Politics without Democracy: A Study of the New Principal Officials Accountability in Hong Kong

his Article seeks to discuss a range of issues related to the POAS. These issues include: The one country, two systems framework; The background to the introduction of the POAS; The fundamentals of the POAS; The notion of accountability pre- and post-POAS; An evaluation of executive government systems; The issues arising from the implementation of POAS; and, A best practice ministerial model for Hong Kong

L’impact de l’évolution climatique à Hong Kong et dans le delta de la rivière des Perles

Cet article constitue une première tentative, sur la base des informations disponibles, de brosser un tableau des conséquences de l’évolution climatique dans la région du grand delta de la rivière des Perles (Hong Kong, Macao et le delta de la rivière des Perles). On compte parmi les nombreux effets du réchauffement climatique l’élévation du niveau de la mer qui représente un souci majeur pour cette région déjà extrêmement vulnérable du fait de sa position géographique (le sud du delta se situe entre 0,3 et 0,4 mètre au-dessous du niveau moyen de la mer) et de son urbanisation. Il faudrait mener des recherches plus poussées et construire des modèles pour que les autorités, la communauté d’affaires et la société civile puissent mieux saisir les effets du changement climatique dans cette partie du monde. Cet article montre que l’évolution du climat peut avoir de graves conséquences sur l’économie régionale — celle-ci représente près de 10% du PNB chinois — et présente quelques mesures que le gouvernement et la communauté d’affaires auront à étudier pour faire face à la situation à venir

The Impact of Climate Change in Hong Kong and the Pearl River Delta

This article represents a first attempt to pull together relevant materials with the aim of providing a broad-brush view of how climate change may affect Greater Pearl River Delta (GPRD) region (Hong Kong, Macau and the Pearl River Delta). Among the various consequences of climate change, rising sea levels are a matter of great concern for the GPRD region, which is made vulnerable both by its physical geography (the southern part of the delta lies between - 0.3m to 0.4m relative to mean sea level (MSL)) and its urban development. More in-depth research and modeling remain to be done so that the authorities, business and civil society can better understand climate impacts on the region, but this article shows that climate change could have a big impact on the regional economy, which represents nearly 10% of China’s GNP. The paper concludes with a discussion of the measures that government and businesses will need to consider in order to adapt to these future conditions

The Impact of Climate Change in Hong Kong and the Pearl River Delta

This article represents a first attempt to pull together relevant materials with the aim of providing a broad-brush view of how climate change may affect Greater Pearl River Delta (GPRD) region (Hong Kong, Macau and the Pearl River Delta). Among the various consequences of climate change, rising sea levels are a matter of great concern for the GPRD region, which is made vulnerable both by its physical geography (the southern part of the delta lies between - 0.3m to 0.4m relative to mean sea level (MSL)) and its urban development. More in-depth research and modeling remain to be done so that the authorities, business and civil society can better understand climate impacts on the region, but this article shows that climate change could have a big impact on the regional economy, which represents nearly 10% of China’s GNP. The paper concludes with a discussion of the measures that government and businesses will need to consider in order to adapt to these future conditions

Adaptive immunity restricts replication of novel murine astroviruses

The mechanisms of astrovirus pathogenesis are largely unknown, in part due to a lack of a small-animal model of disease. Using shotgun sequencing and a custom analysis pipeline, we identified two novel astroviruses capable of infecting research mice, murine astrovirus (MuAstV) STL1 and STL2. Subsequent analysis revealed the presence of at least two additional viruses (MuAstV STL3 and STL4), suggestive of a diverse population of murine astroviruses in research mice. Complete genomic characterization and subsequent phylogenetic analysis showed that MuAstV STL1 to STL4 are members of the mamastrovirus genus and are likely members of a new mamastrovirus genogroup. Using Rag1(−/−) mice deficient in B and T cells, we demonstrate that adaptive immunity is required to control MuAstV infection. Furthermore, using Stat1(−/−) mice deficient in innate signaling, we demonstrate a role for the innate immune response in the control of MuAstV replication. Our results demonstrate that MuAstV STL permits the study of the mechanisms of astrovirus infection and host-pathogen interactions in a genetically manipulable small-animal model. Finally, we detected MuAstV in commercially available mice, suggesting that these viruses may be present in academic and commercial research mouse facilities, with possible implications for interpretation of data generated in current mouse models of disease

