Didactics in the explanation of modern architectural works: four architectural pieces seen from the viewpoint of six authors

La historia de la arquitectura en la docencia cuenta con los textos como un soporte fundamental y dentro de estos, con la explicación que se hace de las obras. ¿Qué sistema didáctico emplean sus autores? ¿Cómo se articula en estas explicaciones la descripción textual con las imágenes? ¿Qué relación hay entre las explicaciones y el predicamento que sigue cada autor? Todas esas preguntas fueron tratadas aquí a partir de examinar cuatro obras canónicas a través de los textos de seis autores, igualmente importantes dentro de la historiografía de la arquitectura moderna. El objetivo fue descifrar el sistema didáctico y los dispositivos que intervienen en esta forma explicativa que bien podría considerarse un género literario en sí mismo.Teaching History of Architecture is primarily performed by text- based approach; in this case, books present the description of architectural pieces. This poses certain queries like: What didactic method is used by their authors? How do these explanations articulate textual description with images? What is the connection between the explanations and the predicament every author faces? These questions are addressed here after analyzing four canonical pieces through the books of six different authors, all of them equally relevant within architecture’s modern historiography. The purpose was to unravel the didactic method and the mechanisms involved in this explanatory form which mayitself be considered a literary genre

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

4to. Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad. Memoria académica

Este volumen acoge la memoria académica de la Cuarta edición del Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad, CITIS 2017, desarrollado entre el 29 de noviembre y el 1 de diciembre de 2017 y organizado por la Universidad Politécnica Salesiana (UPS) en su sede de Guayaquil. El Congreso ofreció un espacio para la presentación, difusión e intercambio de importantes investigaciones nacionales e internacionales ante la comunidad universitaria que se dio cita en el encuentro. El uso de herramientas tecnológicas para la gestión de los trabajos de investigación como la plataforma Open Conference Systems y la web de presentación del Congreso http://citis.blog.ups.edu.ec/, hicieron de CITIS 2017 un verdadero referente entre los congresos que se desarrollaron en el país. La preocupación de nuestra Universidad, de presentar espacios que ayuden a generar nuevos y mejores cambios en la dimensión humana y social de nuestro entorno, hace que se persiga en cada edición del evento la presentación de trabajos con calidad creciente en cuanto a su producción científica. Quienes estuvimos al frente de la organización, dejamos plasmado en estas memorias académicas el intenso y prolífico trabajo de los días de realización del Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad al alcance de todos y todas

Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

High-energy Lasers: Compact ultra-intense lasers and nanostructures open a path to extreme pressures

Irradiation of aligned nanowire arrays with ultrashort laser pulses of relativistic intensity produces matter in the ultrahigh-energy density regime characterized by gigabar pressures, enabling new experiments in high-energy physics.Fil: Rocca, J. J.. Department Of Electrical And Engineering; Estados UnidosFil: Shlyaptsev, V. N.. Department Of Electrical And Engineering; Estados UnidosFil: Hollinger, R.. Department Of Electrical And Engineering; Estados UnidosFil: Bargsten, C.. Department Of Electrical And Engineering; Estados UnidosFil: Pukhov, A.. Heinrich-heine-universität Düsseldorf; AlemaniaFil: Kaymak, V.. Heinrich-heine-universität Düsseldorf; AlemaniaFil: Tommasini, R.. Lawrence Livermore National Laboratory; Estados UnidosFil: Londoño, Roberto. Lawrence Livermore National Laboratory; Estados UnidosFil: Park, J.. Lawrence Livermore National Laboratory; Estados UnidosFil: Capeluto, Maria Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentin

Heterozygous nonsense variants in the ferritin heavy-chain gene FTH1 cause a neuroferritinopathy

Summary: Ferritin, the iron-storage protein, is composed of light- and heavy-chain subunits, encoded by FTL and FTH1, respectively. Heterozygous variants in FTL cause hereditary neuroferritinopathy, a type of neurodegeneration with brain iron accumulation (NBIA). Variants in FTH1 have not been previously associated with neurologic disease. We describe the clinical, neuroimaging, and neuropathology findings of five unrelated pediatric patients with de novo heterozygous FTH1 variants. Children presented with developmental delay, epilepsy, and progressive neurologic decline. Nonsense FTH1 variants were identified using whole-exome sequencing, with a recurrent variant (p.Phe171∗) identified in four unrelated individuals. Neuroimaging revealed diffuse volume loss, features of pontocerebellar hypoplasia, and iron accumulation in the basal ganglia. Neuropathology demonstrated widespread ferritin inclusions in the brain. Patient-derived fibroblasts were assayed for ferritin expression, susceptibility to iron accumulation, and oxidative stress. Variant FTH1 mRNA transcripts escape nonsense-mediated decay (NMD), and fibroblasts show elevated ferritin protein levels, markers of oxidative stress, and increased susceptibility to iron accumulation. C-terminal variants in FTH1 truncate ferritin’s E helix, altering the 4-fold symmetric pores of the heteropolymer, and likely diminish iron-storage capacity. FTH1 pathogenic variants appear to act by a dominant, toxic gain-of-function mechanism. The data support the conclusion that truncating variants in the last exon of FTH1 cause a disorder in the spectrum of NBIA. Targeted knockdown of mutant FTH1 transcript with antisense oligonucleotides rescues cellular phenotypes and suggests a potential therapeutic strategy for this pediatric neurodegenerative disorder

Urban violence and public health in Latin America: a sociological explanatory framework Violencia urbana y salud pública en Latinoamérica: un marco sociológico explicativo

Interpersonal violence has become one of the main public health issues in Latin American cities. This article presents a framework for sociological interpretation that operates on three levels, expressed in the factors that originate, foment, or facilitate violence. Macro-social factors include: social inequality due to the increase in wealth versus poverty; the paradox of more schooling with fewer employment opportunities; increasing expectations and the impossibility of meeting them; changes in family structure; and loss of importance of religion in daily life. At the meso-social level the analysis highlights: increased density in poor areas and urban segregation; masculinity cult; and changes in the local drug market. The micro-social level includes: an increase in the number of firearms; alcohol consumption; and difficulties in verbal expression of feelings. The article concludes with an analysis of how violence is leading to the breakdown not only of urban life but also of citizenship as a whole in Latin America.<br>La violencia interpersonal se ha convertido en uno de los principales problemas de salud pública de las ciudades de América Latina. El artículo presenta una interpretación sociológica de la violencia en tres niveles: (a) macro-sociales &shy; la desigualdad social debida al incremento de la riqueza y la pobreza; la paradoja del mayor nivel educativo de las personas, pero las menores oportunidades de empleo, el incremento de las expectativas y de la imposibilidad de satisfacerlas; los cambios en la familia y la pérdida de importancia de la religión en la vida cotidiana de las personas; (b) meso-sociales &shy; el incremento de la densidad en las zonas pobres y la segregación urbana, la cultura de la masculinidad y los cambios en el mercado local de la droga; (c) micro-sociales &shy; el incremento de las armas de fuego, el consumo de alcohol y las dificultades de expresión verbal de los sentimientos por las personas. El artículo concluye con un análisis sobre cómo la violencia está llevando no sólo a la pérdida de las ciudades, sino a la ciudadanía en América Latina

The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project

The PREDICTS project—Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)—has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity