publication date
- 01/01/2008
- Field of study
<p>Abstract</p> <p>Background</p> <p>Research suggests that depressive disorders exist on a continuum, with subthreshold symptoms causing considerable population burden and increasing individual risk of developing major depressive disorder. An alternative strategy to professional treatment of subthreshold depression is population promotion of effective self-help interventions that can be easily applied by an individual without professional guidance. The evidence for self-help interventions for depressive symptoms is reviewed in the present work, with the aim of identifying promising interventions that could inform future health promotion campaigns or stimulate further research.</p> <p>Methods</p> <p>A literature search for randomised controlled trials investigating self-help interventions for depressive disorders or depressive symptoms was performed using PubMed, PsycINFO and the Cochrane Database of Systematic Reviews. Reference lists and citations of included studies were also checked. Studies were grouped into those involving participants with depressive disorders or a high level of depressive symptoms, or non-clinically depressed participants not selected for depression. A number of exclusion criteria were applied, including trials with small sample sizes and where the intervention was adjunctive to antidepressants or psychotherapy.</p> <p>Results</p> <p>The majority of interventions searched had no relevant evidence to review. Of the 38 interventions reviewed, the ones with the best evidence of efficacy in depressive disorders were S-adenosylmethionine, St John's wort, bibliotherapy, computerised interventions, distraction, relaxation training, exercise, pleasant activities, sleep deprivation, and light therapy. A number of other interventions showed promise but had received less research attention. Research in non-clinical samples indicated immediate beneficial effects on depressed mood for distraction, exercise, humour, music, negative air ionisation, and singing; while potential for helpful longer-term effects was found for autogenic training, light therapy, omega 3 fatty acids, pets, and prayer. Many of the trials were poor quality and may not generalise to self-help without professional guidance.</p> <p>Conclusion</p> <p>A number of self-help interventions have promising evidence for reducing subthreshold depressive symptoms. Other forms of evidence such as expert consensus may be more appropriate for interventions that are not feasible to evaluate in randomised controlled trials. There needs to be evaluation of whether promotion to the public of effective self-help strategies for subthreshold depressive symptoms could delay or prevent onset of depressive illness, reduce functional impairment, and prevent progression to other undesirable outcomes such as harmful use of substances.</p
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
- Andersen C
- Anderson C
- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
- Andrew A
- Andrews E
- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
- Apagaki E
- Apostolou K
- Applewhaite C
- Aquino LPG
- Ar P
- Arawwawala D
- Ardern D
- Argue R
- Arkalaki E
- Armaganidis A
- Armstrong J
- Armstrong R
- Arnaoutoglou C
- Arnaoutoglou E
- Arnold G
- Arrandale L
- Arrich J
- Arrigo M
- Arshad H
- Arshad MA
- Arumugam S
- Arustei M
- Arvaniti K
- Arya A
- Arya S
- Asimakos A
- Asudo F
- Athanasakis E
- Atiku M
- Attrill E
- Attwood C
- Auer P
- Avidan M
- Avila Sanchez FJ
- Avila EJD
- Avis J
- Awad H
- Axioti E
- Ayyaz H
- Azam UAA
