885 research outputs found
Flavonoids and ω3-polyunsaturated fatty acid supplementation in renal transplant recipients: new arguments from COVID-19
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Many-core applications to online track reconstruction in HEP experiments
Interest in parallel architectures applied to real time selections is growing
in High Energy Physics (HEP) experiments. In this paper we describe performance
measurements of Graphic Processing Units (GPUs) and Intel Many Integrated Core
architecture (MIC) when applied to a typical HEP online task: the selection of
events based on the trajectories of charged particles. We use as benchmark a
scaled-up version of the algorithm used at CDF experiment at Tevatron for
online track reconstruction - the SVT algorithm - as a realistic test-case for
low-latency trigger systems using new computing architectures for LHC
experiment. We examine the complexity/performance trade-off in porting existing
serial algorithms to many-core devices. Measurements of both data processing
and data transfer latency are shown, considering different I/O strategies
to/from the parallel devices.Comment: Proceedings for the 20th International Conference on Computing in
High Energy and Nuclear Physics (CHEP); missing acks adde
Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts.
Copyright: 2013 Hermann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.PURPOSE: In spite of intense research efforts, pancreatic ductal adenocarcinoma remains one of the most deadly malignancies in the world. We and others have previously identified a subpopulation of pancreatic cancer stem cells within the tumor as a critical therapeutic target and additionally shown that the tumor stroma represents not only a restrictive barrier for successful drug delivery, but also serves as a paracrine niche for cancer stem cells. Therefore, we embarked on a large-scale investigation on the effects of combining chemotherapy, hedgehog pathway inhibition, and mTOR inhibition in a preclinical mouse model of pancreatic cancer. EXPERIMENTAL DESIGN: Prospective and randomized testing in a set of almost 200 subcutaneous and orthotopic implanted whole-tissue primary human tumor xenografts. RESULTS: The combined targeting of highly chemoresistant cancer stem cells as well as their more differentiated progenies, together with abrogation of the tumor microenvironment by targeting the stroma and enhancing tissue penetration of the chemotherapeutic agent translated into significantly prolonged survival in preclinical models of human pancreatic cancer. Most pronounced therapeutic effects were observed in gemcitabine-resistant patient-derived tumors. Intriguingly, the proposed triple therapy approach could be further enhanced by using a PEGylated formulation of gemcitabine, which significantly increased its bioavailability and tissue penetration, resulting in a further improved overall outcome. CONCLUSIONS: This multimodal therapeutic strategy should be further explored in the clinical setting as its success may eventually improve the poor prognosis of patients with pancreatic ductal adenocarcinoma
GPU-based Real-time Triggering in the NA62 Experiment
Over the last few years the GPGPU (General-Purpose computing on Graphics
Processing Units) paradigm represented a remarkable development in the world of
computing. Computing for High-Energy Physics is no exception: several works
have demonstrated the effectiveness of the integration of GPU-based systems in
high level trigger of different experiments. On the other hand the use of GPUs
in the low level trigger systems, characterized by stringent real-time
constraints, such as tight time budget and high throughput, poses several
challenges. In this paper we focus on the low level trigger in the CERN NA62
experiment, investigating the use of real-time computing on GPUs in this
synchronous system. Our approach aimed at harvesting the GPU computing power to
build in real-time refined physics-related trigger primitives for the RICH
detector, as the the knowledge of Cerenkov rings parameters allows to build
stringent conditions for data selection at trigger level. Latencies of all
components of the trigger chain have been analyzed, pointing out that
networking is the most critical one. To keep the latency of data transfer task
under control, we devised NaNet, an FPGA-based PCIe Network Interface Card
(NIC) with GPUDirect capabilities. For the processing task, we developed
specific multiple ring trigger algorithms to leverage the parallel architecture
of GPUs and increase the processing throughput to keep up with the high event
rate. Results obtained during the first months of 2016 NA62 run are presented
