Stability analysis for yield and its attributing traits in advanced breeding lines of rabi sorghum (Sorghum bicolor (L.) Moench)

An experiment was carried out involving twenty three advanced breeding lines along with two checks M 35-1 and Muguthi during rabi season 2012-13 at four locations. Observations were recorded on 10 different characters viz., plant height (cm), stem diameter (cm), ear head length (cm), ear head diameter (cm), days to 50 per cent flowering, days to maturity, 100 seed weight (g), fodder yield per plot (kg), seed yield per plot (kg), and lodging percentage. The pooled analysis of variance revealed that mean sum of squares due to genotypes was significant for ear head diameter, days to 50 per cent flowering, days to maturity and fodder yield, indicating presence of considerable amount of variability in the genotypes. The mean sum of square due to environment + (genotypes x environment) was significant for plant height, ear head length (cm), ear head diameter (cm), days to 50 per cent flowering, fodder yield per plot (kg), seed yield per plot (kg), and lodging percentage characters except stem diameter, days to maturity and 100 seed yield. On the basis of stability parameters a four genotypes viz., GS-6 (2364 kg/ha), GS-16 (2454 kg/ha), GS-22(2775 kg/ha) and GS-23(2978 kg/ha) were found most stable over Gulbarga, Raichur, Bellary and Malnoor environments of Hyderabad Karnataka region

Flow regime mapping in gas-liquid flow in micro-channels

Experiments were conducted in a micro-channel with square cross-section with each side being 3 mm.nbsp Gas-liquid flow is employed for determining the flow patterns with water being liquid phase and nitrogen being gas phase.nbsp Over a wide range of gas and liquid velocities the flow patterns were studied using visual inspection technique.nbsp It is found that four types of flow regimes occurred within the range of variables considered in the present study.nbsp These are bubble flow, slug flow, channel flow and transient flow.nbsp A flow regime map is also constructed

Character association and path analysis in advanced breeding lines of rabi sorghum [Sorghum bicolor (L.) Moench]

The field experiment was carried out using advanced breeding lines of rabi sorghum to study association among the yield and its component traits, direct and indirect effects of traits on the yield. Association studies indicated that seed yield per plot showed significant positive correlation with traits viz., plant height (rp=+0.7243, rg=+0.7409), ear head length (rp=+0.6002, rg=+0.6021), 100 seed weight (rp=+0.1593, rg=+0.1880), fodder yield (rp=+0.9434, rg=+0.9476) and lodging percentage (rp=+0.5263, rg=+0.5646) at both phenotypic and genotypic level.Genotypic correlation was higher magnitude than phenotypic correlation. Revealed increase in ear head length will increase the seed yield. Partitioning of yield and yield components both at phenotypic and genotypic levels into direct and indirect effects revealed that positive direct effects of ear head length (Ppi=+0.2533, Pgi=+0.5241), ear head diameter (Ppi=+0.0669, Pgi=+0.2580), days to maturity (Ppi=+0.0338, Pgi=+0.1193), fodder yield (Ppi=+0.6484, Pgi=+0.7461) were relatively high and followed by less lodging percentage (Ppi=+0.1751, Pgi=+0.2263). Residual effects were Pr=0.1303 and Gr=0.0624 at phenotypic and genotypic levels. Indicating importance of these characters and can be strategically used to improve the seed yield of sorghum

A prospective observational study of prescription pattern of drugs used in the treatment of osteoarthritis in a tertiary care hospital

Background: Treatment of Osteoarthritis aims at reducing pain and improving mobility. NSAIDS are commonly prescribed for symptomatic relief despite well documented adverse effects. Paracetamol with its better safety profile is recommended as the initial analgesic of choice. Osteoarthritis has significant socio-economic impact on the patients and not many studies are available to reflect upon the prescription pattern of drugs in Osteoarthritis. Hence, this study was chosen to generate important feedback to the clinician. The objectives of the study were to study the prescribing pattern of drugs used in the treatment of Osteoarthritis in Tertiary care hospital.Methods: Prescription for 300 osteoarthritis patients collected cross-sectional for 6 months from orthopedic out-patient department were analyzed.Results: 60% of females were affected. Average age of study was 56.46+/- 7.4 years. Knee joint (87.33%) was most commonly affected joint. Average number of drugs prescribed was 2.62 +/- 0.76. Out of 786 drugs prescribed 45.8% were NSAIDs. Paracetamol was underutilized.Conclusions: Paracetamol was underutilized while other NSAIDs were over prescribed