- Azambuja P
- Azevedo C
- Aziz FZ
- Baas P
- Baghirzada L
- Bai H-P
- Bai Y
- Baillie S
- Baines D
- Baio TH
- Bairaktari A
- Baker G
- Baker K-A
- Baker P
- Balain B
- Balaji P
- Balajonda N
- Balanescu A
- Balasubramaniam M
- Baldisserotto S
- Baldwin J
- Baldwin M
- Balfoussia D
- Bali C
- Bandeira ME
- Banerjee R
- Bankewitz C
- Banner-Goodspeed V
- Bao Q
- Barcraft-Barnes H
- Barneto L
- Barnett A
- Baroselli A
- Barraclough J
- Barras J-P
- Barrett S
- Barrett WJ
- Basanth S
- Batchelor N
- Bateman B
- Bates A
- Bates S
- Batista HD
- Bauchmuller K
- Bauer M
- Baumgarten G
- Baxter L
- Beaton C
- Beattie S
- Beavis V
- Bechan S
- Bejia T
- Belciu I
- Belda MT
- Bell G
- Bell R
- Bell S
- Bellandi M
- Bello J
- Beloeil H
- Belskiy V
- Ben-Menachem E
- Benavent P
- Benevento A
- Bengeri S
- Bennett C
- Bennett M
- Bennett R
- Bennett V
- Bentley C
- Beretta L
- Berg A
- Bergin C
- Bernard A
- Berntsen E
- Bertram W
- Bester D
- Bester M
- Bettega F
- Bettinelli A
- Bhardwaj N
- Bhatia K
- Bhula C
- Bi Y
- Biais M
- Biccard BM
- Bidd H
- Bidgoli J
- Biffen A
- Bignami E
- Bilolikar A
- Bin Mustapha MT
- Birch J
- Bishop DG
- Biyase T
- Bizios C
- Blackwell C
- Blackwood D
- Blaj M
- Blakemore SP
- Bland M
- Blunt M
- Blyth K
- Bocchino S
- Bodansky D
- Bodger P
- Boer C
- Boereboom C
- Boggiano V
- Bogner G
- Bolaji B
- Bolton D
- Boone M
- Boschi L
- Boshier P
- Botes M
- Botis I
- Bottini C
- Bottrill F
- Bouchez S
- Boulton K
- Bouris V
- Bourner L
- Boutsikos G
- Bouwman A
- Bouwman RA
- Bowrey S
- Boxall L
- Boyd C
- Bradburn M
- Bradley J
- Branagan G
- Branco T
- Brand B
- Brandsborg B
- Breitenstein S
- Brennan A
- Brennan E
- Brenner L
- Brincat M
- Briscoe R
- Bristogiannis S
- Brooke J
- Brookes J
- Brookes M
- Brooks C
- Broomby R
- Brotto AF
- Brown A
- Brown CW
- Brown G
- Brown J
- Brown J
- Brown L
- Brown R
- Brown R
- Browning J
- Bruma D
- Brunete T
- Brunswicker A
- Bryant H
- Bua E
- Buccimazza I
- Buckley S
- Buerkle C
- Buhre W
- Buhre W
- Buhrer T
- Builu PM
- Buise M
- Bullock C
- Bunwarie B
- Burns K
- Burrows L
- Burrows T
- Burston B
- Burtenshaw A
- Burton M
- Busuioc M
- Butryn I
- Butt G
- Byrne K
- Cabezuelo E
- Cabral R
- Cabral TDN
- Cabrini L
- Cacala S
- Cai F
- Cai Y
- Cain H
- Cairns C
- Cakova V
- Calderwood C
- Callaghan M
- Campbell D
- Campbell D
- Campbell D
- Campbell G
- Campbell G
- Campbell K
- Campbell M
- Campbell T
- Campey L
- Camsooksai J
- Cancho D
- Candido K
- Cang J
- Cannavo M
- Cao J
- Cao Y
- Cao Z
- Cardellino S
- Cardosa J
- Cardoso G
- Cardy J
- Carmino L
- Carp CP
- Carr A
- Carrera R
- Carroll C
- Carroll J
- Caser E
- Castano Moreira B
- Castano B
- Castle G
- Cavanagh S
- Cawthorn L
- Cernea DD
- Chaddock M
- Chaloulis P
- Chan A
- Chan HMH
- Chan M
- Chan P
- Chan V
- Chan WK
- Chan WKJ
- Chan YL
- Chande S
- Chandler B
- Chandra S
- Chandrasekharan S
- Chang YH
- Chaniotaki F
- Charitos E
- Charlalampidoy A
- Charles R
- Chatterjee D
- Chatterjee J
- Chatzimichali CA
- Chau S
- Chazova E
- Cheah C
- Cheah S
- Cheeseman M
- Cheing Y
- Chen C
- Chen C
- Chen F
- Chen F
- Chen H
- Chen J
- Chen J
- Chen L
- Chen L
- Chen L-L
- Chen P
- Chen Q
- Chen R
- Chen S
- Chen S
- Chen S
- Chen Y
- Chen Y
- Chen Y
- Chen Y
- Chen Z
- Cheng B
- Cheng KH
- Cheng Z
- Cheong E
- Cherian R
- Cherrett V
- Chetty RR
- Chew M
- Chhabra A
- Chicken D-W
- Chilinciuc I
- Chin II
- Chirkut S
- Chisbert Cuenca V
- Chlorou D
- Choi H-MD
- Choi S
- Chow L
- Christian R
- Christiansen IC
- Christmas N
- Christodoulidis G
- Christodoulopoulou T
- Christofaki M
- Christoforidis D