A Culturally Sensitive Social Support Intervention for Chinese American Breast Cancer Survivors (Joy Luck Academy): Protocol for a Randomized Controlled Trial

© Qian Lu, Krystal Warmoth, Lingjun Chen, Christine S Wu, Qiao Chu, Yisheng Li, Matthew W Gallagher, Annette L Stanton, Marjorie Kagawa Singer, Lucy Young, Alice Loh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/),BACKGROUND: Breast cancer is the most prevalent type of cancer among Asian American women. Chinese American immigrant breast cancer survivors face unique challenges because of cultural and socioecological factors. They report emotional distress and the need for social, emotional, and spiritual support. However, culturally and linguistically appropriate information for managing survivorship health care is often unavailable. OBJECTIVE: To improve the health outcomes for this underserved and understudied population, we developed, designed, and launched a randomized controlled trial to test the health benefits of a culturally sensitive social support intervention (Joy Luck Academy). In this paper, we describe the research protocol. METHODS: This randomized controlled trial will enroll Chinese-speaking, stage 0 to 3 breast cancer survivors who have completed treatment within the previous 36 months using a community-based participatory research approach. We will randomly assign 168 participants to the intervention or control group. The intervention arm will attend 7 weekly 3.5-hour peer mentor and educational sessions. The control group will receive the educational information. We will assess health outcomes at baseline, immediately after the Joy Luck Academy, and at 1- and 4-month follow-ups. The primary outcome is quality of life, as measured by the Functional Assessment of Cancer Therapy scale. Secondary outcomes include depressive symptoms, positive affect, fatigue, and perceived stress. We will also explore how the intervention influences cortisol levels. To identify how and to whom the program is effective, we will measure social and personal resources and theorized mechanisms and perform qualitative interviews with a subsample of participants to enhance the interpretation of quantitative data. RESULTS: Recruitment began in February 2015, and data collection was completed in February 2019. We expect to complete data management by August 2021 and publish results in 2022. CONCLUSIONS: If the Joy Luck Academy is demonstrated to be effective, it may be easily disseminated as an intervention for other groups of Asian American immigrant breast cancer survivors. Furthermore, similar programs could be integrated into other diverse communities.Peer reviewedFinal Published versio

Improving quality of life through the routine use of the patient concerns inventory for head and neck cancer patients: main results of a cluster preference randomised controlled trial

Funding: UK National Institute for Health Research (NIHR) under its Research for Patient Benefit (RfPB) Programme (Grant Reference Number PB-PG-0215-36047).Purpose The patient concerns inventory (PCI) is a prompt list allowing head and neck cancer (HNC) patients to discuss issues that otherwise might be overlooked. This trial evaluated the effectiveness of using the PCI at routine outpatient clinics for one year after treatment on health-related QOL (HRQOL). Methods   A pragmatic cluster preference randomised control trial with 15 consultants, 8 ‘using’ and 7 ‘not using’ the PCI intervention. Patients treated with curative intent (all sites, disease stages, treatments) were eligible. Results   Consultants saw a median (inter-quartile range) 16 (13–26) patients, with 140 PCI and 148 control patients. Of the pre-specified outcomes, the 12-month results for the mean University of Washington Quality of Life (UW-QOLv4) social-emotional subscale score suggested a small clinical effect of intervention of 4.6 units (95% CI 0.2, 9.0), p = 0.04 after full adjustment for pre-stated case-mix. Results for UW-QOLv4 overall quality of life being less than good at 12 months (primary outcome) also favoured the PCI with a risk ratio of 0.83 (95% CI 0.66, 1.06) and absolute risk 4.8% (− 2.9%, 12.9%) but without achieving statistical significance. Other non-a-priori analyses, including all 12 UWQOL domains and at consultant level also suggested better HRQOL with PCI. Consultation times were unaffected and the number of items selected decreased over time. Conclusion   This novel trial supports the integration of the PCI approach into routine consultations as a simple low-cost means of benefiting HNC patients. It adds to a growing body of evidence supporting the use of patient prompt lists more generally.Publisher PDFPeer reviewe