Institution: Govt. Kilpauk Medical College, Chennai
BACKGROUND: Gastric carcinoma is the fourth most common cancer in the world.
It is a disease of elderly and more common in males. The poor prognosis of
gastric tumour is due to late presentation, nonspecific symptoms and limitations
in treatment options. An association between clinicopathological features and
molecular markers would give a clue toward the relationship between them and
hence provide us an extra tool to combat the high mortality.
METHODS: A retrospective study was conducted in 100 patients with
histopathologically proven gastric adenocarcinoma. In this study , expression of
Immuno histochemical marker HER -2 in gastric adeno carcinoma was analysed
and compared with various clinicopathological markers.
RESULTS: Her -2 Overexpression was seen in 25% of total cases. Positivity for
HER-2/Neu was present in 52% of moderately differentiated tumours, 28% of
well differentiated tumours and 20% of poorly differentiated tumours
CONCLUSION: Statistically significant correlation was found out between Her -2
receptor over expression and different histological grades of gastric adenocarcinoma. Her- 2 receptor over expression is more common in well and moderately differentiated tumours than poorly differentiated tumours