- Chronis C
- Chu HM
- Chu S
- Chua P
- Chukkambotla S
- Chung CKE
- Cifra E
- Ciobanu C
- Ciobotaru OR
- Cirstea E
- Clark R
- Clarkson A
- Clarkson R
- Claxton A
- Clemmons K
- Cloro LM
- Clyde A
- Cobzaru I
- Codita A
- Colangelo A
- Colangelo C
- Colling K
- Collins H
- Collins M
- Collins N
- Colvin C
- Commey T
- Comptaer N
- Conde C
- Conradie A
- Constantin K
- Cook T
- Cooper L
- Cooper L
- Cooper M
- Cooper R
- Cooper S
- Copaciu E
- Cope J
- Copetti E
- Copley E
- Copotoiu SM
- Coppens M
- Corneci D
- Cornell J
- Cornish J
- Correia da Silva RFM
- Corti D
- Costanzo E
- Costelloe H
- Cotter R
- Cotterell S
- Cotterill D
- Coughlan E
- Coulter I
- Coulter S
- Coutinho F
- Cowton A
- Cox H
- Cozar OI
- Craig J
- Craven R
- Craw N
- Craw S
- Creary T
- Cripps H
- Critchley R
- Cronje L
- Cruickshank R
- Cruikshanks A
- Cruz S
- Cueva A
- Cunha P
- Curley G
- Currow H
- Czepanski C
- Czeslick E
- D'Andrea R
- da Costa Fischer BF
- Dafnios N
- Dai H
- Dai Q
- Dai Q
- Dai SY
- Daikou P
- Dalamagka M
- Dalampini E
- Dali-Kemmery L
- Dalton E
- Damant R
- Daniel C
- Daniel GD
- Daniel H
- Daniel H
- Daniel S
- Dankl D
- Darko J
- Darwish S
- Das S
- Dasrath A
- Datson A
- Daubeny T
- Daugaard M
- Davari M
- Dave T
- Davies C
- Davies H
- Davies K
- Davies K
- Davies L
- Davies Z
- Davis E
- Davis F
- Davis S
- Daya B
- De Andres Ibanez JA
- de Araujo DM
- De Baerdemaeker L
- de Beer J
- de Boer HD
- De Bruyne A
- de Campos Ferreira MF
- de Fretes J
- de Gasperi J
- De Hert S
- De Jongh K
- De Kegel D
- De Meyer JN
- De Oliveira MC
- de Rudnicki S
- de Swardt M
- de Vasconcellos K
- de Villiers M
- de Wet J
- Deacon M
- Deblaere I
- Dedemadi G
- Deen T
- Deepak S
- Deighton K
- Deja M
- Delgado Garcia DR
- Delgado Navarro C
- Della Rocca G
- Dempsey G
- Dempster A
- den Hoedt M
- Denham S
- Dent K
- Dermitzaki D
- Desbordes J
- Despotidis V
- Diaconescu C
- Dias F
- Dias S
- Dickson J
- Ditai J
- Divatia J
- Dixon L
- do Nascimento Junior P
- Dobson G
- Docherty P
- Dodiyi-Manuel A
- Dodsworth K
- Dolan R
- Dong B
- Donohue R
- Donovan A
- Douglas J
- Doumos R
- Downes C
- Doyle D
- Dragnea D
- Dragoescu NA
- Drake M
- Drimala M
- Drinkwater Z
- Drummond L
- Du F
- Du F
- Du X
- Duarte C
- Dube NZ
- Duca A
- Dudgeon L
- Dudson R
- Duenser M
- Dumitrascu CO
- Dumitrescu A
- Dunay A
- Dunk N
- Durant E
- Durodola A
- Dursin AN
- Durst A
- Duttchen K
- Dutu M
- Dwyer H
- Dylst D
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44Â 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
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- AbellĂĄn AN
- AbellĂĄn AN
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- AKI Research Group
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- De Backer A
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- De Cassai A
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- De La Fuente-Martos C
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- ENVIN-HELICS Study Group
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- FINNRESUSCI Study Group
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- IPREA Study Group
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
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- Nisula S
- Nobile L
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- Noda E
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- Okayama Research Investigation Organizing Network (ORION)investigators
- Olaechea P
- Olavarria E
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- Plug Working Group
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- Pugliese F