Probing the Role of Magnetic-Field Variations in NOAA AR 8038 in Producing Solar Flare and CME on 12 May 1997

We carried out a multi-wavelength study of a CME and a medium-size 1B/C1.3 flare occurring on 12 May 1997. We present the investigation of magnetic-field variations in the NOAA Active Region 8038 which was observed on the Sun during 7--16 May 1997. Analyses of H{\alpha} filtergrams and MDI/SOHO magnetograms revealed continual but discrete surge activity, and emergence and cancellation of flux in this active region. The movie of these magnetograms revealed two important results that the major opposite polarities of pre-existing region as well as in the emerging flux region (EFR) were approaching towards each other and moving magnetic features (MMF) were ejecting out from the major north polarity at a quasi-periodicity of about ten hrs during 10--13 May 1997. These activities were probably caused by the magnetic reconnection in the lower atmosphere driven by photospheric convergence motions, which were evident in magnetograms. The magnetic field variations such as flux, gradient, and sunspot rotation revealed that free energy was slowly being stored in the corona. The slow low-layer magnetic reconnection may be responsible for this storage and the formation of a sigmoidal core field or a flux rope leading to the eventual eruption. The occurrence of EUV brightenings in the sigmoidal core field prior to the rise of a flux rope suggests that the eruption was triggered by the inner tether-cutting reconnection, but not the external breakout reconnection. An impulsive acceleration revealed from fast separation of the H{\alpha} ribbons of the first 150 seconds suggests the CME accelerated in the inner corona, which is consistent with the temporal profile of the reconnection electric field. In conclusion, we propose a qualitative model in view of framework of a solar eruption involving, mass ejections, filament eruption, CME, and subsequent flare.Comment: 8 figures, accepted for publication in Solar Physic

ECG De-noising using Hybrid Linearization Method

Electrocardiogram (ECG) is a non-invasive tool that monitors the electrical activity of the heart. An ECG signal is highly prone to the disturbances such as noise contamination, artifacts and other signals interference. So, an ECG signal has to be de-noised so that the distortions can be eliminated from the original signal for the perfect diagnosing of the condition and performance of the heart. Extended Kalman Filter (EKF) de-noises an ECG signal to some extent. This project proposes a method called Hybrid Linearization Method which is a combination of Extended Kalman Filter along with Discrete Wavelet Transform (DWT) resulting in an improved de-noised signal

Causality assessment and the severity of the adverse drug reactions in tertiary care hospital: a pharmacovigilance study

Background: Adverse drug reactions (ADRs) constitute a major clinical problem in terms of human suffering and increased health care costs. To study the adverse drug reactions reported in a tertiary care hospital and study of causality assessment and severity of adverse drug reaction (ADR) cases reported.Methods: A prospective observational study was conducted as part of pharmacovigilance program over 12months between September 2015 and August 2016. Adverse drug reactions reported from hospital were filled into Suspected ADR - CDSCO forms and submitted to pharmacovigilance unit. Causal relationship was assessed and categorized by Naranjo’s algorithm and WHO - UMC causality scale. The severity of each ADR was assessed using Modified Hartwig and Siegel scale.Results: Total 120 cases were reported over 12 months. Among them, 66% were in males and 55% were in females. The majority of ADRs were due to antimicrobial agents (40.78%) followed by haematinics (12%) and anti-epileptics (10%). Maximum number of patients (30.25%) reported with dermatological manifestations. Highest number of ADRs was reported from the department of medicine (45%). As per Naranjo’s scale, 54% reports were assessed as probable and 46% classified as possible. Majority of cases were mild to moderate in severity.Conclusions: The pattern of ADRs reported in our hospital is similar with the pattern of studies conducted in other hospitals elsewhere. This study provides a database of ADRs due to commonly used drugs in our hospital, which will help clinicians for their optimum and safe use. Hence effective pharmacovigilance is required for the use of these drugs and their safety assessment

