“It’s Only a Theory : Science, Religion and Attitudes Toward Evolution

The controversy over evolution is a long standing one in American politics. The issue is often depicted as a conflict between science and religion. In this paper the effects of confidence in science and confidence in religion on attitudes toward human evolution are estimated. Bivariate analysis shows that confidence in science is positively related to belief in human evolution, while confidence in religion has a negative relationship. However, these effects become very weak when controls for religious beliefs and affiliation are imposed. Religious variables, rather than attitudes toward science, seem to be the main sources of attitudes toward evolution

Religion, Partisanship, and Attitudes Towards Science Policy

We examine issues involving science which have been contested in recent public debate. These “contested science” issues include human evolution, stem-cell research, and climate change. We find that few respondents evince consistently skeptical attitudes toward science issues, and that religious variables are generally strong predictors of attitudes toward individual issues. Furthermore, and contrary to analyses of elite discourse, partisan identification is not generally predictive of attitudes toward contested scientific issues

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Retrieving e-Health Research: The Challenge of Accessing the Knowledge

The Internet has increasingly become a viable tool for delivering interventions to promote better health behaviors and manage diseases. As an information and communication tool, it leverages the broad reach of mass media with the interactive features of interpersonal channels. As such, the past 10 years has seen a proliferation of pilot studies, evaluative studies and randomized controlled trials designed to test the efficacy of web-based interventions on health outcomes. These efficacy studies look at a variety of ways Internet-based interventions (e-health) can be used across a number of health conditions and in different contexts. In particular, the last two to three years has seen a significant increase in efficacy studies of web-based interventions published in the literature across different disciplines. The challenge of this from a scholarly perspective is that the sheer number of different ways the literature has been described and indexed has made it increasingly difficult for scholars to locate relevant articles and draw clear conclusions about the efficacy of web-based interventions across disparate fields of interest. This study explores how this field of inquiry has grown and matured in the past 10 years by examining the growth of the literature specific to Internet-based health interventions and to explore the changes in terminologies used to describe this field. A frequency analysis of keywords used to describe web-based health intervention studies was conducted on over 150 peer-reviewed journal articles and a listing of high-value keywords were generated. A large number of unique keywords were discovered to be associated with the body of publications located according to the methodology described. The results of this study will be of specific use to researchers interested in web-based health interventions and will be of practical value in aiding their literature searches. This keyword analysis also reveals interesting insights into the development of an emerging interdisciplinary field of inquiry based on how scholarly activities are being described and/or represented across disciplines and specializations

American Clergy on Evolution and Creationism

Beliefs about evolution and the teaching of creationism among Evangelical Protestant, Mainline Protestant, and Roman Catholic clergy are compared. We hypothesize that Evangelical ministers will be less supportive of evolution than either Mainline clergy or Catholic priests, and that the attitudinal correlates of beliefs about evolution will be similar for all three groups. We also hypothesize that support for teaching creationism will be more pronounced among Evangelical ministers, but that the sources of such support will be similar across religious groups. All hypotheses were confirmed, except that beliefs in the inerrancy of the Bible, or concerning beliefs about evolution, are not related to support for teaching creationism among Catholic priests

Dietary supplements, guideline alignment and biochemical nutrient status in pregnancy: findings from the Queensland Family Cohort pilot study

In high-income nations, multiple micronutrient (MMN) supplementation during pregnancy is a common practice. We aimed to describe maternal characteristics associated with supplement use and daily dose of supplemental nutrients consumed in pregnancy, and whether guideline alignment and nutrient status are related to supplement use. The Queensland Family Cohort is a prospective, Australian observational longitudinal study. Maternal characteristics, nutrient intake from food and supplements, and biochemical nutrient status were assessed in the second trimester (n = 127). Supplement use was reported by 89% of participants, of whom 91% reported taking an MMN supplement. Participants who received private obstetric care, had private health insurance and had greater alignment to meat/vegetarian alternatives recommendations were more likely to report MMN supplement use. Private obstetric care and general practitioner shared care were associated with higher daily dose of supplemental nutrients consumed compared with midwifery group practice. There was high reliance on supplements to meet nutrient reference values for folate, iodine and iron, but only plasma folate concentrations were higher in MMN supplement versus nonsupplement users. Exceeding the upper level of intake for folic acid and iron was more likely among combined MMN and individual supplement/s users, and associated with higher plasma concentrations of the respective nutrients. Given the low alignment with food group recommendations and potential risks associated with high MMN supplement use, whole food diets should be emphasized. This study confirms the need to define effective strategies for optimizing nutrient intake in pregnancy, especially among those most vulnerable where MMN supplement use may be appropriate.</p