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- Rapid Diagnosis of Infections in the Critically Ill Team
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- ReVA Research Network and the PROVE Network Investigators
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- Ruiz-Rodriguez JC
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- Runge I
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- Rutten AM
- Rydingsward JE
- Saadat F
- Sabetian G
- SabeÄŒĆikovs O
- Sabirov D
- Sadamoto Y
- Sadamoto Y
- Sadamoto Y
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- Saha T
- Saigal S
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- Saito N
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- Sakieva FI
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- Sandiumenge A
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- Santana JD
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- Santana MC
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- Santana PS
- Santana PS
- Santana SR
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- Santiago AI
- Santiago AI
- Santos F
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- Sanz NM
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- Savin I
- Savvidou S
- Sawamura A
- Sawamura A
- Sawamura A
- Sawamura A
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- Scales DC
- Scanziani E
- Scanziani E
- Schaller SJ
- Schlaepfer P
- Schleifer J
- Schmid RM
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- Schneider AG
- Schoenenberger JA
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- Stubbs C
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- Suchomel P
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- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez MJ
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- SĂĄnchez PC
- SĂĄnchez PC
- SĂĄnchez-Elvira LA
- Tabatabaei HR
- Tabei SH
- Taccone F
- Taccone FS
- Taccone FS
- Taccone FS
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- Taccone FS
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- WIND study group
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- Yılmaz G
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- Ălvarez JT
- Ălvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-GĂłmez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
- Andrade-Silva M
- Andres AM
- Angelini S
- Ann D
- Anozie UC
- Ansari MY
- Antas P
- Antebi A
- AntĂłn Z
- Anwar T
- Apetoh L
- Apostolova N
- Araki T
- Araki Y
- Arasaki K
- Araya J
- AraĂșjo WL
- Arden C
- Arguelles S
- Arias E
- Arikkath J
- Arimoto H
- Ariosa AR
- Armstrong-James D
- Arnauné-Pelloquin L
- Aroca A
- Arroyo DS
- Arsov I
- Artero R
- Arévalo M-A
- Asaro DML
- Aschner M
- Ashrafizadeh M
- Ashur-Fabian O
- Atanasov AG
- Au AK
- Auberger P
- Auner HW
- Aurelian L
- Autelli R
- Avagliano L
- Aveic S
- Aveleira CA
- Avin-Wittenberg T
- Aydin Y
- Ayton S
- Ayyadevara S
- Azzopardi M
- Baba M
- Backer JM
- Backues SK
- Bae D-H
- Bae O-N
- Bae SH
- Baehrecke EH
- Baek A
- Baek S-H
- Baek SH
- Bagetta G
- Bagniewska-Zadworna A
- Bai H
- Bai J
- Bai X
- Bai Y
- Bairagi N
- Baksi S
- Balazadeh S
- Balbi T
- Baldari CT
- Balduini W
- Ballabio A
- Ballester M
- Balzan R
- Bandopadhyay R
- Banerjee S
- Banerjee S
- Bao Y
- Baptista MS
- Baracca A
- Barbati C
- Bargiela A
- BarilĂ D
- Barlow PG
- Barmada SJ
- Barreiro E
- Barreto GE
- Bartek J
- Bartel B
- Bartolome A
- Barve GR
- Basagoudanavar SH
- Bassham DC
- Bast RC
- Basu A
- Batoko H
- Batten I
