Behaviour of factors II, VII, IX and X in bleeding complications during long-term treatment with Coumarin

In 20 patients suffering from bleeding complications during long-term treatment with phenprocoumon, the depression of the activity of Factors II, VII, IX and X, on the average, was found to be stronger than in so-called adequately treated patients, whereas no statistically significant differences could be demonstrated between the average activity of the 4 factors. The individual variations between the 4 factors were higher than those found in normal individuals and adequately treated patients. Thrombotest activity appeared to be considerably lower than the average factor activity. This discrepancy is mainly caused by the action of the recently discovered circulating anticoagulant occurring in coumarin-treated or vitamin K-deficient patients

Phase Estimation and Phase Ambiguity Resolution by Message Passing

Several code-aided algorithms for phase estimation have recently been proposed. While some of them are ad-hoc, others are derived in a systematic way. The latter can be divided into two different classes: phase estimators derived from the expectation-maximization (EM) principle and estimators that are approximations of the sum-product message passing algorithm. In this paper, the main differences and similarities between these two classes of phase estimation algorithms are outlined and their performance and complexity is compared. Furthermore, an alternative criterion for phase ambiguity resolution is presented and compared to an EM based approach proposed earlier

Loop series for discrete statistical models on graphs

In this paper we present derivation details, logic, and motivation for the loop calculus introduced in \cite{06CCa}. Generating functions for three inter-related discrete statistical models are each expressed in terms of a finite series. The first term in the series corresponds to the Bethe-Peierls (Belief Propagation)-BP contribution, the other terms are labeled by loops on the factor graph. All loop contributions are simple rational functions of spin correlation functions calculated within the BP approach. We discuss two alternative derivations of the loop series. One approach implements a set of local auxiliary integrations over continuous fields with the BP contribution corresponding to an integrand saddle-point value. The integrals are replaced by sums in the complimentary approach, briefly explained in \cite{06CCa}. A local gauge symmetry transformation that clarifies an important invariant feature of the BP solution, is revealed in both approaches. The partition function remains invariant while individual terms change under the gauge transformation. The requirement for all individual terms to be non-zero only for closed loops in the factor graph (as opposed to paths with loose ends) is equivalent to fixing the first term in the series to be exactly equal to the BP contribution. Further applications of the loop calculus to problems in statistical physics, computer and information sciences are discussed.Comment: 20 pages, 3 figure

Improved count rate corrections for highest data quality with PILATUS detectors

A Monte Carlo simulation is presented, which computes the rate correction factors taking into account the detector settings and the time structure of the X-ray beam. The results show good agreement with experimentally determined correction factors

The Effect of Preterm Birth on Thalamic and Cortical Development

Preterm birth is a leading cause of cognitive impairment in childhood and is associated with cerebral gray and white matter abnormalities. Using multimodal image analysis, we tested the hypothesis that altered thalamic development is an important component of preterm brain injury and is associated with other macro- and microstructural alterations. T1- and T2-weighted magnetic resonance images and 15-direction diffusion tensor images were acquired from 71 preterm infants at term-equivalent age. Deformation-based morphometry, Tract-Based Spatial Statistics, and tissue segmentation were combined for a nonsubjective whole-brain survey of the effect of prematurity on regional tissue volume and microstructure. Increasing prematurity was related to volume reduction in the thalamus, hippocampus, orbitofrontal lobe, posterior cingulate cortex, and centrum semiovale. After controlling for prematurity, reduced thalamic volume predicted: lower cortical volume; decreased volume in frontal and temporal lobes, including hippocampus, and to a lesser extent, parietal and occipital lobes; and reduced fractional anisotropy in the corticospinal tracts and corpus callosum. In the thalamus, reduced volume was associated with increased diffusivity. This demonstrates a significant effect of prematurity on thalamic development that is related to abnormalities in allied brain structures. This suggests that preterm delivery disrupts specific aspects of cerebral development, such as the thalamocortical system