1,345 research outputs found
A wideband CPW ring power combiner with low insertion loss and high port isolation
In this paper we present a coplanar waveguide (CPW)-based ring power combiner that exhibits less than 0.8 dB insertion loss, better than 15 dB port match and higher than 22 dB isolation loss over the frequency range from 50 GHz to 100 GHz. Compared with the conventional 2-way Wilkinson combiner, the proposed ring power combiner replaces the resistor between the two input ports with two quasi quarter-wave CPWs, a 180º CPW phase inverter, and two resistors that lead to frequency-insensitive port isolation and wideband port match. The power combiner is realized using an electron beam-based GaAs MMIC process along with simple electron beam airbridge technology. These results agree well with 3D full-wave simulations
Phase-sensitive FMCW radar system for high-precision Antarctic ice shelf profile monitoring
Ice shelves fringe much of the Antarctic continent, and, despite being up to 2 km thick, are vulnerable to climate change. Owing to their role in helping to control the ice sheet contribution to sea level change there is great interest in measuring the rate at which they are melting into the ocean. This study describes the development and deployment of an ice-penetrating phase-sensitive FMCW radar, sufficiently robust and with sufficiently low-power consumption to be run through the Antarctic winter as a standalone instrument, yet with the stability and mm-precision needed to detect the very slow changes in ice shelf thickness in this exceptionally demanding environment. A number of elegant processing techniques are described to achieve reliable, high-precision performance and results presented on field data obtained from the Larsen-C ice shelf, Antarctica
Incidence of lymph node metastases in clinical early-stage mucinous and seromucinous ovarian carcinoma: a retrospective cohort study
Objective:
The use of lymph node sampling during staging procedures in clinical early-stage mucinous ovarian carcinoma (MOC) is an ongoing matter of debate. Furthermore, the incidence of lymph node metastases (LNM) in MOC in relation to tumour grade (G) is unknown. We aimed to determine the incidence of LNM in clinical early-stage MOC per tumour grade.
Design:
Retrospective study with data from the Dutch Pathology Registry (PALGA).
Setting:
The Netherlands, 2002–2012.
Population or sample:
Patients with MOC.
Methods:
Histology reports on patients with MOC diagnosed in the Netherlands between 2002 and 2012 were obtained from PALGA. Reports were reviewed for diagnosis, tumour grade and presence of LNM. Clinical data, surgery reports and radiology reports of patients with LNM were retrieved from hospital files.
Main outcome measures:
Incidence of LNM, disease-free survival (DFS).
Results:
Of 915 patients with MOC, 426 underwent lymph node sampling. Cytoreductive surgery was performed in 267 patients. The other 222 patients received staging without lymph node sampling. In eight of 426 patients, LNM were discovered by sampling. In four of 190 (2.1%) patients with G1 MOC, LNM were present, compared with one of 115 (0.9%) patients with G2 MOC and three of 22 (13.6%) patients with G3 MOC. Tumour grade was not specified in 99 patients. Patients with clinical early-stage MOC had no DFS benefit from lymph node sampling.
Conclusions:
LNM are rare in early-stage G1 and G2 MOC without clinical suspicion of LNM. Therefore, lymph node sampling can be omitted in these patients
Incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos(t)ide therapy: A systematic review
Background & Aims: Chronic hepatitis B patients are at increased risk for hepatocellular carcinoma (HCC). The effect of medium-term nucleos(t)ide analogue therapy on HCC incidence is unclear; therefore, we systematically reviewed all the data on HCC incidence from studies in chronic hepatitis B patients treated with nucleos(t)ide analogues. Methods: We performed a literature search to identify studies with chronic hepatitis B patients treated with nucleos(t)ide analogues for ⩾24months. Results: Twenty-one studies including 3881 treated and 534 untreated patients met our inclusion criteria. HCC was diagnosed in 2.8% and 6.4% of treated and untreated patients, respectively, during a 46 (32–108) month period (p=0.003), in 10.8% and 0.5% of nucleos(t)ide naive patients with and without cirrhosis (p<0.001) and in 17.6% and 0% of lamivudine resistance patients with and without cirrhosis (p<0.001). HCC developed less frequently in nucleos(t)ide naive patients compared to those without virological remission (2.3% vs 7.5%, p<0.001), but there was no difference between lamivudine resistance patients with or without virological response to rescue therapy (5.9% vs 8.8%, p=0.466). Conclusions: Chronic hepatitis B patients receiving medium-term nucleos(t)ide analogue therapy had a significantly lower incidence of HCC compared to untreated patients but treatment does not completely eliminate the risk of HCC. Among the treated patients, cirrhosis, HBeAg negative at baseline and failure to remain in virological remission were associated with an increased risk of HCC
Intravenous immunoglobulin (IVIg) dampens neuronal toll-like receptor-mediated responses in ischemia
10.1186/s12974-015-0294-8Journal of Neuroinflammation12
Micro-SQUID technique for studying the temperature dependence of switching fields of single nanoparticles
An improved micro-SQUID technique is presented allowing us to measure the
temperature dependence of the magnetisation switching fields of single
nanoparticles well above the critical superconducting temperature of the SQUID.
