Decision support system for the expert assessment of social risks

The study is devoted to the development of decision support systems in the expert assessment of social risk

Algorithm for individual learning content formation in automated machine learning system

The study describes the algorithms used in the formation of individual learning content which can be used in machine learning. The algorithm for generating educational content based on the input test procedure, thereby reducing the number of elementary units of knowledge in the educational conten

System analysis of properties of coatings and indicators of the process of plasma and electrolytic oxidations quality

The article is devoted to solution of the problem of systematization of the parameters for the model that associate the properties of the obtained coatings with the qualitative properties of coatings on the basis of the method of plasma-electrolytic oxidation (PEO) of valve metals. Nowadays for the synthesis of the required parameters of technological processing regimes (electrical regimes, concentrations of the components of the electrolyte) in the process of coatings’ forming various measured parameters of the coating are use

Plasticity of an extra-strong nanocrystalline stainless steel controlled by the "dislocation-segregation'' interaction

We study three structurally different states of nanocrystalline 316 steel and show that the state, where boundaries containing excess concentration of alloying elements are combined with mobile dislocations in grain interiors, allows maintaining extraordinarily high strength and remarkably enhanced plasticity. Underlying mechanisms featuring interaction between the segregations and mobile dislocations are discussed

Значимость математического моделирования работы крупных насосных станций

The article presents main design and structure principles of pumping stations. It specifies basic requirements for the favorable hydraulic operation conditions of the pumping units. The article also describes the designing cases, when computational modeling is necessary to analyse activity of pumping station and provide its reliable operation. A specific example of the large pumping station with submersible pumps describes the process of computational modeling of its operation. As the object of simulation was selected the underground pumping station with a diameter of 26 m and a depth of 13 m, divided into two independent branches, equipped with 8 submersible pumps. The objective of this work was to evaluate the effectiveness of the design solution by CFD methods, to analyze the design of the inlet chamber, to identify possible difficulties with the operation of the facility. In details are described the structure of the considered pumping station and applied computational models of physical processes. The article gives the detailed formulation of the task of simulation and the methods of its solving and presents the initial and boundary conditions. It describes the basic operation modes of the pumping station. The obtained results were presented as the flow patterns for each operation mode with detailed explanations. Data obtained as a result of CFD, prove the correctness of the general design solutions of the project. The submersible pump operation at the minimum water level was verified, was confirmed a lack of vortex formation as well as were proposed measures to improve the operating conditions of the facility. In the inlet chamber there are shown the stagnant zones, requiring separate schedule of cleaning. The measure against floating debris and foam was proposed. It justifies the use of computational modeling (CFD) for the verifying and adjusting of the projects of large pumping stations as a much more precise tool that takes into account all the features of the object compared to the empirical formulas.Приводится современный подход к проектированию крупных насосных станций. Описывается конструктивное оформление заглубленной станции диаметром 26 метров, глубиной 13 метров, с погружными насосными агрегатами. Представлены результаты гидродинамического моделирования (CFD) конкретного объекта. Проводится анализ разработанной проектом приемной камеры с целью определения возможных проблем при эксплуатации насосной станции и предлагаются меры для улучшения условий ее работы. Приведено сравнение расчета минимальных уровней воды в насосных станциях по эмпирическим зависимостям и с помощью метода вычислительной гидродинамики. Обосновано применение гидродинамического моделирования для проверки и корректировки проектов крупных насосных станций как значительно более точного инструмента по сравнению с эмпирическими формулами, учитывающего все особенности объекта. DOI: 10.7463/aplts.0415.081236

Status of ART-XC/SRG Instrument

Spectrum Roentgen Gamma (SRG) is an X-ray astrophysical observatory, developed by Russia in collaboration with Germany. The mission will be launched in March 2016 from Baikonur, by a Zenit rocket with a Fregat booster and placed in a 6-month-period halo orbit around L2. The scientific payload consists of two independent telescopes - a soft-x-ray survey instrument, eROSITA, being provided by Germany and a medium-x-ray-energy survey instrument ART-XC being developed by Russia. ART-XC will consist of seven independent, but co-aligned, telescope modules. The NASA Marshall Space Flight Center (MSFC) is fabricating the flight mirror modules for the ART-XC/SRG. Each mirror module will be aligned with a focal plane CdTe double-sided strip detectors which will operate over the energy range of 6-30 keV, with an angular resolution of less than 1, a field of view of approximately 34 and an expected energy resolution of about 10 percent at 14 keV

HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation.

The internal ribosome entry site (IRES) of the hepatitis C virus (HCV) drives noncanonical initiation of protein synthesis necessary for viral replication. Functional studies of the HCV IRES have focused on 80S ribosome formation but have not explored its role after the 80S ribosome is poised at the start codon. Here, we report that mutations of an IRES domain that docks in the 40S subunit's decoding groove cause only a local perturbation in IRES structure and result in conformational changes in the IRES-rabbit 40S subunit complex. Functionally, the mutations decrease IRES activity by inhibiting the first ribosomal translocation event, and modeling results suggest that this effect occurs through an interaction with a single ribosomal protein. The ability of the HCV IRES to manipulate the ribosome provides insight into how the ribosome's structure and function can be altered by bound RNAs, including those derived from cellular invaders