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- Zhang X
- Zhang X
- Zhang X
- Zhang X-W
- Zhang XD
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y-D
- Zhang Y-Y
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
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- Zhivotovsky B
- Zhong Q
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- Zhou Z
- Zhou Z-Y
- Zhu B
- Zhu C
- Zhu G-Q
- Zhu H
- Zhu H
- Zhu H
- Zhu W-G
- Zhu Y
- Zhu Y
- Zhuang H
- Zhuang X
- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
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- Zou Z
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- Zwerschke W
- Ălvarez ĂMC
- Ăvalos Y
- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Engineered herpes simplex viruses efficiently infect and kill CD133+ human glioma xenograft cells that express CD111
- Author
- A Salmaggi
- A Wu
- B Das
- BS Kwon
- C Allen
- C Krummenacher
- C Krummenacher
- Catherine P. Langford
- CL Bi
- CR Miller
- D Beier
- D Shukla
- G Guzman
- G Liu
- G Paraskevakou
- G Zhou
- G Zhou
- G. Yancey Gillespie
- Gregory K. Friedman
- H Jiang
- H Kamiyama
- HD Hemmati
- J Chou
- J Dings
- J Skog
- Jacqueline N. Parker
- James M. Markert
- Jennifer M. Coleman
- JM Markert
- JM Markert
- JN Parker
- K Camphausen
- KA Cassady
- Kevin A. Cassady
- KM Joo
- M Lopez
- MA Rueger
- MS Warner
- NN Khodarev
- P DellâAlbani
- PG Spear
- PM Ejercito
- R Galli
- R Rampling
- R Stupp
- RI Montgomery
- RJ Geraghty
- S Andreansky
- S Bao
- S Harrow
- SA Simpson
- SK Singh
- SK Singh
- SM Evans
- T Mineta
- V Papanastassiou
- YY Huang
- Z Yu
- Z Yu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
ERGâTMPRSS2 rearrangement is shared by concurrent prostatic adenocarcinoma and prostatic small cell carcinoma and absent in small cell carcinoma of the urinary bladder: evidence supporting monoclonal origin
- Author
- A Gopalan
- Adeboye O Osunkoya
- Antonio Lopez-Beltran
- B Furusato
- B Han
- B Helpap
- B Helpap
- BS Carver
- CC Guo
- DE Hansel
- DS Schron
- G Attard
- Gregory T MacLennan
- J Clark
- JI Epstein
- Jiaoti Huang
- JL Yao
- JM Mosquera
- JM Mosquera
- Jorge L Yao
- JR Mackey
- JS Palmgren
- K Iljin
- Liang Cheng
- M Andreoiu
- M Barry
- ME Stein
- N Cerveira
- PA Abrahamsson
- PA di Sant'Agnese
- PE Spiess
- R Albadine
- R Esgueva
- R Mehra
- R Mehra
- RA Simon
- RE Wenk
- RJ Amato
- Rodolfo Montironi
- S Perner
- S Zhang
- SA Tomlins
- SA Tomlins
- Sean R Williamson
- Shaobo Zhang
- SM Falzarano
- Steven Shen
- SW Fine
- VJ Scheble
- VJ Scheble
- W Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Transcription start site profiling uncovers divergent transcription and enhancer-associated RNAs in Drosophila melanogaster
- Author
- A Jenett
- A Jory
- A Mayer
- A Rada-Iglesias
- A Saunders
- A Verdel
- A. Gregory Matera
- AR Quinlan
- B Langmead
- Brian D. Strahl
- BS Scruggs
- C Wakano
- CD Arnold
- CD Kaplan
- DA Gilchrist
- DA Hendrix
- Daniel J. McKay
- DJ McKay
- E Segal
- EA Rach
- F Ozsolak
- F RamĂrez
- G Liang
- GE Zentner
- GW Muse
- HD Lipshitz
- J Yang
- JD Buenrostro
- JM Vera
- K Adelman
- K Takahashi
- Karen Adelman
- KM Dorighi
- LJ Core
- LJ Core
- M Lubas
- M Rye
- M-C Keogh
- MI Love
- Michael P. Meers
- MJ Carrozza
- MP Creyghton
- N Kaplan
- ND Trinklein
- O Hallikas
- P Carninci
- P Lopez
- P Preker
- PC FitzGerald
- PJ Mitchell
- PR Andersen
- RA Hoskins
- Robert J. Duronio
- S Buratowski
- S Djebali
- S Heinz
- S Nechaev
- SHC Duttke
- T Henriques
- T Ni
- T-K Kim
- TI Lee
- TN Mavrich
- W Li
- WJ Kent
- Y Lorch
- Y Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study