Our first measurements on 3 nm cobalt nanoparticle embedded in a niobium matrix
are compared to the Neel Brown model describing the magnetisation reversal by
thermal activation over a single anisotropy barrier.Comment: 3 pages, 4 figures; conference proceeding: 1st Joint European
Magnetic Symposia (JEMS'01), Grenoble (France), 28th August - 1st September,
200
Are neuromodulation interventions associated with changes in the gut microbiota?:A systematic review
A Bayesian nonparametric method for detecting rapid changes in disease transmission
Whether an outbreak of infectious disease is likely to grow or dissipate is determined through the time-varying reproduction number, Rt. Real-time or retrospective identification of changes in Rt following the imposition or relaxation of interventions can thus contribute important evidence about disease transmission dynamics which can inform policymaking. Here, we present a method for estimating shifts in Rt within a renewal model framework. Our method, which we call EpiCluster, is a Bayesian nonparametric model based on the Pitman-Yor process. We assume that Rt is piecewise-constant, and the incidence data and priors determine when or whether Rt should change and how many times it should do so throughout the series. We also introduce a prior which induces sparsity over the number of changepoints. Being Bayesian, our approach yields a measure of uncertainty in Rt and its changepoints. EpiCluster is fast, straightforward to use, and we demonstrate that it provides automated detection of rapid changes in transmission, either in real-time or retrospectively, for synthetic data series where the Rt profile is known. We illustrate the practical utility of our method by fitting it to case data of outbreaks of COVID-19 in Australia and Hong Kong, where it finds changepoints coinciding with the imposition of non-pharmaceutical interventions. Bayesian nonparametric methods, such as ours, allow the volume and complexity of the data to dictate the number of parameters required to approximate the process and should find wide application in epidemiology
Nonequilibrium Atom-Dielectric Forces Mediated by a Quantum Field
In this paper we give a first principles microphysics derivation of the
nonequilibrium forces between an atom, treated as a three dimensional harmonic
oscillator, and a bulk dielectric medium modeled as a continuous lattice of
oscillators coupled to a reservoir. We assume no direct interaction between the
atom and the medium but there exist mutual influences transmitted via a common
electromagnetic field. By employing concepts and techniques of open quantum
systems we introduce coarse-graining to the physical variables - the medium,
the quantum field and the atom's internal degrees of freedom, in that order -
to extract their averaged effects from the lowest tier progressively to the top
tier. The first tier of coarse-graining provides the averaged effect of the
medium upon the field, quantified by a complex permittivity (in the frequency
domain) describing the response of the dielectric to the field in addition to
its back action on the field through a stochastic forcing term. The last tier
of coarse- graining over the atom's internal degrees of freedom results in an
equation of motion for the atom's center of mass from which we can derive the
force on the atom. Our nonequilibrium formulation provides a fully dynamical
description of the atom's motion including back action effects from all other
relevant variables concerned. In the long-time limit we recover the known
results for the atom-dielectric force when the combined system is in
equilibrium or in a nonequilibrium stationary state.Comment: 24 pages, 2 figure
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