Derek Mahon's Seascapes Mediated through Greece: Antiquity in Modernity, Nature in Abstraction.

The article investigates various approaches to seascape in selected poems of the contemporary Irish poet, Derek Mahon, set against the background of references to Michael Longley, Seamus Heaney or Odysseus Elytis. The sea provides a perspective that cannot be overestimated in trying to get an insight into the communication and the clash between the culture of the South and the North. The two nations have often glimpsed at their reflection in the mirror of the surrounding seas, their history and mentality determined by their geographical position and largely insular experience. Elements such as the isolation from the mainland; the perception of the sea as a personification of the force ruling over life and death, as a threat and a promise; or the focus on some characteristic natural phenomena such as light or surface dominate the seascape imagery both in Greek and Irish literature. The sea often constitutes a border of antagonistic and complementary worlds: dream and reality, light and darkness, male and female, the real world and the underworld – and the vantage point of the poet changes accordingly. Some poems under discussion also explore a series of myths linked with the sea, the best known of which, the Odyssey, has remained a frame of reference for numerous contemporary Greek and Irish poets. Elytis's Cyclades or Longley's Mayo provide us with examples of 'private homelands'. As Longley once observed, “his part of Mayo” reminds him of Ithaca (sandy and remote) and of Greece in general: “I’ve often thought that that part of Ireland . . . looks like Greece. Or Greece looks like a dust-bowl version of Ireland,” which triggers further deliberations on seascape as the common ground for the two countries. Just as Elytis's Cyclades or Longley's Mayo, Mahon’s Cyclades provide us with examples of 'private homelands'. The focus of this article is Derek Mahon’s seascapes: purely Greek (‘Aphrodite’s Pool’), Irish seen through the prism of the Greek ones (‘Achill’) and purely Irish (‘Recalling Aran’). The level of abstraction in the last category is compared with Odysseus Elytis’s imagery of the Cyclades, while the first poem demystifies a practice which I termed as ‘myth trading’, one of consumerist tourism techniques

A Study of Cosmic Ray Composition in the Knee Region using Multiple Muon Events in the Soudan 2 Detector

Deep underground muon events recorded by the Soudan 2 detector, located at a depth of 2100 meters of water equivalent, have been used to infer the nuclear composition of cosmic rays in the "knee" region of the cosmic ray energy spectrum. The observed muon multiplicity distribution favors a composition model with a substantial proton content in the energy region 800,000 - 13,000,000 GeV/nucleus.Comment: 38 pages including 11 figures, Latex, submitted to Physical Review

Calculation of the Phase Behavior of Lipids

The self-assembly of monoacyl lipids in solution is studied employing a model in which the lipid's hydrocarbon tail is described within the Rotational Isomeric State framework and is attached to a simple hydrophilic head. Mean-field theory is employed, and the necessary partition function of a single lipid is obtained via a partial enumeration over a large sample of molecular conformations. The influence of the lipid architecture on the transition between the lamellar and inverted-hexagonal phases is calculated, and qualitative agreement with experiment is found.Comment: to appear in Phys.Rev.

Search for the Proton Decay Mode proton to neutrino K+ in Soudan 2

We have searched for the proton decay mode proton to neutrino K+ using the one-kiloton Soudan 2 high resolution calorimeter. Contained events obtained from a 3.56 kiloton-year fiducial exposure through June 1997 are examined for occurrence of a visible K+ track which decays at rest into mu+ nu or pi+ pi0. We found one candidate event consistent with background, yielding a limit, tau/B > 4.3 10^{31} years at 90% CL with no background subtraction.Comment: 13 pages, Latex, 3 tables and 3 figures, Accepted by Physics Letters

Classification of Westminster Parliamentary constituencies using e-petition data

In a representative democracy it is important that politicians have knowledge of the desires, aspirations and concerns of their constituents. Opportunities to gauge these opinions are however limited and, in the era of novel data, thoughts turn to what alternative, secondary, data sources may be available to keep politicians informed about local concerns. One such source of data are signatories to electronic petitions (e-petitions). Such e-petitions have risen greatly in popularity over the past decade and allow members of the public to initiate and sign an e-petition online, with popular e-petitions resulting in media attention, a response from the government or ultimately a debate in parliament. These data are thus novel in their availability and have not yet been widely used for research purposes. In this article we will use the e-petition data to show how semantic classes of Westminster Parliamentary constituencies, fitted as Gaussian finite mixture models via EM algorithm, can be used to typify constituencies. We identify four classes: Domestic Liberals; International Liberals; Nostalgic Brits and Rural Concerns, and illustrate how they map onto electoral results. The findings and the utility of this approach to incorporate new e-petitions and adapt to changes in electoral geography are discussed

Evaluating predictive pharmacogenetic signatures of adverse events in colorectal cancer patients treated with fluoropyrimidines

The potential clinical utility of genetic markers associated with response to fluoropyrimidine treatment in colorectal cancer patients remains controversial despite extensive study. Our aim was to test the clinical validity of both novel and previously identified markers of adverse events in a broad clinical setting. We have conducted an observational pharmacogenetic study of early adverse events in a cohort study of 254 colorectal cancer patients treated with 5-fluorouracil or capecitabine. Sixteen variants of nine key folate (pharmacodynamic) and drug metabolising (pharmacokinetic) enzymes have been analysed as individual markers and/or signatures of markers. We found a significant association between TYMP S471L (rs11479) and early dose modifications and/or severe adverse events (adjusted OR = 2.02 [1.03; 4.00], p = 0.042, adjusted OR = 2.70 [1.23; 5.92], p = 0.01 respectively). There was also a significant association between these phenotypes and a signature of DPYD mutations (Adjusted OR = 3.96 [1.17; 13.33], p = 0.03, adjusted OR = 6.76 [1.99; 22.96], p = 0.002 respectively). We did not identify any significant associations between the individual candidate pharmacodynamic markers and toxicity. If a predictive test for early adverse events analysed the TYMP and DPYD variants as a signature, the sensitivity would be 45.5 %, with a positive predictive value of just 33.9 % and thus poor clinical validity. Most studies to date have been under-powered to consider multiple pharmacokinetic and pharmacodynamic variants simultaneously but this and similar individualised data sets could be pooled in meta-analyses to resolve uncertainties about the potential clinical utility of these markers