ANALYSIS OF ADVERSE DRUG REACTIONS SPONTANEOUSLY REPORTED TO ADVERSE DRUG MONITORING CENTRE OF A TERTIARY CARE HOSPITAL–PROSPECTIVE STUDY

Objective: To assess ADRs with reference to causative drugs, organ systems involved and seriousness of reactions.Methods: A prospective study conducted over a period of 1 y. The spontaneous adverse drug reactions reported between July 2016 and July 2017 at AMC centre BRIMS, Bidar were analyzed using Naranjo's scale. Causality assessment of suspected drugs involved, system affected, and seriousness of reactions was assessed.Results: GIT system was most commonly involved, followed by generalized features, skin and appendages, CNS i. e, extrapyramidal system and dizziness, hearing and vestibular systems.Conclusion: Majority of the ADRs reported were mild to moderate severity and 20% can be categorized as severe reactions, which needed to treat under hospitalizatio

ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF SAPONIN FROM ABUTILON INDICUM LEAVES

ABSTRACTObjective: Aim of this study is to analyze the antibacterial and antioxidant potential of crude saponin extract (CSE) from Abutilon indicum leaves.Methods: CSE was subjected for gas chromatography-mass spectrometry (GC-MS) analysis to identify its components. Antibacterial potentialwas analyzed using agar well diffusion method and minimum inhibitory concentration (MIC) was detected using 96-well plate method, againstStaphylococcus aureus (MTCC: 3160) and Escherichia coli (MTCC: 443). DNA damage study was performed using comet assay. Antioxidant capabilitywas studied using 2,2-diphenyl-1-picrylhydrazyl scavenging assay.Results: GC-MS analysis suggested a library match to benzene-1-4-bis(phenylmethyl), with a molecular weight of 258 g/mol to be the majorcomponent in the CSE at 21.25 RT. CSE demonstrated 96.16% free radical scavenging activity at 2.5 mg/ml concentration. CSE demonstrateda significant antibacterial activity in the well diffusion assay, S. aureus 17 mm and E. coli 15 mm, with a MIC value of 1.11 mg/ml. Comet assaydemonstrated no DNA damage.Conclusion: These results conclude that CSE of A. indicum leaves possesses promising antibacterial and antioxidant potential.Keywords: Abutilon indicum, Saponin, Escherichia coli, Staphylococcus aureus, 2,2-diphenyl-1-picrylhydrazyl, Antibacterial assay

Analysis of Human Epidermal Growth Factor Receptor -2 Expression in Gastric Adenocarcinoma

Institution: Govt. Kilpauk Medical College, Chennai BACKGROUND: Gastric carcinoma is the fourth most common cancer in the world. It is a disease of elderly and more common in males. The poor prognosis of gastric tumour is due to late presentation, nonspecific symptoms and limitations in treatment options. An association between clinicopathological features and molecular markers would give a clue toward the relationship between them and hence provide us an extra tool to combat the high mortality. METHODS: A retrospective study was conducted in 100 patients with histopathologically proven gastric adenocarcinoma. In this study , expression of Immuno histochemical marker HER -2 in gastric adeno carcinoma was analysed and compared with various clinicopathological markers. RESULTS: Her -2 Overexpression was seen in 25% of total cases. Positivity for HER-2/Neu was present in 52% of moderately differentiated tumours, 28% of well differentiated tumours and 20% of poorly differentiated tumours CONCLUSION: Statistically significant correlation was found out between Her -2 receptor over expression and different histological grades of gastric adenocarcinoma. Her- 2 receptor over expression is more common in well and moderately differentiated tumours than poorly differentiated tumours