Search for Lorentz violation in short-range gravity

A search for sidereal variations in the force between two planar tungsten oscillators separated by about 80 $\mu m$ sets the first experimental limits on Lorentz violation involving quadratic couplings of the Riemann curvature, consistent with no effect at the level of $10 ^{(-7)}$ $m^{(2)}$

Inhibitor Mediated Protein Degradation

SummaryThe discovery of drugs that cause the degradation of their target proteins has been largely serendipitous. Here we report that the tert-butyl carbamate-protected arginine (Boc3Arg) moiety provides a general strategy for the design of degradation-inducing inhibitors. The covalent inactivators ethacrynic acid and thiobenzofurazan cause the specific degradation of glutathione-S-transferase when linked to Boc3Arg. Similarly, the degradation of dihydrofolate reductase is induced when cells are treated with the noncovalent inhibitor trimethoprim linked to Boc3Arg. Degradation is rapid and robust, with 30%–80% of these abundant target proteins consumed within 1.3–5 hr. The proteasome is required for Boc3Arg-mediated degradation, but ATP is not necessary and the ubiquitin pathways do not appear to be involved. These results suggest that the Boc3Arg moiety may provide a general strategy to construct inhibitors that induce targeted protein degradation

Generating Neutrino Mass in the 331 Model

A mechanism for generating small tree-level Majorana mass for neutrinos is implemented in the 331 Model. No additional fermions or scalars need to be added, and no mass scale greater than a few TeV is invoked.Comment: LaTex, 7 pages, no figures. Revised version to appear in Phys. Rev.

Stability of the Scalar Potential and Symmetry Breaking in the Economical 3-3-1 Model

A detailed study of the criteria for stability of the scalar potential and the proper electroweak symmetry breaking pattern in the economical 3-3-1 model, is presented. For the analysis we use, and improve, a method previously developed to study the scalar potential in the two-Higgs-doublet extension of the standard model. A new theorem related to the stability of the potential is stated. As a consequence of this study, the consistency of the economical 3-3-1 model emerges.Comment: to be published in EPJ C, 13 page

Crystal Structure and Physical Properties of U3T3Sn4 (T = Ni, Cu) Single-Crystals

Heat capacity experiments, crystal structure determination and transmission electron microscopy have been carried out on U3Cu3Sn4 single-crystals. U3Cu3Sn4 was confirmed to be a heavy-fermion antiferromagnet (TN=13(1) K) with a low temperature electronic heat capacity coefficient gamma=390 mJ/molUK2. Low temperature heat capacity experiments on a U3Ni3Sn4 single-crystal indicate that below 0.4 K there is a crossover between the previously observed non-Fermi liquid behavior and a Fermi liquid state.Comment: 12 pages (incl. 2 tables & 4 figures), to appear in Physica

Sub-millimeter Tests of the Gravitational Inverse-square Law

Motivated by a variety of theories that predict new effects, we tested the gravitational 1/r^2 law at separations between 10.77 mm and 137 microns using two different 10-fold azimuthally symmetric torsion pendulums and rotating 10-fold symmetric attractors. Our work improves upon other experiments by up to a factor of about 100. We found no deviation from Newtonian physics at the 95% confidence level and interpret these results as constraints on extensions of the Standard Model that predict Yukawa or power-law forces. We set a constraint on the largest single extra dimension (assuming toroidal compactification and that one extra dimension is significantly larger than all the others) of R <= 160 microns, and on two equal-sized large extra dimensions of R <= 130 microns. Yukawa interactions with |alpha| >= 1 are ruled out at 95% confidence for lambda >= 197 microns. Extra-dimensions scenarios stabilized by radions are restricted to unification masses M >= 3.0 TeV/c^2, regardless of the number of large extra dimensions. We also provide new constraints on power-law potentials V(r)\propto r^{-k} with k between 2 and 5 and on the gamma_5 couplings of pseudoscalars with m <= 10 meV/c^2.Comment: 34 pages, 38 figure

Static quantities of the W boson in the SU_L(3) X U_X(1) model with right-handed neutrinos

The static electromagnetic properties of the $W$ boson, $\Delta \kappa$ and $\Delta Q$, are calculated in the SU_L(3)} \times U_X(1) model with right-handed neutrinos. The new contributions from this model arise from the gauge and scalar sectors. In the gauge sector there is a new contribution from a complex neutral gauge boson $Y^0$ and a singly-charged gauge boson $Y^\pm$. The mass of these gauge bosons, called bileptons, is expected to be in the range of a few hundreds of GeV according to the current bounds from experimental data. If the bilepton masses are of the order of 200 GeV, the size of their contribution is similar to that obtained in other weakly coupled theories. However the contributions to both $\Delta Q$ and $\Delta \kappa$ are negligible for very heavy or degenerate bileptons. As for the scalar sector, an scenario is examined in which the contribution to the $W$ form factors is identical to that of a two-Higgs-doublet model. It is found that this sector would not give large corrections to $\Delta \kappa$ and $\Delta Q$.Comment: New material included. Final version to apppear in Physical Review

Spin-Dependent Macroscopic Forces from New Particle Exchange

Long-range forces between macroscopic objects are mediated by light particles that interact with the electrons or nucleons, and include spin-dependent static components as well as spin- and velocity-dependent components. We parametrize the long-range potential between two fermions assuming rotational invariance, and find 16 different components. Applying this result to electrically neutral objects, we show that the macroscopic potential depends on 72 measurable parameters. We then derive the potential induced by the exchange of a new gauge boson or spinless particle, and compare the limits set by measurements of macroscopic forces to the astrophysical limits on the couplings of these particles.Comment: 37 page

Discrete symmetries, invisible axion and lepton number symmetry in an economic 3-3-1 model

We show that Peccei-Quinn and lepton number symmetries can be a natural outcome in a 3-3-1 model with right-handed neutrinos after imposing a Z_11 x Z_2 symmetry. This symmetry is suitably accommodated in this model when we augmented its spectrum by including merely one singlet scalar field. We work out the breaking of the Peccei-Quinn symmetry, yielding the axion, and study the phenomenological consequences. The main result of this work is that the solution to the strong CP problem can be implemented in a natural way, implying an invisible axion phenomenologically unconstrained, free of domain wall formation and constituting a good candidate for the cold dark matter.Comment: 17 pages, Revtex

Novel sources of Flavor Changed Neutral Currents in the 331RHN331_{RHN} model

Sources of Flavor Changed Neutral Currents (FCNC) naturally emerge from a well motivated framework called 3-3-1 with right-handed neutrinos model, $331_{RHN}$ for short, mediated by an extra neutral gauge boson $Z^{\prime}$. Following previous works we calculate these sources and in addition we derive new ones coming from CP-even and -odd neutral scalars which appear due to their non-diagonal interactions with the physical standard quarks. Furthermore we show that bounds related to the neutral mesons systems $K_L-K_S$ and $D_1^0 - D_2^0$ may be significantly strengthened in the presence of these new interactions allowing us to infer stronger constraints on the parameter space of the model.Comment: Published version. 10 pages, 6 figure