and discussed
Progress and status of APEmille
We report on the progress and status of the APEmille project: a SIMD parallel
computer with a peak performance in the TeraFlops range which is now in an
advanced development phase. We discuss the hardware and software architecture,
and present some performance estimates for Lattice Gauge Theory (LGT)
applications.Comment: Talk presented at LATTICE97, 3 pages, Late
apeNEXT: A multi-TFlops Computer for Simulations in Lattice Gauge Theory
We present the APE (Array Processor Experiment) project for the development
of dedicated parallel computers for numerical simulations in lattice gauge
theories. While APEmille is a production machine in today's physics simulations
at various sites in Europe, a new machine, apeNEXT, is currently being
developed to provide multi-Tflops computing performance. Like previous APE
machines, the new supercomputer is largely custom designed and specifically
optimized for simulations of Lattice QCD.Comment: Poster at the XXIII Physics in Collisions Conference (PIC03),
Zeuthen, Germany, June 2003, 3 pages, Latex. PSN FRAP15. Replaced for adding
forgotten autho
NEMO: A Project for a km Underwater Detector for Astrophysical Neutrinos in the Mediterranean Sea
The status of the project is described: the activity on long term
characterization of water optical and oceanographic parameters at the Capo
Passero site candidate for the Mediterranean km neutrino telescope; the
feasibility study; the physics performances and underwater technology for the
km; the activity on NEMO Phase 1, a technological demonstrator that has
been deployed at 2000 m depth 25 km offshore Catania; the realization of an
underwater infrastructure at 3500 m depth at the candidate site (NEMO Phase 2).Comment: Proceeding of ISCRA 2006, Erice 20-27 June 200
Measurement of the atmospheric muon flux with the NEMO Phase-1 detector
The NEMO Collaboration installed and operated an underwater detector
including prototypes of the critical elements of a possible underwater km3
neutrino telescope: a four-floor tower (called Mini-Tower) and a Junction Box.
The detector was developed to test some of the main systems of the km3
detector, including the data transmission, the power distribution, the timing
calibration and the acoustic positioning systems as well as to verify the
capabilities of a single tridimensional detection structure to reconstruct muon
tracks. We present results of the analysis of the data collected with the NEMO
Mini-Tower. The position of photomultiplier tubes (PMTs) is determined through
the acoustic position system. Signals detected with PMTs are used to
reconstruct the tracks of atmospheric muons. The angular distribution of
atmospheric muons was measured and results compared with Monte Carlo
simulations.Comment: Astrop. Phys., accepte
Trend of salt intake measured by 24-h urine collection in the Italian adult population between the 2008 and 2018 CUORE project surveys
Background and aims: The WHO Global Action Plan for the Prevention of non-communicable diseases (NCDs) recommends a 30% relative reduction in mean population salt/sodium intake. The study assessed the trend in the habitual salt intake of the Italian adult population from 2008 to 2012 to 2018–2019 based on 24-h urinary sodium excretion, in the framework of the CUORE Project/MINISAL-GIRCSI/MENO SALE PIU’ SALUTE national surveys. Methods and results: Data were from cross-sectional surveys of randomly selected age and sex–stratified samples of resident persons aged 35–74 years in 10 (out of 20) Italian Regions distributed in North, Centre and South of the Country. Urinary sodium and creatinine measurements were carried out in a central laboratory. The analyses included 942 men and 916 women examined in 2008–2012, and 967 men and 1010 women examined in 2018–2019. The age-standardized mean daily population salt (sodium chloride) intake was 10.8 g (95% CI 10.5–11.1) in men and 8.3 g (8.1–8.5) in women in 2008–2012 and respectively 9.5 g (9.3–9.8) and 7.2 g (7.0–7.4) in 2018–2019. A statistically significant (p<0.0001) salt intake reduction was thus observed over 10 years for both genders, and all age, body mass index (BMI) and educational classes. Conclusions: The average daily salt intake of the Italian general adult population remains higher than the WHO recommended level, but a significant reduction of 12% in men and 13% in women has occurred in the past ten years. These results encourage the initiatives undertaken by the Italian Ministry of Health aimed at the reduction of salt intake at the population level
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